Dr. Madden conducts clinical research with a focus on finding risk factors for critical illness and its complications. This has included vitamin D deficiency and its relationship to illness severity and organ failure, quality improvement in severe sepsis and septic shock management, sedation management, early mobilization from critical illness, and delirium assessment. Current clinical research focuses on causes of delirium in critically ill children, as well as its assessment and management.


Dr. Madden graduated from Brown University and Washington University Medical School at Saint Louis. She completed pediatrics residency, chief residency and pediatric critical care fellowship at Boston Children’s Hospital. She is currently an associate in the division of Pediatric Critical Care, and an Instructor in Anaesthesia at Harvard Medical School. Dr. Madden has studied various areas of clinical research, including vitamin D deficiency in critically ill children, sepsis management, delirium, and sedation in pediatric critical illness. After completing a clinical research fellowship at Harvard Medical School in 2012 with a Master’s of Medical Science, she has been involved in quality improvement initiatives in the division, as well as conducting clinical research projects. Dr. Madden serves as the physician lead for critical care on her hospital’s steering committee of a national “Improving Pediatric Sepsis Outcomes” collaborative (Children’s Hospital Association.)


Publications powered by Harvard Catalyst Profiles

  1. Comparison of Manual and Automated Sepsis Screening Tools in a Pediatric Emergency Department. Pediatrics. 2021 Feb; 147(2). View abstract
  2. Effect of a Sepsis Screening Algorithm on Care of Children with False-Positive Sepsis Alerts. J Pediatr. 2021 Jan 27. View abstract
  3. Toward a Better Understanding of Burnout Syndrome: Lump less, Split More. Crit Care Med. 2020 Jun; 48(6):930-931. View abstract
  4. Measuring Central Cholinergic Inhibition As a Risk Factor for Delirium Remains a Challenge. Pediatr Crit Care Med. 2020 06; 21(6):590-591. View abstract
  5. Exposure to Anticholinergic Medications in Pediatric Severe Sepsis and Feasibility of Delirium Screening. J Pediatr Intensive Care. 2020 Dec; 9(4):271-276. View abstract
  6. Performance of an Automated Screening Algorithm for Early Detection of Pediatric Severe Sepsis. Pediatr Crit Care Med. 2019 12; 20(12):e516-e523. View abstract
  7. Anticholinergic Medication Burden in Pediatric Prolonged Critical Illness: A Potentially Modifiable Risk Factor for Delirium. Pediatr Crit Care Med. 2018 10; 19(10):917-924. View abstract
  8. Reading the Smoke Signals: What Is the Meaning of Burnout Among Pediatric Critical Care Physicians? Crit Care Med. 2018 01; 46(1):168-170. View abstract
  9. The authors reply. Pediatr Crit Care Med. 2018 01; 19(1):87-88. View abstract
  10. Caring for Long Length of Stay Patients in the Neonatal ICU and PICU: How Do We Ensure Coherent Decisions When the Physicians Are Continuously Rotating? Pediatr Crit Care Med. 2017 09; 18(9):907-908. View abstract
  11. Differentiating Delirium From Sedative/Hypnotic-Related Iatrogenic Withdrawal Syndrome: Lack of Specificity in Pediatric Critical Care Assessment Tools. Pediatr Crit Care Med. 2017 Jun; 18(6):580-588. View abstract
  12. Delirium in Critically Ill Children: An International Point Prevalence Study. Crit Care Med. 2017 Apr; 45(4):584-590. View abstract
  13. Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections. Pediatr Crit Care Med. 2017 02; 18(2):103-111. View abstract
  15. Case Report of a Child after Hematopoietic Cell Transplantation with Acute Aspergillus Tracheobronchitis as a Cause for Respiratory Failure. Case Rep Pediatr. 2016; 2016:9676234. View abstract
  16. Critically Ill Children Have Low Vitamin D-Binding Protein, Influencing Bioavailability of Vitamin D. Ann Am Thorac Soc. 2015 Nov; 12(11):1654-61. View abstract
  17. Vitamin D deficiency in critically ill children. Pediatrics. 2012 Sep; 130(3):421-8. View abstract
  18. Survival of neonates with enteroviral myocarditis requiring extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2011 May; 12(3):314-8. View abstract