Treatments for Tuberculosis (TB) in Children

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How is TB treated?

TB infection

Your child will need to take medicine to keep his infection from developing into TB disease. The most common medicine used for this is called Isoniazid (INH). It normally takes six to nine months for the medicine to kill the TB germs.

TB disease

If your child has TB disease, he will need to take several different medicines. This is because there are a lot of germs to be killed. Taking several medicines will do a better job of killing all of the germs and preventing them from becoming resistant to the medicines.

The most common medicines used to cure TB disease are:

  • isoniazid (INH)
  • rifampin (RIF)
  • ethambutol
  • pyrazinamide

What are the dangerous side effects of medicines for TB?

The side effects listed below are serious. If your child has any of these symptoms, call your doctor immediately:

  • no appetite
  • nausea
  • vomiting
  • yellowish skin or eyes
  • fever for three or more days
  • abdominal pain
  • tingling fingers or toes
  • skin rash
  • easy bleeding
  • aching joints
  • dizziness
  • tingling or numbness around the mouth
  • bruises easily
  • blurred or changed vision
  • ringing in the ears
  • hearing loss

Why is the course of treatment so long?

The course of treatment is long because TB bacteria die very slowly—it takes at least six months for the medicine to kill all the TB germs in your child's body. We understand that no one likes long courses of treatment—whether you're taking or administering—but it's absolutely necessary that it be completed fully.

What happens if my child stops taking his medicine or doesn't take it regularly?

It is very important that your child takes his or her medicine the way your doctor or nurse has prescribed it. Otherwise, there are two serious dangers:

  • The TB bacteria will start to grow again and your child will stay sick or get worse.
  • The bacteria may become resistant to the medications your child is taking. Your child may need new, different medicines to kill the TB bacteria if the old medicines no longer work. These new medicines must be taken for a longer time and usually have more serious side effects.

What if my child starts feeling better sooner?

Your child will probably start feeling well after only a few weeks of treatment. But the TB bacteria are still alive. Your child must continue to take his medicine regularly until all the TB bacteria are dead.

What happens if my child forgets to take their medicine?

If your child forgets to take their pills one day, skip that dose and have him take the next scheduled dose. Notify your doctor or nurse when this occurs.

How can I keep my child from spreading TB?

The single most important thing is to make sure your child takes all of his medicine, exactly as directed.

You also need to attend all of your follow-up clinic appointments, so your doctor or nurse can see how your child is doing.

Also, make sure your child:

  • always covers his mouth with a tissue when he coughs, sneezes, or laughs.
  • put tissues in a closed bag and throws it away
  • stays home from school
  • avoids close contact with others
  • sleeps in a bedroom away from other family members
  • airs out his room (TB spreads in small closed spaces where air doesn't move)

Remember, TB is spread through the air. People cannot get infected with TB bacteria through handshakes, sitting on toilet seats or sharing dishes and utensils with someone who has TB.

What is multidrug-resistant TB (MDR TB)?

Sometimes TB bacteria become resistant to two or more of the most important medicines: INH and RIF. This is called multidrug-resistant TB, or MDR TB. This is a serious problem.

If your child has MDR TB disease, he must be treated with special medicines. These medicines are not as good as the usual medicines for TB and may cause more side effects. Also, he will probably need to see a TB expert who can closely observe his treatment to make sure it is working.

If you have spent time with someone sick with MDR TB disease, you may become infected with these multidrug-resistant bacteria. If you have a positive skin test reaction, you may be given medicine to keep from developing MDR TB disease.

We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”
- Sandra L. Fenwick, President and CEO

Boston Children's Hospital 300 Longwood Avenue, Boston, MA 02115 617-355-6000 | 800-355-7944

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