Martha Murray, MD
Orthopedic Surgeon-in-Chief, Orthopedics and Sports Medicine Department
Professor of Orthopedic Surgery, Harvard Medical School
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Martha Murray, MD
Orthopedic Surgeon-in-Chief, Orthopedics and Sports Medicine Department
Professor of Orthopedic Surgery, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
BS, Mechanical Engineering
University of Delaware
1987
Newark
NJ
Graduate School
MS, Materials Science and Engineering
Stanford University
1990
Stanford
CA
Medical School
University of Pennsylvania
1994
Philadelphia
PA
Internship
Massachusetts General Hospital
1995
Boston
MA
Residency
Harvard Combined Orthopedic Residency Program
1999
Boston
MA
Fellowship
Boston Children's Hospital
2002
Boston
MA
Certifications
American Board of Orthopedic Surgery (General)
American Board of Orthopedic Surgery (Sports Medicine)
Professional History
Dr. Murray is internationally recognized as an expert in the care of sports injuries of the knee, including injuries to the anterior cruciate ligament (ACL) and meniscus. She has won multiple national awards for her work advancing the care of patients with these injuries, including the Kappa Delta and Cabaud Memorial Awards, respectively the highest research awards in orthopedic surgery and sports medicine.
She is currently working with the National Football League Players Association and the National Institutes of Health to develop a novel technique of ACL surgery: bridge-enhanced ACL repair, which uses a scaffold to help the ACL heal and avoids the need for taking a graft to replace the ACL.
Dr. Murray has over 70 publications in the area of ACL and meniscus surgery. She has specialized in the care of patients with knee injuries, including ACL, meniscus and osteochondritis dissecans lesions, for the past 15 years.
Approach to Care
Providing excellent care of a physical injury, whether surgical or non-surgical, is the primary goal of my practice. However, I also feel it is important for physicians to recognize there are often other issues that may accompany the injury — whether they be social, emotional or intellectual. I feel that understanding the athlete and their entire response to injury is important in obtaining an excellent result after treatment. I also strongly encourage the team approach of working with the athlete, their families and other care providers, including physical therapists and certified athletic trainers, as I think this is the most reliable way to obtain consistently good results for my patients.
Publications
Advancement of an automatic segmentation pipeline for metallic artifact removal in post-surgical ACL MRI. View Abstract
Bridge-Enhanced Anterior Cruciate Ligament Restoration: 6-Year Results From the First-in-Human Cohort Study. View Abstract
Pediatric and Adolescent Distal Radius Fractures: Current Concepts and Treatment Recommendations. View Abstract
Telehealth Potential in Pediatric Orthopaedics and Sports Medicine Care is Comparable to In-Person Care But Disparities Remain. View Abstract
Prevalence and Predictors of Concomitant Meniscal Surgery During Pediatric and Adolescent ACL Reconstruction: Analysis of 4729 Patients Over 20 Years at a Tertiary-Care Regional Children's Hospital. View Abstract
Comprehensive evaluation of magnetic resonance imaging sequences for signal intensity based assessment of anterior cruciate ligament healing following surgical treatment. View Abstract
American Academy of Orthopaedic Surgeons Technology Overview Summary: Platelet-Rich Plasma (PRP) for Knee Osteoarthritis. View Abstract
Musculoskeletal health: an ecological study assessing disease burden and research funding. View Abstract
Prevalence and Predictors of Concomitant Meniscal and Ligamentous Injuries Associated With ACL Surgery: An Analysis of 20 Years of ACL Reconstruction at a Tertiary Care Children's Hospital. View Abstract
How Research Improves Clinical Care: The Case for Orthopaedic Surgeon Research Leadership and Collaboration: AOA Critical Issues Symposium. View Abstract
Microscopic and transcriptomic changes in porcine synovium one year following disruption of the anterior cruciate ligament. View Abstract
LigaNET: A multi-modal deep learning approach to predict the risk of subsequent anterior cruciate ligament injury after surgery. View Abstract
Transcriptomic changes in porcine articular cartilage one year following disruption of the anterior cruciate ligament. View Abstract
Responding to ACL Injury and its Treatments: Comparative Gene Expression between Articular Cartilage and Synovium. View Abstract
Predicting anterior cruciate ligament failure load with T2* relaxometry and machine learning as a prospective imaging biomarker for revision surgery. View Abstract
Quantitative MRI Biomarkers to Predict Risk of Reinjury Within 2 Years After Bridge-Enhanced ACL Restoration. View Abstract
Hydrogel treatment for idiopathic osteoarthritis in a Dunkin Hartley Guinea pig model. View Abstract
Preoperative Risk Factors for Subsequent Ipsilateral ACL Revision Surgery After an ACL Restoration Procedure. View Abstract
Changes in the Cross-Sectional Profile of Treated Anterior Cruciate Ligament Within 2 Years After Surgery. View Abstract
Three-dimensional magnetic resonance imaging analysis shows sex-specific patterns in changes in anterior cruciate ligament cross-sectional area along its length. View Abstract
Effects of Male and Female Sex on the Development of Posttraumatic Osteoarthritis in the Porcine Knee After Anterior Cruciate Ligament Surgery. View Abstract
Early MRI-based quantitative outcomes are associated with a positive functional performance trajectory from 6 to 24 months post-ACL surgery. View Abstract
Automated segmentation of the healed anterior cruciate ligament from T2 * relaxometry MRI scans. View Abstract
Predicting severity of cartilage damage in a post-traumatic porcine model: Synovial fluid and gait in a support vector machine. View Abstract
The FDA and Ensuring Safety and Effectiveness of Devices, Biologics, and Technology. View Abstract
Articular cartilage and synovium may be important sources of post-surgical synovial fluid inflammatory mediators. View Abstract
Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL). View Abstract
Psychological Readiness to Return to Sport at 6 Months Is Higher After Bridge-Enhanced ACL Restoration Than Autograft ACL Reconstruction: Results of a Prospective Randomized Clinical Trial. View Abstract
ACL Size, but Not Signal Intensity, Is Influenced by Sex, Body Size, and Knee Anatomy. View Abstract
Earlier Resolution of Symptoms and Return of Function After Bridge-Enhanced Anterior Cruciate Ligament Repair As Compared With Anterior Cruciate Ligament Reconstruction. View Abstract
Regional Differences in Anterior Cruciate Ligament Signal Intensity After Surgical Treatment. View Abstract
Effects of radiation dose and nitrogen purge on collagen scaffold properties. View Abstract
Peripheral shift in the viable chondrocyte population of the medial femoral condyle after anterior cruciate ligament injury in the porcine knee. View Abstract
Optimizing outcomes of ACL surgery-Is autograft reconstruction the only reasonable option? View Abstract
Enrichment of inflammatory mediators in the synovial fluid is associated with slower progression of mild to moderate osteoarthritis in the porcine knee. View Abstract
Terminal sterilization influences the efficacy of an extracellular matrix-blood composite for treating posttraumatic osteoarthritis in the rat model. View Abstract
Bridge-Enhanced Anterior Cruciate Ligament Repair Leads to Greater Limb Asymmetry and Less Cartilage Damage Than Untreated ACL Transection or ACL Reconstruction in the Porcine Model. View Abstract
A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament. View Abstract
Automated magnetic resonance image segmentation of the anterior cruciate ligament. View Abstract
Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair. View Abstract
Females Have Earlier Muscle Strength and Functional Recovery After Bridge-Enhanced Anterior Cruciate Ligament Repair. View Abstract
Resolution of Pain and Predictors of Postoperative Opioid use after Bridge-Enhanced Anterior Cruciate Ligament Repair and Anterior Cruciate Ligament Reconstruction. View Abstract
Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial. View Abstract
Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis. View Abstract
Risk of Secondary ACL Injury in Adolescents Prescribed Functional Bracing After ACL Reconstruction. View Abstract
Clinical Approach in Youth Sports Medicine: Patients' and Guardians' Desired Characteristics in Sports Medicine Surgeons. View Abstract
Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair. View Abstract
Changes in Cross-sectional Area and Signal Intensity of Healing Anterior Cruciate Ligaments and Grafts in the First 2 Years After Surgery. View Abstract
Predictors of Healing Ligament Size and Magnetic Resonance Signal Intensity at 6 Months After Bridge-Enhanced Anterior Cruciate Ligament Repair. View Abstract
Bridge-Enhanced Anterior Cruciate Ligament Repair: Two-Year Results of a First-in-Human Study. View Abstract
Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. View Abstract
Anatomic Features of the Tibial Plateau Predict Outcomes of ACL Reconstruction Within 7 Years After Surgery. View Abstract
Clinical Approach in Youth Sports Medicine: Patients' and Guardians' Desired Characteristics in Sports Medicine Surgeons. View Abstract
Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. View Abstract
Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL. View Abstract
Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage. View Abstract
Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. View Abstract
Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair. View Abstract
Sensitivity of ACL volume and T2* relaxation time to magnetic resonance imaging scan conditions. View Abstract
The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study. View Abstract
Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model. View Abstract
Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. View Abstract
Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. View Abstract
Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold. View Abstract
Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model. View Abstract
Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds. View Abstract
Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model. View Abstract
Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing. View Abstract
T2* relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model. View Abstract
Bridge-enhanced ACL repair: A review of the science and the pathway through FDA investigational device approval. View Abstract
Bio-enhanced repair of the anterior cruciate ligament. View Abstract
Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model. View Abstract
Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model. View Abstract
Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. View Abstract
A normative study of the synovial fluid proteome from healthy porcine knee joints. View Abstract
Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair? View Abstract
The Effect of Perioperative Ketorolac on the Clinical Failure Rate of Meniscal Repair. View Abstract
Improving the clinical efficiency of T2(*) mapping of ligament integrity. View Abstract
Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction. View Abstract
Basic science of anterior cruciate ligament injury and repair. View Abstract
Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury. View Abstract
T2 * MR relaxometry and ligament volume are associated with the structural properties of the healing ACL. View Abstract
Histologic Predictors of Maximum Failure Loads Differ between the Healing ACL and ACL Grafts after 6 and 12 Months In Vivo. View Abstract
Increasing platelet concentration in platelet-rich plasma inhibits anterior cruciate ligament cell function in three-dimensional culture. View Abstract
Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury. View Abstract
2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues. View Abstract
Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery. View Abstract
Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013. View Abstract
In Situ, noninvasive, T2*-weighted MRI-derived parameters predict ex vivo structural properties of an anterior cruciate ligament reconstruction or bioenhanced primary repair in a porcine model. View Abstract
Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study. View Abstract
Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation, and collagen gene expression. View Abstract
Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. View Abstract
Safety of intra-articular use of atelocollagen for enhanced tissue repair. View Abstract
Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model. View Abstract
The use of magnetic resonance imaging to predict ACL graft structural properties. View Abstract
Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells. View Abstract
The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials. View Abstract
The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots. View Abstract
A comparative anatomical study of the human knee and six animal species. View Abstract
Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression. View Abstract
Effect of anterior cruciate healing on the uninjured ligament insertion site. View Abstract
Treating anterior cruciate ligament tears in skeletally immature patients. View Abstract
Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold. View Abstract
Platelet activation by collagen provides sustained release of anabolic cytokines. View Abstract
Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. View Abstract
The potential for primary repair of the ACL. View Abstract
VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL. View Abstract
Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model. View Abstract
Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament. View Abstract
The effect of skeletal maturity on functional healing of the anterior cruciate ligament. View Abstract
Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals. View Abstract
Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. View Abstract
Age dependence of expression of growth factor receptors in porcine ACL fibroblasts. View Abstract
BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. View Abstract
Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite. View Abstract
Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. View Abstract
The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. View Abstract
Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. View Abstract
Collagen density significantly affects the functional properties of an engineered provisional scaffold. View Abstract
Translational studies in anterior cruciate ligament repair. View Abstract
Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis. View Abstract
Posterior periosteal disruption in Salter-Harris Type II fractures of the distal femur: evidence for a hyperextension mechanism. View Abstract
Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament. View Abstract
TRITON-X is most effective among three decellularization agents for ACL tissue engineering. View Abstract
Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffolds. View Abstract
Storage conditions do not have detrimental effect on allograft collagen or scaffold performance. View Abstract
Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. View Abstract
The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. View Abstract
Genome-wide expression analysis of intra- and extraarticular connective tissue. View Abstract
Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model. View Abstract
Current status and potential of primary ACL repair. View Abstract
Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study. View Abstract
Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold model. View Abstract
Activation of platelet-rich plasma using soluble type I collagen. View Abstract
Strategies to improve anterior cruciate ligament healing and graft placement. View Abstract
In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. View Abstract
The Musculoskeletal System View Abstract
Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. View Abstract
Lateral entry compared with medial and lateral entry pin fixation for completely displaced supracondylar humeral fractures in children. A randomized clinical trial. View Abstract
Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. View Abstract
Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament View Abstract
Type I Collagen as a Platelet Activator in Platelet-Rich Plasma Hydrogels View Abstract
Enhanced Histologic Repair in a Central Defect in the ACL with a Collagen-PRP Scaffold View Abstract
Effect of Collagen Source on Human ACL Cell Proliferation and Platelet Activation View Abstract
The Effect of Collagen Concentration on Platelet-Rich Plasma Hydrogels View Abstract
Histologic Differences in Healing of Intra-Articular and Extra-Articular Ligament Wounds View Abstract
Enhanced Histologic Repair in a Central Defect in the Anterior Cruciate Ligament with a Collagen-Platelet Rich Plasma Scaffold View Abstract
Activation of Platelet-Rich Plasma Using Soluble Type I Collagen View Abstract
Increased blood lead levels in an adolescent girl from a retained bullet. A case report. View Abstract
Pathologic characteristics of the torn human meniscus. View Abstract
Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. View Abstract
The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. View Abstract
The central ACL defect as a model for failure of intra-articular healing. View Abstract
Biology and Gene-Based Therapy View Abstract
Methods and Procedures for Ligament Repair, View Abstract
Multilineage Mesenchymal Differentiation Potential of Cells Migrating out of the Anterior Cruciate Ligament View Abstract
Enhancement of suture repair of the ACL using a collagen-PRP hydrogel View Abstract
Biologic Replacement for Fibrin Clot View Abstract
Delivery Device for Tissue Repair View Abstract
Anterior Cruciate Ligament Healing and Primary Repair View Abstract
Anterior Cruciate Ligament Healing and Primary Repair View Abstract
In Situ IGF-1 Gene Transfer Enhances Healing Response in the Anterior Cruciate Ligament View Abstract
The Effect of Insoluble Collagen Morphology on Fibroblast Migration, Proliferation and Collagen Production View Abstract
Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. View Abstract
Interspecies variation in the fibroblast distribution of the anterior cruciate ligament. View Abstract
Osteochondral defects of the talus treated with autologous bone grafting. View Abstract
The death of articular chondrocytes after intra-articular fracture in humans. View Abstract
Novel Biological Approaches to Enhance Primary Repair of the Anterior Cruciate Ligament View Abstract
In Situ IGF-1 Gene Transfer for Enhancing Healing of the ACL – Evaluation in an in vitro model. Basic Science Poster Prize View Abstract
Biologic Replacement for Fibrin Clot View Abstract
The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. View Abstract
Ligaments View Abstract
The Effect of selected growth factors on human anterior cruciate ligament cell interactions with a three dimensional collagen-GAG scaffold View Abstract
Musculoskeletal Medicine. Bernstein, J. Senior Editor View Abstract
Meniscus View Abstract
Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1. View Abstract
The effect of age on the response to injury in the human ACL View Abstract
The Musculoskeletal System View Abstract
The effects of selected crosslinking protocols on human ACL cell interactions with 3-D collagen-GAG scaffolds View Abstract
Changes in cell number density and smooth muscle actin expression after rupture of the human rotator cuff tendon View Abstract
The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. View Abstract
Biologic Replacement for Fibrin Clot View Abstract
Distribution of smooth muscle actin-containing cells in the human meniscus. View Abstract
The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. View Abstract
Effect of the intra-articular environment on healing of the ruptured anterior cruciate ligament View Abstract
Gender differences in the histology of the human anterior cruciate ligament View Abstract
Histological changes in the human anterior cruciate ligament after rupture. View Abstract
Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. View Abstract
Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds. View Abstract
Biologic Replacement for Fibrin Clot for Intra-articular Use View Abstract
Outgrowth of Chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin View Abstract
Biologic Replacement for Fibrin Clot for Intra-articular Use, Provisional application View Abstract
E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program View Abstract
Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. View Abstract
Guided Tissue Regeneration of the ACL: Preliminary Studies View Abstract
E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program View Abstract
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