Continuous electroencephalography is the gold standard for seizure detection and determination of underlying cerebral function in critically ill neonates and children. Electrographic seizures are noted to affect 10-50% of critically ill children in the intensive care unit. The impact of electrographic seizures on outcome in this patient population remains unclear. Studies suggest that seizure burden may influence neurologic outcome. Other studies have shown an association between electrographic status epilepticus and in-hospital mortality.

Our lab is investigating the impact of electrographic seizures and how they may relate to outcome in critically ill children in both the neonatal and pediatric intensive care unit. We are interested in further defining subpopulations of critically ill children such as children requiring extracorporeal membrane oxygenation, those that are status post congenital heart disease surgery, neonates that are premature, and neonates suspected of having hypoxic ischemic injury to name a few. We are also focusing on seizure prediction in these subpopulations using early clinical and electrographic features.


Arnold Sansevere received his M.D. from Drexel University College of medicine. He completed a pediatric residency at Schneider’s Children’s Hospital in New Hyde Park, NY. He went on to complete his child neurology residency and epilepsy fellowship at Boston Children’s Hospital. His main interests are in continuous EEG monitoring in the neonatal and pediatric intensive care unit as well as medical education.


Publications powered by Harvard Catalyst Profiles

  1. Interleukin-6 Blockade With Tocilizumab in Anakinra-Refractory Febrile Infection-Related Epilepsy Syndrome (FIRES). Child Neurol Open. 2020 Jan-Dec; 7:2329048X20979253. View abstract
  2. EEG features of brain injury during extracorporeal membrane oxygenation in children. Neurology. 2020 09 08; 95(10):e1372-e1380. View abstract
  3. Posterior-onset Rasmussen's encephalitis with ipsilateral cerebellar atrophy and uveitis resistant to rituximab. Epilepsy Behav Rep. 2020; 14:100360. View abstract
  4. Electroencephalographic Reporting for Refractory Status Epilepticus. J Clin Neurophysiol. 2019 Sep; 36(5):365-370. View abstract
  5. Seizure Prediction Models in the Neonatal Intensive Care Unit. J Clin Neurophysiol. 2019 May; 36(3):186-194. View abstract
  6. Conventional and quantitative EEG in status epilepticus. Seizure. 2019 May; 68:38-45. View abstract
  7. Machine Learning for Outcome Prediction in Electroencephalograph (EEG)-Monitored Children in the Intensive Care Unit. J Child Neurol. 2018 07; 33(8):546-553. View abstract
  8. Post-arrest therapeutic hypothermia in pediatric patients with congenital heart disease. Resuscitation. 2018 05; 126:83-89. View abstract
  9. Time to continuous electroencephalogram in repeated admissions to the pediatric intensive care unit. Seizure. 2018 Jan; 54:19-26. View abstract
  10. Continuous EEG in Pediatric Critical Care: Yield and Efficiency of Seizure Detection. J Clin Neurophysiol. 2017 Sep; 34(5):421-426. View abstract
  11. Electrographic Seizures in Preterm Neonates in the Neonatal Intensive Care Unit. J Child Neurol. 2017 Sep; 32(10):880-885. View abstract
  12. Diagnostic and Therapeutic Management of a First Unprovoked Seizure in Children and Adolescents With a Focus on the Revised Diagnostic Criteria for Epilepsy. J Child Neurol. 2017 07; 32(8):774-788. View abstract
  13. Time to electroencephalography is independently associated with outcome in critically ill neonates and children. Epilepsia. 2017 03; 58(3):420-428. View abstract
  14. Neurophysiological evidence of preserved connectivity in tuber tissue. Epilepsy Behav Case Rep. 2017; 7:64-68. View abstract
  15. Development and Feasibility Testing of a Critical Care EEG Monitoring Database for Standardized Clinical Reporting and Multicenter Collaborative Research. J Clin Neurophysiol. 2016 Apr; 33(2):133-40. View abstract