ABOUT THE RESEARCHER

OVERVIEW

Dr. Sun’s research interests focus on the roles of neurovascular interaction and neuroinflammation in the development of vascular eye disorders including neovascular AMD, retinopathy of prematurity and diabetic retinopathy and tumorigenesis using mouse models, and develop effective ways to treat or prevent vision loss and cancer. Her current research projects include: 1) the mechanisms of neurovascular interaction in controlling retinal neovascularization; 2) SOCS3 mediates retinal neovascularization and neuroinflammation; 3) c-Fos controls neovascularization and inflammation.

BACKGROUND

Dr. Ye Sun obtained her PhD from Jilin University at China and completed her postdoctoral fellowship training at Department of Urology/Surgery at Boston Children’s Hospital before joining Department of Ophthalmology at Boston Children’s Hospital.

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Referral for Intervention in Severe Symptomatic Aortic Stenosis: Some Progress But Further Room for Improvement. J Am Coll Cardiol. 2021 11 30; 78(22):2144-2146. View abstract
  2. Quantification of retinal blood leakage in fundus fluorescein angiography in a retinal angiogenesis model. Sci Rep. 2021 10 06; 11(1):19903. View abstract
  3. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 Aug; 6(35):eaba7457. View abstract
  4. Glycolysis links reciprocal activation of myeloid cells and endothelial cells in the retinal angiogenic niche. Sci Transl Med. 2020 08 05; 12(555). View abstract
  5. Targeting Neuroinflammation in Neovascular Retinal Diseases. Front Pharmacol. 2020; 11:234. View abstract
  6. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. View abstract
  7. Targeting Neurovascular Interaction in Retinal Disorders. Int J Mol Sci. 2020 Feb 22; 21(4). View abstract
  8. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). View abstract
  9. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. View abstract
  10. MicroRNA-145 Regulates Pathological Retinal Angiogenesis by Suppression of TMOD3. Mol Ther Nucleic Acids. 2019 Jun 07; 16:335-347. View abstract
  11. Thrombocytopenia is associated with severe retinopathy of prematurity. JCI Insight. 2018 10 04; 3(19). View abstract
  12. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. View abstract
  13. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. View abstract
  14. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. View abstract
  15. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View abstract
  16. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View abstract
  17. Sema3f Protects Against Subretinal Neovascularization In Vivo. EBioMedicine. 2017 Apr; 18:281-287. View abstract
  18. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. View abstract
  19. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View abstract
  20. Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Circ Res. 2016 Mar 18; 118(6):957-969. View abstract
  21. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View abstract
  22. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. View abstract
  23. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View abstract
  24. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View abstract
  25. A mouse model of urofacial syndrome with dysfunctional urination. Hum Mol Genet. 2015 Apr 01; 24(7):1991-9. View abstract
  26. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View abstract
  27. The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway. Oncogene. 2015 May 07; 34(19):2527-37. View abstract
  28. The canonical wnt signal restricts the glycogen synthase kinase 3/fbw7-dependent ubiquitination and degradation of eya1 phosphatase. Mol Cell Biol. 2014 Jul; 34(13):2409-17. View abstract
  29. Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts. Dev Biol. 2014 Jan 01; 385(1):41-51. View abstract
  30. EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. Cancer Res. 2013 Jul 15; 73(14):4488-99. View abstract
  31. Asymmetric requirement of surface epithelial ß-catenin during the upper and lower jaw development. Dev Dyn. 2012 Apr; 241(4):663-74. View abstract
  32. Six1 and Eya1 are critical regulators of peri-cloacal mesenchymal progenitors during genitourinary tract development. Dev Biol. 2011 Dec 01; 360(1):186-94. View abstract
  33. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr; 121(4):1585-95. View abstract
  34. A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases. Int J Biochem Cell Biol. 2008; 40(10):2090-7. View abstract
  35. Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol. 2007 Aug; 27(15):5393-402. View abstract
  36. The molecular mechanism of protecting cells against oxidative stress by 2-selenium-bridged beta-cyclodextrin with glutathione peroxidase activity. Biochim Biophys Acta. 2005 Apr 15; 1743(3):199-204. View abstract
  37. Selenium-containing 15-mer peptides with high glutathione peroxidase-like activity. J Biol Chem. 2004 Sep 03; 279(36):37235-40. View abstract
  38. Protection of epidermal cells against UVB injury by the antioxidant selenium-containing single-chain Fv catalytic antibody. Arch Biochem Biophys. 2003 Apr 01; 412(1):90-4. View abstract