Comparative genomics with a focus on aging and age-related diseases, leveraging natural examples of exceptional longevity to decipher mechanisms facilitating senescence resistance. Animals that resist the rigors of time well past a human lifespan, that maintain health and function for centuries, will inform therapies to delay and/or prevent aging and age-related diseases in people.


Publications powered by Harvard Catalyst Profiles

  1. Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. Curr Biol. 2020 Jul 20; 30(14):2805-2814.e3. View abstract
  2. celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. Elife. 2020 01 27; 9. View abstract
  3. Longevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis. PLoS One. 2015; 10(11):e0143680. View abstract
  4. Superior proteome stability in the longest lived animal. Age (Dordr). 2014 Jun; 36(3):9597. View abstract
  5. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014 Feb; 69(2):119-30. View abstract
  6. Efficient derivation of embryonic stem cells from nuclear transfer and parthenogenetic embryos derived from cryopreserved oocytes. Cell Reprogram. 2010 Apr; 12(2):203-11. View abstract