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The symptoms of CLOVES can vary a great deal from child to child and can range from mild to severe. They are always present at birth but might not be noticeable right away, depending on how extensive they are.
Generally, in order to be diagnosed with CLOVES syndrome, a child will have one or more of the following:
Less common symptoms can include:
Research by Matthew Warman, MD, director of Boston Children’s Orthopedic Research Laboratories and pathologist Kyle Kurek, MD, has revealed that CLOVES is caused by mutations in a gene called PIK3CA. These mutations arise spontaneously in the womb, while a baby is developing. Thus far, there are no known risk factors that would make these mutations more or less likely to occur.
We are grateful to have been ranked #1 on U.S. News & World Report's list of the best children's hospitals in the nation for the third year in a row, an honor we could not have achieved without the patients and families who inspire us to do our very best for them. Thanks to you, Boston Children's is a place where we can write the greatest children's stories ever told.”