ABOUT THE RESEARCHER

OVERVIEW

Dr. Mansbach has been performing multicenter bronchiolitis and respiratory virus research with the Emergency Medicine Network (www.emnet-usa.org) for more than a decade. He has been Principal Investigator, site Principal Investigator, or Co-Investigator of multiple industry, foundation, and NIH grants. Currently, Dr. Mansbach is BCH Site-PI and on the Steering Committee for a NIH-funded multicenter study following 921 infants hospitalized with bronchiolitis for the development of recurrent wheezing and eventual asthma. He is PI of an NIH/NIAID grant examining the relation of viral persistence and the airway microbiome to recurrent wheezing and asthma in these 921 infants. He is also actively investigating the tracheal microbiome before, during, and after lower respiratory infections in children and young adults with a tracheostomy.

Active Projects:

2009-2014 Vitamin D deficiency and the severity of bronchiolitis

K23 AI077801
Principal Investigator

This study examines the vitamin D level of the children enrolled for the U01 study at Boston Children’s Hospital.

BACKGROUND

Dr. Mansbach graduated from Haverford College and Duke University School of Medicine before coming to Boston Children’s Hospital as an intern. He has been at Boston Children’s Hospital ever since. He completed a hospitalist and adolescent medicine fellowship, and now spends the majority of his time investigating bronchiolitis and respiratory viruses. He obtained a Masters of Public Health from the Harvard School of Public Health.

PUBLICATIONS

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  1. Proteome signature difference between respiratory viruses is associated with severity of bronchiolitis. Pediatr Allergy Immunol. 2021 Jul 27. View abstract
  2. Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma. Nat Commun. 2021 06 14; 12(1):3601. View abstract
  3. Utility of Inflammatory Markers in Hospitalized Children With Skin Erythema. Hosp Pediatr. 2021 Jun; 11(6):627-631. View abstract
  4. Integrated associations of nasopharyngeal and serum metabolome with bronchiolitis severity and asthma: A multicenter prospective cohort study. Pediatr Allergy Immunol. 2021 07; 32(5):905-916. View abstract
  5. Detection of Respiratory Syncytial Virus or Rhinovirus Weeks After Hospitalization for Bronchiolitis and the Risk of Recurrent Wheezing. J Infect Dis. 2021 02 03; 223(2):268-277. View abstract
  6. A joint modeling approach for longitudinal microbiome data improves ability to detect microbiome associations with disease. PLoS Comput Biol. 2020 12; 16(12):e1008473. View abstract
  7. Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma. J Allergy Clin Immunol. 2021 Jun; 147(6):2108-2117. View abstract
  8. Serum soluble receptor for advanced glycation end-products (sRAGE) in infants with bronchiolitis: Associations with acute severity and recurrent wheeze. Clin Infect Dis. 2020 Nov 10. View abstract
  9. Pediatric Hospitalizations During the COVID-19 Pandemic. Pediatrics. 2020 12; 146(6). View abstract
  10. A comparison of childhood asthma case definitions based on parent-reported data. Ann Epidemiol. 2021 03; 55:64-68.e4. View abstract
  11. Association of endemic coronaviruses with nasopharyngeal metabolome and microbiota among infants with severe bronchiolitis: a prospective multicenter study. Pediatr Res. 2021 05; 89(7):1594-1597. View abstract
  12. Being Mindful About Follow-up Care After Pediatric Hospitalization for Bronchiolitis. JAMA Pediatr. 2020 09 01; 174(9):e201945. View abstract
  13. Machine learning-based prediction of acute severity in infants hospitalized for bronchiolitis: a multicenter prospective study. Sci Rep. 2020 07 03; 10(1):10979. View abstract
  14. Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study. Pediatr Allergy Immunol. 2020 10; 31(7):755-766. View abstract
  15. Severe Coronavirus Bronchiolitis in the Pre-COVID-19 Era. Pediatrics. 2020 09; 146(3). View abstract
  16. Association of rhinovirus species with nasopharyngeal metabolome in bronchiolitis infants: A multicenter study. Allergy. 2020 09; 75(9):2379-2383. View abstract
  17. In infants with severe bronchiolitis: dual-transcriptomic profiling of nasopharyngeal microbiome and host response. Pediatr Res. 2020 08; 88(2):144-146. View abstract
  18. Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing. J Allergy Clin Immunol. 2020 02; 145(2):518-527.e8. View abstract
  19. Trends in Bronchiolitis Hospitalizations in the United States: 2000-2016. Pediatrics. 2019 12; 144(6). View abstract
  20. Bronchiolitis severity is related to recurrent wheezing by age 3 years in a prospective, multicenter cohort. Pediatr Res. 2020 02; 87(3):428-430. View abstract
  21. Respiratory Virus Epidemiology Among US Infants With Severe Bronchiolitis: Analysis of 2 Multicenter, Multiyear Cohort Studies. Pediatr Infect Dis J. 2019 08; 38(8):e180-e183. View abstract
  22. Association of respiratory viruses with serum metabolome in infants with severe bronchiolitis. Pediatr Allergy Immunol. 2019 12; 30(8):848-851. View abstract
  23. Association of Serum Albumin With Apnea in Infants With Bronchiolitis: A Secondary Analysis of Data From the MARC-35 Study. JAMA Netw Open. 2019 07 03; 2(7):e197100. View abstract
  24. Association of Rhinovirus C Bronchiolitis and Immunoglobulin E Sensitization During Infancy With Development of Recurrent Wheeze. JAMA Pediatr. 2019 06 01; 173(6):544-552. View abstract
  25. Serum Metabolome Is Associated With the Nasopharyngeal Microbiota and Disease Severity Among Infants With Bronchiolitis. J Infect Dis. 2019 05 24; 219(12):2005-2014. View abstract
  26. Haemophilus-Dominant Nasopharyngeal Microbiota Is Associated With Delayed Clearance of Respiratory Syncytial Virus in Infants Hospitalized for Bronchiolitis. J Infect Dis. 2019 05 05; 219(11):1804-1808. View abstract
  27. Rhinovirus Species in Children With Severe Bronchiolitis: Multicenter Cohort Studies in the United States and Finland. Pediatr Infect Dis J. 2019 03; 38(3):e59-e62. View abstract
  28. Association of type 2 cytokines in severe rhinovirus bronchiolitis during infancy with risk of developing asthma: A multicenter prospective study. Allergy. 2019 07; 74(7):1374-1377. View abstract
  29. Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis. J Allergy Clin Immunol. 2019 05; 143(5):1925-1928.e7. View abstract
  30. Circulating 25-hydroxyvitamin D, nasopharyngeal microbiota, and bronchiolitis severity. Pediatr Allergy Immunol. 2018 12; 29(8):877-880. View abstract
  31. Tracheal Microbiota in Patients With a Tracheostomy Before, During and After an Acute Respiratory Infection. Pediatr Infect Dis J. 2018 11; 37(11):e269-e271. View abstract
  32. Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity. J Pediatr. 2018 12; 203:416-422.e1. View abstract
  33. Severe bronchiolitis profiles and risk of recurrent wheeze by age 3 years. J Allergy Clin Immunol. 2019 04; 143(4):1371-1379.e7. View abstract
  34. Overcoming the Bronchiolitis Blues: Embracing Global Collaboration and Disease Heterogeneity. Pediatrics. 2018 09; 142(3). View abstract
  35. Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi-center prospective cohort study. Clin Exp Allergy. 2018 08; 48(8):1063-1067. View abstract
  36. Serum 25-hydroxyvitamin D, metabolome, and bronchiolitis severity among infants-A multicenter cohort study. Pediatr Allergy Immunol. 2018 06; 29(4):441-445. View abstract
  37. Multicenter Study of Albuterol Use Among Infants Hospitalized with Bronchiolitis. West J Emerg Med. 2018 May; 19(3):475-483. View abstract
  38. Respiratory Syncytial Virus and Rhinovirus Bronchiolitis Are Associated With Distinct Metabolic Pathways. J Infect Dis. 2018 03 13; 217(7):1160-1169. View abstract
  39. Circulating 25-hydroxyvitamin D, nasopharyngeal airway metabolome, and bronchiolitis severity. Allergy. 2018 05; 73(5):1135-1140. View abstract
  40. RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NF?B signaling. Pediatr Res. 2018 03; 83(3):606-614. View abstract
  41. The association between anterior nares and nasopharyngeal microbiota in infants hospitalized for bronchiolitis. Microbiome. 2018 01 03; 6(1):2. View abstract
  42. Nasal Airway Microbiota Profile and Severe Bronchiolitis in Infants: A Case-control Study. Pediatr Infect Dis J. 2017 Nov; 36(11):1044-1051. View abstract
  43. Associations of Nasopharyngeal Metabolome and Microbiome with Severity among Infants with Bronchiolitis. A Multiomic Analysis. Am J Respir Crit Care Med. 2017 10 01; 196(7):882-891. View abstract
  44. Serum LL-37 Levels Associated With Severity of Bronchiolitis and Viral Etiology. Clin Infect Dis. 2017 Sep 15; 65(6):967-975. View abstract
  45. The temporal dynamics of the tracheal microbiome in tracheostomised patients with and without lower respiratory infections. PLoS One. 2017; 12(8):e0182520. View abstract
  46. Clinical Profiles of Respiratory Syncytial Virus Subtypes A AND B Among Children Hospitalized with Bronchiolitis. Pediatr Infect Dis J. 2017 08; 36(8):808-810. View abstract
  47. Multicenter Observational Study of the Use of Nebulized Hypertonic Saline to Treat Children Hospitalized for Bronchiolitis From 2008 to 2014. Hosp Pediatr. 2017 Jul 31. View abstract
  48. Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case-control study. BMC Res Notes. 2017 Jul 26; 10(1):325. View abstract
  49. The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis. Allergy. 2017 Nov; 72(11):1796-1800. View abstract
  50. Household siblings and nasal and fecal microbiota in infants. Pediatr Int. 2017 Apr; 59(4):473-481. View abstract
  51. Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis. J Allergy Clin Immunol. 2017 04; 139(4):1383-1386.e6. View abstract
  52. Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis. Eur Respir J. 2016 11; 48(5):1329-1339. View abstract
  53. The Fecal Microbiota Profile and Bronchiolitis in Infants. Pediatrics. 2016 07; 138(1). View abstract
  54. A clustering approach to identify severe bronchiolitis profiles in children. Thorax. 2016 08; 71(8):712-8. View abstract
  55. Trends in Infectious Disease Hospitalizations in US Children, 2000 to 2012. Pediatr Infect Dis J. 2016 06; 35(6):e158-63. View abstract
  56. Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota. J Allergy Clin Immunol. 2016 06; 137(6):1909-1913.e4. View abstract
  57. Children Hospitalized with Rhinovirus Bronchiolitis Have Asthma-Like Characteristics. J Pediatr. 2016 05; 172:202-204.e1. View abstract
  58. Detection of respiratory syncytial virus and rhinovirus in healthy infants. BMC Res Notes. 2015 Nov 25; 8:718. View abstract
  59. Prenatal Versus Postnatal Tobacco Smoke Exposure and Intensive Care Use in Children Hospitalized With Bronchiolitis. Acad Pediatr. 2016 07; 16(5):446-452. View abstract
  60. Clinical Endpoints for Respiratory Syncytial Virus Prophylaxis Trials in Infants and Children in High-income and Middle-income Countries. Pediatr Infect Dis J. 2015 Oct; 34(10):1086-92. View abstract
  61. Eligibility for palivizumab prophylaxis in a cohort of children with severe bronchiolitis. Pediatr Int. 2015 Oct; 57(5):1031-4. View abstract
  62. Association Between Hyponatremia and Higher Bronchiolitis Severity Among Children in the ICU With Bronchiolitis. Hosp Pediatr. 2015 Jul; 5(7):385-9. View abstract
  63. Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season. Pediatr Infect Dis J. 2015 Jun; 34(6):566-70. View abstract
  64. Use of Cough and Cold Medications in Severe Bronchiolitis before and after a Health Advisory Warning against Their Use. J Pediatr. 2015 Jul; 167(1):196-8.e1-2. View abstract
  65. Variability of intensive care management for children with bronchiolitis. Hosp Pediatr. 2015 Apr; 5(4):175-84. View abstract
  66. Rhinovirus-induced bronchiolitis: Lack of association between virus genomic load and short-term outcomes. J Allergy Clin Immunol. 2015 Aug; 136(2):509-12.e11. View abstract
  67. Hospital course and discharge criteria for children hospitalized with bronchiolitis. J Hosp Med. 2015 Apr; 10(4):205-11. View abstract
  68. Risk factors for requiring intensive care among children admitted to ward with bronchiolitis. Acad Pediatr. 2015 Jan-Feb; 15(1):77-81. View abstract
  69. Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland. J Infect Dis. 2015 May 15; 211(10):1550-9. View abstract
  70. Variability in inpatient management of children hospitalized with bronchiolitis. Acad Pediatr. 2015 Jan-Feb; 15(1):69-76. View abstract
  71. Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis. Pediatr Infect Dis J. 2014 Aug; 33(8):809-13. View abstract
  72. Hospital length-of-stay is associated with rhinovirus etiology of bronchiolitis. Pediatr Infect Dis J. 2014 Aug; 33(8):829-34. View abstract
  73. Racial/ethnic differences in the presentation and management of severe bronchiolitis. J Hosp Med. 2014 Sep; 9(9):565-72. View abstract
  74. Recent evidence on the management of bronchiolitis. Curr Opin Pediatr. 2014 Jun; 26(3):328-33. View abstract
  75. Infectious pathogens and bronchiolitis outcomes. Expert Rev Anti Infect Ther. 2014 Jul; 12(7):817-28. View abstract
  76. Temporal trends in emergency department visits for bronchiolitis in the United States, 2006 to 2010. Pediatr Infect Dis J. 2014 Jan; 33(1):11-8. View abstract
  77. Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis. J Allergy Clin Immunol. 2014 Apr; 133(4):1220-2. View abstract
  78. Apnea in children hospitalized with bronchiolitis. Pediatrics. 2013 Nov; 132(5):e1194-201. View abstract
  79. Trends in bronchiolitis hospitalizations in the United States, 2000-2009. Pediatrics. 2013 Jul; 132(1):28-36. View abstract
  80. Altitude and environmental climate effects on bronchiolitis severity among children presenting to the emergency department. J Environ Health. 2012 Oct; 75(3):8-15; quiz 54. View abstract
  81. Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis. J Allergy Clin Immunol. 2012 Oct; 130(4):1007-8.e1. View abstract
  82. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation. Pediatrics. 2012 Sep; 130(3):e492-500. View abstract
  83. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med. 2012 Aug; 166(8):700-6. View abstract
  84. Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study. Pediatr Infect Dis J. 2012 Jul; 31(7):767-9. View abstract
  85. National study of antibiotic use in emergency department visits for pneumonia, 1993 through 2008. Acad Emerg Med. 2012 May; 19(5):562-8. View abstract
  86. Serum 25-hydroxyvitamin D levels among Boston trainee doctors in winter. Nutrients. 2012 03; 4(3):197-207. View abstract
  87. Clinical features can help predict which infants with bronchiolitis will need hospital admission. J Pediatr. 2012 Jan; 160(1):174-5. View abstract
  88. Low serum 25-hydroxyvitamin D levels are associated with increased risk of viral coinfections in wheezing children. J Allergy Clin Immunol. 2010 Nov; 126(5):1074-6, 1076.e1-4. View abstract
  89. Insurance status and the variable management of children presenting to the emergency department with bronchiolitis. Pediatr Emerg Care. 2010 Oct; 26(10):716-21. View abstract
  90. Prospective multicenter study of bronchiolitis: predictors of an unscheduled visit after discharge from the emergency department. Acad Emerg Med. 2010 Apr; 17(4):376-82. View abstract
  91. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol. 2010 May; 202(5):436.e1-8. View abstract
  92. Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma. Clin Lab Med. 2009 Dec; 29(4):741-55. View abstract
  93. Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D? Pediatrics. 2009 Nov; 124(5):1404-10. View abstract
  94. Factors associated with longer emergency department length of stay for children with bronchiolitis : a prospective multicenter study. Pediatr Emerg Care. 2009 Oct; 25(10):636-41. View abstract
  95. Variability in the diagnostic labeling of nonbacterial lower respiratory tract infections: a multicenter study of children who presented to the emergency department. Pediatrics. 2009 Apr; 123(4):e573-81. View abstract
  96. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009 Feb 23; 169(4):384-90. View abstract
  97. Vitamin D, respiratory infections, and asthma. Curr Allergy Asthma Rep. 2009 Jan; 9(1):81-7. View abstract
  98. Prospective multicenter bronchiolitis study: predicting intensive care unit admissions. Acad Emerg Med. 2008 Oct; 15(10):887-94. View abstract
  99. Bronchiolitis: lingering questions about its definition and the potential role of vitamin D. Pediatrics. 2008 Jul; 122(1):177-9. View abstract
  100. Variations in admission practices for adolescents with anorexia nervosa: a North American sample. J Adolesc Health. 2008 Nov; 43(5):425-31. View abstract
  101. Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department. Pediatrics. 2008 Apr; 121(4):680-8. View abstract
  102. Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. Acad Emerg Med. 2008 Feb; 15(2):111-8. View abstract
  103. US outpatient office visits for bronchiolitis, 1993-2004. Ambul Pediatr. 2007 Jul-Aug; 7(4):304-7. View abstract
  104. Evaluation of compliance with palivizumab recommendations in a multicenter study of young children presenting to the emergency department with bronchiolitis. Pediatr Emerg Care. 2007 Jun; 23(6):362-7. View abstract
  105. Variation in IRB responses to a standard, observational pediatric research protocol. Academic Emergency Medicine. 2007; 14(4):377-380. View abstract
  106. Variation in institutional review board responses to a standard, observational, pediatric research protocol. Acad Emerg Med. 2007 Apr; 14(4):377-80. View abstract
  107. Evidence Based Medicine. Comprehensive Pediatric Hospital Medicine. Zauoutis LB, Chiang VW, editors. 2007; 32-35. View abstract
  108. U.S. Outpatient office visits for bronchiolitis, 1993-2004. Ambulatory Pediatrics. 2007; 7(4):304-307. View abstract
  109. Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics. 2006 Dec; 118(6):2418-23. View abstract
  110. Multicenter Study of Bronchiolitis in the Emergency Department. Oral Presentation. American Academy of Pediatrics National Convention and Exhibition. 2006. View abstract
  111. Testicular torsion and risk factors for orchiectomy. Arch Pediatr Adolesc Med. 2005 Dec; 159(12):1167-71. View abstract
  112. Bronchiolitis in US emergency departments 1992 to 2000: epidemiology and practice variation. Pediatr Emerg Care. 2005 Apr; 21(4):242-7. View abstract
  113. Variation in Admission for Adolescents with Anorexia Nervosa: A North American Sample. Poster. Society for Adolescent Medicine Annual Conference. 2005. View abstract
  114. Two children with Lyme disease presenting with persistent headache. Pediatrics. 2003; 112: e477-e479. Reprinted in Review Series Neurology. 2004; 2:10-12. View abstract
  115. Lyme disease presenting with persistent headache. Pediatrics. 2003 Dec; 112(6 Pt 1):e477-9. View abstract
  116. Which psychiatric patients board on the medical service? Pediatrics. 2003 Jun; 111(6 Pt 1):e693-8. View abstract
  117. A practical guide to prescribing oral contraceptives. Contemporary Pediatrics. 2001; 18(10):111-126. Reprinted in Contemporary OB/GYN. 2001; 46(11):87-104 and Patient Care [serial online] June. 2003. View abstract
  118. Optimizing the care of hospitalized youth. Poster. Society for Adolescent Medicine Annual Conference. 2002. View abstract
  119. Demystifying delayed puberty. Contemporary Pediatrics. 2001; 18(4): 43-60. Reprinted in Contemporary OB/GYN. 2001; 46(8):39-54. View abstract
  120. New seizures in a 6 year-old: Expanding Horizons. Contemporary Pediatrics. 1999; 16(8):25-33. View abstract
  121. Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels. Carcinogenesis. 1996 Jan; 17(1):171-4. View abstract