ABOUT THE RESEARCHER

OVERVIEW

Dr. Vajapeyam's research interests are in the areas of MR image and data processing, with special emphasis on brain tumors and diffusion. His research goals include: Developing image and data analysis methods for magnetic resonance imaging and magnetic resonance spectroscopy Studying white matter development of the human brain in infancy and childhood Diffusion tensor imaging and tractography in the human brain Applications of magnetic resonance methods for the characterization, assessment and treatment of human brain neoplasms 

 

BACKGROUND

Dr. Vajapeyam did his undergraduate work in mechanical engineering at the Indian Institute of Technology in Madras, India. He earned his ME and PhD degrees in mechanical engineering from the University of Delaware and completed a 3-year postdoctoral fellowship at Children’s Hospital Boston in 1997.

PUBLICATIONS

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  1. MR Imaging Correlates for Molecular and Mutational Analyses in Children with Diffuse Intrinsic Pontine Glioma. AJNR Am J Neuroradiol. 2020 05; 41(5):874-881. View abstract
  2. Advanced ADC Histogram, Perfusion, and Permeability Metrics Show an Association with Survival and Pseudoprogression in Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium. AJNR Am J Neuroradiol. 2020 04; 41(4):718-724. View abstract
  3. Quantifying radiation therapy response using apparent diffusion coefficient (ADC) parametric mapping of pediatric diffuse intrinsic pontine glioma: a report from the pediatric brain tumor consortium. J Neurooncol. 2019 May; 143(1):79-86. View abstract
  4. MR Imaging-Based Radiomic Signatures of Distinct Molecular Subgroups of Medulloblastoma. AJNR Am J Neuroradiol. 2019 01; 40(1):154-161. View abstract
  5. Magnetic resonance imaging and spectroscopy evidence of efficacy for adrenal and gonadal hormone replacement therapy in anorexia nervosa. Bone. 2018 05; 110:335-342. View abstract
  6. Multiparametric Analysis of Permeability and ADC Histogram Metrics for Classification of Pediatric Brain Tumors by Tumor Grade. AJNR Am J Neuroradiol. 2018 Mar; 39(3):552-557. View abstract
  7. Bone marrow fat content in 70 adolescent girls with anorexia nervosa: Magnetic resonance imaging and magnetic resonance spectroscopy assessment. Pediatr Radiol. 2017 Jul; 47(8):952-962. View abstract
  8. Correlation of 18F-FDG PET and MRI Apparent Diffusion Coefficient Histogram Metrics with Survival in Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium. J Nucl Med. 2017 08; 58(8):1264-1269. View abstract
  9. Automated Processing of Dynamic Contrast-Enhanced MRI: Correlation of Advanced Pharmacokinetic Metrics with Tumor Grade in Pediatric Brain Tumors. AJNR Am J Neuroradiol. 2017 Jan; 38(1):170-175. View abstract
  10. Apparent diffusion coefficient histogram metrics correlate with survival in diffuse intrinsic pontine glioma: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol. 2016 05; 18(5):725-34. View abstract
  11. A phase I trial and PK study of cediranib (AZD2171), an orally bioavailable pan-VEGFR inhibitor, in children with recurrent or refractory primary CNS tumors. Childs Nerv Syst. 2015 Sep; 31(9):1433-45. View abstract
  12. Pediatric brain tumor consortium multisite assessment of apparent diffusion coefficient z-axis variation assessed with an ice-water phantom. Acad Radiol. 2015 Mar; 22(3):363-9. View abstract
  13. White matter microstructure and cognition in adolescents with congenital heart disease. J Pediatr. 2014 Nov; 165(5):936-44.e1-2. View abstract
  14. 18F-FDG PET and MR imaging associations across a spectrum of pediatric brain tumors: a report from the pediatric brain tumor consortium. J Nucl Med. 2014 Sep; 55(9):1473-80. View abstract
  15. Efficacy of bevacizumab plus irinotecan in children with recurrent low-grade gliomas--a Pediatric Brain Tumor Consortium study. Neuro Oncol. 2014 Jan; 16(2):310-7. View abstract
  16. Exploratory evaluation of MR permeability with 18F-FDG PET mapping in pediatric brain tumors: a report from the Pediatric Brain Tumor Consortium. J Nucl Med. 2013 Aug; 54(8):1237-43. View abstract
  17. Adolescents with D-transposition of the great arteries repaired in early infancy demonstrate reduced white matter microstructure associated with clinical risk factors. J Thorac Cardiovasc Surg. 2013 Sep; 146(3):543-9.e1. View abstract
  18. Lack of efficacy of bevacizumab + irinotecan in cases of pediatric recurrent ependymoma--a Pediatric Brain Tumor Consortium study. Neuro Oncol. 2012 Nov; 14(11):1404-12. View abstract
  19. The use of magnetic resonance imaging to predict ACL graft structural properties. J Biomech. 2011 Nov 10; 44(16):2843-6. View abstract
  20. MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol. 2011 Apr; 13(4):417-27. View abstract
  21. Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. J Nucl Med. 2011 Feb; 52(2):188-95. View abstract
  22. DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium. Childs Nerv Syst. 2011 Jan; 27(1):11-8. View abstract
  23. Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. J Clin Oncol. 2010 Jun 20; 28(18):3069-75. View abstract
  24. Bone marrow changes in adolescent girls with anorexia nervosa. J Bone Miner Res. 2010 Feb; 25(2):298-304. View abstract
  25. Catheter angiography, MR angiography, and MR perfusion in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol. 2009 Feb; 30(2):E19; author reply E20. View abstract
  26. The Neuroimaging Center of the Pediatric Brain Tumor Consortium-collaborative neuroimaging in pediatric brain tumor research: a work in progress. AJNR Am J Neuroradiol. 2007 Apr; 28(4):603-7. View abstract
  27. Phase II study of thalidomide and radiation in children with newly diagnosed brain stem gliomas and glioblastoma multiforme. J Neurooncol. 2007 Mar; 82(1):95-101. View abstract
  28. Magnetization transfer studies of the fast and slow tissue water diffusion components in the human brain. NMR Biomed. 2005 May; 18(3):186-94. View abstract
  29. Fat fractions and spectral T2 values in vertebral bone marrow in HIV- and non-HIV-infected men: a 1H spectroscopic imaging study. Magn Reson Med. 2004 Sep; 52(3):552-8. View abstract
  30. Prolonged T*2 values in newborn versus adult brain: Implications for fMRI studies of newborns. Magn Reson Med. 2004 Jun; 51(6):1287-91. View abstract
  31. Early experience alters brain function and structure. Pediatrics. 2004 Apr; 113(4):846-57. View abstract
  32. Biexponential diffusion tensor analysis of human brain diffusion data. Magn Reson Med. 2004 Feb; 51(2):321-30. View abstract
  33. Normal and ischemic epiphysis of the femur: diffusion MR imaging study in piglets. Radiology. 2003 Jun; 227(3):825-32. View abstract
  34. A functional magnetic resonance imaging study of paced finger tapping in children. Pediatr Neurol. 2003 Feb; 28(2):89-95. View abstract
  35. Biexponential apparent diffusion coefficient parametrization in adult vs newborn brain. Magn Reson Imaging. 2001 Jun; 19(5):659-68. View abstract
  36. Childhood moyamoya disease: hemodynamic MRI. Pediatr Radiol. 1997 Sep; 27(9):727-35. View abstract
  37. Multivoxel proton MR spectroscopy and hemodynamic MR imaging of childhood brain tumors: preliminary observations. AJNR Am J Neuroradiol. 1997 Feb; 18(2):203-18. View abstract