The major goal of Dr. Kreidberg's laboratory work is to understand the mechanisms of organogenesis and how the abnormal regulation of developmental pathways leads to disease. His laboratory has identified several major pathways that regulate normal kidney development and how aberrant regulation of these pathways leads to kidney disease.


Dr. Kreidberg received his MD and PhD from Johns Hopkins University School of Medicine. He completed his internship and at Boston Children's Hospital Boston and a postdoctoral fellowship at the Whitehead Institute.


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  1. Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury. Sci Adv. 2020 Jul; 6(30):eabb5460. View abstract
  2. EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells. Development. 2018 07 18; 145(14). View abstract
  3. Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease. Am J Pathol. 2018 01; 188(1):84-94. View abstract
  4. WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015 Apr 01; 142(7):1254-66. View abstract
  5. Genome-Wide Analysis of Wilms' Tumor 1-Controlled Gene Expression in Podocytes Reveals Key Regulatory Mechanisms. J Am Soc Nephrol. 2015 Sep; 26(9):2097-104. View abstract
  6. Identification of novel glycans with disialylated structures in a3 integrin from mouse kidney cells with the phenotype of polycystic kidney disease. J Proteome Res. 2014 Nov 07; 13(11):4901-9. View abstract
  7. Dicer function is required in the metanephric mesenchyme for early kidney development. Am J Physiol Renal Physiol. 2014 Apr 01; 306(7):F764-72. View abstract
  8. Introduction to the 12th International Workshop on Developmental Nephrology. Pediatr Nephrol. 2014 Apr; 29(4):497-8. View abstract
  9. a6ß1 and a7ß1 integrins are required in Schwann cells to sort axons. J Neurosci. 2013 Nov 13; 33(46):17995-8007. View abstract
  10. Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth. PLoS One. 2013; 8(8):e73554. View abstract
  11. GPR56 functions together with a3ß1 integrin in regulating cerebral cortical development. PLoS One. 2013; 8(7):e68781. View abstract
  12. Constitutive activation of the mTOR signaling pathway within the normal glomerulus. Biochem Biophys Res Commun. 2012 Aug 24; 425(2):244-9. View abstract
  13. c-Met and NF-?B-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease. J Am Soc Nephrol. 2012 Aug; 23(8):1309-18. View abstract
  14. MicroRNAs in renal development. Pediatr Nephrol. 2013 Feb; 28(2):219-25. View abstract
  15. The long and short of microRNAs in the kidney. J Am Soc Nephrol. 2012 Mar; 23(3):400-4. View abstract
  16. WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol. 2011 Jul; 22(7):1286-96. View abstract
  17. The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. J Am Soc Nephrol. 2011 Jun; 22(6):1053-63. View abstract
  18. Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol. 2011 Apr 25; 5:56. View abstract
  19. Dystroglycan does not contribute significantly to kidney development or function, in health or after injury. Am J Physiol Renal Physiol. 2011 Mar; 300(3):F811-20. View abstract
  20. Expression regulation and function of heparan sulfate 6-O-endosulfatases in the spermatogonial stem cell niche. Glycobiology. 2011 Feb; 21(2):152-61. View abstract
  21. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease. J Clin Invest. 2010 Oct; 120(10):3617-28. View abstract
  22. Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF. Am J Pathol. 2010 Sep; 177(3):1534-48. View abstract
  23. WT1 and kidney progenitor cells. Organogenesis. 2010 Apr-Jun; 6(2):61-70. View abstract
  24. Genomic characterization of Wilms' tumor suppressor 1 targets in nephron progenitor cells during kidney development. Development. 2010 Apr; 137(7):1189-203. View abstract
  25. siRNA therapy for glomerulonephritis. J Am Soc Nephrol. 2010 Apr; 21(4):549-51. View abstract
  26. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Mol Biol Cell. 2009 Nov; 20(21):4596-610. View abstract
  27. Alpha3beta1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3. J Cell Sci. 2009 Jun 01; 122(Pt 11):1778-87. View abstract
  28. Netrin-1-alpha3beta1 integrin interactions regulate the migration of interneurons through the cortical marginal zone. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7595-600. View abstract
  29. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development. 2009 Mar; 136(5):843-53. View abstract
  30. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24. View abstract
  31. Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures. Dev Dyn. 2008 Nov; 237(11):3128-41. View abstract
  32. Podocyte-derived BMP7 is critical for nephron development. J Am Soc Nephrol. 2008 Nov; 19(11):2181-91. View abstract
  33. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol. 2008 Nov; 19(11):2069-75. View abstract
  34. Wilms' tumor-1: a riddle wrapped in a mystery, inside a kidney. Kidney Int. 2008 Aug; 74(4):411-2. View abstract
  35. Integrins and matrix in the glomerulus: old mysteries and new insights. J Am Soc Nephrol. 2008 Apr; 19(4):650-1. View abstract
  36. Development of the renal glomerulus: good neighbors and good fences. Development. 2008 Feb; 135(4):609-20. View abstract
  37. Analysis of Netrin 1 receptors during inner ear development. Int J Dev Biol. 2007; 51(5):409-13. View abstract
  38. Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa. Development. 2005 Dec; 132(24):5437-49. View abstract
  39. Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development. Cereb Cortex. 2005 Oct; 15(10):1632-6. View abstract
  40. alpha3beta1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development. Development. 2004 Dec; 131(24):6023-31. View abstract
  41. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem. 2004 Aug 13; 279(33):34827-32. View abstract
  42. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol. 2004 Oct; 287(4):F602-11. View abstract
  43. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest. 2004 May; 113(10):1390-7. View abstract
  44. Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol. 2004 Apr 15; 268(2):429-40. View abstract
  45. alpha3beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPmu expression and cell-cell adhesion. J Cell Biol. 2003 Dec 22; 163(6):1351-62. View abstract
  46. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. J Cell Biol. 2003 Oct 13; 163(1):177-88. View abstract
  47. Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol. 2003 Sep 16; 13(18):1625-9. View abstract
  48. Podocyte differentiation and glomerulogenesis. J Am Soc Nephrol. 2003 Mar; 14(3):806-14. View abstract
  49. None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion. Dev Biol. 2003 Feb 15; 254(2):226-37. View abstract
  50. Role of the WT1 tumor suppressor in murine hematopoiesis. Blood. 2003 Apr 01; 101(7):2570-4. View abstract
  51. A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol. 2002 Aug; 13(8):2058-67. View abstract
  52. Regulation of cadherin junctions during mouse submandibular gland development. Dev Dyn. 2002 Jul; 224(3):321-33. View abstract
  53. A mammal-specific exon of WT1 is not required for development or fertility. Mol Cell Biol. 2002 Jun; 22(12):4433-8. View abstract
  54. Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology. Mol Biol Cell. 2002 Mar; 13(3):767-81. View abstract
  55. Kidneys and sex, the Wilms' tumor connection. Pediatr Res. 2002 Feb; 51(2):128. View abstract
  56. Applications of adhesion molecule gene knockout cell lines. Methods Cell Biol. 2002; 69:309-24. View abstract
  57. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol. 2001 Oct 15; 238(2):289-302. View abstract
  58. Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1. Mol Biol Cell. 2001 Oct; 12(10):2975-86. View abstract
  59. Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn. 2001 Sep; 222(1):26-39. View abstract
  60. Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits. Dev Biol. 2001 May 15; 233(2):449-67. View abstract
  61. Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland. Dev Dyn. 2001 Apr; 220(4):337-49. View abstract
  62. Functions of alpha3beta1 integrin. Curr Opin Cell Biol. 2000 Oct; 12(5):548-53. View abstract
  63. alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. J Cell Sci. 2000 Sep; 113 ( Pt 17):3051-62. View abstract
  64. Mouse keratinocytes immortalized with large T antigen acquire alpha3beta1 integrin-dependent secretion of MMP-9/gelatinase B. J Cell Sci. 2000 Aug; 113 ( Pt 16):2909-21. View abstract
  65. Integrins in kidney development, function, and disease. Am J Physiol Renal Physiol. 2000 Aug; 279(2):F233-42. View abstract
  66. Reelin binds alpha3beta1 integrin and inhibits neuronal migration. Neuron. 2000 Jul; 27(1):33-44. View abstract
  67. The LIM homeobox gene Lhx9 is essential for mouse gonad formation. Nature. 2000 Feb 24; 403(6772):909-13. View abstract
  68. Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Dev Biol. 1999 Nov 15; 215(2):264-77. View abstract
  69. (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization. J Cell Sci. 1999 Sep; 112 ( Pt 17):2925-35. View abstract
  70. Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse. Development. 1999 Sep; 126(17):3957-68. View abstract
  71. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development. 1999 May; 126(9):1845-57. View abstract
  72. Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct. Mol Reprod Dev. 1999 Apr; 52(4):366-75. View abstract
  73. Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development. 1999 Apr; 126(8):1655-64. View abstract
  74. Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex. Neuron. 1999 Feb; 22(2):277-89. View abstract
  75. Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet. 1999; 24(3-4):252-62. View abstract
  76. Neuronal receptors mediating responses to antibodyactivated laminin-1. J Neurosci. 1998 Dec 01; 18(23):9703-15. View abstract
  77. Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes. J Cell Biol. 1998 Sep 07; 142(5):1357-69. View abstract
  78. alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol. 1997 May 05; 137(3):729-42. View abstract
  79. Induction of p21 by the Wilms' tumor suppressor gene WT1. Cancer Res. 1997 Apr 15; 57(8):1429-34. View abstract
  80. Differential regulation of two sets of mesonephric tubules by WT-1. Development. 1997 Apr; 124(7):1293-9. View abstract
  81. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development. 1996 Nov; 122(11):3537-47. View abstract
  82. Gene targeting in kidney development. Med Pediatr Oncol. 1996 Nov; 27(5):445-52. View abstract
  83. Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. Dev Biol. 1996 May 01; 175(2):301-13. View abstract
  84. WT-1 is required for early kidney development. Cell. 1993 Aug 27; 74(4):679-91. View abstract
  85. Genetic analysis of the human thymidine kinase gene promoter. Mol Cell Biol. 1986 Aug; 6(8):2903-9. View abstract