Jon A. Vanderhoof, MD
Gastroenterologist, Division of Gastroenterology, Hepatology and Nutrition
Senior Lecturer of Pediatrics, Harvard Medical School
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Jon A. Vanderhoof, MD
Gastroenterologist, Division of Gastroenterology, Hepatology and Nutrition
Senior Lecturer of Pediatrics, Harvard Medical School
Medical Services
Languages
English
Education
Undergraduate School
University of Nebraska
Lincoln
NE
Medical School
University of Nebraska College of Medicine
Omaha
NE
Internship
University of Nebraska Medical Center
Omaha
NE
Residency
University of Nebraska
Omaha
NE
Residency
Pediatric Gastroenterology
UCLA Medical Center
Los Angeles
CA
Certifications
American Board of Pediatrics (General)
American Board of Pediatrics (Gastroenterology)
Professional History
Dr. Jon Vanderhoof joined the faculty at the University of Nebraska College of Medicine in Omaha, Nebraska in 1976 and served as their first Chief of Pediatric Gastroenterology. During his time there, he was instrumental in initiating and developing the intestinal failure program and intestinal transplantation program at the institution. Dr. Vanderhoof was also Executive Director of the Center for Human Nutrition in Omaha and, for a five-year period, chaired the Department of Pediatrics at Creighton University, also in Omaha. In 2002, he became VP for Global Medical Affairs at Mead Johnson Nutrition, a position he held for 9 ½ years. Dr. Vanderhoof has since resumed his academic career at Boston Children’s Hospital where he serves as an attending physician within the Center for Advanced Intestinal Rehabilitation.
Approach to Care
I believe the very best medical care ought to be available to children who are in need of specialized expertise. I have a long-standing interest in the scientific side of medicine. At the same time, I enjoy interacting with and helping people. Medicine provides a unique opportunity to combine the two.
Publications
Infant formula with added Lacticaseibacillus rhamnosus GG supported adequate growth and was well tolerated in healthy term infants: a randomized controlled trial. View Abstract
Extensively Hydrolyzed Formula and Infant Colic Symptoms: Secondary Analysis of a Prospective Cohort Study. View Abstract
Clinician Experience with Using Hypoallergenic Formulas to Treat Infants with Suspected Cow's Milk Protein Allergy: A Secondary Analysis of a Prospective Survey Cohort. View Abstract
Short-term symptom improvement in infants with suspected cow's milk protein allergy using amino acid formula: a prospective cohort analysis. View Abstract
Pediatric Colonic Xanthomas, a Previously Unreported Colonoscopic Finding. View Abstract
Extensively Hydrolyzed Formula Improves Allergic Symptoms in the Short Term in Infants with Suspected Cow's Milk Protein Allergy. View Abstract
The role of probiotics and postbiotics in modulating the gut microbiome-immune system axis in the pediatric age. View Abstract
Stool microbiome, pH and short/branched chain fatty acids in infants receiving extensively hydrolyzed formula, amino acid formula, or human milk through two months of age. View Abstract
Bifidobacterium longum Subspecies infantis (B. infantis) in Pediatric Nutrition: Current State of Knowledge. View Abstract
Stool pH and Short/Branched Chain Fatty Acids in Infants Receiving Extensively Hydrolyzed Formula, Amino Acid Formula, or Human Milk Through Two Months of Age (P11-076-19). View Abstract
Stool Microbiota in Infants Receiving Extensively Hydrolyzed Formula, Amino Acid Formula, or Human Milk Through Two Months of Age (FS04-07-19). View Abstract
Factors Associated with the Development of Immune Tolerance in Children with Cow's Milk Allergy. View Abstract
A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions. View Abstract
Chapter 4. The Relationship Between the European and North American Societies for Pediatric Gastroenterology, Hepatology and Nutrition. View Abstract
An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. View Abstract
Evaluation of an Amino Acid-Based Formula in Infants Not Responding to Extensively Hydrolyzed Protein Formula. View Abstract
Iron Requirements for Infants with Cow Milk Protein Allergy. View Abstract
[In time: misuse and overuse of amino acid formulas in cow milk allergy]. View Abstract
Fermentation pattern of infant formulas containing different prebiotics. View Abstract
Fecal calprotectin and pediatric juvenile polyps. View Abstract
Allergic colitis in monozygotic preterm twins. View Abstract
New prebiotic blend of polydextrose and galacto-oligosaccharides has a bifidogenic effect in young infants. View Abstract
Stool pattern changes in toddlers consuming a follow-on formula supplemented with polydextrose and galactooligosaccharides. View Abstract
Probiotics in the management of children with allergy and other disorders of intestinal inflammation. View Abstract
Diagnosis of cow milk allergy in the gut, never an easy task. View Abstract
Collagenous colitis in a 4-year-old child: response to budesonide. View Abstract
Tolerance of a standard intact protein formula versus a partially hydrolyzed formula in healthy, term infants. View Abstract
National Institutes of Health Gastrointestinal Microbiota and Advances in Prebiotic and Probiotic Research conference summary. View Abstract
Probiotics in allergy management. View Abstract
Hypoallergenicity and effects on growth and tolerance of a new amino acid-based formula with DHA and ARA. View Abstract
Probiotics in the United States. View Abstract
Role of an intestinal rehabilitation program in the treatment of advanced intestinal failure. View Abstract
Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. View Abstract
A retrospective, case-control pilot study of the natural history of pediatric gastroesophageal reflux. View Abstract
Enteric microbial flora, bacterial overgrowth, and short-bowel syndrome. View Abstract
Pediatric applications of probiotics. View Abstract
A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease. View Abstract
Effect of a barley breakfast cereal on blood glucose and insulin response in normal and diabetic patients. View Abstract
Current and potential uses of probiotics. View Abstract
Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. View Abstract
Intestinal rehabilitation and the short bowel syndrome: part 2. View Abstract
Intestinal rehabilitation and the short bowel syndrome: part 1. View Abstract
New and emerging therapies for short bowel syndrome in children. View Abstract
Multicenter experience with upper gastrointestinal polyps in pediatric patients with familial adenomatous polyposis. View Abstract
Lactobacillus GG in inducing and maintaining remission of Crohn's disease. View Abstract
Functional liver recovery parallels autologous gut salvage in short bowel syndrome. View Abstract
Administration of oral probiotic bacteria to pregnant women causes temporary infantile colonization. View Abstract
Hydrolyzed versus nonhydrolyzed protein diet in short bowel syndrome in children. View Abstract
Enteral and parenteral nutrition in the care of patients with short-bowel syndrome. View Abstract
Efficacy of a pre-thickened infant formula: a multicenter, double-blind, randomized, placebo-controlled parallel group trial in 104 infants with symptomatic gastroesophageal reflux. View Abstract
Overview of considerations for the pediatric patient receiving home parenteral and enteral nutrition. View Abstract
Role of probiotics in the management of patients with food allergy. View Abstract
Clinical quiz: windsock duodenal web. View Abstract
Montelukast: use in pediatric patients with eosinophilic gastrointestinal disease. View Abstract
Limitations of probiotic therapy in acute, severe dehydrating diarrhea. View Abstract
New and emerging therapies for short bowel syndrome in children. View Abstract
Analysis of the effect of intestinal resection on rat ileal bile Acid transporter expression and on bile Acid and cholesterol homeostasis. View Abstract
Probiotics in pediatrics. View Abstract
Intestinal transplantation at the University of Nebraska Medical Center: 1990 to 2001. View Abstract
Autoimmune enteropathy in a child: response to infliximab therapy. View Abstract
The Shwachman Award of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, 2001: acceptance. View Abstract
Functional foods and probiotics: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. View Abstract
Research agenda for pediatric gastroenterology, hepatology and nutrition: transplantation. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. View Abstract
Allergic disorders of the gastrointestinal tract. View Abstract
Randomized clinical trial of soy formula with and without added fiber in antibiotic-induced diarrhea. View Abstract
The role of eicosanoids in the process of adaptation following massive bowel resection in the rat. View Abstract
Allergic constipation: association with infantile milk allergy. View Abstract
Probiotics: future directions. View Abstract
Enteral nutrition in short bowel syndrome. View Abstract
Saccharomyces boulardii does not stimulate mucosal hyperplasia after intestinal resection in the rat. View Abstract
The role of probiotics in the treatment of intestinal infections and inflammation. View Abstract
Long-term outcome of intestinal lengthening. View Abstract
A multicenter long-term safety and efficacy trial of preterm formula supplemented with long-chain polyunsaturated fatty acids. View Abstract
What's new in the management of short gut syndrome in children. View Abstract
Isolated intestinal transplantation for intestinal failure. View Abstract
Randomized multicenter trial documenting the efficacy and safety of a lactose-free and a lactose-containing formula for term infants. View Abstract
Nutrition in pediatric inflammatory bowel disease. View Abstract
Probiotics and intestinal inflammatory disorders in infants and children. View Abstract
Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children. View Abstract
Evaluation of a long-chain polyunsaturated fatty acid supplemented formula on growth, tolerance, and plasma lipids in preterm infants up to 48 weeks postconceptional age. View Abstract
Enteral and parenteral nutrition in patients with short-bowel syndrome. View Abstract
Dietary lipids influence intestinal adaptation after massive bowel resection. View Abstract
Chronic diarrhea. View Abstract
Molecular analysis of the adaptive response of intestinal bile acid transport after ileal resection in the rat. View Abstract
Abnormal expression of brush-border membrane transporters in the duodenal mucosa of two patients with microvillus inclusion disease. View Abstract
Use of probiotics in childhood gastrointestinal disorders. View Abstract
Pretransplant management and small bowel-liver transplantation in an infant with microvillus inclusion disease. View Abstract
Synchronous intestinal transplantation inhibits post resection adaptation. View Abstract
Food hypersensitivity in children. View Abstract
Transplanted small bowel and expression of the insulin-like growth factor binding proteins. View Abstract
Treatment strategies for small bowel bacterial overgrowth in short bowel syndrome. View Abstract
Nutritional management of regurgitation in infants. View Abstract
Immunonutrition: the role of carbohydrates. View Abstract
Increasing oral fluids in chronic constipation in children. View Abstract
Correlation of mucosal disaccharidase activities with histology in evaluation of rejection following intestinal transplantation. View Abstract
Methotrexate in patients with Crohn's disease after 6-mercaptopurine. View Abstract
Lack of inhibitory effect of octreotide on intestinal adaptation in short bowel syndrome in the rat. View Abstract
Production of insulin-like growth factor I (IGF-I) and IGF-binding proteins by rat intestinal stromal cells in vitro. View Abstract
Short-bowel syndrome in children and adults. View Abstract
Intolerance to protein hydrolysate infant formulas: an underrecognized cause of gastrointestinal symptoms in infants. View Abstract
Growth hormone and glutamine do not stimulate intestinal adaptation following massive small bowel resection in the rat. View Abstract
Influence of bacterial overgrowth and intestinal inflammation on duration of parenteral nutrition in children with short bowel syndrome. View Abstract
Gastroenteric inflammation in children with ulcerative colitis. View Abstract
Introduction of 6-mercaptopurine in Crohn's disease patients during the perioperative period: a preliminary evaluation of recurrence of disease. View Abstract
Use of soy fiber in acute diarrhea in infants and toddlers. View Abstract
Soy-polysaccharide-supplemented soy formula enhances mucosal disaccharidase levels following massive small intestinal resection in rats. View Abstract
Diagnosis and treatment of chronic intestinal pseudo-obstruction in children: report of consensus workshop. View Abstract
Intestinal transplantation in children. View Abstract
Results of IGF-1 studies show promise in the treatment of intestinal disorders. View Abstract
Preoperative estimation in living related donor transplantation: clinical correlation and donor/recipient ratio. View Abstract
Living related donor liver transplantation at the University of Nebraska Medical Center (1996). View Abstract
Combined liver/small bowel transplantation using a blood group compatible but nonidentical donor. View Abstract
Short bowel syndrome. View Abstract
Growth hormone did not enhance mucosal hyperplasia after small-bowel resection. View Abstract
Short bowel syndrome in children and small intestinal transplantation. View Abstract
Preliminary experience with intestinal transplantation in infants and children. View Abstract
Expression of insulin-like growth factor-II and insulin-like growth factor binding proteins during Caco-2 cell proliferation and differentiation. View Abstract
Clinical denouement and mutation analysis of patients with cystic fibrosis undergoing liver transplantation for biliary cirrhosis. View Abstract
Effect of glutamine-supplemented elemental diet on mucosal adaptation following bowel resection in rats. View Abstract
Short bowel syndrome in children. View Abstract
Surgical approach to short-bowel syndrome. Experience in a population of 160 patients. View Abstract
On the importance of cholecystokinin in neonatal pancreatic growth and secretory development in guinea pigs. View Abstract
Growth stimulation by transfection of intestinal epithelial cells with an antisense insulin-like growth factor binding protein-2 construct. View Abstract
Immunosuppressive drugs and hypertrophic cardiomyopathy. View Abstract
Treatment of cyclic vomiting in childhood with erythromycin. View Abstract
Effect of intestinal harvesting and perfusion on serum and tissue diamine oxidase levels. View Abstract
Dexamethasone inhibits mucosal adaptation after small bowel resection. View Abstract
Preoperative evaluation of donor liver volume in pediatric living related liver transplantation: how accurate is it? View Abstract
Effects of dietary menhaden oil on mucosal adaptation after small bowel resection in rats. View Abstract
Treatment of cyclic vomiting in childhood with erythromycin. View Abstract
Olsalazine versus sulfasalazine in mild to moderate childhood ulcerative colitis: results of the Pediatric Gastroenterology Collaborative Research Group Clinical Trial. View Abstract
Regulatory peptides and intestinal growth. View Abstract
Postnatal development of circulating cholecystokinin and secretin, pancreatic growth, and exocrine function in guinea pigs. View Abstract
Magnesium acetate vs. magnesium gluconate supplementation in short bowel syndrome. View Abstract
Secretion of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 by intestinal epithelial (IEC-6) cells: implications for autocrine growth regulation. View Abstract
Truncated and native insulinlike growth factor I enhance mucosal adaptation after jejunoileal resection. View Abstract
Short bowel syndrome. View Abstract
Effects of oral supplementation of glutamine on small intestinal mucosal mass following resection. View Abstract
A jejunoileal bypass rat model for rapid study of the effects of vitamin malabsorption. View Abstract
Influence of portagen and pregestimil on essential fatty acid status in infantile liver disease. View Abstract
The intestinal absorption of 3-O-methyl-D-glucose in methotrexate-treated rats: an in vivo study of small bowel function. View Abstract
Effect of dietary menhaden oil on normal growth and development and on ameliorating mucosal injury in rats. View Abstract
Experience with intestinal lengthening for the short-bowel syndrome. View Abstract
Long-term central venous access in pediatric liver transplantation recipients: role of percutaneous insertion of subclavian Broviac catheters. View Abstract
Neonatal hepatitis and extrahepatic biliary atresia associated with cytomegalovirus infection in twins. View Abstract
Elevated plasma aluminum levels in normal infants receiving antacids containing aluminum. View Abstract
Characterization of type I and type II insulin-like growth factor receptors in an intestinal epithelial cell line. View Abstract
Effects of dietary lipids on recovery from mucosal injury. View Abstract
Suppression of diamine oxidase activity enhances postresection ileal proliferation in the rat. View Abstract
Home TPN in sparsely populated areas. View Abstract
Effects of dietary linoleic acid on mucosal adaptation after small bowel resection. View Abstract
Liver transplantation therapy for children: Part 2. View Abstract
Nitrogen balance in adult hospitalized patients with the use of a pediatric amino acid model. View Abstract
Morphological and functional effects of 16,16-dimethyl-prostaglandin-E2 on mucosal adaptation after massive distal small bowel resection in the rat. View Abstract
Reduced mucosal prostaglandin synthesis after massive small bowel resection. View Abstract
Liver transplantation therapy for children: Part 1. View Abstract
Essential fatty acid deficiency and postresection mucosal adaptation in the rat. View Abstract
Augmentation of postresection mucosal hyperplasia by plerocercoid growth factor (PGF). Analog of human growth hormone. View Abstract
Juvenile polysaccharidosis with cardioskeletal myopathy. View Abstract
Failure of blind small bowel biopsy in the diagnosis of intestinal lymphangiectasia. View Abstract
Short bowel syndrome in children and adults. View Abstract
Hepatocarcinoma in a child with the Alagille syndrome. View Abstract
Nutritional support for the infant with extrahepatic biliary atresia. View Abstract
Augmentation of mucosal adaptation following massive small-bowel resection by 16,16-dimethyl-prostaglandin E2 in the rat. View Abstract
Effect of zinc deficiency on mucosal hyperplasia following 70% bowel resection. View Abstract
Growth of intestinal neomucosa on prosthetic materials. View Abstract
Familial occurrence of protracted diarrhea of infancy. View Abstract
Orthotopic liver transplantation for type I Crigler-Najjar syndrome. View Abstract
Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels. View Abstract
Intestinal abnormalities with central nervous system malignancy. View Abstract
Effects of isolated zinc deficiency on the composition of skeletal muscle, liver and bone during growth in rats. View Abstract
Lack of correlation of small bowel biopsy and clinical course of patients with intractable diarrhea of infancy. View Abstract
Reduced effect of taxol on plasma protein secretion by developing rat liver. View Abstract
The importance of luminal factors in neomucosal growth. View Abstract
Effects of short-term isolated zinc deficiency on intestinal growth and activities of several brush border enzymes in weaning rats. View Abstract
Effect of intestinal location on growth and function of neomucosa. View Abstract
Intestinal tapering and lengthening for short bowel syndrome. View Abstract
Effect of high percentage medium-chain triglyceride diet on mucosal adaptation following massive bowel resection in rats. View Abstract
Increasing inhibition of hepatic protein secretion by colchicine during development. View Abstract
Comparison of techniques for growing small bowel neomucosa. View Abstract
Effect of casein versus casein hydrolysate on mucosal adaptation following massive bowel resection in infant rats. View Abstract
Reduced effect of microtubule inhibitors on hepatic protein secretion in the fetal rat. View Abstract
Stability of vitamin and mineral concentrations of a low-birth-weight infant formula during continuous enteral feeding. View Abstract
Potential for mucosal adaptation following massive small bowel resection in 3-week-old versus 8-week-old rats. View Abstract
Effect of chronic ethanol ingestion on zinc absorption in rat small intestine. View Abstract
Hair and plasma zinc levels following exclusion of biliopancreatic secretions from functioning gastrointestinal tract in humans. View Abstract
Hepatic protein synthesis and secretion after jejunoileal bypass in the rat. View Abstract
A new parenteral nutrition solution for the treatment of infants with gastrointestinal disorders. View Abstract
Continuous enteral feedings. An important adjunct to the management of complex congenital heart disease. View Abstract
Zinc absorption following massive small-bowel resection in the rat. View Abstract
Current treatment of Reye's syndrome. View Abstract
Effect of antibiotics in the prevention of jejunoileal bypass-induced liver dysfunction. View Abstract
Variation in liver histology in Alagille's syndrome. View Abstract
A rapid procedure for small intestinal biopsy in infants and children. View Abstract
Etiology of jejunoileal bypass-induced liver dysfunction in rats. View Abstract
Effect of improved absorption on development of jejunoileal bypass-induced liver dysfunction in rats. View Abstract
Role of defunctionalized bowel in jejunoileal bypass-induced liver disease in rats. View Abstract
Determination of the site of zinc absorption in rat small intestine. View Abstract
Manometric diagnosis of lower esophageal sphincter incompetence in infants: use of a small, single-lumen perfused catheter. View Abstract
Impaired hepatic drug metabolism after jejunoileal bypass in rats. View Abstract
Esophageal ulcers in immunodeficiency with elevated levels of IgM and neutropenia. View Abstract
Effects of nicotinic aicd on induction of hepatic drug metabolizing enzymes by chronic ethanol administration. View Abstract
Proctosigmoidoscopy and rectal biopsy in infants and children. View Abstract
Proctosigmoidoscopy and rectal biopsy in children. View Abstract
Severe Coombs negative hemolytic anemia in hepatitis B. View Abstract
Congenital chloridorrhea: unexplained growth retardation. View Abstract
Fatal hepatic necrosis due to isoniazid chemoprophylaxis in a 15-year-old girl. View Abstract
Letter: Hiatal hernia and gastroesophageal reflux. View Abstract
The role of exploratory laparotomy for chronic abdominal pain in children. View Abstract