Evans Syndrome

What is Evans syndrome?

Evans syndrome is an autoimmune disorder in which antibodies attack red blood cells (RBC), which deliver oxygen to body tissues, platelets (which help blood clot), and/or neutrophils (a type of white blood cell). The disorder resembles a combination of autoimmune hemolytic anemia (the destruction of young red blood cells), thrombocytopenia (too few platelets), and neutropenia (too few neutrophils). These may occur simultaneously or one may follow the other.

There is no known genetic cause of Evans syndrome, and occurrences in families are rare. It is considered a chronic disease, with periods of remission and exacerbation. Thrombocytopenia recurs in about 60 percent of patients, while autoimmune hemolytic anemia (AIHA) recurs in about 30 percent.

How we care for Evans syndrome

Children with Evans syndrome are treated at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. Our Blood Disorders Center provides comprehensive diagnostic, treatment, and preventive services for a wide range of non-malignant blood disorders, including Evans syndrome. Your child will receive care from some of the world’s most experienced hematologists.