PUBLICATIONS

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  1. What Every Reader Should Know About Studies Using Electronic Health Record Data but May be Afraid to Ask. J Med Internet Res. 2021 01 10. View abstract
  2. Structural impact on SARS-CoV-2 spike protein by D614G substitution. bioRxiv. 2020 Oct 13. View abstract
  3. International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ Digit Med. 2020; 3:109. View abstract
  4. Virtual Screening for Ligand Discovery at the s1 Receptor. ACS Med Chem Lett. 2020 Aug 13; 11(8):1555-1561. View abstract
  5. Children's rare disease cohorts: an integrative research and clinical genomics initiative. NPJ Genom Med. 2020; 5:29. View abstract
  6. Children's rare disease cohorts: an integrative research and clinical genomics initiative. NPJ Genom Med. 2020 Jul 06; 5(1):29. View abstract
  7. RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution. Nucleic Acids Res. 2020 07 02; 48(W1):W218-W229. View abstract
  8. A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7. Proc Natl Acad Sci U S A. 2020 03 03; 117(9):4653-4663. View abstract
  9. In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors. ChemMedChem. 2018 12 06; 13(23):2479-2483. View abstract
  10. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. View abstract
  11. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 06 05; 23(10):3091-3101. View abstract
  12. Development of the Precision Link Biobank at Boston Children's Hospital: Challenges and Opportunities. J Pers Med. 2017 Dec 15; 7(4). View abstract
  13. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. RNA Biol. 2017 12 02; 14(12):1756-1765. View abstract
  14. MightyScreen: An Open-Source Visualization Application for Screening Data Analysis. SLAS Discov. 2018 02; 23(2):218-223. View abstract
  15. LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation. Cell Rep. 2017 03 14; 18(11):2664-2675. View abstract
  16. Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):E1848-E1856. View abstract
  17. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017 02 07; 25(2):287-294. View abstract
  18. Pulmonary Vasculopathy Associated with FIGF Gene Mutation. Am J Pathol. 2017 Jan; 187(1):25-32. View abstract
  19. Extension of research data repository system to support direct compute access to biomedical datasets: enhancing Dataverse to support large datasets. Ann N Y Acad Sci. 2017 01; 1387(1):95-104. View abstract
  20. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. 2016 07 07; 19(1):66-80. View abstract
  21. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. View abstract
  22. Pinpointing RNA-Protein Cross-Links with Site-Specific Stable Isotope-Labeled Oligonucleotides. J Am Chem Soc. 2015 Dec 16; 137(49):15378-81. View abstract
  23. A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99. View abstract
  24. AppCiter: A Web Application for Increasing Rates and Accuracy of Scientific Software Citation. Structure. 2015 May 05; 23(5):807-808. View abstract
  25. Science and technology consortia in U.S. biomedical research: a paradigm shift in response to unsustainable academic growth. Bioessays. 2015 Feb; 37(2):119-22. View abstract
  26. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View abstract
  27. Chemical interrogation of the malaria kinome. Chembiochem. 2014 Sep 05; 15(13):1920-30. View abstract
  28. Structural biology computing: Lessons for the biomedical research sciences. Biopolymers. 2013 Nov; 99(11):809-16. View abstract
  29. Collaboration gets the most out of software. Elife. 2013 Sep 10; 2:e01456. View abstract
  30. Optimizing peer review of software code. Science. 2013 Jul 19; 341(6143):236-7. View abstract
  31. A quick guide to software licensing for the scientist-programmer. PLoS Comput Biol. 2012; 8(7):e1002598. View abstract
  32. Research priorities. Shining light into black boxes. Science. 2012 Apr 13; 336(6078):159-60. View abstract
  33. Adapting federated cyberinfrastructure for shared data collection facilities in structural biology. J Synchrotron Radiat. 2012 May; 19(Pt 3):462-7. View abstract
  34. A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr. 2012 Mar; 68(Pt 3):261-7. View abstract
  35. Conformational locking upon cooperative assembly of notch transcription complexes. Structure. 2012 Feb 08; 20(2):340-9. View abstract
  36. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nat Chem Biol. 2011 Nov 13; 8(1):72-7. View abstract
  37. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. View abstract
  38. Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 2011 Jan 27; 469(7331):564-7. View abstract
  39. Protein structure determination by exhaustive search of Protein Data Bank derived databases. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21476-81. View abstract
  40. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chem Biol. 2010 Jul 16; 5(7):701-11. View abstract
  41. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85. View abstract
  42. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol. 2008 Jul 18; 3(7):429-36. View abstract
  43. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4. View abstract
  44. Structure and function of an essential component of the outer membrane protein assembly machine. Science. 2007 Aug 17; 317(5840):961-4. View abstract
  45. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5348-53. View abstract
  46. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2103-8. View abstract
  47. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9244-9. View abstract
  48. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10; 124(5):973-83. View abstract
  49. Lipid-protein interactions in double-layered two-dimensional AQP0 crystals. Nature. 2005 Dec 01; 438(7068):633-8. View abstract
  50. Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9. View abstract
  51. Aquaporin-0 membrane junctions reveal the structure of a closed water pore. Nature. 2004 May 13; 429(6988):193-7. View abstract
  52. An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site. Nat Struct Biol. 2003 Oct; 10(10):807-11. View abstract
  53. How does radiation damage in protein crystals depend on X-ray dose? Structure. 2003 Jan; 11(1):13-9. View abstract
  54. Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes. J Immunol. 2001 Sep 15; 167(6):3276-84. View abstract
  55. Structure, Function and Interactions of Enzyme IIA from the Phosphoenolpyruvate:lactose Phosphotransferase. 2000. View abstract
  56. The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system. Structure. 1997 Jun 15; 5(6):775-88. View abstract
  57. Crystallization and preliminary structural studies of lactose-specific enzyme IIA from Lactococcus lactis. Acta Crystallogr D Biol Crystallogr. 1996 Nov 01; 52(Pt 6):1199-201. View abstract