Maxim Pimkin, MD, PhD

Physician, Cancer and Blood Disorders Center
Instructor in Pediatrics, Harvard Medical School
Image
Maxim Pimkin, MD, PhD

Maxim Pimkin, MD, PhD

Physician, Cancer and Blood Disorders Center
Instructor in Pediatrics, Harvard Medical School

Medical Services

Languages
English
Education
Medical School
Smolensk State Medical Academy
Russia
Residency
Children's Hospital of Pittsburgh of UPMC
Pittsburgh
PA
Fellowship
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
Boston
MA
Certifications
American Board of Pediatrics (General)
Professional History

While a medical student in Russia, my research was focused on various aspects of clinical and molecular microbiology. After graduating from medical school, I pursued a Ph.D. in biochemistry and my research under the mentorship of Dr. G. Douglas Markham at the Fox Chase Cancer Center in Philadelphia was focused on the role of the metabolic enzyme IMP dehydrogenase in the regulation of purine and energy metabolism. Subsequently, my interest in pediatric hematology/oncology and blood development prompted me to join the laboratory of Dr. Mitchell Weiss at the Children’s Hospital of Philadelphia, where I studied the global transcriptional networks that govern hematopoietic lineage priming and specification. In 2011 I joined a Pediatric Residency program at the Children’s Hospital of Pittsburgh, which I finished in 2014, followed by fellowship training in Pediatric Hematology Oncology at the Boston Children’s/Dana-Farber Cancer and Blood Disorders Center from 2014-2017. I am looking forward to a productive academic career where I hope to combine clinical work with basic research in hematopoiesis, stem cell biology and cancer, with the ultimate goal of establishing an independent, NIH-funded laboratory.

Publications

Clinical and immunophenotype correlating with response to immunotherapy in paediatric patients with primary liver carcinoma. A case series. View Abstract
FISH-Flow to quantify nascent and mature ribosomal RNA in mouse and human cells. View Abstract
Construction and validation of customized genomes for human and mouse ribosomal DNA mapping. View Abstract
Rapid-kinetics degron benchmarking reveals off-target activities and mixed agonism-antagonism of MYB inhibitors. View Abstract
Leukemia core transcriptional circuitry is a sparsely interconnected hierarchy stabilized by incoherent feed-forward loops. View Abstract
Control of ribosomal RNA synthesis by hematopoietic transcription factors. View Abstract
Transcriptional Plasticity Drives Leukemia Immune Escape. View Abstract
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts. View Abstract
Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells. View Abstract
A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia. View Abstract
Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesis. View Abstract
Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis. View Abstract
Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. View Abstract
The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. View Abstract
An encyclopedia of mouse DNA elements (Mouse ENCODE). View Abstract
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. View Abstract
A regulatory role of the Bateman domain of IMP dehydrogenase in adenylate nucleotide biosynthesis. View Abstract
Inosine 5'-monophosphate dehydrogenase. View Abstract
The CBS subdomain of inosine 5'-monophosphate dehydrogenase regulates purine nucleotide turnover. View Abstract
Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. View Abstract
Recombinant nucleases CEL I from celery and SP I from spinach for mutation detection. View Abstract
Characterization of a periplasmic S1-like nuclease coded by the Mesorhizobium loti symbiosis island. View Abstract
Multiple outbreaks of nosocomial salmonellosis in Russia and Belarus caused by a single clone of Salmonella enterica serovar Typhimurium producing an extended-spectrum beta-lactamase. View Abstract
Prevalence and molecular epidemiology of CTX-M extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals. View Abstract