Dr. Landrigan is Research Director of Inpatient Pediatrics at Boston Children’s Hospital and a practicing pediatric hospitalist. He seeks to study and improve the safety and quality of care for hospitalized children. Over the past decade, he has served as the principal investigator of a series of cohort studies, randomized controlled trials, and multi-center intervention projects that have evaluated the effectiveness of novel interventions designed to improve patient safety.  He has strong interests in the effects of physicians' sleep deprivation, work schedules, teamwork, and handoffs of care.  He was the first Chair, and is a current Executive Council Member of the Pediatric Research in Inpatient Settings (PRIS) Network, the only federally funded hospitalist research network in the U.S.

Major goals of Dr. Landrigan's work include:

  • To develop rigorous systems for studying the quality and safety of hospital care
  • To develop innovative approaches to the organization of inpatient care, such as interventions designed to improve physicians' working conditions, teamwork, and handoffs
  • To carefully evaluate the effectiveness of interventions designed to improve care, and to continuously improve these interventions to achieve optimal safety and health
  • To broadly disseminate effective innovations through education and health policy efforts

Active Projects

2012-2017 Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety

NHLBI U01 HL111478
Principal Investigator

In the ROSTERS (Randomized Order Safety Trial Evaluating Resident Schedules) project, we are working with the Sleep Research Network to conduct a six-center randomized controlled crossover trial evaluating the effect on patient safety, resident safety, and resident education of eliminating shifts >16 hours for 2nd and 3rd year pediatric residents in pediatric intensive care units.

2013-2014 The I-PASS Electronic Family Sign out:  A Technological Innovation to Empower and Engage Families of Hospitalized Patients

Web Site: I-PASS Study

Taking on Tomorrow Innovation Program, Boston Children’s Hospital
Principal Investigator

In this study, we are developing a computerized handoff tool for families, to facilitate provider-family communication during hospitalization.

2014-2017 Bringing I-PASS to the Bedside:  a Communication Bundle to Improve Patient Safety and Experience

Web Site: I-PASS Study

Patient Centered Outcomes Research Institute (PCORI) R-CDR-1306-03556
Principal Investigator

In this 10-center study that builds on the I-PASS Study, we are testing the effects on patient safety, care processes, and workflow of adapting and integrating I-PASS communication tools and strategies into family centered rounds and other family communications throughout the day. The manner in which adoption across sites is affected by patient and hospital-level variables will be assessed.



Dr. Landrigan received his BA from Haverford College, his MD from Mount Sinai School of Medicine and his MPH from the Harvard School of Public Health. He completed his pediatrics residency and a fellowship in hospital medicine / health services research at Boston Children's Hospital, as well as a health policy fellowship at the U.S. Department of Health and Human Services. He has received numerous research and teaching awards including Boston Children’s Hospital’s Janeway Award for Excellence in Clinical Teaching, the Sleep Research Society’s Young Investigator Award, the Society of Hospital Medicine’s Excellence in Research Award, and Academy Health’s Nemours Child Health Services Research Award.  He is an elected member of the Society for Pediatric Research, the American Society for Clinical Investigation, and the American Pediatric Society.

Selected Publications

  1. Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly CM, Stone PH, Lockley SW, Bates DW, Czeisler CA. Effect of reducing interns' work hours on serious medical errors in intensive care units. New Engl J Med. 2004;351(18):1838-1848.
  2. Rothschild JM, Landrigan CP, Cronin JW, Kaushal R, Lockley SE, Burdick E, Stone PH, Lilly CM, Katz JT, Czeisler CA, Bates DW. The Critical Care Safety Study: the incidence and nature of adverse events and near-misses in intensive care. Crit Care Med. 2005;33(8):1694-1700.
  3. Walsh KE, Adams WG, Bauchner H, Vinci RJ, Chessare JB, Cooper MR, Hebert PM, Schainker EG, Landrigan CP. Medication errors related to computerized order entry for children. Pediatrics. 2006;118(5):1872-1879.
  4. Landrigan CP, Barger LK, Cade BE, Ayas NT, Czeisler CA. Interns’ compliance with Accreditation Council for Graduate Medical Education work-hour limits.  JAMA.2006;296(9):1063-1070.
  5. Fahrenkopf AM, Sectish TC, Barger LK, Sharek PJ, Lewin D, Chiang VW, Edwards S, Wiedermann BL, Landrigan CP. Rates of medication errors among depressed and burned out Residents: A prospective cohort study.  BMJ. 2008;336(7642):488-491. PMCID: PMC2258399.
  6. Landrigan CP, Fahrenkopf AM, Lewin D, Sharek PJ, Barger LK, Eisner M, Edwards S, Chiang VW, Wiedermann BL, Sectish TC. Effects of the Accreditation Council for Graduate Medical Education duty hour limits on sleep, work hours, and safety.  Pediatrics. 2008;122(2):250-258.
  7. Rothschild JM, Keohane CA, Rogers S, Gardner R, Lipsitz SR, Salzberg CA, Yu T, Yoon CS, Williams DH, Wien MF, Czeisler CA, Bates DW, Landrigan CP. Risks of complications by attending physicians after performing nighttime procedures.  JAMA. 2009;302(14):1565-1572.
  8. Starmer AJ, Sectish TC, Simon DW, Keohane C, McSweeney ME, Chung EY, Yoon CS, Lipsitz SR, Wassner AJ, Harper MB, Landrigan CP.  Rates of medical errors and preventable adverse events among hospitalized children following implementation of a resident handoff bundle. JAMA. 2013;310(21):2262-2270.
  9. Landrigan CP, Parry G, Bones CB, Hackbarth AD, Goldmann DA, Sharek PJ. Temporal trends in rates of patient harm due to medical care. New Engl J Med.2010;363(22):2124-2134.
  10. Sharek PJ, Parry G, Goldmann DA, Bones CB, Hackbarth AD, Rhoda D, Murphy C, Landrigan CP. Performance characteristics of a methodology to quantify adverse events over time in hospitalized patients.  Health Serv Res 2011; 46:654-678. PMCID: PMC3064924