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Omegaven saves livers
Many children who have complex liver or intestinal surgery can’t eat normally for a long time after. These children are placed on an intravenous method of feeding called parenteral nutrition (PN).
Back in 2001, surgeon Mark Puder, MD, surgical resident Jenna Garza, MD, and pharmacist Kathy Gura, PharmD, decided to conduct studies in mice to see why PN was causing liver disease. They found evidence that the fat used in standard PN solutions, called Intralipid was contributing to liver disease by causing fat to accumulate in the liver.
They then tested Omegaven, an IV fat mixture made from fish oil. Fish oil contains omega-3 fatty acids, which have been shown to prevent fat accumulation and have anti-inflammatory properties.
As they hoped, PN using Omegaven as the fat prevented liver injury in the mice.
Surgeon Rusty Jennings, MD, who directs Children's Advanced Fetal Care Center, had heard of Puder's research and wanted to try Omegaven in one of his patient. Since Omegaven isn't approved for use in the U.S., Puder had to receive special permission from the FDA to use Omegaven rather than Intralipid in his PN solution.
Within 8 weeks, the baby's liver function improved so much that he was removed from the liver transplant list.
Puder later treated a second child, a premature baby whose bowel had ruptured; he too had complete resolution of liver disease.
Puder and colleagues are now conducting a formal clinical trial, and have received funding from the March of Dimes aimed at preventing liver disease in PN recipients. Their work has caused a worldwide shift in treatment. More than 100 children at Children’s Hospital have received Omegaven, and over 90 percent of them are still alive.
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”