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1 Boston Children's Hospital | Education

Medical School

Yale University School of Medicine

2009, New Haven, CT

Internship

Pediatrics

Boston Combined Residency Program (BCRP)

2010, Boston, MA

Residency

Pediatrics

Boston Combined Residency Program (BCRP)

2012, Boston, MA

Fellowship

Pediatric Infectious Diseases

Boston Children's Hospital

2015, Boston, MA

1 Boston Children's Hospital | Publications

  1. Enteric glia regulate Paneth cell secretion and intestinal microbial ecology. Elife. 2025 Apr 14; 13. View Enteric glia regulate Paneth cell secretion and intestinal microbial ecology. Abstract

  2. Functional diversification of dietary plant small molecules by the gut microbiome. Cell. 2025 Apr 03; 188(7):1967-1983.e22. View Functional diversification of dietary plant small molecules by the gut microbiome. Abstract

  3. RELMß sets the threshold for microbiome-dependent oral tolerance. Nature. 2025 Feb; 638(8051):760-768. View RELMß sets the threshold for microbiome-dependent oral tolerance. Abstract

  4. Enteric glia regulate Paneth cell secretion and intestinal microbial ecology. bioRxiv. 2024 Dec 23. View Enteric glia regulate Paneth cell secretion and intestinal microbial ecology. Abstract

  5. ABO blood groups and galectins: Implications in transfusion medicine and innate immunity. Semin Immunol. 2024 Jul-Sep; 74-75:101892. View ABO blood groups and galectins: Implications in transfusion medicine and innate immunity. Abstract

  6. Galectin-4 Antimicrobial Activity Primarily Occurs Through its C-Terminal Domain. Mol Cell Proteomics. 2024 May; 23(5):100747. View Galectin-4 Antimicrobial Activity Primarily Occurs Through its C-Terminal Domain. Abstract

  7. Stress Ulcer Prophylaxis Versus Placebo-A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease. Pediatr Crit Care Med. 2024 Feb 01; 25(2):118-127. View Stress Ulcer Prophylaxis Versus Placebo-A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease. Abstract

  8. C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation. Nature. 2023 Oct; 622(7983):611-618. View C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation. Abstract

  9. Blood group A enhances SARS-CoV-2 infection. Blood. 2023 08 24; 142(8):742-747. View Blood group A enhances SARS-CoV-2 infection. Abstract

  10. Bacterial amylases enable glycogen degradation by the vaginal microbiome. Nat Microbiol. 2023 09; 8(9):1641-1652. View Bacterial amylases enable glycogen degradation by the vaginal microbiome. Abstract

  11. Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip. Microbiome. 2022 11 26; 10(1):201. View Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip. Abstract

  12. Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens. iScience. 2022 Jul 15; 25(7):104482. View Innate immune Galectin-7 specifically targets microbes that decorate themselves in blood group-like antigens. Abstract

  13. The gut microbiome. Curr Biol. 2022 03 28; 32(6):R257-R264. View The gut microbiome. Abstract

  14. Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Cell. 2022 02 03; 185(3):513-529.e21. View Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Abstract

  15. Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Nature. 2021 03; 591(7851):633-638. View Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Abstract

  16. Ecological rules for the assembly of microbiome communities. PLoS Biol. 2021 02; 19(2):e3001116. View Ecological rules for the assembly of microbiome communities. Abstract

  17. Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex. J Clin Invest. 2021 02 01; 131(3). View Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex. Abstract

  18. Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD). Trials. 2020 Jun 29; 21(1):590. View Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD). Abstract

  19. Distribution and storage of inflammatory memory in barrier tissues. Nat Rev Immunol. 2020 05; 20(5):308-320. View Distribution and storage of inflammatory memory in barrier tissues. Abstract

  20. Understanding Competition and Cooperation within the Mammalian Gut Microbiome. Curr Biol. 2019 06 03; 29(11):R538-R544. View Understanding Competition and Cooperation within the Mammalian Gut Microbiome. Abstract

  21. Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types. BMC Biol. 2018 06 05; 16(1):62. View Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types. Abstract

  22. The evolution of the host microbiome as an ecosystem on a leash. Nature. 2017 08 02; 548(7665):43-51. View The evolution of the host microbiome as an ecosystem on a leash. Abstract

  23. Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. Nat Microbiol. 2016 07 25; 1(10):16125. View Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota. Abstract

  24. The evolution of cooperation within the gut microbiota. Nature. 2016 05 12; 533(7602):255-9. View The evolution of cooperation within the gut microbiota. Abstract

  25. Another Reason to Thank Mom: Gestational Effects of Microbiota Metabolites. Cell Host Microbe. 2016 Apr 13; 19(4):425-7. View Another Reason to Thank Mom: Gestational Effects of Microbiota Metabolites. Abstract

  26. Host Selection of Microbiota via Differential Adhesion. Cell Host Microbe. 2016 Apr 13; 19(4):550-9. View Host Selection of Microbiota via Differential Adhesion. Abstract

  27. The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease. Trends Immunol. 2015 Oct; 36(10):578-604. View The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease. Abstract

  28. Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):1929-36. View Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Abstract

  29. Immunology: Starve a fever, feed the microbiota. Nature. 2014 Oct 30; 514(7524):576-7. View Immunology: Starve a fever, feed the microbiota. Abstract

  30. An ecological network of polysaccharide utilization among human intestinal symbionts. Curr Biol. 2014 Jan 06; 24(1):40-49. View An ecological network of polysaccharide utilization among human intestinal symbionts. Abstract

  31. Innate and adaptive immune connections in inflammatory bowel diseases. Curr Opin Gastroenterol. 2010 Nov; 26(6):572-7. View Innate and adaptive immune connections in inflammatory bowel diseases. Abstract

  32. Toll-like receptors and cancer. Nat Rev Cancer. 2009 Jan; 9(1):57-63. View Toll-like receptors and cancer. Abstract

  33. Innate immune recognition of the indigenous microbial flora. Mucosal Immunol. 2008 Nov; 1 Suppl 1:S10-4. View Innate immune recognition of the indigenous microbial flora. Abstract

  34. Role of toll-like receptors in tissue repair and tumorigenesis. Biochemistry (Mosc). 2008 May; 73(5):555-61. View Role of toll-like receptors in tissue repair and tumorigenesis. Abstract

  35. T cell responses to human endogenous retroviruses in HIV-1 infection. PLoS Pathog. 2007 Nov; 3(11):e165. View T cell responses to human endogenous retroviruses in HIV-1 infection. Abstract

  36. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science. 2007 Jul 06; 317(5834):124-7. View Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Abstract

  37. Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest. 2007 Jan; 117(1):83-6. View Prostaglandin-secreting cells: a portable first aid kit for tissue repair. Abstract

  38. Why cancer and inflammation? Yale J Biol Med. 2006 Dec; 79(3-4):123-30. View Why cancer and inflammation? Abstract

  39. Retraction: Regulation of class II expression in monocytic cells after HIV-1 infection. J Immunol. 2006 Nov 01; 177(9):6561. View Retraction: Regulation of class II expression in monocytic cells after HIV-1 infection. Abstract

  40. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity. 2006 Aug; 25(2):319-29. View Role of toll-like receptors in spontaneous commensal-dependent colitis. Abstract

  41. Role of the innate immune system and host-commensal mutualism. Curr Top Microbiol Immunol. 2006; 308:1-18. View Role of the innate immune system and host-commensal mutualism. Abstract

  42. Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. AIDS Res Hum Retroviruses. 2006 Jan; 22(1):52-6. View Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. Abstract

  43. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004 Jul 23; 118(2):229-41. View Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Abstract

  44. Regulation of class II expression in monocytic cells after HIV-1 infection. J Immunol. 2001 Aug 15; 167(4):2331-42. View Regulation of class II expression in monocytic cells after HIV-1 infection. Abstract

1 Boston Children's Hospital | Education

Medical School

University Nacional Autonoma de Mexico

1981, Mexico City, Mexico

Internship

Boston City Hospital

1982, Boston, MA

Residency

Massachusetts General Hospital

1984, Boston, MA

Fellowship

Boston Children's Hospital

1987, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

College of William and Mary

Williamsburg, VA

Medical School

Eastern Virginia Medical School

Norfolk, VA

Residency

University of North Carolina

Chapel Hill, NC

Fellowship

Boston Children's Hospital

Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Medical School

State University of New York at Buffalo

2009, Buffalo, NY

Internship

Washington University in St. Louis

2010, St. Louis, MO

Residency

Washington University in St. Louis

2012, St. Louis, MO

Fellowship

Harvard Medical School

2015, Boston, MA

Fellowship

Harvard Medical School

2017, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Medical School

Tufts University School of Medicine

1990, Boston, MA

Internship

Pediatrics

Boston Children's Hospital

1991, Boston, MA

Residency

Boston Children's Hospital

1993, Boston, MA

Fellowship

Pediatric Infectious Diseases; Pediatric Emergency Medicine

Boston Children's Hospital

1996, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Medical School

University of Massachusetts Medical School

1999, Worcester, MA

Residency

2002

Boston Children's Hospital

Boston, MA

Fellowship

Emergency Medicine

Boston Children's Hospital

2005, Boston, MA

Graduate School

Harvard School of Public Health

2009, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

Harvard College

1983, Cambridge, MA

Medical School

Harvard Medical School

1991, Boston, MA

Internship

Massachusetts General Hospital

1992, Boston, MA

Residency

Massachusetts General Hospital

1997, Boston, MA

Fellowship

Boston Children's Hospital

1999, Boston, MA

Fellowship

Massachusetts General Hospital

1999, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

University of North Carolina

1993, Chapel Hill, NC

Graduate School

MMSc

Harvard Medical School

2006, Boston, MA

Medical School

Wake Forest University

1997, Winston-Salem, NC

Internship

Floating Hospital for Children

1998, Boston, MA

Residency

Floating Hospital for Children

2001, Boston, MA

Fellowship

Critical Care Medicine

Boston Children's Hospital

2004, Boston, MA

1 Boston Children's Hospital | Publications

1 Boston Children's Hospital | Education

Undergraduate School

University of Notre Dame

1986, Notre Dame, IL

Medical School

MD

University of Michigan Medical School

1990, Ann Arbor, MI

Medical School

DMD

University of Pennsylvania School of Dental Medicine

1993, Philadelphia, PA

Graduate School

MBA

Melbourne Business School

2004, Melbourne, Australia

Internship

General Surgery

University of Michigan

1991, Ann Arbor, MI

Residency

Otolaryngology

Massachusetts Eye and Ear Infirmary

1997, Boston, MA

Residency

Plastic Surgery

Brigham & Women's Hospital / Boston Children's Hospital

1999, Boston, MA

Fellowship

Craniofacial Surgery

Royal Children's Hospital

2000, Melbourne, Australia

1 Boston Children's Hospital | Publications

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