Dr. Mansbach has been performing multicenter bronchiolitis and respiratory virus research with the Emergency Medicine Network (www.emnet-usa.org) for more than a decade. He has been Principal Investigator, site Principal Investigator, or Co-Investigator of multiple industry, foundation, and NIH grants. Currently, Dr. Mansbach is BCH Site-PI and on the Steering Committee for a NIH-funded multicenter study following 921 infants hospitalized with bronchiolitis for the development of recurrent wheezing and eventual asthma. He is PI of an NIH/NIAID grant examining the relation of viral persistence and the airway microbiome to recurrent wheezing and asthma in these 921 infants. He is also actively investigating the tracheal microbiome before, during, and after lower respiratory infections in children and young adults with a tracheostomy.

Active Projects:

2009-2014 Vitamin D deficiency and the severity of bronchiolitis

K23 AI077801
Principal Investigator

This study examines the vitamin D level of the children enrolled for the U01 study at Boston Children’s Hospital.


Dr. Mansbach graduated from Haverford College and Duke University School of Medicine before coming to Boston Children’s Hospital as an intern. He has been at Boston Children’s Hospital ever since. He completed a hospitalist and adolescent medicine fellowship, and now spends the majority of his time investigating bronchiolitis and respiratory viruses. He obtained a Masters of Public Health from the Harvard School of Public Health.


Publications powered by Harvard Catalyst Profiles

  1. Nasopharyngeal metatranscriptome profiles of infants with bronchiolitis and risk of childhood asthma: a multicentre prospective study. Eur Respir J. 2021 Dec 16. View abstract
  2. Role of nasal microbiota and host response in infants with respiratory syncytial virus infection: Causal questions about respiratory outcomes. J Allergy Clin Immunol. 2021 Dec 11. View abstract
  3. Serum Soluble Receptor for Advanced Glycation End Products in Infants With Bronchiolitis: Associations With Acute Severity and Recurrent Wheeze. Clin Infect Dis. 2021 11 02; 73(9):e2665-e2672. View abstract
  4. Severe bronchiolitis profiles and risk of asthma development in Finnish children. J Allergy Clin Immunol. 2021 Oct 05. View abstract
  5. Late Pre-term Infants with Severe Bronchiolitis and Risk of Asthma by Age 5 Years. J Pediatr. 2021 Sep 29. View abstract
  6. Urinary Tract Infections in Children with Vesicoureteral Reflux Are Accompanied by Alterations in Urinary Microbiota and Metabolome Profiles. Eur Urol. 2021 Sep 17. View abstract
  7. Proteome signature difference between respiratory viruses is associated with severity of bronchiolitis. Pediatr Allergy Immunol. 2021 11; 32(8):1869-1872. View abstract
  8. Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma. Nat Commun. 2021 06 14; 12(1):3601. View abstract
  9. Utility of Inflammatory Markers in Hospitalized Children With Skin Erythema. Hosp Pediatr. 2021 06; 11(6):627-631. View abstract
  10. Integrated associations of nasopharyngeal and serum metabolome with bronchiolitis severity and asthma: A multicenter prospective cohort study. Pediatr Allergy Immunol. 2021 07; 32(5):905-916. View abstract
  11. Detection of Respiratory Syncytial Virus or Rhinovirus Weeks After Hospitalization for Bronchiolitis and the Risk of Recurrent Wheezing. J Infect Dis. 2021 02 03; 223(2):268-277. View abstract
  12. A joint modeling approach for longitudinal microbiome data improves ability to detect microbiome associations with disease. PLoS Comput Biol. 2020 12; 16(12):e1008473. View abstract
  13. Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma. J Allergy Clin Immunol. 2021 06; 147(6):2108-2117. View abstract
  14. Pediatric Hospitalizations During the COVID-19 Pandemic. Pediatrics. 2020 12; 146(6). View abstract
  15. A comparison of childhood asthma case definitions based on parent-reported data. Ann Epidemiol. 2021 03; 55:64-68.e4. View abstract
  16. Association of endemic coronaviruses with nasopharyngeal metabolome and microbiota among infants with severe bronchiolitis: a prospective multicenter study. Pediatr Res. 2021 05; 89(7):1594-1597. View abstract
  17. Being Mindful About Follow-up Care After Pediatric Hospitalization for Bronchiolitis. JAMA Pediatr. 2020 09 01; 174(9):e201945. View abstract
  18. Machine learning-based prediction of acute severity in infants hospitalized for bronchiolitis: a multicenter prospective study. Sci Rep. 2020 07 03; 10(1):10979. View abstract
  19. Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study. Pediatr Allergy Immunol. 2020 10; 31(7):755-766. View abstract
  20. Severe Coronavirus Bronchiolitis in the Pre-COVID-19 Era. Pediatrics. 2020 09; 146(3). View abstract
  21. Association of rhinovirus species with nasopharyngeal metabolome in bronchiolitis infants: A multicenter study. Allergy. 2020 09; 75(9):2379-2383. View abstract
  22. In infants with severe bronchiolitis: dual-transcriptomic profiling of nasopharyngeal microbiome and host response. Pediatr Res. 2020 08; 88(2):144-146. View abstract
  23. Increased Moraxella and Streptococcus species abundance after severe bronchiolitis is associated with recurrent wheezing. J Allergy Clin Immunol. 2020 02; 145(2):518-527.e8. View abstract
  24. Trends in Bronchiolitis Hospitalizations in the United States: 2000-2016. Pediatrics. 2019 12; 144(6). View abstract
  25. Bronchiolitis severity is related to recurrent wheezing by age 3 years in a prospective, multicenter cohort. Pediatr Res. 2020 02; 87(3):428-430. View abstract
  26. Respiratory Virus Epidemiology Among US Infants With Severe Bronchiolitis: Analysis of 2 Multicenter, Multiyear Cohort Studies. Pediatr Infect Dis J. 2019 08; 38(8):e180-e183. View abstract
  27. Association of respiratory viruses with serum metabolome in infants with severe bronchiolitis. Pediatr Allergy Immunol. 2019 12; 30(8):848-851. View abstract
  28. Association of Serum Albumin With Apnea in Infants With Bronchiolitis: A Secondary Analysis of Data From the MARC-35 Study. JAMA Netw Open. 2019 07 03; 2(7):e197100. View abstract
  29. Association of Rhinovirus C Bronchiolitis and Immunoglobulin E Sensitization During Infancy With Development of Recurrent Wheeze. JAMA Pediatr. 2019 06 01; 173(6):544-552. View abstract
  30. Serum Metabolome Is Associated With the Nasopharyngeal Microbiota and Disease Severity Among Infants With Bronchiolitis. J Infect Dis. 2019 05 24; 219(12):2005-2014. View abstract
  31. Haemophilus-Dominant Nasopharyngeal Microbiota Is Associated With Delayed Clearance of Respiratory Syncytial Virus in Infants Hospitalized for Bronchiolitis. J Infect Dis. 2019 05 05; 219(11):1804-1808. View abstract
  32. Rhinovirus Species in Children With Severe Bronchiolitis: Multicenter Cohort Studies in the United States and Finland. Pediatr Infect Dis J. 2019 03; 38(3):e59-e62. View abstract
  33. Association of type 2 cytokines in severe rhinovirus bronchiolitis during infancy with risk of developing asthma: A multicenter prospective study. Allergy. 2019 07; 74(7):1374-1377. View abstract
  34. Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis. J Allergy Clin Immunol. 2019 05; 143(5):1925-1928.e7. View abstract
  35. Circulating 25-hydroxyvitamin D, nasopharyngeal microbiota, and bronchiolitis severity. Pediatr Allergy Immunol. 2018 12; 29(8):877-880. View abstract
  36. Tracheal Microbiota in Patients With a Tracheostomy Before, During and After an Acute Respiratory Infection. Pediatr Infect Dis J. 2018 11; 37(11):e269-e271. View abstract
  37. Vitamin D Status at the Time of Hospitalization for Bronchiolitis and Its Association with Disease Severity. J Pediatr. 2018 12; 203:416-422.e1. View abstract
  38. Severe bronchiolitis profiles and risk of recurrent wheeze by age 3 years. J Allergy Clin Immunol. 2019 04; 143(4):1371-1379.e7. View abstract
  39. Overcoming the Bronchiolitis Blues: Embracing Global Collaboration and Disease Heterogeneity. Pediatrics. 2018 09; 142(3). View abstract
  40. Nasopharyngeal CCL5 in infants with severe bronchiolitis and risk of recurrent wheezing: A multi-center prospective cohort study. Clin Exp Allergy. 2018 08; 48(8):1063-1067. View abstract
  41. Serum 25-hydroxyvitamin D, metabolome, and bronchiolitis severity among infants-A multicenter cohort study. Pediatr Allergy Immunol. 2018 06; 29(4):441-445. View abstract
  42. Multicenter Study of Albuterol Use Among Infants Hospitalized with Bronchiolitis. West J Emerg Med. 2018 May; 19(3):475-483. View abstract
  43. Respiratory Syncytial Virus and Rhinovirus Bronchiolitis Are Associated With Distinct Metabolic Pathways. J Infect Dis. 2018 03 13; 217(7):1160-1169. View abstract
  44. Circulating 25-hydroxyvitamin D, nasopharyngeal airway metabolome, and bronchiolitis severity. Allergy. 2018 05; 73(5):1135-1140. View abstract
  45. RSV vs. rhinovirus bronchiolitis: difference in nasal airway microRNA profiles and NF?B signaling. Pediatr Res. 2018 03; 83(3):606-614. View abstract
  46. The association between anterior nares and nasopharyngeal microbiota in infants hospitalized for bronchiolitis. Microbiome. 2018 01 03; 6(1):2. View abstract
  47. Nasal Airway Microbiota Profile and Severe Bronchiolitis in Infants: A Case-control Study. Pediatr Infect Dis J. 2017 Nov; 36(11):1044-1051. View abstract
  48. Associations of Nasopharyngeal Metabolome and Microbiome with Severity among Infants with Bronchiolitis. A Multiomic Analysis. Am J Respir Crit Care Med. 2017 10 01; 196(7):882-891. View abstract
  49. Serum LL-37 Levels Associated With Severity of Bronchiolitis and Viral Etiology. Clin Infect Dis. 2017 Sep 15; 65(6):967-975. View abstract
  50. The temporal dynamics of the tracheal microbiome in tracheostomised patients with and without lower respiratory infections. PLoS One. 2017; 12(8):e0182520. View abstract
  51. Clinical Profiles of Respiratory Syncytial Virus Subtypes A AND B Among Children Hospitalized with Bronchiolitis. Pediatr Infect Dis J. 2017 08; 36(8):808-810. View abstract
  52. Multicenter Observational Study of the Use of Nebulized Hypertonic Saline to Treat Children Hospitalized for Bronchiolitis From 2008 to 2014. Hosp Pediatr. 2017 Jul 31. View abstract
  53. Sphingolipid metabolism potential in fecal microbiome and bronchiolitis in infants: a case-control study. BMC Res Notes. 2017 Jul 26; 10(1):325. View abstract
  54. The relationship between nasopharyngeal CCL5 and microbiota on disease severity among infants with bronchiolitis. Allergy. 2017 Nov; 72(11):1796-1800. View abstract
  55. Household siblings and nasal and fecal microbiota in infants. Pediatr Int. 2017 Apr; 59(4):473-481. View abstract
  56. Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis. J Allergy Clin Immunol. 2017 04; 139(4):1383-1386.e6. View abstract
  57. Association of nasopharyngeal microbiota profiles with bronchiolitis severity in infants hospitalised for bronchiolitis. Eur Respir J. 2016 11; 48(5):1329-1339. View abstract
  58. The Fecal Microbiota Profile and Bronchiolitis in Infants. Pediatrics. 2016 07; 138(1). View abstract
  59. A clustering approach to identify severe bronchiolitis profiles in children. Thorax. 2016 08; 71(8):712-8. View abstract
  60. Trends in Infectious Disease Hospitalizations in US Children, 2000 to 2012. Pediatr Infect Dis J. 2016 06; 35(6):e158-63. View abstract
  61. Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota. J Allergy Clin Immunol. 2016 06; 137(6):1909-1913.e4. View abstract
  62. Children Hospitalized with Rhinovirus Bronchiolitis Have Asthma-Like Characteristics. J Pediatr. 2016 05; 172:202-204.e1. View abstract
  63. Detection of respiratory syncytial virus and rhinovirus in healthy infants. BMC Res Notes. 2015 Nov 25; 8:718. View abstract
  64. Prenatal Versus Postnatal Tobacco Smoke Exposure and Intensive Care Use in Children Hospitalized With Bronchiolitis. Acad Pediatr. 2016 07; 16(5):446-452. View abstract
  65. Clinical Endpoints for Respiratory Syncytial Virus Prophylaxis Trials in Infants and Children in High-income and Middle-income Countries. Pediatr Infect Dis J. 2015 Oct; 34(10):1086-92. View abstract
  66. Eligibility for palivizumab prophylaxis in a cohort of children with severe bronchiolitis. Pediatr Int. 2015 Oct; 57(5):1031-4. View abstract
  67. Association Between Hyponatremia and Higher Bronchiolitis Severity Among Children in the ICU With Bronchiolitis. Hosp Pediatr. 2015 Jul; 5(7):385-9. View abstract
  68. Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season. Pediatr Infect Dis J. 2015 Jun; 34(6):566-70. View abstract
  69. Use of Cough and Cold Medications in Severe Bronchiolitis before and after a Health Advisory Warning against Their Use. J Pediatr. 2015 Jul; 167(1):196-8.e1-2. View abstract
  70. Variability of intensive care management for children with bronchiolitis. Hosp Pediatr. 2015 Apr; 5(4):175-84. View abstract
  71. Rhinovirus-induced bronchiolitis: Lack of association between virus genomic load and short-term outcomes. J Allergy Clin Immunol. 2015 Aug; 136(2):509-12.e11. View abstract
  72. Hospital course and discharge criteria for children hospitalized with bronchiolitis. J Hosp Med. 2015 Apr; 10(4):205-11. View abstract
  73. Risk factors for requiring intensive care among children admitted to ward with bronchiolitis. Acad Pediatr. 2015 Jan-Feb; 15(1):77-81. View abstract
  74. Respiratory syncytial virus genomic load and disease severity among children hospitalized with bronchiolitis: multicenter cohort studies in the United States and Finland. J Infect Dis. 2015 May 15; 211(10):1550-9. View abstract
  75. Variability in inpatient management of children hospitalized with bronchiolitis. Acad Pediatr. 2015 Jan-Feb; 15(1):69-76. View abstract
  76. Multicenter study of viral etiology and relapse in hospitalized children with bronchiolitis. Pediatr Infect Dis J. 2014 Aug; 33(8):809-13. View abstract
  77. Hospital length-of-stay is associated with rhinovirus etiology of bronchiolitis. Pediatr Infect Dis J. 2014 Aug; 33(8):829-34. View abstract
  78. Racial/ethnic differences in the presentation and management of severe bronchiolitis. J Hosp Med. 2014 Sep; 9(9):565-72. View abstract
  79. Recent evidence on the management of bronchiolitis. Curr Opin Pediatr. 2014 Jun; 26(3):328-33. View abstract
  80. Infectious pathogens and bronchiolitis outcomes. Expert Rev Anti Infect Ther. 2014 Jul; 12(7):817-28. View abstract
  81. Temporal trends in emergency department visits for bronchiolitis in the United States, 2006 to 2010. Pediatr Infect Dis J. 2014 Jan; 33(1):11-8. View abstract
  82. Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis. J Allergy Clin Immunol. 2014 Apr; 133(4):1220-2. View abstract
  83. Apnea in children hospitalized with bronchiolitis. Pediatrics. 2013 Nov; 132(5):e1194-201. View abstract
  84. Trends in bronchiolitis hospitalizations in the United States, 2000-2009. Pediatrics. 2013 Jul; 132(1):28-36. View abstract
  85. Altitude and environmental climate effects on bronchiolitis severity among children presenting to the emergency department. J Environ Health. 2012 Oct; 75(3):8-15; quiz 54. View abstract
  86. Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis. J Allergy Clin Immunol. 2012 Oct; 130(4):1007-8.e1. View abstract
  87. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation. Pediatrics. 2012 Sep; 130(3):e492-500. View abstract
  88. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med. 2012 Aug; 166(8):700-6. View abstract
  89. Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study. Pediatr Infect Dis J. 2012 Jul; 31(7):767-9. View abstract
  90. National study of antibiotic use in emergency department visits for pneumonia, 1993 through 2008. Acad Emerg Med. 2012 May; 19(5):562-8. View abstract
  91. Serum 25-hydroxyvitamin D levels among Boston trainee doctors in winter. Nutrients. 2012 03; 4(3):197-207. View abstract
  92. Clinical features can help predict which infants with bronchiolitis will need hospital admission. J Pediatr. 2012 Jan; 160(1):174-5. View abstract
  93. Low serum 25-hydroxyvitamin D levels are associated with increased risk of viral coinfections in wheezing children. J Allergy Clin Immunol. 2010 Nov; 126(5):1074-6, 1076.e1-4. View abstract
  94. Insurance status and the variable management of children presenting to the emergency department with bronchiolitis. Pediatr Emerg Care. 2010 Oct; 26(10):716-21. View abstract
  95. Prospective multicenter study of bronchiolitis: predictors of an unscheduled visit after discharge from the emergency department. Acad Emerg Med. 2010 Apr; 17(4):376-82. View abstract
  96. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol. 2010 May; 202(5):436.e1-8. View abstract
  97. Respiratory viruses in bronchiolitis and their link to recurrent wheezing and asthma. Clin Lab Med. 2009 Dec; 29(4):741-55. View abstract
  98. Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D? Pediatrics. 2009 Nov; 124(5):1404-10. View abstract
  99. Factors associated with longer emergency department length of stay for children with bronchiolitis : a prospective multicenter study. Pediatr Emerg Care. 2009 Oct; 25(10):636-41. View abstract
  100. Variability in the diagnostic labeling of nonbacterial lower respiratory tract infections: a multicenter study of children who presented to the emergency department. Pediatrics. 2009 Apr; 123(4):e573-81. View abstract
  101. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009 Feb 23; 169(4):384-90. View abstract
  102. Vitamin D, respiratory infections, and asthma. Curr Allergy Asthma Rep. 2009 Jan; 9(1):81-7. View abstract
  103. Prospective multicenter bronchiolitis study: predicting intensive care unit admissions. Acad Emerg Med. 2008 Oct; 15(10):887-94. View abstract
  104. Bronchiolitis: lingering questions about its definition and the potential role of vitamin D. Pediatrics. 2008 Jul; 122(1):177-9. View abstract
  105. Variations in admission practices for adolescents with anorexia nervosa: a North American sample. J Adolesc Health. 2008 Nov; 43(5):425-31. View abstract
  106. Prospective multicenter study of bronchiolitis: predicting safe discharges from the emergency department. Pediatrics. 2008 Apr; 121(4):680-8. View abstract
  107. Prospective multicenter study of the viral etiology of bronchiolitis in the emergency department. Acad Emerg Med. 2008 Feb; 15(2):111-8. View abstract
  108. US outpatient office visits for bronchiolitis, 1993-2004. Ambul Pediatr. 2007 Jul-Aug; 7(4):304-7. View abstract
  109. Evaluation of compliance with palivizumab recommendations in a multicenter study of young children presenting to the emergency department with bronchiolitis. Pediatr Emerg Care. 2007 Jun; 23(6):362-7. View abstract
  110. Variation in IRB responses to a standard, observational pediatric research protocol. Academic Emergency Medicine. 2007; 14(4):377-380. View abstract
  111. Variation in institutional review board responses to a standard, observational, pediatric research protocol. Acad Emerg Med. 2007 Apr; 14(4):377-80. View abstract
  112. Evidence Based Medicine. Comprehensive Pediatric Hospital Medicine. Zauoutis LB, Chiang VW, editors. 2007; 32-35. View abstract
  113. U.S. Outpatient office visits for bronchiolitis, 1993-2004. Ambulatory Pediatrics. 2007; 7(4):304-307. View abstract
  114. Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics. 2006 Dec; 118(6):2418-23. View abstract
  115. Multicenter Study of Bronchiolitis in the Emergency Department. Oral Presentation. American Academy of Pediatrics National Convention and Exhibition. 2006. View abstract
  116. Testicular torsion and risk factors for orchiectomy. Arch Pediatr Adolesc Med. 2005 Dec; 159(12):1167-71. View abstract
  117. Bronchiolitis in US emergency departments 1992 to 2000: epidemiology and practice variation. Pediatr Emerg Care. 2005 Apr; 21(4):242-7. View abstract
  118. Variation in Admission for Adolescents with Anorexia Nervosa: A North American Sample. Poster. Society for Adolescent Medicine Annual Conference. 2005. View abstract
  119. Two children with Lyme disease presenting with persistent headache. Pediatrics. 2003; 112: e477-e479. Reprinted in Review Series Neurology. 2004; 2:10-12. View abstract
  120. Lyme disease presenting with persistent headache. Pediatrics. 2003 Dec; 112(6 Pt 1):e477-9. View abstract
  121. Which psychiatric patients board on the medical service? Pediatrics. 2003 Jun; 111(6 Pt 1):e693-8. View abstract
  122. A practical guide to prescribing oral contraceptives. Contemporary Pediatrics. 2001; 18(10):111-126. Reprinted in Contemporary OB/GYN. 2001; 46(11):87-104 and Patient Care [serial online] June. 2003. View abstract
  123. Optimizing the care of hospitalized youth. Poster. Society for Adolescent Medicine Annual Conference. 2002. View abstract
  124. Demystifying delayed puberty. Contemporary Pediatrics. 2001; 18(4): 43-60. Reprinted in Contemporary OB/GYN. 2001; 46(8):39-54. View abstract
  125. New seizures in a 6 year-old: Expanding Horizons. Contemporary Pediatrics. 1999; 16(8):25-33. View abstract
  126. Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels. Carcinogenesis. 1996 Jan; 17(1):171-4. View abstract