ABOUT THE RESEARCHER

OVERVIEW

The Rowe Lab is interested in the developmental maturation of the blood forming system to better understand childhood blood diseases.

BACKGROUND

Grant Rowe received his MD and PhD degrees from the University of Michigan. He completed residency in the Boston Combined Residency Program and clinical fellowship at the Dana-Farber Cancer Institute

PUBLICATIONS

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  1. Induced pluripotent stem cells in disease modelling and drug discovery. Nat Rev Genet. 2019 07; 20(7):377-388. View abstract
  2. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019 03 04; 216(3):527-538. View abstract
  3. Lin28b regulates age-dependent differences in murine platelet function. Blood Adv. 2019 01 08; 3(1):72-82. View abstract
  4. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018 06 05; 23(10):3091-3101. View abstract
  5. Reconstruction of complex single-cell trajectories using CellRouter. Nat Commun. 2018 03 01; 9(1):892. View abstract
  6. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 05 25; 545(7655):432-438. View abstract
  7. Developmental regulation of myeloerythroid progenitor function by the Lin28b-let-7-Hmga2 axis. J Exp Med. 2016 07 25; 213(8):1497-512. View abstract
  8. Engineering Hematopoietic Stem Cells: Lessons from Development. Cell Stem Cell. 2016 06 02; 18(6):707-720. View abstract
  9. Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence. J Exp Med. 2015 May 04; 212(5):633-48. View abstract
  10. The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy. Leukemia. 2015 Jun; 29(6):1320-30. View abstract