ABOUT THE RESEARCHER

OVERVIEW

Dr. O'Connell is interested in the molecular regulation of intestinal and immune development in the premature infant and neonate. She has research training in innate immunity, T cell genetics, intestinal stem cell biology, and orphan disease. The therapeutic targets of work in her lab are necrotizing enterocolitis (NEC) and neonatal infection, however this work may have much broader implications for other disease states. The current focuses of work in the lab include:


Role of Wnt2b in the intestine

  1. Role of Wnt2b in the intestine
  2. Regulation of early intestinal development
  3. Orphan disease characterization
  4. Modeling tissue specific immune development

BACKGROUND

Dr. O'Connell is a traditional MD/PhD physician scientist committed to excellence in both clinical care and scientific investigation. She has distinguished clinical expertise in neonatal immunity, with board certifications in both neonatology and allergy/immunology, as well as a doctorate in immunology.

PUBLICATIONS

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  1. Novel variants in the stem cell niche factor WNT2B define the disease phenotype as a congenital enteropathy with ocular dysgenesis. Eur J Hum Genet. 2021 Jun; 29(6):998-1007. View abstract
  2. Gene and Stem Cell Therapies for Fetal Care: A Review. JAMA Pediatr. 2020 10 01; 174(10):985-991. View abstract
  3. Primary immunodeficiency testing in a Massachusetts tertiary care NICU: persistent challenges in the extremely premature population. Pediatr Res. 2021 02; 89(3):549-553. View abstract
  4. Hypersensitivity to tetracyclines: Skin testing, graded challenge, and desensitization regimens. Ann Allergy Asthma Immunol. 2020 06; 124(6):589-593. View abstract
  5. Risk-factors Associated With Poor Outcomes in VEO-IBD Secondary to XIAP Deficiency: A Case Report and Literature Review. J Pediatr Gastroenterol Nutr. 2019 07; 69(1):e13-e18. View abstract
  6. Mammalian Hbs1L deficiency causes congenital anomalies and developmental delay associated with Pelota depletion and 80S monosome accumulation. PLoS Genet. 2019 02; 15(2):e1007917. View abstract
  7. Primary Immunodeficiency in the NICU. Neoreviews. 2019 02; 20(2):e67-e78. View abstract
  8. Duplicate skin prick testing in the assessment of food allergy. J Allergy Clin Immunol Pract. 2019 Feb; 7(2):675-677. View abstract
  9. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. View abstract
  10. NeoReviews. Perinatal Transient Myeloproliferative Disorder in Trisomy 21. 2016; 17(11):e636-e644. View abstract
  11. Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome. Front Immunol. 2014; 5:340. View abstract
  12. Paravertebral mushroom: identification of a novel species of Phellinus as a human pathogen in chronic granulomatous disease. J Clin Microbiol. 2014 Jul; 52(7):2726-9. View abstract
  13. Successful desensitization to brentuximab vedotin after anaphylaxis. Clin Lymphoma Myeloma Leuk. 2014 Apr; 14(2):e73-5. View abstract
  14. Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis. Infect Immun. 2013 Sep; 81(9):3346-55. View abstract
  15. Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice. Infect Immun. 2011 Jul; 79(7):2770-8. View abstract
  16. Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment. Microbes Infect. 2011 Jun; 13(6):536-44. View abstract
  17. IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages. Parasite Immunol. 2009 Dec; 31(12):741-9. View abstract