Moyamoya Program | Research and Innovation

 Our current research projects with promise for treating moyamoya and pediatric stroke include:

Neurosurgeon’s pioneering technique helps thousands of children

The longest longitudinal study was conducted by Dr. Ed Smith and Dr. Micheal Scott documenting the innovation of pial synangiosis surgery. The Moyamoya Program at Boston Children's has shown to have fewer complications during surgery, shorter hospital stays, better recovery outcomes and the best long term outcomes. Their techniques have been spread to hospitals around the world. 

Evaluating possible growth factors in blood, cerebrospinal fluid and urine

Boston Children’s neurosurgeon Edward Smith, MD, and his colleagues are studying molecular compounds and growth factors in blood and in cerebrospinal fluid. They believe that these growth factors may yield crucial insights into the causes and progression of moyamoya, and may lead to new therapies not only for that disorder, but also for cancer and other conditions involving the proliferation of blood vessels.

Considering possible nonsurgical treatments for moyamoya

Dr. Smith is also working to determine whether new drug therapies may provide a reasonable alternative to surgery for children with moyamoya.

Identifying biological warning signs for moyamoya

Our researchers are working to identify telltale proteins in blood and urine that could serve as early warning signals for the presence of disease by developing a urinary biomarker panel.

Understanding the role of certain proteins in moyamoya and other disorders

Dr. Smith is investigating whether specific molecules may be culpable in the onset of several diseases of the central nervous system, including moyamoya, brain tumors and vascular malformations of the brain.


For highlights of previous research on moyamoya and related diseases, read our Selected Publications