ABOUT THE RESEARCHER

OVERVIEW

The Ke Yuan lab will dissect the critical role of pericytes during angiogenesis and aim to understand abnormal vascular remodeling in pulmonary arterial hypertension (PAH) and other pulmonary vascular diseases. The ultimate goal is to identify potential therapeutic targets that could be exploited for the development of new drugs capable of preventing abnormal vessel remodeling and obliteration in PAH.

BACKGROUND

Ke received her PhD in Biology from Temple University, PA in 2011, and was then a postdoctoral fellow at the Division of Pulmonary Critical Care Medicine at Stanford University until 2015 when she joined the faculty. Ke has been recognized nationally as a Parker B Francis Fellow, a fellow of American Heart Association (AHA) and a recipient of AHA Scientist Development Grant, Cournand and Comroe Young Investigator Award.

Selected Publications

  1. Yuan K, Shamskhou EA, Orcholski ME, Nathan A, Reddy S, Honda H, Mani V, Zeng Y, Ozen MO, Wang L, Demirci U, Tian W, Nicolls MR, de Jesus Perez VA. Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension. Circulation. 2019;139(14):1710-24. doi: 10.1161/CIRCULATIONAHA.118.037642. PubMed PMID: 30586764; PMCID: PMC6443444.
  2. Yuan K, Shao NY, Hennigs JK, Discipulo M, Orcholski ME, Shamskhou E, Richter A, Hu X, Wu JC, de Jesus Perez VA. Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. Am J Pathol. 2016;186(9):2500-14. doi: 10.1016/j.ajpath.2016.05.016. PubMed PMID: 27456128; PMCID: PMC5012507.
  3. Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Am J Pathol. 2015;185(1):69-84. doi: 10.1016/j.ajpath.2014.09.013. PubMed PMID: 25447046; PMCID: PMC4278244.
  4. de Jesus Perez VA*, Yuan K*, Lyuksyutova MA, Dewey F, Orcholski ME, Shuffle EM, Mathur M, Yancy L, Jr., Rojas V, Li CG, Cao A, Alastalo TP, Khazeni N, Cimprich KA, Butte AJ, Ashley E, Zamanian RT. Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014;189(10):1260-72. doi: 10.1164/rccm.201310-1749OC. PubMed PMID: 24702692; PMCID: PMC4225850.* co-first author
  5. Yuan K, Lian Z, Sun B, Clayton MM, Ng IO, Feitelson MA. Role of miR-148a in hepatitis B associated hepatocellular carcinoma. PLoS One. 2012;7(4):e35331. doi: 10.1371/journal.pone.0035331. PubMed PMID: 22496917; PMCID: PMC3322146.
  6. Yuan K, Orcholski M, Tian X, Liao X, de Jesus Perez VA. MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension. Expert Opin Ther Targets. 2013;17(5):557-64. doi: 10.1517/14728222.2013.765863. PubMed PMID: 23379818.
  7. Sung YK*, Yuan K*, de Jesus Perez VA. Novel approaches to pulmonary arterial hypertension drug discovery. Expert Opin Drug Discov. 2016;11(4):407-14. doi: 10.1517/17460441.2016.1153625. PubMed PMID: 26901465; PMCID: PMC4933595.*co-first author
  8. Yuan K, Orcholski M, Huang NF and V de Jesus Perez, In Vivo Study Of Human Endothelial–Pericyte Interactions by Implantation Of Matrigel Plugs In SCID Mice, JOVE, 12/19/2016, Issue 118; doi: 10.3791/54617
  9. Yuan K, Cai L, Ngok SP, Ma L, Botham CM. Ten Simple Rules for Writing a Postdoctoral Fellowship. PLoS Comput Biol. 2016;12(7):e1004934. doi: 10.1371/journal.pcbi.1004934. PubMed PMID: 27415752; PMCID: PMC4945040.
  10. de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M. Loss of adenomatous poliposis coli-alpha3 integrin interaction promotes endothelial apoptosis in mice and humans. Circ Res. 2012;111(12):1551-64. doi: 10.1161/CIRCRESAHA.112.267849. PubMed PMID: 23011394; PMCID: PMC3821702

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Klouda T, Condon D, Hao Y, Tian W, Lvova M, Chakraborty A, Nicolls MR, Zhou X, Raby BA, Yuan K. From 2D to 3D: Promising Advances in Imaging Lung Structure. Front Med (Lausanne). 2020; 7:343. View abstract
  2. Yuan K, Liu Y, Zhang Y, Nathan A, Tian W, Yu J, Sweatt AJ, Shamshou EA, Condon D, Chakraborty A, Agarwal S, Auer N, Zhang S, Wu JC, Zamanian RT, Nicolls MR, de Jesus Perez VA. Mural Cell SDF1 Signaling Is Associated with the Pathogenesis of Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol. 2020 06; 62(6):747-759. View abstract
  3. Yuan K, Shamskhou EA, Orcholski ME, Nathan A, Reddy S, Honda H, Mani V, Zeng Y, Ozen MO, Wang L, Demirci U, Tian W, Nicolls MR, de Jesus Perez VA. Loss of Endothelium-Derived Wnt5a Is Associated With Reduced Pericyte Recruitment and Small Vessel Loss in Pulmonary Arterial Hypertension. Circulation. 2019 04 02; 139(14):1710-1724. View abstract
  4. Shamskhou EA, Verghese L, Yuan K, de Jesus Perez VA. EMAPII: A Key Player in HIV-Nef-induced Pulmonary Vasculopathy. Am J Respir Cell Mol Biol. 2019 Mar; 60(3):257-258. View abstract
  5. Shamskhou EA, Kratochvil MJ, Orcholski ME, Nagy N, Kaber G, Steen E, Balaji S, Yuan K, Keswani S, Danielson B, Gao M, Medina C, Nathan A, Chakraborty A, Bollyky PL, De Jesus Perez VA. Hydrogel-based delivery of Il-10 improves treatment of bleomycin-induced lung fibrosis in mice. Biomaterials. 2019 05; 203:52-62. View abstract
  6. Qin L, Kao YW, Lin YL, Peng BY, Deng WP, Chen TM, Lin KC, Yuan KS, Wu AT, Shia BC, Wu SY. Combination of recurrent oral aphthae and dry eye syndrome may constitute an independent risk factor for oral cavity cancer in elderly women. Cancer Manag Res. 2018; 10:3273-3281. View abstract
  7. Qin L, Kao YW, Lin YL, Peng BY, Deng WP, Chen TM, Lin KC, Yuan KS, Wu ATH, Shia BC, Wu SY. Recurrent aphthous stomatitis may be a precursor or risk factor for specific cancers: A case-control frequency-matched study. Cancer Med. 2018 08; 7(8):4104-4114. View abstract
  8. Orcholski ME, Yuan K, Rajasingh C, Tsai H, Shamskhou EA, Dhillon NK, Voelkel NF, Zamanian RT, de Jesus Perez VA. Drug-induced pulmonary arterial hypertension: a primer for clinicians and scientists. . 2018 06 01; 314(6):L967-L983. View abstract
  9. Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo TP, Berry G, Zamanian RT, de Jesus Perez VA. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. . 2017 08 01; 313(2):L252-L266. View abstract
  10. Yuan K, Orcholski ME, Huang NF, de Jesus Perez VA. In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse. J Vis Exp. 2016 12 19; (118). View abstract
  11. Yuan K, Shao NY, Hennigs JK, Discipulo M, Orcholski ME, Shamskhou E, Richter A, Hu X, Wu JC, de Jesus Perez VA. Increased Pyruvate Dehydrogenase Kinase 4 Expression in Lung Pericytes Is Associated with Reduced Endothelial-Pericyte Interactions and Small Vessel Loss in Pulmonary Arterial Hypertension. Am J Pathol. 2016 09; 186(9):2500-14. View abstract
  12. Yuan K, Cai L, Ngok SP, Ma L, Botham CM. Ten Simple Rules for Writing a Postdoctoral Fellowship. PLoS Comput Biol. 2016 07; 12(7):e1004934. View abstract
  13. Sung YK, Yuan K, de Jesus Perez VA. Novel approaches to pulmonary arterial hypertension drug discovery. Expert Opin Drug Discov. 2016; 11(4):407-14. View abstract
  14. Takahashi J, Orcholski M, Yuan K, de Jesus Perez V. PDGF-dependent ß-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension. FEBS Lett. 2016 Jan; 590(1):101-9. View abstract
  15. Vattulainen-Collanus S, Akinrinade O, Li M, Koskenvuo M, Li CG, Rao SP, de Jesus Perez V, Yuan K, Sawada H, Koskenvuo JW, Alvira C, Rabinovitch M, Alastalo TP. Loss of PPAR? in endothelial cells leads to impaired angiogenesis. J Cell Sci. 2016 Feb 15; 129(4):693-705. View abstract
  16. Brunner NW, Zamanian RT, Ikeno F, Mitsutake Y, Connolly AJ, Shuffle E, Yuan K, Orcholski M, Lyons J, de Jesus Perez VA. Optical Coherence Tomography of Pulmonary Arterial Walls in Humans and Pigs (Sus scrofa domesticus). Comp Med. 2015 Jun; 65(3):217-24. View abstract
  17. Chang YT, Tseng CN, Tannenberg P, Eriksson L, Yuan K, de Jesus Perez VA, Lundberg J, Lengquist M, Botusan IR, Catrina SB, Tran PK, Hedin U, Tran-Lundmark K. Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension. Cardiovasc Res. 2015 Jul 01; 107(1):20-31. View abstract
  18. Jiang X, Nguyen TT, Tian W, Sung YK, Yuan K, Qian J, Rajadas J, Sallenave JM, Nickel NP, de Jesus Perez V, Rabinovitch M, Nicolls MR. Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection. Am J Transplant. 2015 Jul; 15(7):1768-81. View abstract
  19. Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, Kuchinsky A, Hazen SL, Jukema JW, Ganesh SK, Nabel EG, Channon K, Leon MB, Charest A, Quertermous T, Ashley EA. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. J Clin Invest. 2014 Dec; 124(12):5159-74. View abstract
  20. Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Am J Pathol. 2015 Jan; 185(1):69-84. View abstract
  21. de Jesus Perez V, Yuan K, Alastalo TP, Spiekerkoetter E, Rabinovitch M. Targeting the Wnt signaling pathways in pulmonary arterial hypertension. Drug Discov Today. 2014 Aug; 19(8):1270-6. View abstract
  22. Li M, Vattulainen S, Aho J, Orcholski M, Rojas V, Yuan K, Helenius M, Taimen P, Myllykangas S, De Jesus Perez V, Koskenvuo JW, Alastalo TP. Loss of bone morphogenetic protein receptor 2 is associated with abnormal DNA repair in pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1118-28. View abstract
  23. de Jesus Perez VA, Yuan K, Lyuksyutova MA, Dewey F, Orcholski ME, Shuffle EM, Mathur M, Yancy L, Rojas V, Li CG, Cao A, Alastalo TP, Khazeni N, Cimprich KA, Butte AJ, Ashley E, Zamanian RT. Whole-exome sequencing reveals TopBP1 as a novel gene in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 May 15; 189(10):1260-72. View abstract
  24. Tian W, Jiang X, Sung YK, Qian J, Yuan K, Nicolls MR. Leukotrienes in pulmonary arterial hypertension. Immunol Res. 2014 May; 58(2-3):387-93. View abstract
  25. Brunner N, de Jesus Perez VA, Richter A, Haddad F, Denault A, Rojas V, Yuan K, Orcholski M, Liao X. Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery. Pulm Circ. 2014 Mar; 4(1):10-24. View abstract
  26. Chen HM, Hu ZK, Zheng XL, Yuan ZS, Xu ZB, Yuan LQ, Perez VA, Yuan K, Orcholski M, Liao XB. Effectiveness of YouTube as a Source of Medical Information on Heart Transplantation. Interact J Med Res. 2013 Nov 21; 2(2):e28. View abstract
  27. Jiang X, Hsu JL, Tian W, Yuan K, Olcholski M, Perez Vde J, Semenza GL, Nicolls MR. Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus. J Mol Med (Berl). 2013 Sep; 91(9):1081-93. View abstract
  28. Liao XB, Zhang ZY, Yuan K, Liu Y, Feng X, Cui RR, Hu YR, Yuan ZS, Gu L, Li SJ, Mao DA, Lu Q, Zhou XM, de Jesus Perez VA, Yuan LQ. MiR-133a modulates osteogenic differentiation of vascular smooth muscle cells. Endocrinology. 2013 Sep; 154(9):3344-52. View abstract
  29. Yuan K, Orcholski M, Tian X, Liao X, de Jesus Perez VA. MicroRNAs: promising therapeutic targets for the treatment of pulmonary arterial hypertension. Expert Opin Ther Targets. 2013 May; 17(5):557-64. View abstract
  30. de Jesus Perez VA, Yuan K, Orcholski ME, Sawada H, Zhao M, Li CG, Tojais NF, Nickel N, Rajagopalan V, Spiekerkoetter E, Wang L, Dutta R, Bernstein D, Rabinovitch M. Loss of adenomatous poliposis coli-a3 integrin interaction promotes endothelial apoptosis in mice and humans. Circ Res. 2012 Dec 07; 111(12):1551-64. View abstract
  31. Yuan K, Lian Z, Sun B, Clayton MM, Ng IO, Feitelson MA. Role of miR-148a in hepatitis B associated hepatocellular carcinoma. PLoS One. 2012; 7(4):e35331. View abstract