Researcher | Research Overview
Dr. Brennan-Krohn’s research involves the evaluation of antimicrobial combinations for synergistic activity against multidrug-resistant Gram-negative bacteria, specifically carbapenem-resistant Enterobacteriaceae (CRE). These pathogens, which are increasing in frequency worldwide, are very challenging to treat and tend to affect patients critically ill patients, in whom antibiotic selection may be complicated by factors including underlying illness and drug-drug interactions. Combination therapy is frequently used to treat such infections, with the goal of achieving synergistic activity between two drugs, but much remains to be understood about the mechanisms of action of antimicrobial combinations and about how to determine which combinations, if any, are likely to be effective against which pathogens. Dr. Brennan-Krohn’s research aims to identify promising combination regimens and to improve diagnostic methods for synergy testing.
Researcher | Research Background
Dr. Brennan-Krohn earned her BA in Classics from Brown University and her MD from Stanford University School of Medicine, then completed a Pediatrics residency and pediatric Infectious Diseases fellowship at Boston Children’s Hospital. She also completed a medical microbiology fellowship at Beth Israel Deaconess Medical Center and is a diplomate of the American Board of Medical Microbiology. Dr. Brennan-Krohn joined the division of Infectious Diseases as faculty in 2017. Her research is performed in the laboratory of Dr. James Kirby at Beth Israel Deaconess Medical Center.