Overview

Kosuke Kawai is interested in innovative application of advanced statistical methods. Exemplary in this respect is his employment of a three-level hierarchical mixed-effects model to account for the correlation between ears in a longitudinal study of children with cochlear implants. He also conducts research on herpes zoster epidemiology to identify risk factors and appropriate strategies for prevention. We demonstrated that the incidence of herpes zoster has increased by more than 4-fold from 1945 to 2007.

Background

Kosuke Kawai received his doctorate degree from the Harvard School of Public Health. As a senior biostatistician and epidemiologist in the Department of Otolaryngology at Boston Children’s Hospital, he actively collaborates with clinical faculty members and research staff.

PUBLICATIONS

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  1. The impact of social distancing during the COVID-19 pandemic on rates of pediatric idiopathic intussusception. Pediatr Radiol. 2021 Oct 09. View abstract
  2. A Retrospective Study of Hearing Loss in Patients Diagnosed with Peroxisome Biogenesis Disorders in the Zellweger Spectrum. Ear Hear. 2021 Sep 15. View abstract
  3. Persistent Postural-Perceptual Dizziness in Children and Adolescents. Otol Neurotol. 2021 09 01; 42(8):e1093-e1100. View abstract
  4. Racial/Ethnic and Socioeconomic Disparities in Adult Vaccination Coverage. Am J Prev Med. 2021 10; 61(4):465-473. View abstract
  5. Audiologic Phenotype and Progression in Pediatric STRC-Related Autosomal Recessive Hearing Loss. Laryngoscope. 2021 Dec; 131(12):E2897-E2903. View abstract
  6. Utility of Inflammatory Markers in Hospitalized Children With Skin Erythema. Hosp Pediatr. 2021 06; 11(6):627-631. View abstract
  7. Balloon Dilation for Obstructive Eustachian Tube Dysfunction in Children. Otol Neurotol. 2021 04 01; 42(4):566-572. View abstract
  8. Barriers to Voice Therapy in Dysphonic Children. J Voice. 2021 Feb 23. View abstract
  9. Validation of the Nasal Obstruction Symptom Evaluation Scale in Pediatric Patients. Laryngoscope. 2021 09; 131(9):E2594-E2598. View abstract
  10. Improvement of Pulmonary Function in Cystic Fibrosis Patients following Endoscopic Sinus Surgery. Laryngoscope. 2021 09; 131(9):1930-1938. View abstract
  11. Benign Paroxysmal Positional Vertigo in Children and Adolescents With Concussion. Sports Health. 2021 Jul-Aug; 13(4):380-386. View abstract
  12. Dark-adapted threshold and electroretinogram for diagnosis of Usher syndrome. Doc Ophthalmol. 2021 08; 143(1):39-51. View abstract
  13. Postoperative Disposition Following Pediatric Sistrunk Procedures: A National Database Query. Laryngoscope. 2021 07; 131(7):E2352-E2355. View abstract
  14. Obesity as a Possible Risk Factor for Pediatric Sensorineural Hearing Loss. Laryngoscope. 2021 06; 131(6):1416-1419. View abstract
  15. Does Ibuprofen Increase Bleed Risk for Pediatric Tonsillectomy? Otolaryngol Head Neck Surg. 2021 07; 165(1):187-196. View abstract
  16. Perioperative pain control and tympanostomy tube outcomes. Int J Pediatr Otorhinolaryngol. 2020 Nov; 138:110337. View abstract
  17. Temporal Pattern of Radiographic Findings of Costochondral Junction Rib Fractures on Serial Skeletal Surveys in Suspected Infant Abuse. AJR Am J Roentgenol. 2021 06; 216(6):1649-1658. View abstract
  18. Incidence, Time Course, and Implications of Electrode Abnormalities in Pediatric Cochlear Implant Recipients. Ear Hear. 2020 08 20; 42(2):334-342. View abstract
  19. Multifactorial Characteristics of Pediatric Dizziness and Imbalance. Laryngoscope. 2021 04; 131(4):E1308-E1314. View abstract
  20. Women in Otolaryngology: Experiences of Being Female in the Specialty. Laryngoscope. 2021 02; 131(2):E380-E387. View abstract
  21. Role of Surgery in Rhabdomyosarcoma of the Head and Neck in Children. Laryngoscope. 2021 03; 131(3):E984-E992. View abstract
  22. A 10-year Retrospective Review of Botulinum Toxin Injections and Surgical Management of Sialorrhea. Cureus. 2020 May 01; 12(5):e7916. View abstract
  23. Pediatric Subperiosteal Abscess Secondary to Acute Sinusitis: A Systematic Review and Meta-analysis. Laryngoscope. 2020 12; 130(12):2906-2912. View abstract
  24. Torticollis in children with enlarged vestibular aqueducts. Int J Pediatr Otorhinolaryngol. 2020 Apr; 131:109862. View abstract
  25. Ultraviolet Radiation Exposure and the Risk of Herpes Zoster in Three Prospective Cohort Studies. Mayo Clin Proc. 2020 02; 95(2):283-292. View abstract
  26. Carbon dioxide laser versus cold-steel supraglottoplasty: A comparison of post-operative outcomes. Int J Pediatr Otorhinolaryngol. 2020 Mar; 130:109843. View abstract
  27. Undernutrition at PICU Admission Is Predictor of 60-Day Mortality and PICU Length of Stay in Critically Ill Children. J Acad Nutr Diet. 2020 02; 120(2):219-229. View abstract
  28. To drain or not to drain following a Sistrunk procedure: A dual institutional experience. Int J Pediatr Otorhinolaryngol. 2019 Dec; 127:109645. View abstract
  29. Balloon Sinuplasty Utilization in the Pediatric Population: A National Database Perspective. Otolaryngol Head Neck Surg. 2019 10; 161(4):683-687. View abstract
  30. Risk of Herpes Zoster in Cancer Patients and the Promise of New Vaccines. J Infect Dis. 2019 06 05; 220(1):1-2. View abstract
  31. Readmissions following ambulatory pediatric endoscopic sinus surgery. Laryngoscope. 2019 12; 129(12):2681-2686. View abstract
  32. Evaluation of Aspiration in Infants With Laryngomalacia and Recurrent Respiratory and Feeding Difficulties. JAMA Otolaryngol Head Neck Surg. 2019 02 01; 145(2):146-151. View abstract
  33. Prevalence of voice disturbances in pediatric airway patients: Are we missing anything? Int J Pediatr Otorhinolaryngol. 2019 Mar; 118:59-61. View abstract
  34. Risk Factors for Multiple Hemorrhages Following Tonsil Surgery in Children. Laryngoscope. 2019 12; 129(12):2765-2770. View abstract
  35. Medialization Laryngoplasty in Pediatric Patients With Unilateral Vocal Fold Immobility: A Case Series. Ann Otol Rhinol Laryngol. 2019 Feb; 128(2):145-151. View abstract
  36. Aspiration in children with unilateral vocal fold paralysis. Laryngoscope. 2019 03; 129(3):569-573. View abstract
  37. Twelve-month outcomes of Eustachian tube procedures for management of patulous Eustachian tube dysfunction. Laryngoscope. 2019 01; 129(1):222-228. View abstract
  38. Pediatric vincristine-related vocal fold paralysis. Int J Pediatr Otorhinolaryngol. 2018 11; 114:166-169. View abstract
  39. Duplicate skin prick testing in the assessment of food allergy. J Allergy Clin Immunol Pract. 2019 Feb; 7(2):675-677. View abstract
  40. Does Clarithromycin Cause Hearing Loss? A 12-Year Review of Clarithromycin Therapy for Nontuberculous Mycobacterial Lymphadenitis in Children. Ann Otol Rhinol Laryngol. 2018 Oct; 127(10):687-693. View abstract
  41. Voice Abnormalities and Laryngeal Pathology in Preterm Children. Ann Otol Rhinol Laryngol. 2018 Aug; 127(8):508-513. View abstract
  42. Ambulatory Visits for Otitis Media before and after the Introduction of Pneumococcal Conjugate Vaccination. J Pediatr. 2018 10; 201:122-127.e1. View abstract
  43. In Reply-Human Immunodeficiency Virus and Herpes Zoster: Could the Link Be Ignored? Mayo Clin Proc. 2018 06; 93(6):808. View abstract
  44. Validation of a portable hearing assessment tool: Agilis Health Mobile Audiogram. Int J Pediatr Otorhinolaryngol. 2018 Oct; 113:94-98. View abstract
  45. Changes in Scope of Procedures Performed by Pediatric Otolaryngologists in the Past Decade. JAMA Otolaryngol Head Neck Surg. 2018 Apr 01; 144(4):322-329. View abstract
  46. Otolaryngologic Manifestations of Klippel-Feil Syndrome in Children. JAMA Otolaryngol Head Neck Surg. 2018 Mar 01; 144(3):238-243. View abstract
  47. Development and validation of a quality of life instrument for patients with laryngeal cleft. Int J Pediatr Otorhinolaryngol. 2018 May; 108:143-150. View abstract
  48. Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia. JAMA Otolaryngol Head Neck Surg. 2018 02 01; 144(2):164-168. View abstract
  49. Enlarged Vestibular Aqueduct and Cochlear Implants: The Effect of Early Counseling on the Length of Time Between Candidacy and Implantation. Otol Neurotol. 2018 02; 39(2):e90-e95. View abstract
  50. Impact of Antiretroviral Therapy on the Risk of Herpes Zoster among Human Immunodeficiency Virus-Infected Individuals in Tanzania. Am J Trop Med Hyg. 2018 02; 98(2):396-401. View abstract
  51. Silent aspiration: Who is at risk? Laryngoscope. 2018 08; 128(8):1952-1957. View abstract
  52. Risk Factors for Herpes Zoster: A Systematic Review and Meta-analysis. Mayo Clin Proc. 2017 Dec; 92(12):1806-1821. View abstract
  53. Utility of Adjunctive Procedures With Balloon Dilation of the Eustachian Tube. Laryngoscope Investig Otolaryngol. 2017 12; 2(6):337-343. View abstract
  54. Adverse impacts of chronic pain on health-related quality of life, work productivity, depression and anxiety in a community-based study. Fam Pract. 2017 11 16; 34(6):656-661. View abstract
  55. Microbiology of the Upper and Lower Airways in Pediatric Cystic Fibrosis Patients. Otolaryngol Head Neck Surg. 2017 08; 157(2):302-308. View abstract
  56. Routine airway surveillance in pediatric tracheostomy patients. Int J Pediatr Otorhinolaryngol. 2017 Jun; 97:1-4. View abstract
  57. Do post-tonsillectomy patients who report bleeding require observation if no bleeding is present on exam? Int J Pediatr Otorhinolaryngol. 2017 Apr; 95:75-79. View abstract
  58. Association between work time loss and quality of life in patients with Herpes Zoster: a pooled analysis of the MASTER studies. Health Qual Life Outcomes. 2017 Jan 18; 15(1):11. View abstract
  59. Nasal septal perforation in children: Presentation, etiology, and management. Int J Pediatr Otorhinolaryngol. 2017 Jan; 92:176-180. View abstract
  60. Complications of turbinate reduction surgery in combination with tonsillectomy in pediatric patients. Laryngoscope. 2017 08; 127(8):1920-1923. View abstract
  61. Characterizing mortality in pediatric tracheostomy patients. Laryngoscope. 2017 07; 127(7):1701-1706. View abstract
  62. Paradoxical vocal fold motion in children presenting with exercise induced dyspnea. Int J Pediatr Otorhinolaryngol. 2016 Nov; 90:165-169. View abstract
  63. Nasal versus tracheobronchial biopsies to diagnose primary ciliary dyskinesia: A meta-analysis. Laryngoscope. 2017 01; 127(1):6-13. View abstract
  64. Indications of pediatric tracheostomy over the last 30 years: Has anything changed? Int J Pediatr Otorhinolaryngol. 2016 Aug; 87:144-7. View abstract
  65. Healthcare resource utilization and costs associated with herpes zoster in the US. J Med Econ. 2016 Oct; 19(10):928-35. View abstract
  66. Increasing Incidence of Herpes Zoster Over a 60-year Period From a Population-based Study. Clin Infect Dis. 2016 07 15; 63(2):221-6. View abstract
  67. Usefulness of Upper Airway Endoscopy in the Evaluation of Pediatric Pulmonary Aspiration. JAMA Otolaryngol Head Neck Surg. 2016 Apr; 142(4):339-43. View abstract
  68. Sinus Computed Tomography Imaging in Pediatric Cystic Fibrosis: Added Value? Otolaryngol Head Neck Surg. 2016 07; 155(1):160-5. View abstract
  69. Endoscopic Radiofrequency Ablation-Assisted Resection of Juvenile Nasopharyngeal Angiofibroma: Comparison with Traditional Endoscopic Technique. Otolaryngol Head Neck Surg. 2016 06; 154(6):1145-8. View abstract
  70. Annual incidence rates of herpes zoster among an immunocompetent population in the United States. BMC Infect Dis. 2015 Nov 06; 15:502. View abstract
  71. Evaluation and Management of Chronic Aspiration in Children With Normal Upper Airway Anatomy. JAMA Otolaryngol Head Neck Surg. 2015 Nov; 141(11):1006-11. View abstract
  72. Peripheral vestibular loss detected in pediatric patients using a smartphone-based test of the subjective visual vertical. Int J Pediatr Otorhinolaryngol. 2015 Dec; 79(12):2094-8. View abstract
  73. To stent or not to stent? A meta-analysis of endonasal congenital bilateral choanal atresia repair. Laryngoscope. 2016 Jan; 126(1):218-27. View abstract
  74. Predictors of postherpetic neuralgia in patients with herpes zoster: a pooled analysis of prospective cohort studies from North and Latin America and Asia. Int J Infect Dis. 2015 May; 34:126-31. View abstract
  75. Clinical and economic burden of herpes zoster and postherpetic neuralgia in patients from the National Skin Centre, Singapore. Dermatologica Sinica. 2015; 4(33):201-205. View abstract
  76. Herpes zoster-associated severity and duration of pain, health-related quality of life, and healthcare utilization in Taiwan: a prospective observational study. Int J Dermatol. 2015; 54(5):529-36. View abstract
  77. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014 Jun 10; 4(6):e004833. View abstract
  78. Cost-effectiveness of vaccination against herpes zoster and postherpetic neuralgia: a critical review. Vaccine. 2014 Mar 26; 32(15):1645-53. View abstract
  79. Burden of illness, quality of life, and healthcare utilization among patients with herpes zoster in South Korea: a prospective clinical-epidemiological study. Int J Infect Dis. 2014 Mar; 20:23-30. View abstract
  80. Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis. Clin Microbiol Infect. 2014 May; 20(5):416-23. View abstract
  81. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiol Infect. 2014 Jul; 142(7):1505-9. View abstract
  82. The epidemiological and economic impact of a quadrivalent human papillomavirus (hpv) vaccine in Estonia. BMC Infect Dis. 2013 Jul 03; 13:304. View abstract
  83. Impact of carbapenem resistance on clinical and economic outcomes among patients with Acinetobacter baumannii infection in Colombia. Clin Microbiol Infect. 2014 Feb; 20(2):174-80. View abstract
  84. Factors associated with receipt of two doses of varicella vaccine among adolescents in the United States. Pediatr Infect Dis J. 2013 May; 32(5):538-42. View abstract
  85. Healthcare costs in patients with Acinetobacter baumannii infection in Colombia. Infectio. 2013; 4(17):185-192. View abstract
  86. Estimated health and economic impact of quadrivalent HPV (types 6/11/16/18) vaccination in Brazil using a transmission dynamic model. BMC Infect Dis. 2012 Oct 09; 12:250. View abstract
  87. Burden of rotavirus gastroenteritis and distribution of rotavirus strains in Asia: a systematic review. Vaccine. 2012 Feb 08; 30(7):1244-54. View abstract
  88. Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania. Int J Tuberc Lung Dis. 2011 Oct; 15(10):1380-9. View abstract
  89. Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: meta-analysis and meta-regression. Bull World Health Organ. 2011 Jun 01; 89(6):402-411B. View abstract
  90. Role of selenium in HIV infection. Nutr Rev. 2010 Nov; 68(11):671-81. View abstract
  91. Sex differences in the effects of maternal vitamin supplements on mortality and morbidity among children born to HIV-infected women in Tanzania. Br J Nutr. 2010 Jun; 103(12):1784-91. View abstract
  92. A randomized trial to determine the optimal dosage of multivitamin supplements to reduce adverse pregnancy outcomes among HIV-infected women in Tanzania. Am J Clin Nutr. 2010 Feb; 91(2):391-7. View abstract
  93. Geophagy (Soil-eating) in relation to Anemia and Helminth infection among HIV-infected pregnant women in Tanzania. Am J Trop Med Hyg. 2009 Jan; 80(1):36-43. View abstract
  94. Parents' and teachers' communication about HIV and sex in relation to the timing of sexual initiation among young adolescents in Tanzania. Scand J Public Health. 2008 Nov; 36(8):879-88. View abstract