Current Environment:

Summary

The goal of Advanced Fetal Imaging - Phase II is to advance fetal MRI imaging by designing MRI coils specifically for pregnant women and testing recently developed MRI image acquisition techniques. The investigators aim to more reliably obtain higher quality fetal MRI images when compared to current clinical fetal MRI.

Conditions

Pregnancy

Recruitment Status

Recruiting

Detailed Description

The main aim of this project is to evaluate and optimize the existing clinical magnetic resonance (MR) techniques for fetal imaging, and to also implement and test new MR technologies that would improve fetal imaging in general. This involves the development of new pulse sequences and image acquisition schemes that "freeze" fetal motion and hence provide improved image quality and robustness for both structural (T1- and T2- weighted, susceptibility and FLAIR imaging) and physiological imaging (diffusion, perfusion, spectroscopy, resting-state functional MRI, etc). The scope of this project also includes testing of newly developed radio frequency (RF) receive-only coil arrays that would inherently provide the means for faster imaging of the fetus, and thus complement the software developments.

Eligibility Criteria

Inclusion Criteria:

60 Minute Full Research MRI Scan:

Gestational age between 18 and 40 weeks

AND

Pregnant women with a healthy pregnancy

OR

Pregnant women with a concern for fetal/placental abnormalities referred for a clinical fetal MRI by their obstetrician

OR
Pregnant women with a concern for fetal/placental abnormalities NOT referred for a clinical fetal MRI by their obstetrician

15 Minute Add-On Research Scan:

Gestational age between 18 and 40 weeks

AND

Pregnant women with a concern for fetal abnormalities referred for a clinical fetal MRI by their obstetrician

AND
The clinical fetal MRI will occur at Boston Children's Hospital

Exclusion Criteria:

Pregnant women with a contraindication to MRI (implanted metal, non-removable piercings, pacemaker, etc)
Pregnant women who are claustrophobic
Pregnant women who are medically unstable for an MRI

Intervention

Intervention Type

Intervention Name

Device

Investigational MRI coil designed for pregnant women

Procedure

MRI Scan

Phase

Not Applicable

Gender

Female

Minimum Age

18 Years

Maximum Age

45 Years

Download Date

August 9, 2021

Principal Investigator

Ellen Grant

Primary Contact Information

P. Ellen Grant, MD

857-218-5111

ellen.grant@childrens.harvard.edu

For more information on this trial, visit clinicaltrials.gov.

Contact

For more information and to contact the study team: