Deletions linked to TP53 loss drive cancer through p53-independent mechanisms.
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Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
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Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.
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Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases.
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Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.
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Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.
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On-chip synthesis and screening of a sialoside library yields a high affinity ligand for Siglec-7.
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Click and pick: identification of sialoside analogues for siglec-based cell targeting.
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Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome.
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High-throughput screening for inhibitors of sialyl- and fucosyltransferases.
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Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells.
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