ABOUT THE RESEARCHER

OVERVIEW

Jurriaan M. Peters MD, PhD, is the principal epileptologist at the Multidisciplinary Tuberous Sclerosis Clinic at Boston Children’s Hospital. His research in the Laboratory of Translational Neuroimaging and in the Computational Radiology Laboratory focuses on novel MRI and EEG modeling techniques in the localization of the seizure onset zone in children with medically refractory epilepsy, on how focal lesions give rise to a generalized epileptic encephalopathy, and on early medical and surgical treatment of epilepsy to mitigate detrimental effects on neurodevelopment.

BACKGROUND

Dr. Peters is an Assistant Professor of Neurology at Harvard Medical School, and is a pediatric neurologist with additional expertise in epilepsy, clinical neurophysiology and neuroimaging. He earned his MD at the Catholic University of Leuven, Belgium, and his PhD at the University of Utrecht, the Netherlands. He did his Child Neurology training and Clinical Neurophysiology fellowship training at Boston Children’s Hospital.

PUBLICATIONS

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  1. High-Density EEG in Current Clinical Practice and Opportunities for the Future. J Clin Neurophysiol. 2021 Mar 01; 38(2):112-123. View abstract
  2. Tuber Locations Associated with Infantile Spasms Map to a Common Brain Network. Ann Neurol. 2021 Apr; 89(4):726-739. View abstract
  3. Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding. J Child Neurol. 2021 Jun; 36(7):575-582. View abstract
  4. Patient-Specific Sensor Registration for Electrical Source Imaging Using a Deformable Head Model. IEEE Trans Biomed Eng. 2021 Jan; 68(1):267-275. View abstract
  5. LEARNING TO DETECT BRAIN LESIONS FROM NOISY ANNOTATIONS. Proc IEEE Int Symp Biomed Imaging. 2020 Apr; 2020:1910-1914. View abstract
  6. A structural brain network of genetic vulnerability to psychiatric illness. Mol Psychiatry. 2020 May 06. View abstract
  7. Deep learning in rare disease. Detection of tubers in tuberous sclerosis complex. PLoS One. 2020; 15(4):e0232376. View abstract
  8. The Connectivity Fingerprint of the Fusiform Gyrus Captures the Risk of Developing Autism in Infants with Tuberous Sclerosis Complex. Cereb Cortex. 2020 04 14; 30(4):2199-2214. View abstract
  9. Pilot Study of Neurodevelopmental Impact of Early Epilepsy Surgery in Tuberous Sclerosis Complex. Pediatr Neurol. 2020 08; 109:39-46. View abstract
  10. EEG Spectral Features in Sleep of Autism Spectrum Disorders in Children with Tuberous Sclerosis Complex. J Autism Dev Disord. 2020 Mar; 50(3):916-923. View abstract
  11. Update on Drug Management of Refractory Epilepsy in Tuberous Sclerosis Complex. Paediatr Drugs. 2020 Feb; 22(1):73-84. View abstract
  12. Clinical Reasoning: A 6-week-old infant with migrating focal seizures. Neurology. 2020 01 28; 94(4):178-183. View abstract
  13. Lesion-Constrained Electrical Source Imaging: A Novel Approach in Epilepsy Surgery for Tuberous Sclerosis Complex. J Clin Neurophysiol. 2020 Jan; 37(1):79-86. View abstract
  14. Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder. J Neurodev Disord. 2019 12 16; 11(1):36. View abstract
  15. Scalp EEG spikes predict impending epilepsy in TSC infants: A longitudinal observational study. Epilepsia. 2019 12; 60(12):2428-2436. View abstract
  16. Reproducibility of Structural and Diffusion Tensor Imaging in the TACERN Multi-Center Study. Front Integr Neurosci. 2019; 13:24. View abstract
  17. Resting-State fMRI Networks in Children with Tuberous Sclerosis Complex. J Neuroimaging. 2019 11; 29(6):750-759. View abstract
  18. Increased electroencephalography connectivity precedes epileptic spasm onset in infants with tuberous sclerosis complex. Epilepsia. 2019 08; 60(8):1721-1732. View abstract
  19. The Evolution of Subclinical Seizures in Children With Tuberous Sclerosis Complex. J Child Neurol. 2019 10; 34(12):770-777. View abstract
  20. White matter mean diffusivity correlates with myelination in tuberous sclerosis complex. Ann Clin Transl Neurol. 2019 07; 6(7):1178-1190. View abstract
  21. Seizure Prediction Models in the Neonatal Intensive Care Unit. J Clin Neurophysiol. 2019 May; 36(3):186-194. View abstract
  22. Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism. Ann Neurol. 2019 06; 85(6):921-926. View abstract
  23. Multi-Resolution Graph Based Volumetric Cortical Basis Functions From Local Anatomic Features. IEEE Trans Biomed Eng. 2019 12; 66(12):3381-3392. View abstract
  24. Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy. Clin Neurophysiol. 2019 04; 130(4):491-504. View abstract
  25. Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex. Pediatr Neurol. 2019 01; 90:24-30. View abstract
  26. High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. Epilepsy Res. 2018 12; 148:1-7. View abstract
  27. Corpus Callosum White Matter Diffusivity Reflects Cumulative Neurological Comorbidity in Tuberous Sclerosis Complex. Cereb Cortex. 2018 10 01; 28(10):3665-3672. View abstract
  28. Surgical resection of ripple onset predicts outcome in pediatric epilepsy. Ann Neurol. 2018 09; 84(3):331-346. View abstract
  29. Presurgical language fMRI: Technical practices in epilepsy surgical planning. Hum Brain Mapp. 2018 10; 39(10):4032-4042. View abstract
  30. A Comparison of Point and Complete Electrode Models in a Finite Difference Model of Invasive Electrode Measurements. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:4677-4680. View abstract
  31. Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol. 2018 06; 83(6):1133-1146. View abstract
  32. Vigabatrin for Epileptic Spasms and Tonic Seizures in Tuberous Sclerosis Complex. J Child Neurol. 2018 07; 33(8):519-524. View abstract
  33. Detailed Magnetic Resonance Imaging (MRI) Analysis in Infantile Spasms. J Child Neurol. 2018 05; 33(6):405-412. View abstract
  34. Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning. Hum Brain Mapp. 2018 07; 39(7):2777-2785. View abstract
  35. Response to clobazam in continuous spike-wave during sleep. Dev Med Child Neurol. 2018 03; 60(3):283-289. View abstract
  36. Presentation and Diagnosis of Tuberous Sclerosis Complex in Infants. Pediatrics. 2017 Dec; 140(6). View abstract
  37. Localization of stereo-electroencephalography signals using a finite difference complete electrode model. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:3600-3603. View abstract
  38. Systemic Manifestations in Pyridox(am)ine 5'-Phosphate Oxidase Deficiency. Pediatr Neurol. 2017 Nov; 76:47-53. View abstract
  39. Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep. Epilepsy Res. 2017 02; 130:74-80. View abstract
  40. Dynamic Electrical Source Imaging (DESI) of Seizures and Interictal Epileptic Discharges Without Ensemble Averaging. IEEE Trans Med Imaging. 2017 01; 36(1):98-110. View abstract
  41. Extensions to a manifold learning framework for time-series analysis on dynamic manifolds in bioelectric signals. Phys Rev E. 2016 04; 93(4):042218. View abstract
  42. A pediatric epilepsy diagnostic tool for use in resource-limited settings: A pilot study. Epilepsy Behav. 2016 06; 59:57-61. View abstract
  43. SCN2A-Related Early-Onset Epileptic Encephalopathy Responsive to Phenobarbital. J Pediatr Epilepsy. 2016 Mar; 5(1):42-46. View abstract
  44. Improved fidelity of brain microstructure mapping from single-shell diffusion MRI. Med Image Anal. 2015 Dec; 26(1):268-86. View abstract
  45. Tubers are neither static nor discrete: Evidence from serial diffusion tensor imaging. Neurology. 2015 Nov 03; 85(18):1536-45. View abstract
  46. Clinical Electroencephalographic Biomarker for Impending Epilepsy in Asymptomatic Tuberous Sclerosis Complex Infants. Pediatr Neurol. 2016 Jan; 54:29-34. View abstract
  47. Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism. Neurotherapeutics. 2015 Jul; 12(3):572-83. View abstract
  48. Teaching video neuroimages: nonepileptic myoclonus in a neonate following severe hypoxic-ischemic injury. Neurology. 2015 Mar 24; 84(12):e90. View abstract
  49. Altered Structural Brain Networks in Tuberous Sclerosis Complex. Cereb Cortex. 2016 May; 26(5):2046-58. View abstract
  50. Localization of sleep spindles, k-complexes, and vertex waves with subdural electrodes in children. J Clin Neurophysiol. 2014 Aug; 31(4):367-74. View abstract
  51. Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience. Epilepsia. 2014 Aug; 55(8):1235-44. View abstract
  52. Treatment for continuous spikes and waves during sleep (CSWS): survey on treatment choices in North America. Epilepsia. 2014 Jul; 55(7):1099-108. View abstract
  53. Clobazam: effect on frequency of seizures and safety profile in different subgroups of children with epilepsy. Pediatr Neurol. 2014 Jul; 51(1):60-6. View abstract
  54. A fully Bayesian inference framework for population studies of the brain microstructure. Med Image Comput Comput Assist Interv. 2014; 17(Pt 1):25-32. View abstract
  55. Insult to injury: transient encephalopathy in a brain-injured adolescent. J Paediatr Child Health. 2014 May; 50(5):411-4. View abstract
  56. Clinical value of magnetoencephalographic spike propagation represented by spatiotemporal source analysis: correlation with surgical outcome. Epilepsy Res. 2014 Feb; 108(2):280-8. View abstract
  57. A mathematical framework for the registration and analysis of multi-fascicle models for population studies of the brain microstructure. IEEE Trans Med Imaging. 2014 Feb; 33(2):504-17. View abstract
  58. Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep. Pediatr Neurol. 2013 Sep; 49(3):163-170.e4. View abstract
  59. Diffusion tensor imaging and related techniques in tuberous sclerosis complex: review and future directions. Future Neurol. 2013 Sep; 8(5):583-597. View abstract
  60. Continuous Spikes and Waves during Sleep: Electroclinical Presentation and Suggestions for Management. Epilepsy Res Treat. 2013; 2013:583531. View abstract
  61. [The brain functional network of children with autism: redundancy and disconnection]. Med Sci (Paris). 2013 Jun-Jul; 29(6-7):567-9. View abstract
  62. Electrode localization for planning surgical resection of the epileptogenic zone in pediatric epilepsy. Int J Comput Assist Radiol Surg. 2014 Jan; 9(1):91-105. View abstract
  63. Brain functional networks in syndromic and non-syndromic autism: a graph theoretical study of EEG connectivity. BMC Med. 2013 Feb 27; 11:54. View abstract
  64. A magnetic resonance imaging study of cerebellar volume in tuberous sclerosis complex. Pediatr Neurol. 2013 Feb; 48(2):105-10. View abstract
  65. Automated quantification of spikes. Epilepsy Behav. 2013 Feb; 26(2):143-52. View abstract
  66. Whole Brain Group Network Analysis Using Network Bias and Variance Parameters. 2012; (in press):Proc IEEE Int Conf Biom Imag. View abstract
  67. Electrical status epilepticus in sleep: clinical presentation and pathophysiology. Pediatr Neurol. 2012 Dec; 47(6):390-410. View abstract
  68. The tower of Babel: survey on concepts and terminology in electrical status epilepticus in sleep and continuous spikes and waves during sleep in North America. Epilepsia. 2013 Apr; 54(4):741-50. View abstract
  69. Impaired language pathways in tuberous sclerosis complex patients with autism spectrum disorders. Cereb Cortex. 2013 Jul; 23(7):1526-32. View abstract
  70. Clinical staging and electroencephalographic evolution of continuous spikes and waves during sleep. Epilepsia. 2012 Jul; 53(7):1185-95. View abstract
  71. Short-term response of sleep-potentiated spiking to high-dose diazepam in electric status epilepticus during sleep. Pediatr Neurol. 2012 May; 46(5):312-8. View abstract
  72. WHOLE BRAIN GROUP NETWORK ANALYSIS USING NETWORK BIAS AND VARIANCE PARAMETERS. Proc IEEE Int Symp Biomed Imaging. 2012 May; 2012:1511-1514. View abstract
  73. Early thalamic lesions in patients with sleep-potentiated epileptiform activity. Neurology. 2012 May 29; 78(22):1721-7. View abstract
  74. Patients with electrical status epilepticus in sleep share similar clinical features regardless of their focal or generalized sleep potentiation of epileptiform activity. J Child Neurol. 2013 Jan; 28(1):83-9. View abstract
  75. Behavioral measures and EEG monitoring using the Brain Symmetry Index during the Wada test in children. Epilepsy Behav. 2012 Mar; 23(3):247-53. View abstract
  76. Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis. Pediatrics. 2012 Mar; 129(3):e806-11. View abstract
  77. Registration and analysis of white matter group differences with a multi-fiber model. Med Image Comput Comput Assist Interv. 2012; 15(Pt 3):313-20. View abstract
  78. Loss of white matter microstructural integrity is associated with adverse neurological outcome in tuberous sclerosis complex. Acad Radiol. 2012 Jan; 19(1):17-25. View abstract
  79. Spinal cord involvement in a child with raccoon roundworm (Baylisascaris procyonis) meningoencephalitis. Pediatr Radiol. 2012 Mar; 42(3):369-73. View abstract
  80. Continuous spike and waves during sleep and electrical status epilepticus in sleep. J Clin Neurophysiol. 2011 Apr; 28(2):154-64. View abstract
  81. Guillain-Barré syndrome in a child with pain: lessons learned from a late diagnosis. Acta Paediatr. 2010 Oct; 99(10):1589-91. View abstract
  82. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia. 2010 Jul; 51(7):1319-22. View abstract
  83. Rapid resolution of diffusion weighted MRI abnormality in a patient with a stuttering stroke. BMJ Case Rep. 2010; 2010. View abstract
  84. Picture of the month--quiz case. Moyamoya disease. Arch Pediatr Adolesc Med. 2009 Feb; 163(2):179-80. View abstract
  85. Intracranial penetration of a halo pin causing an epileptic seizure. J Bone Joint Surg Br. 2006 Dec; 88(12):1654-5. View abstract
  86. Tijdschr Neurol Neurochir. Neuromonitoring met on-line qEEG tijdens carotisendarteriectomie: ervaringen met de Brain Symmetry Index. 2005; 106(4):143-150. View abstract
  87. A brain symmetry index (BSI) for online EEG monitoring in carotid endarterectomy. Clin Neurophysiol. 2004 May; 115(5):1189-94. View abstract
  88. Event-related correlations in learning impaired children during A hybrid go/no-go choice reaction visual-motor task. Clin Electroencephalogr. 2003 Jul; 34(3):99-109. View abstract
  89. Tijdschr Neurol Neurochir. Continue EEG-monitoring op de intensive care. 2003; 104(5):276-282. View abstract
  90. Population study of benign rolandic epilepsy: is treatment needed? Neurology. 2001 Aug 14; 57(3):537-9. View abstract