ABOUT THE RESEARCHER

OVERVIEW

Jane Newburger's goals are to improve the diagnosis, treatment, and outcome of children with Kawasaki disease and to minimize neurologic problems that may occur after surgery for congenital heart disease. Dr. Newburger has focused on performing randomized trials of new therapies for these conditions.

Dr. Newburger designed an NIH-funded multicenter randomized trial comparing treatments for Kawasaki disease and directed the coordinating center for the study. The first phase of that trial compared high-dose intravenous gamma globulin plus aspirin to aspirin alone during the acute stage of the disease; the second phase compared the effects of two dose regimens of intravenous gamma globulin. Her other prospective studies in Kawasaki disease have focused on its epidemiology and long-term effects.

Recent dramatic reductions in cardiac surgical mortality have been accompanied by the recognition that the survivors frequently are frequently left with neurologic deficits, including mental retardation, seizures, cerebral palsy, and lifelong language and learning disorders. The majority of such brain injuries may be attributable to the support techniques used to protect vital organs during cardiac repair.

One of Dr. Newburger's early studies drew upon the database of the Regional Infant Cardiac Program, a prospective cohort study that collected perioperative and follow-up data on children with heart disease in New England. This work demonstrated that longer duration of cyanosis--reduced oxygen to the tissues--had an adverse effect on cognitive function. Subsequently, she has been principal investigator for a series of randomized clinical trials comparing the effects of different techniques for vital organ support during surgery--first on how well the patient does after surgery and, more recently, on the patient's subsequent neurologic and developmental function.

BACKGROUND

Jane Newburger received her MD from Harvard Medical School and MPH from Harvard School of Public Health. She completed an internship, residency, and fellowship at Boston Children's Hospital.

PUBLICATIONS

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  1. Mistaken MIS-C: A Case Series of Bacterial Enteritis Mimicking MIS-C. Pediatr Infect Dis J. 2021 04 01; 40(4):e159-e161. View abstract
  2. Cyclophosphamide use in treatment of refractory Kawasaki disease with coronary artery aneurysms. Pediatr Rheumatol Online J. 2021 Mar 17; 19(1):31. View abstract
  3. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021 03 16; 325(11):1074-1087. View abstract
  4. Biological Pathways in Adolescent Aortic Stiffness. J Am Heart Assoc. 2021 Mar 16; 10(6):e018419. View abstract
  5. Detailed Assessment of Left Ventricular Function in Multisystem Inflammatory Syndrome in Children Using Strain Analysis. CJC Open. 2021 Feb 25. View abstract
  6. Socioeconomic and Racial/Ethnic Disparities in Multisystem Inflammatory Syndrome. Pediatrics. 2021 Feb 18. View abstract
  7. The Electrocardiogram in Multisystem Inflammatory Syndrome in Children: Mind Your Ps and Qs. J Pediatr. 2021 Feb 02. View abstract
  8. Myocardial fibrosis in patients with a history of Kawasaki disease. Int J Cardiol Heart Vasc. 2021 Feb; 32:100713. View abstract
  9. Performance on the ROCF at 8 Years Predicts Academic Achievement at 16 Years in Individuals with Dextro-Transposition of the Great Arteries. J Int Neuropsychol Soc. 2021 Jan 14; 1-8. View abstract
  10. Multiple Emergency Department Visits for a Diagnosis of Kawasaki Disease: An Examination of Risk Factors and Outcomes. J Pediatr. 2021 Jan 13. View abstract
  11. Comparison Between Currently Recommended Long-Term Medical Management of Coronary Artery Aneurysms After Kawasaki Disease and Actual Reported Management in the Last Two Decades. Pediatr Cardiol. 2021 Mar; 42(3):676-684. View abstract
  12. Six-Year Neurodevelopmental Outcomes for Children With Single-Ventricle Physiology. Pediatrics. 2021 Feb; 147(2). View abstract
  13. Commentary on Gastrointestinal Symptoms Followed by Shock in a Febrile 7-Year-Old Child during the COVID-19 Pandemic. Clin Chem. 2021 01 08; 67(1):59-60. View abstract
  14. Challenges to randomized trials in adult and congenital cardiac and thoracic surgery. Ann Thorac Surg. 2021 Jan 04. View abstract
  15. Association of Financial Hardship Because of Medical Bills With Adverse Outcomes Among Families of Children With Congenital Heart Disease. JAMA Cardiol. 2020 Dec 16. View abstract
  16. The origins and development of the Cardiac Neurodevelopmental Outcome Collaborative: creating innovative clinical, quality improvement, and research opportunities - Corrigendum. Cardiol Young. 2021 Jan; 31(1):175. View abstract
  17. Variation in the management of Kawasaki disease in Australia and New Zealand: A survey of paediatricians. J Paediatr Child Health. 2020 Dec 09. View abstract
  18. Rare genetic variation at transcription factor binding sites modulates local DNA methylation profiles. PLoS Genet. 2020 11; 16(11):e1009189. View abstract
  19. High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies. J Infect Dis. 2020 11 09; 222(11):1853-1857. View abstract
  20. Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children. Circulation. 2021 01 05; 143(1):78-88. View abstract
  21. Regional Brain Growth Trajectories in Fetuses with Congenital Heart Disease. Ann Neurol. 2021 01; 89(1):143-157. View abstract
  22. Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children. J Clin Invest. 2020 11 02; 130(11):5942-5950. View abstract
  23. The origins and development of the cardiac neurodevelopment outcome collaborative: creating innovative clinical, quality improvement, and research opportunities. Cardiol Young. 2020 Nov; 30(11):1597-1602. View abstract
  24. Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children: A Call to Action. J Am Coll Cardiol. 2020 10 27; 76(17):1962-1964. View abstract
  25. Variations in practice in cardiac neurodevelopmental follow-up programs. Cardiol Young. 2020 Nov; 30(11):1603-1608. View abstract
  26. Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease. JAMA Cardiol. 2020 Oct 21. View abstract
  27. Trajectories in Neurodevelopmental, Health-Related Quality of Life, and Functional Status Outcomes by Socioeconomic Status and Maternal Education in Children with Single Ventricle Heart Disease. J Pediatr. 2021 Feb; 229:289-293.e3. View abstract
  28. Socioeconomic Status and Long-term Outcomes in Single Ventricle Heart Disease. Pediatrics. 2020 10; 146(4). View abstract
  29. Primary adjunctive corticosteroid therapy is associated with improved outcomes for patients with Kawasaki disease with coronary artery aneurysms at diagnosis. Arch Dis Child. 2021 03; 106(3):247-252. View abstract
  30. In Memoriam: Jaqueline A. Noonan. J Am Coll Cardiol. 2020 Sep 22; 76(12):1498-1500. View abstract
  31. Atrioventricular Block in Children With Multisystem Inflammatory Syndrome. Pediatrics. 2020 11; 146(5). View abstract
  32. Randomized Controlled Trial of Working Memory Intervention in Congenital Heart Disease. J Pediatr. 2020 12; 227:191-198.e3. View abstract
  33. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach. Eur J Pediatr. 2021 Feb; 180(2):307-322. View abstract
  34. Screening for Intracranial Aneurysms in Coarctation of the Aorta: A Decision and Cost-Effectiveness Analysis. Circ Cardiovasc Qual Outcomes. 2020 08; 13(8):e006406. View abstract
  35. Medium-Term Complications Associated With Coronary Artery Aneurysms After Kawasaki Disease: A Study From the International Kawasaki Disease Registry. J Am Heart Assoc. 2020 08 04; 9(15):e016440. View abstract
  36. Association of Isolated Congenital Heart Disease with Fetal Brain Maturation. AJNR Am J Neuroradiol. 2020 08; 41(8):1525-1531. View abstract
  37. Low-Molecular-Weight Heparin vs Warfarin for Thromboprophylaxis in Children With Coronary Artery Aneurysms After Kawasaki Disease: A Pragmatic Registry Trial. Can J Cardiol. 2020 Oct; 36(10):1598-1607. View abstract
  38. Reply. J Pediatr. 2020 09; 224:184-185.e1. View abstract
  39. De Novo Damaging Variants, Clinical Phenotypes, and Post-Operative Outcomes in Congenital Heart Disease. Circ Genom Precis Med. 2020 08; 13(4):e002836. View abstract
  40. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020 07 23; 383(4):334-346. View abstract
  41. Genomic analyses implicate noncoding de novo variants in congenital heart disease. Nat Genet. 2020 08; 52(8):769-777. View abstract
  42. Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD). Trials. 2020 Jun 29; 21(1):590. View abstract
  43. Technical Performance Score's Association With Arterial Switch Operation Outcomes. Ann Thorac Surg. 2021 04; 111(4):1367-1373. View abstract
  44. Multisystem Inflammatory Syndrome in Children in Association With COVID-19. Circulation. 2020 08 04; 142(5):437-440. View abstract
  45. Registry-based trials: a potential model for cost savings? Cardiol Young. 2020 Jun; 30(6):807-817. View abstract
  46. Missed or delayed diagnosis of Kawasaki disease during the 2019 novel coronavirus disease (COVID-19) pandemic. J Pediatr. 2020 Jul; 222:261-262. View abstract
  47. EM-mosaic detects mosaic point mutations that contribute to congenital heart disease. Genome Med. 2020 04 29; 12(1):42. View abstract
  48. Prevalence and Prognostic Association of a Clinical Diagnosis of Depression in Adult Congenital Heart Disease: Results of the Boston Adult Congenital Heart Disease Biobank. J Am Heart Assoc. 2020 05 05; 9(9):e014820. View abstract
  49. Management of Myocardial Infarction in Children with Giant Coronary Artery Aneurysms after Kawasaki Disease. J Pediatr. 2020 06; 221:230-234. View abstract
  50. Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC Basic Transl Sci. 2020 Apr; 5(4):376-386. View abstract
  51. Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome: A Decision Analysis. Circ Cardiovasc Qual Outcomes. 2020 04; 13(4):e006127. View abstract
  52. Abnormal Left-Hemispheric Sulcal Patterns Correlate with Neurodevelopmental Outcomes in Subjects with Single Ventricular Congenital Heart Disease. Cereb Cortex. 2020 03 21; 30(2):476-487. View abstract
  53. Health-Related Quality of Life in Children, Adolescents, and Adults With a Fontan Circulation: A Meta-Analysis. J Am Heart Assoc. 2020 03 17; 9(6):e014172. View abstract
  54. Multicentre validation of a computer-based tool for differentiation of acute Kawasaki disease from clinically similar febrile illnesses. Arch Dis Child. 2020 08; 105(8):772-777. View abstract
  55. Development and Utility of Quality Metrics for Ambulatory Pediatric Cardiology in Kawasaki Disease. Clin Pediatr (Phila). 2020 03; 59(3):245-251. View abstract
  56. The Bayley-III scale may underestimate neurodevelopmental disability after cardiac surgery in infants. Eur J Cardiothorac Surg. 2020 01 01; 57(1):63-71. View abstract
  57. Variation in care for children undergoing the Fontan operation for hypoplastic left heart syndrome. Cardiol Young. 2019 Dec; 29(12):1510-1516. View abstract
  58. The Pediatric Heart Network Residual Lesion Score Study: Design and objectives. J Thorac Cardiovasc Surg. 2020 07; 160(1):218-223.e1. View abstract
  59. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2020 02; 79(2):225-231. View abstract
  60. Anti-thrombosis management of patients with Kawasaki disease: Results from an international survey. Int J Cardiol. 2020 05 15; 307:154-158. View abstract
  61. Introduction to the Mini-Symposium: Ethical Dilemmas in Caring for the Hearts of Children. Ann Thorac Surg. 2019 11; 108(5):1277. View abstract
  62. Behavior and Quality of Life at 6 Years for Children With Hypoplastic Left Heart Syndrome. Pediatrics. 2019 11; 144(5). View abstract
  63. De novo and recessive forms of congenital heart disease have distinct genetic and phenotypic landscapes. Nat Commun. 2019 10 17; 10(1):4722. View abstract
  64. Autism and Congenital Heart Disease: Evidence and Unresolved Questions. Pediatrics. 2019 11; 144(5). View abstract
  65. Abnormalities in cerebral hemodynamics and changes with surgical intervention in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2020 05; 159(5):2012-2021. View abstract
  66. Mental health care for parents of babies with congenital heart disease during intensive care unit admission: Systematic review and statement of best practice. Early Hum Dev. 2019 12; 139:104837. View abstract
  67. A multi-national trial of a direct oral anticoagulant in children with cardiac disease: Design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study. Am Heart J. 2019 11; 217:52-63. View abstract
  68. Enhancing efficiency and scientific impact of a clinical trials network: the Pediatric Heart Network Integrated CARdiac Data and Outcomes (iCARD) Collaborative. Cardiol Young. 2019 Sep; 29(9):1121-1126. View abstract
  69. Early-Emerging Sulcal Patterns Are Atypical in Fetuses with Congenital Heart Disease. Cereb Cortex. 2019 07 22; 29(8):3605-3616. View abstract
  70. Is Echocardiography Critical in Patients With Kawasaki Disease With a Z-Score < 2 6 Weeks From Onset?-Reply. JAMA Pediatr. 2019 07 01; 173(7):700-701. View abstract
  71. Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association. Circulation. 2019 Jul 01; CIR0000000000000696. View abstract
  72. Impact of Socioeconomic Status on Outcomes of Patients with Kawasaki Disease. J Pediatr. 2019 09; 212:87-92. View abstract
  73. Variation in the management of Kawasaki disease. Arch Dis Child. 2020 10; 105(10):1004-1006. View abstract
  74. Correction of d-Transposition of the Great Arteries Sooner Rather Than Later. Circulation. 2019 06 11; 139(24):2739-2741. View abstract
  75. Risk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population. J Am Heart Assoc. 2019 06 04; 8(11):e011319. View abstract
  76. Factors Associated With Adverse Outcomes After Repair of Anomalous Coronary From Pulmonary Artery. Ann Thorac Surg. 2019 09; 108(3):785-791. View abstract
  77. Failure to validate association of mannose-binding lectin deficiency with adverse neurodevelopmental outcomes after cardiac surgery in infants. J Thorac Cardiovasc Surg. 2019 Jun; 157(6):e397-e398. View abstract
  78. Early Neurodevelopmental Outcomes in Children Supported with ECMO for Cardiac Indications. Pediatr Cardiol. 2019 Jun; 40(5):1072-1083. View abstract
  79. Etanercept as Adjunctive Primary Therapy in Kawasaki Disease. Pediatrics. 2019 06; 143(6). View abstract
  80. Treatment Intensification in Patients With Kawasaki Disease and Coronary Aneurysm at Diagnosis. Pediatrics. 2019 06; 143(6). View abstract
  81. Gestational Age, Birth Weight, and Outcomes Six Years After the Norwood Procedure. Pediatrics. 2019 05; 143(5). View abstract
  82. PREVAPIX-ALL: Apixaban Compared to Standard of Care for Prevention of Venous Thrombosis in Paediatric Acute Lymphoblastic Leukaemia (ALL)-Rationale and Design. Thromb Haemost. 2019 May; 119(5):844-853. View abstract
  83. The Kawasaki Disease Comparative Effectiveness (KIDCARE) trial: A phase III, randomized trial of second intravenous immunoglobulin versus infliximab for resistant Kawasaki disease. Contemp Clin Trials. 2019 04; 79:98-103. View abstract
  84. The Congenital Heart Technical Skill Study: Rationale and Design. World J Pediatr Congenit Heart Surg. 2019 03; 10(2):137-144. View abstract
  85. Reflections on mentoring. Congenit Heart Dis. 2019 Mar; 14(2):126-127. View abstract
  86. Improving neurodevelopmental outcomes in children with congenital heart disease: protocol for a randomised controlled trial of working memory training. BMJ Open. 2019 02 19; 9(2):e023304. View abstract
  87. Aortic Valve Replacement With Bovine Pericardial Tissue Valve in Children and Young Adults. Circulation. 2019 02 12; 139(7):983-985. View abstract
  88. Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations. Circ Cardiovasc Imaging. 2019 02; 12(2):e007865. View abstract
  89. Visual-spatial processing style is associated with psychopathology in adolescents with critical congenital heart disease. Clin Neuropsychol. 2019 05; 33(4):760-778. View abstract
  90. Ascending Aorta Size at Birth Predicts White Matter Microstructure in Adolescents Who Underwent Fontan Palliation. J Am Heart Assoc. 2018 12 18; 7(24):e010395. View abstract
  91. Association of Initially Normal Coronary Arteries With Normal Findings on Follow-up Echocardiography in Patients With Kawasaki Disease. JAMA Pediatr. 2018 12 01; 172(12):e183310. View abstract
  92. The Use of Non-ionic Contrast Agent for Lymphangiography and Embolization of the Thoracic Duct. Cardiovasc Intervent Radiol. 2019 Mar; 42(3):481-483. View abstract
  93. Neurodevelopmental assessment of infants with congenital heart disease in the early postoperative period. Congenit Heart Dis. 2019 Mar; 14(2):236-245. View abstract
  94. Longitudinal Associations between Neurodevelopment and Psychosocial Health Status in Patients with Repaired D-Transposition of the Great Arteries. J Pediatr. 2019 01; 204:38-45.e1. View abstract
  95. Variation in care for infants undergoing the Stage II palliation for hypoplastic left heart syndrome. Cardiol Young. 2018 Oct; 28(10):1109-1115. View abstract
  96. Working Memory Training: A Promising Intervention? Crit Care Med. 2018 07; 46(7):1199-1201. View abstract
  97. Altered White Matter Microstructure Correlates with IQ and Processing Speed in Children and Adolescents Post-Fontan. J Pediatr. 2018 09; 200:140-149.e4. View abstract
  98. The Pediatric Heart Network Scholar Award programme: a unique mentored award embedded within a multicentre network. Cardiol Young. 2018 Jun; 28(6):854-861. View abstract
  99. Renin-Angiotensin-Aldosterone System Inhibitors for Right Ventricular Dysfunction in Tetralogy of Fallot: Quo Vadis? Circulation. 2018 04 03; 137(14):1472-1474. View abstract
  100. Disparities in Outcomes and Resource Use After Hospitalization for Cardiac Surgery by Neighborhood Income. Pediatrics. 2018 03; 141(3). View abstract
  101. Heart failure after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial. J Heart Lung Transplant. 2018 07; 37(7):879-885. View abstract
  102. Recommendations to Enhance Pediatric Cardiovascular Drug Development: Report of a Multi-Stakeholder Think Tank. J Am Heart Assoc. 2018 02 10; 7(4). View abstract
  103. Neighborhood Socioeconomic Status and Outcomes Following the Norwood Procedure: An Analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial Public Data Set. J Am Heart Assoc. 2018 02 02; 7(3). View abstract
  104. Transplant-Free Survival and Interventions at 6 Years in the SVR Trial. Circulation. 2018 05 22; 137(21):2246-2253. View abstract
  105. Kawasaki Disease. Pediatr Rev. 2018 Feb; 39(2):78-90. View abstract
  106. Graph theory analysis of cortical thickness networks in adolescents with d-transposition of the great arteries. Brain Behav. 2018 02; 8(2):e00834. View abstract
  107. Coronary Stenosis after Kawasaki Disease: Size Matters. J Pediatr. 2018 03; 194:8-10. View abstract
  108. Role of intravenous immunoglobulin in the treatment of Kawasaki disease. Int J Rheum Dis. 2018 Jan; 21(1):64-69. View abstract
  109. Probabilistic tractography-based thalamic parcellation in healthy newborns and newborns with congenital heart disease. J Magn Reson Imaging. 2018 06; 47(6):1626-1637. View abstract
  110. Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands. Nat Genet. 2017 Nov; 49(11):1593-1601. View abstract
  111. Genetic contribution to neurodevelopmental outcomes in congenital heart disease: are some patients predetermined to have developmental delay? Curr Opin Pediatr. 2017 10; 29(5):529-533. View abstract
  112. Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial. J Thorac Cardiovasc Surg. 2017 11; 154(5):1703-1710.e3. View abstract
  113. Learning and Memory in Adolescents With Critical Biventricular Congenital Heart Disease. J Int Neuropsychol Soc. 2017 09; 23(8):627-639. View abstract
  114. Kawasaki disease: Medical therapies. Congenit Heart Dis. 2017 Sep; 12(5):641-643. View abstract
  115. Kawasaki disease: State of the art. Congenit Heart Dis. 2017 Sep; 12(5):633-635. View abstract
  116. Predicting Coronary Artery Aneurysms in Kawasaki Disease at a North American Center: An Assessment of Baseline z Scores. J Am Heart Assoc. 2017 May 31; 6(6). View abstract
  117. Safety and Efficacy of Warfarin Therapy in Kawasaki Disease. J Pediatr. 2017 10; 189:61-65. View abstract
  118. Psychiatric Disorders and Function in Adolescents with Tetralogy of Fallot. J Pediatr. 2017 08; 187:165-173. View abstract
  119. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017 Apr 25; 135(17):e927-e999. View abstract
  120. Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. Sci Rep. 2017 03 09; 7:44117. View abstract
  121. Kawasaki disease and immunisation: A systematic review. Vaccine. 2017 03 27; 35(14):1770-1779. View abstract
  122. Neurodevelopmental Outcome in Children after Fetal Cardiac Intervention for Aortic Stenosis with Evolving Hypoplastic Left Heart Syndrome. J Pediatr. 2017 05; 184:130-136.e4. View abstract
  123. Visuospatial processing in adolescents with critical congenital heart disease: Organization, integration, and implications for academic achievement. Child Neuropsychol. 2018 05; 24(4):451-468. View abstract
  124. Development of Quality Metrics in Ambulatory Pediatric Cardiology. J Am Coll Cardiol. 2017 Feb 07; 69(5):541-555. View abstract
  125. Reduced cortical volume and thickness and their relationship to medical and operative features in post-Fontan children and adolescents. Pediatr Res. 2017 Jun; 81(6):881-890. View abstract
  126. Psychiatric Disorders in Adolescents With Single Ventricle Congenital Heart Disease. Pediatrics. 2017 Mar; 139(3). View abstract
  127. A Pediatric Cardiology Fellowship Boot Camp improves trainee confidence. Cardiol Young. 2016 Dec; 26(8):1514-1521. View abstract
  128. Training fellows in paediatric cardiology: the Harvard experience. Cardiol Young. 2016 Dec; 26(8):1499-1506. View abstract
  129. Kawasaki disease and immunisation: Standardised case definition & guidelines for data collection, analysis. Vaccine. 2016 12 12; 34(51):6582-6596. View abstract
  130. Assessment of Growth 6 Years after the Norwood Procedure. J Pediatr. 2017 01; 180:270-274.e6. View abstract
  131. White Matter Volume Predicts Language Development in Congenital Heart Disease. J Pediatr. 2017 02; 181:42-48.e2. View abstract
  132. Implementation of a Quality Improvement Bundle Improves Echocardiographic Imaging after Congenital Heart Surgery in Children. J Am Soc Echocardiogr. 2016 12; 29(12):1163-1170.e3. View abstract
  133. Completeness and Accuracy of Local Clinical Registry Data for Children Undergoing Heart Surgery. Ann Thorac Surg. 2017 Feb; 103(2):629-636. View abstract
  134. Early-Term Birth in Single-Ventricle Congenital Heart Disease After the Fontan Procedure: Neurodevelopmental and Psychiatric Outcomes. J Pediatr. 2016 12; 179:96-103. View abstract
  135. Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population. J Am Heart Assoc. 2016 09 15; 5(9). View abstract
  136. Anomalous Aortic Origin of Coronary Arteries: A Single-Center Experience. Semin Thorac Cardiovasc Surg. 2016 Winter; 28(4):791-800. View abstract
  137. Kawasaki Disease and Exposure to Fine Particulate Air Pollution. J Pediatr. 2016 10; 177:179-183.e1. View abstract
  138. Impact of Surgical Complexity on Health-Related Quality of Life in Congenital Heart Disease Surgical Survivors. J Am Heart Assoc. 2016 07 22; 5(7). View abstract
  139. Trends in Congenital Heart Disease: The Next Decade. Circulation. 2016 Jun 21; 133(25):2716-33. View abstract
  140. Organizational topology of brain and its relationship to ADHD in adolescents with d-transposition of the great arteries. Brain Behav. 2016 08; 6(8):e00504. View abstract
  141. Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury. Circulation. 2016 May 17; 133(20):1951-62. View abstract
  142. Emerging Research Directions in Adult Congenital Heart Disease: A Report From an NHLBI/ACHA Working Group. J Am Coll Cardiol. 2016 Apr 26; 67(16):1956-64. View abstract
  143. Processing speed, executive function, and academic achievement in children with dextro-transposition of the great arteries: Testing a longitudinal developmental cascade model. Neuropsychology. 2016 10; 30(7):874-885. View abstract
  144. Kawasaki Disease. J Am Coll Cardiol. 2016 Apr 12; 67(14):1738-49. View abstract
  145. Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial). Contemp Clin Trials. 2016 05; 48:70-5. View abstract
  146. Heart block following stage 1 palliation of hypoplastic left heart syndrome. J Thorac Cardiovasc Surg. 2016 Jul; 152(1):189-94. View abstract
  147. Neuropsychological Status and Structural Brain Imaging in Adolescents With Single Ventricle Who Underwent the Fontan Procedure. J Am Heart Assoc. 2015 Dec 14; 4(12). View abstract
  148. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science. 2015 Dec 04; 350(6265):1262-6. View abstract
  149. Perioperative cerebral hemodynamics and oxygen metabolism in neonates with single-ventricle physiology. Biomed Opt Express. 2015 Dec 01; 6(12):4749-67. View abstract
  150. Altered Gray Matter in Adolescents with d-Transposition of the Great Arteries. J Pediatr. 2016 Feb; 169:36-43.e1. View abstract
  151. Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015. J Am Heart Assoc. 2015 Nov 05; 4(11). View abstract
  152. Growth Asymmetry, Head Circumference, and Neurodevelopmental Outcomes in Infants with Single Ventricles. J Pediatr. 2016 Jan; 168:220-225.e1. View abstract
  153. Factors affecting Fontan length of stay: Results from the Single Ventricle Reconstruction trial. J Thorac Cardiovasc Surg. 2016 Mar; 151(3):669-675.e1. View abstract
  154. Coronary Artery Aneurysm Measurement and Z Score Variability in Kawasaki Disease. J Am Soc Echocardiogr. 2016 Feb; 29(2):150-7. View abstract
  155. Impact of Variability in Echocardiographic Interpretation on Assessment of Adequacy of Repair Following Congenital Heart Surgery: A Pilot Study. Pediatr Cardiol. 2016 Jan; 37(1):144-50. View abstract
  156. Differentiating standardized clinical assessment and management plans from clinical practice guidelines. Acad Med. 2015 Aug; 90(8):1002. View abstract
  157. Associations Between Day of Admission and Day of Surgery on Outcome and Resource Utilization in Infants With Hypoplastic Left Heart Syndrome Who Underwent Stage I Palliation (from the Single Ventricle Reconstruction Trial). Am J Cardiol. 2015 Oct 15; 116(8):1263-9. View abstract
  158. Left Ventricular Strain and Myocardial Fibrosis in Congenital Aortic Stenosis. Am J Cardiol. 2015 Oct 15; 116(8):1257-62. View abstract
  159. Prevalence of Undiagnosed Structural Heart Disease in Children Undergoing Echocardiography for Kawasaki Disease. Clin Pediatr (Phila). 2016 Jun; 55(6):557-9. View abstract
  160. Patterns of Lipid Lowering Therapy among Children Ages 8-20 Years. J Pediatr. 2015 Jul; 167(1):113-9.e1. View abstract
  161. Neurodevelopmental outcomes after cardiac surgery in infancy. Pediatrics. 2015 May; 135(5):816-25. View abstract
  162. Task Force 8: Pediatric Cardiology Fellowship Training in Research and Scholarly Activity. J Am Coll Cardiol. 2015 Aug 11; 66(6):740-7. View abstract
  163. Task Force 8: Pediatric Cardiology Fellowship Training in Research and Scholarly Activity. SPCTPD/ACC/AAP/AHA. Circulation. 2015 Aug 11; 132(6):e107-13. View abstract
  164. 2015 SPCTPD/ACC/AAP/AHA Training Guidelines for Pediatric Cardiology Fellowship Programs (Revision of the 2005 Training Guidelines for Pediatric Cardiology Fellowship Programs). J Am Coll Cardiol. 2015 Mar 13. View abstract
  165. Relationship of white matter network topology and cognitive outcome in adolescents with d-transposition of the great arteries. Neuroimage Clin. 2015; 7:438-48. View abstract
  166. Quality of life in pediatric patients affected by electrophysiologic disease. Heart Rhythm. 2015 May; 12(5):899-908. View abstract
  167. Management of Kawasaki disease in resource-limited settings. Pediatr Infect Dis J. 2015 Jan; 34(1):94-6. View abstract
  168. Executive Function in Children and Adolescents with Critical Cyanotic Congenital Heart Disease. J Int Neuropsychol Soc. 2015 Jan; 21(1):34-49. View abstract
  169. Carotid artery intima-media thickness measurements in the youth: reproducibility and technical considerations. J Am Soc Echocardiogr. 2015 Mar; 28(3):309-16. View abstract
  170. Idiopathic pericarditis and pericardial effusion in children: contemporary epidemiology and management. J Am Heart Assoc. 2014 Nov 07; 3(6):e001483. View abstract
  171. Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial. J Am Coll Cardiol. 2014 Nov 11; 64(19):2026-35. View abstract
  172. Predictors of health-related quality of life in adolescents with tetralogy of Fallot. J Pediatr. 2015 Jan; 166(1):132-8. View abstract
  173. Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease. Circulation. 2014 Sep 30; 130(14):1192-203. View abstract
  174. Cardiology patient page. Neurodevelopmental outcomes in congenital heart disease. Circulation. 2014 Sep 30; 130(14):e124-6. View abstract
  175. White matter microstructure and cognition in adolescents with congenital heart disease. J Pediatr. 2014 Nov; 165(5):936-44.e1-2. View abstract
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  258. Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging and spectroscopy. Circulation. 2010 Jan 05; 121(1):26-33. View abstract
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  260. Parent- versus child-reported functional health status after the Fontan procedure. Pediatrics. 2009 Nov; 124(5):e942-9. View abstract
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  265. Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease. J Thorac Cardiovasc Surg. 2009 Aug; 138(2):374-81. View abstract
  266. Cerebral oximetry during infant cardiac surgery: evaluation and relationship to early postoperative outcome. Anesth Analg. 2009 Apr; 108(4):1122-31. View abstract
  267. Endothelial pulse amplitude testing: feasibility and reproducibility in adolescents. J Pediatr. 2009 Jun; 154(6):901-5. View abstract
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  269. Behaviour at eight years in children with surgically corrected transposition: The Boston Circulatory Arrest Trial. Cardiol Young. 2009 Feb; 19(1):86-97. View abstract
  270. Associated symptoms in the ten days before diagnosis of Kawasaki disease. J Pediatr. 2009 Apr; 154(4):592-595.e2. View abstract
  271. Reexamining the emperor's new clothes: ambiguities in current cardiac screening recommendations for youth with attention deficit hyperactivity disorder. Circ Cardiovasc Qual Outcomes. 2008 Nov; 1(2):134-7. View abstract
  272. Cardiology patient pages. Kawasaki disease. Circulation. 2008 Aug 12; 118(7):e110-2. View abstract
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  275. Resistance to intravenous immunoglobulin in children with Kawasaki disease. J Pediatr. 2008 Jul; 153(1):117-21. View abstract
  276. The effect of hematocrit during hypothermic cardiopulmonary bypass in infant heart surgery: results from the combined Boston hematocrit trials. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):355-60. View abstract
  277. Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):347-54, 354.e1-4. View abstract
  278. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. J Am Dent Assoc. 2008 Jan; 139 Suppl:3S-24S. View abstract
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  282. Are patients with Kawasaki disease at risk for premature atherosclerosis? J Pediatr. 2007 Sep; 151(3):225-8. View abstract
  283. Characteristics of children discharged from hospitals in the United States in 2000 with the diagnosis of acute rheumatic fever. Pediatrics. 2007 Sep; 120(3):503-8. View abstract
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  285. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. J Am Dent Assoc. 2007 Jun; 138(6):739-45, 747-60. View abstract
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  288. Kawasaki disease. Curr Treat Options Cardiovasc Med. 2007 Apr; 9(2):148-58. View abstract
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  292. Cardiac troponin increases among runners in the Boston Marathon. Ann Emerg Med. 2007 Feb; 49(2):137-43, 143.e1. View abstract
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  294. Factors determining access to surgery for children with congenital cardiac disease in Guatemala, Central America. Cardiol Young. 2006 Aug; 16(4):385-91. View abstract
  295. Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination Surveys. Clin Chem. 2006 Jul; 52(7):1325-30. View abstract
  296. Early postoperative outcomes in a series of infants with hypoplastic left heart syndrome undergoing stage I palliation operation with either modified Blalock-Taussig shunt or right ventricle to pulmonary artery conduit. Pediatr Crit Care Med. 2006 May; 7(3):238-44. View abstract
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  301. Hypoxic-ischemic brain injury in infants with congenital heart disease dying after cardiac surgery. Acta Neuropathol. 2005 Dec; 110(6):563-78. View abstract
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  307. Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease. J Infect Dis. 2005 Jul 15; 192(2):344-9. View abstract
  308. Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. Pediatrics. 2005 Jul; 116(1):e89-93. View abstract
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  310. Hyponatremia among runners in the Boston Marathon. N Engl J Med. 2005 Apr 14; 352(15):1550-6. View abstract
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  313. Risk factors for readmission after neonatal cardiac surgery. Ann Thorac Surg. 2004 Dec; 78(6):1972-8; discussion 1978. View abstract
  314. Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery. Pediatr Res. 2005 Jan; 57(1):35-41. View abstract
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  316. Prediction of IQ and achievement at age 8 years from neurodevelopmental status at age 1 year in children with D-transposition of the great arteries. Pediatrics. 2004 Nov; 114(5):e572-6. View abstract
  317. Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation. 2004 Oct 19; 110(16):2494-7. View abstract
  318. Elevated basic fibroblast growth factor levels in patients with pulmonary arterial hypertension. Chest. 2004 Oct; 126(4):1255-61. View abstract
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  327. The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: results of a randomized trial in infants. J Thorac Cardiovasc Surg. 2003 Dec; 126(6):1765-74. View abstract
  328. The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003 Nov; 126(5):1397-403. View abstract
  329. Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg. 2003 Nov; 126(5):1385-96. View abstract
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  337. Time course of early induction of intracellular adhesion molecule-1 messenger RNA during reperfusion, following cardiopulmonary bypass with hypothermic circulatory arrest in lambs. Pediatr Crit Care Med. 2003 Jan; 4(1):83-8. View abstract
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  349. Hyperlipidemia in children and adolescents. Am Heart J. 2001 Sep; 142(3):433-9. View abstract
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