Comparative genomics with a focus on aging and age-related diseases, leveraging natural examples of exceptional longevity to decipher mechanisms facilitating senescence resistance. Animals that resist the rigors of time well past a human lifespan, that maintain health and function for centuries, will inform therapies to delay and/or prevent aging and age-related diseases in people.


Publications powered by Harvard Catalyst Profiles

  1. Refining Convergent Rate Analysis with Topology in Mammalian Longevity and Marine Transitions. Mol Biol Evol. 2021 Jul 29. View abstract
  2. Footprints in the Sand: Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity. Front Genet. 2021; 12:678073. View abstract
  3. Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. Curr Biol. 2020 07 20; 30(14):2805-2814.e3. View abstract
  4. celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. Elife. 2020 01 27; 9. View abstract
  5. Longevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis. PLoS One. 2015; 10(11):e0143680. View abstract
  6. Superior proteome stability in the longest lived animal. Age (Dordr). 2014 Jun; 36(3):9597. View abstract
  7. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014 Feb; 69(2):119-30. View abstract
  8. Efficient derivation of embryonic stem cells from nuclear transfer and parthenogenetic embryos derived from cryopreserved oocytes. Cell Reprogram. 2010 Apr; 12(2):203-11. View abstract