Dr. Ozonoff's research focuses on the development and application of methods for surveillance of health and disease. This includes public health surveillance, especially infectious disease surveillance, as well as hospital-based surveillance, with emphasis on patient safety and healthcare quality. He leverages his training in mathematics, statistics, epidemiology, and data science to achieve population-based improvement in the health of children and adults.


Dr. Ozonoff is Associate Professor of Pediatrics at Harvard Medical School, faculty scientist within the Division of Infectious Diseases at Boston Children's Hospital, and Adjunct Associate Professor of Biostatistics at the Boston University School of Public Health. His scientific research is focused on development and application of surveillance methods in the fields of public health, healthcare quality, and patient safety. He is Principal Investigator of a 5-year project funded by the Agency for Healthcare Research and Quality (AHRQ), "Patient safety surveillance using machine learning and free text clinical notes" (R01 HS026246-01A1) and leads the Data Management Core for the Precision Vaccines Program at BCH. He holds advisory and consulting roles with state agencies including the Massachusetts Cancer Registry, the Massachusetts Office of Population Health, and the Massachusetts Bureau of Environmental Health.


Publications powered by Harvard Catalyst Profiles

  1. Anxiety and depression in colorectal cancer survivors: Are there differences by sexual orientation? Psychooncology. 2021 Oct 20. View abstract
  2. Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life. Cytokine. 2021 12; 148:155704. View abstract
  3. Pediatric Hospital Readmissions for Infants With Neonatal Opioid Withdrawal Syndrome, 2016-2019. Hosp Pediatr. 2021 09; 11(9):979-988. View abstract
  4. Variation in hospital performance measures from the Turkey Ministry of Health. Int J Qual Health Care. 2021 Aug 12; 33(3). View abstract
  5. Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro. Front Immunol. 2021; 12:674334. View abstract
  6. Health-related quality of life among colorectal cancer survivors of diverse sexual orientations. Cancer. 2021 Oct 15; 127(20):3847-3855. View abstract
  7. Bell's palsy and SARS-CoV-2 vaccines-an unfolding story - Authors' reply. Lancet Infect Dis. 2021 09; 21(9):1211-1212. View abstract
  8. Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life. Front Immunol. 2021; 12:578700. View abstract
  9. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21. View abstract
  10. Predictive Value of Direct Disk Diffusion Testing from Positive Blood Cultures in a Children's Hospital and Its Utility in Antimicrobial Stewardship. J Clin Microbiol. 2021 05 19; 59(6). View abstract
  11. Human Blood Plasma Shapes Distinct Neonatal TLR-Mediated Dendritic Cell Activation via Expression of the MicroRNA Let-7g. Immunohorizons. 2021 04 30; 5(4):246-256. View abstract
  12. Follow-up surveillance among colorectal cancer survivors of different sexual orientations. J Cancer Surviv. 2021 Apr 14. View abstract
  13. Assessing the relationship between symptoms and health care utilization in colorectal cancer survivors of different sexual orientations. Support Care Cancer. 2021 Oct; 29(10):5821-5830. View abstract
  14. Bell's palsy and SARS-CoV-2 vaccines. Lancet Infect Dis. 2021 04; 21(4):450-452. View abstract
  15. COVID-19 Misinformation Spread in Eight Countries: Exponential Growth Modeling Study. J Med Internet Res. 2020 12 15; 22(12):e24425. View abstract
  16. Treadmill injuries in children. Am J Emerg Med. 2021 08; 46:495-498. View abstract
  17. Bacteriology of pediatric breast abscesses beyond the neonatal period. Am J Emerg Med. 2021 03; 41:193-196. View abstract
  18. Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life. Front Immunol. 2020; 11:578505. View abstract
  19. A cloud-based bioinformatic analytic infrastructure and Data Management Core for the Expanded Program on Immunization Consortium. J Clin Transl Sci. 2020 Sep 22; 5(1):e52. View abstract
  20. Survivors' Perceptions of Quality of Colorectal Cancer Care by Sexual Orientation. Am J Clin Oncol. 2020 09; 43(9):660-666. View abstract
  21. Clinician Perceptions of Timing and Presentation of Drug-Drug Interaction Alerts. Appl Clin Inform. 2020 05; 11(3):487-496. View abstract
  22. Survivors' Perceptions of Quality of Colorectal Cancer Care by Sexual Orientation. Am J Clin Oncol. 2020 Jun 26. View abstract
  23. Utility of Blood Cultures and Empiric Antibiotics in Febrile Pediatric Hemophilia Patients With Central Venous Access Devices. Pediatr Emerg Care. 2020 Apr 28. View abstract
  24. Transgender individuals' cancer survivorship: Results of a cross-sectional study. Cancer. 2020 06 15; 126(12):2829-2836. View abstract
  25. Licensed Bacille Calmette-Guérin (BCG) formulations differ markedly in bacterial viability, RNA content and innate immune activation. Vaccine. 2020 02 24; 38(9):2229-2240. View abstract
  26. Neighborhood Characteristics and Colorectal Cancer Survivors' Quality of Care. Health Equity. 2019; 3(1):619-627. View abstract
  27. Perspectives on Patient Safety and Medical Malpractice: A Comparison of Medical and Legal Systems in Italy and the United States. J Patient Saf. 2019 12; 15(4):e78-e81. View abstract
  28. The power of peers: an effectiveness evaluation of a cluster-controlled trial of group antenatal care in rural Nepal. Reprod Health. 2019 Oct 22; 16(1):150. View abstract
  29. Cyclic AMP in human preterm infant blood is associated with increased TLR-mediated production of acute-phase and anti-inflammatory cytokines in vitro. Pediatr Res. 2020 11; 88(5):717-725. View abstract
  30. Cancer survivors' access to care and quality of life: Do sexual minorities fare worse than heterosexuals? Cancer. 2019 09 01; 125(17):3079-3085. View abstract
  31. Dynamic molecular changes during the first week of human life follow a robust developmental trajectory. Nat Commun. 2019 03 12; 10(1):1092. View abstract
  32. Population-based surveillance of congenital heart defects among adolescents and adults: surveillance methodology. Birth Defects Res. 2018 11 15; 110(19):1395-1403. View abstract
  33. Analysis of Healthcare Institutional Costs of Pediatric Home Parenteral Nutrition Central Line Infections. J Pediatr Gastroenterol Nutr. 2018 10; 67(4):e77-e81. View abstract
  34. Resilience Among Breast Cancer Survivors of Different Sexual Orientations. LGBT Health. 2018 07; 5(5):295-302. View abstract
  35. Enhanced central venous catheter bundle for pediatric parenteral-dependent intestinal failure. Am J Infect Control. 2018 11; 46(11):1284-1289. View abstract
  36. Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood in vitro. F1000Res. 2018; 7:616. View abstract
  37. Correction: Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis. PLoS One. 2018; 13(5):e0197532. View abstract
  38. Virtual Telemedicine Visits in Pediatric Home Parenteral Nutrition Patients: A Quality Improvement Initiative. Telemed J E Health. 2019 01; 25(1):60-65. View abstract
  39. An Investigation of Drug-Drug Interaction Alert Overrides at a Pediatric Hospital. Hosp Pediatr. 2018 05; 8(5):293-299. View abstract
  40. Innovative Discharge Process for Families with Pediatric Short Bowel Syndrome: A Prospective Nonrandomized Trial. JPEN J Parenter Enteral Nutr. 2018 11; 42(8):1295-1303. View abstract
  41. Adherence to guidelines for testing and treatment of children with pharyngitis: a retrospective study. BMC Pediatr. 2018 02 09; 18(1):43. View abstract
  42. Functionality of hospital information systems: results from a survey of quality directors at Turkish hospitals. BMC Med Inform Decis Mak. 2018 01 12; 18(1):6. View abstract
  43. Hospital Variation in Neonatal Abstinence Syndrome Incidence, Treatment Modalities, Resource Use, and Costs Across Pediatric Hospitals in the United States, 2013 to 2016. Hosp Pediatr. 2018 01; 8(1):15-20. View abstract
  44. It's in Your Hands: An Educational Initiative to Improve Parent/Family Hand Hygiene Compliance. Dimens Crit Care Nurs. 2017 Nov/Dec; 36(6):327-333. View abstract
  45. Clinical Significance of Incidentally Detected Torus Tubarius Calcification. J Comput Assist Tomogr. 2017 Sep/Oct; 41(5):828-832. View abstract
  46. Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis. PLoS One. 2017; 12(4):e0175936. View abstract
  47. Medication Reconciliation Failures in Children and Young Adults With Chronic Disease During Intensive and Intermediate Care. Pediatr Crit Care Med. 2017 Apr; 18(4):370-377. View abstract
  48. TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. JCI Insight. 2017 03 23; 2(6):e91020. View abstract
  49. Thyroid dysfunction in patients with Down syndrome: Results from a multi-institutional registry study. . 2017 Jun; 173(6):1539-1545. View abstract
  50. Continued Use of Warfarin in Veterans with Atrial Fibrillation After Dementia Diagnosis. J Am Geriatr Soc. 2017 Feb; 65(2):249-256. View abstract
  51. Practical issues in the measurement of child survival in health systems trials: experience developing a digital community-based mortality surveillance programme in rural Nepal. BMJ Glob Health. 2016; 1(4):e000050. View abstract
  52. Results of a Regional Effort to Improve Warfarin Management. Ann Pharmacother. 2017 May; 51(5):373-379. View abstract
  53. Advancing the Measurement of Care Coordination in Pediatric Behavioral Health. J Dev Behav Pediatr. 2016 10; 37(8):674-84. View abstract
  54. Detecting celiac disease in patients with Down syndrome. . 2016 12; 170(12):3098-3105. View abstract
  55. Technical Performance Score Predicts Resource Utilization in Congenital Cardiac Procedures. J Am Coll Cardiol. 2016 06 07; 67(22):2696-8. View abstract
  56. Combining Healthcare-Based and Participatory Approaches to Surveillance: Trends in Diarrheal and Respiratory Conditions Collected by a Mobile Phone System by Community Health Workers in Rural Nepal. PLoS One. 2016; 11(4):e0152738. View abstract
  57. Operating Room Clinicians' Attitudes and Perceptions of a Pediatric Surgical Safety Checklist at 1 Institution. J Patient Saf. 2016 Mar; 12(1):44-50. View abstract
  58. Unifocal versus multifocal mandibular fractures and injury location. Emerg Radiol. 2016 Apr; 23(2):161-7. View abstract
  59. Pilot experience with opebacan/rBPI 21 in myeloablative hematopoietic cell transplantation. F1000Res. 2015; 4:1480. View abstract
  60. Percent Time in Range with Warfarin as a Performance Measure: How Long a Sampling Frame Is Needed? Jt Comm J Qual Patient Saf. 2015 Dec; 41(12):561-8. View abstract
  61. Improving Anticoagulation Measurement Novel Warfarin Composite Measure. Circ Cardiovasc Qual Outcomes. 2015 Nov; 8(6):600-7. View abstract
  62. Comparison of the Abilities of Summary Measures of International Normalized Ratio Control to Predict Clinically Relevant Bleeding. Circ Cardiovasc Qual Outcomes. 2015 Sep; 8(5):524-31. View abstract
  63. National down syndrome patient database: Insights from the development of a multi-center registry study. . 2015 Nov; 167A(11):2520-6. View abstract
  64. Sexual Minority Women's Health Behaviors and Outcomes After Breast Cancer. LGBT Health. 2015 Sep; 2(3):221-7. View abstract
  65. Predicting outcomes among patients with atrial fibrillation and heart failure receiving anticoagulation with warfarin. Thromb Haemost. 2015 Jul; 114(1):70-7. View abstract
  66. Impact of Mandatory Public Reporting of Central Line-Associated Bloodstream Infections on Blood Culture and Antibiotic Utilization in Pediatric and Neonatal Intensive Care Units. Infect Control Hosp Epidemiol. 2015 Aug; 36(8):878-85. View abstract
  67. Group A streptococcal bacteremia without a source is associated with less severe disease in children. Pediatr Infect Dis J. 2015 Apr; 34(4):447-9. View abstract
  68. Clinical associations of incidentally detected parotid gland calcification on CT. Laryngoscope. 2015 Jun; 125(6):1360-5. View abstract
  69. Improving quality measurement for anticoagulation: adding international normalized ratio variability to percent time in therapeutic range. Circ Cardiovasc Qual Outcomes. 2014 Sep; 7(5):664-9. View abstract
  70. Stratifying the risks of oral anticoagulation in patients with liver disease. Circ Cardiovasc Qual Outcomes. 2014 May; 7(3):461-7. View abstract
  71. Use of multiple data sources for surveillance of work-related amputations in Massachusetts, comparison with official estimates and implications for national surveillance. Am J Ind Med. 2014 Oct; 57(10):1120-32. View abstract
  72. Sexual minority population density and incidence of lung, colorectal and female breast cancer in California. BMJ Open. 2014 Mar 26; 4(3):e004461. View abstract
  73. Explaining racial disparities in anticoagulation control: results from a study of patients at the Veterans Administration. Am J Med Qual. 2015 May; 30(3):214-22. View abstract
  74. The effect of spatial aggregation on performance when mapping a risk of disease. Int J Health Geogr. 2014 Mar 13; 13:9. View abstract
  75. Outcomes of anticoagulation therapy in patients with mental health conditions. J Gen Intern Med. 2014 Jun; 29(6):855-61. View abstract
  76. Engaging in secondhand smoke reduction discussions with parents of hospitalized pediatric patients: a national survey of pediatric nurses in the United States. Prev Med. 2014 May; 62:83-8. View abstract
  77. Prenatal influenza exposure and cardiovascular events in adulthood. Influenza Other Respir Viruses. 2014 Jan; 8(1):83-90. View abstract
  78. A comparison of marginal and conditional models for capture-recapture data with application to human rights violations data. Biometrics. 2013 Dec; 69(4):1022-32. View abstract
  79. Correlation of mucositis during head and neck radiotherapy with computed tomography perfusion imaging of the oropharyngeal mucosa. J Comput Assist Tomogr. 2013 Jul-Aug; 37(4):499-504. View abstract
  80. After breast cancer: sexual functioning of sexual minority survivors. J Sex Res. 2014; 51(6):681-9. View abstract
  81. Distance-based mapping of disease risk. Int J Biostat. 2013 May 07; 9(2):265-90. View abstract
  82. Identifying the risks of anticoagulation in patients with substance abuse. J Gen Intern Med. 2013 Oct; 28(10):1333-9. View abstract
  83. Gaps in monitoring during oral anticoagulation: insights into care transitions, monitoring barriers, and medication nonadherence. Chest. 2013 Mar; 143(3):751-757. View abstract
  84. Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ. 2013 Jan 30; 346:f174. View abstract
  85. Age-related apparent diffusion coefficient changes in the normal brain. Radiology. 2013 Feb; 266(2):575-82. View abstract
  86. Opioid overdose prevention with intranasal naloxone among people who take methadone. J Subst Abuse Treat. 2013 Feb; 44(2):241-7. View abstract
  87. Protective locus against renal scarring on chromosome 11 in affected sib pairs with familial vesicoureteral reflux identified by single nucleotide polymorphism linkage analysis. J Urol. 2012 Oct; 188(4 Suppl):1467-73. View abstract
  88. Health behaviors of cancer survivors of different sexual orientations. Cancer Causes Control. 2012 Sep; 23(9):1489-96. View abstract
  89. Applying the Female Sexual Functioning Index to sexual minority women. J Womens Health (Larchmt). 2012 Apr; 21(4):401-9. View abstract
  90. Effect of disease progression on liver apparent diffusion coefficient and T2 values in a murine model of hepatic fibrosis at 11.7 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):140-6. View abstract
  91. An ecological analysis of colorectal cancer incidence and mortality: differences by sexual orientation. BMC Cancer. 2011 Sep 21; 11:400. View abstract
  92. The business case for quality improvement: oral anticoagulation for atrial fibrillation. Circ Cardiovasc Qual Outcomes. 2011 Jul; 4(4):416-24. View abstract
  93. Correlating computed tomography perfusion changes in the pharyngeal constrictor muscles during head-and-neck radiotherapy to dysphagia outcome. Int J Radiat Oncol Biol Phys. 2012 Feb 01; 82(2):e119-27. View abstract
  94. MRI-based volumetric assessment of joint effusion in knee osteoarthritis using proton density-weighted fat-suppressed and T1-weighted contrast-enhanced fat-suppressed sequences. Skeletal Radiol. 2011 Dec; 40(12):1581-5. View abstract
  95. Cancer survivorship and sexual orientation. Cancer. 2011 Aug 15; 117(16):3796-804. View abstract
  96. Prompt repeat testing after out-of-range INR values: a quality indicator for anticoagulation care. Circ Cardiovasc Qual Outcomes. 2011 May; 4(3):276-82. View abstract
  97. Relevance of current guidelines for organizing an anticoagulation clinic. Am J Manag Care. 2011 Apr; 17(4):284-9. View abstract
  98. Reexamining the recommended follow-up interval after obtaining an in-range international normalized ratio value: results from the Veterans Affairs study to improve anticoagulation. Chest. 2011 Aug; 140(2):359-365. View abstract
  99. Generalized Additive Models and Inflated Type I Error Rates of Smoother Significance Tests. Comput Stat Data Anal. 2011 Jan 01; 55(1):366-374. View abstract
  100. Risk-adjusted percent time in therapeutic range as a quality indicator for outpatient oral anticoagulation: results of the Veterans Affairs Study to Improve Anticoagulation (VARIA). Circ Cardiovasc Qual Outcomes. 2011 Jan 01; 4(1):22-9. View abstract
  101. Power of permutation tests using generalized additive models with bivariate smoothers. J Biom Biostat. 2010 Sep 12; 1(104). View abstract
  102. Law, behavior, and research design: a final note. Am J Ind Med. 2010 Aug; 53(8):856. View abstract
  103. A power comparison of generalized additive models and the spatial scan statistic in a case-control setting. Int J Health Geogr. 2010 Jul 19; 9:37. View abstract
  104. Breast cancer close to the nipple: does this increase the risk of nodal metastasis at diagnosis? Can Assoc Radiol J. 2011 Aug; 62(3):209-14. View abstract
  105. Squamous cell carcinoma of the palatine tonsils: FDG standardized uptake value ratio as a biomarker to differentiate tonsillar carcinoma from physiologic uptake. Radiology. 2010 May; 255(2):578-85. View abstract
  106. Researcher judgment and study design: challenges of using administrative data. Am J Ind Med. 2010 Jan; 53(1):37-41. View abstract
  107. Evidence-based tool for triggering school closures during influenza outbreaks, Japan. Emerg Infect Dis. 2009 Nov; 15(11):1841-3. View abstract
  108. Abdominal 64-MDCT for suspected appendicitis: the use of oral and IV contrast material versus IV contrast material only. AJR Am J Roentgenol. 2009 Nov; 193(5):1282-8. View abstract
  109. Epidemiology of subtherapeutic anticoagulation in the United States. Circ Cardiovasc Qual Outcomes. 2009 Nov; 2(6):591-7. View abstract
  110. Power to detect spatial disturbances under different levels of geographic aggregation. J Am Med Inform Assoc. 2009 Nov-Dec; 16(6):847-54. View abstract
  111. HIV testing among sexually experienced Asian and Pacific Islander young women association with routine gynecologic care. Womens Health Issues. 2009 Jul-Aug; 19(4):279-88. View abstract
  112. Relaxo-volumetric multispectral quantitative magnetic resonance imaging of the brain over the human lifespan: global and regional aging patterns. Magn Reson Imaging. 2009 Sep; 27(7):895-906. View abstract
  113. Screening mammography: does ethnicity influence patient preferences for higher recall rates given the potential for earlier detection of breast cancer? Radiology. 2008 Dec; 249(3):785-91. View abstract
  114. Substance use among Asian Americans and Pacific Islanders sexual minority adolescents: findings from the National Longitudinal Study of Adolescent Health. J Adolesc Health. 2008 Mar; 42(3):275-83. View abstract
  115. Capture-recapture estimates of nonfatal workplace injuries and illnesses. Ann Epidemiol. 2008 Jun; 18(6):500-6. View abstract
  116. Two means of sampling sexual minority women: how different are the samples of women? J LGBT Health Res. 2008; 4(4):143-51. View abstract
  117. Effect of spatial resolution on cluster detection: a simulation study. Int J Health Geogr. 2007 Nov 27; 6:52. View abstract
  118. Educating medical students about radiation oncology: initial results of the oncology education initiative. J Am Coll Radiol. 2007 Oct; 4(10):711-5. View abstract
  119. Effectiveness of warfarin among patients with cancer. J Gen Intern Med. 2007 Jul; 22(7):997-1002. View abstract
  120. Validity of parental reporting of recent episodes of acute otitis media: a Slone Center Office-Based Research (SCOR) Network study. J Am Board Fam Med. 2007 Mar-Apr; 20(2):160-3. View abstract
  121. Cluster detection methods applied to the Upper Cape Cod cancer data. Environ Health. 2005 Sep 15; 4:19. View abstract
  122. Bivariate method for spatio-temporal syndromic surveillance. MMWR Suppl. 2004 Sep 24; 53:59-66. View abstract
  123. The IL12B gene is associated with asthma. Am J Hum Genet. 2004 Oct; 75(4):709-15. View abstract