ABOUT THE RESEARCHER

OVERVIEW

Our lab has three main broad areas of research: drug delivery, biomaterials, and nanomedicine, with considerable overlap between these. Some of our projects are driven by developing new technologies, others by trying to find cures for specific diseases. Pain, otitis media and other otic diseases, ophthalmic diseases, peritoneal adhesions, sepsis, and cancer are among the medical conditions that receive the most attention in our group.

BACKGROUND

Dr. Daniel S. Kohane obtained his MD and a PhD in Physiology from Boston University. He subsequently completed residencies in Pediatrics (Boston Children's Hospital) and Anesthesiology (Massachusetts general Hospital), followed by a fellowship in Pediatric Critical Care (Boston Children's Hospital). He is currently a Senior Associate in Pediatric Critical Care at Boston Children's Hospital at Harvard Medical School, where he directs the Laboratory for Biomaterials and Drug Delivery.

PUBLICATIONS

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  1. Keeping Nanomedicine on Target. Nano Lett. 2021 Jan 13; 21(1):3-5. View abstract
  2. Local anesthesia enhanced with increasing high-frequency ultrasound intensity. Drug Deliv Transl Res. 2020 10; 10(5):1507-1516. View abstract
  3. Steroid-eluting contact lenses for corneal and intraocular inflammation. Acta Biomater. 2020 10 15; 116:149-161. View abstract
  4. Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy. Nano Lett. 2020 07 08; 20(7):5465-5472. View abstract
  5. Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nat Commun. 2020 05 08; 11(1):2323. View abstract
  6. Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives. ACS Appl Mater Interfaces. 2020 Apr 15; 12(15):17314-17320. View abstract
  7. Synthesis of Poly(acyclic orthoester)s: Acid-Sensitive Biomaterials for Enhancing Immune Responses of Protein Vaccine. Angew Chem Int Ed Engl. 2020 04 27; 59(18):7235-7239. View abstract
  8. The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats. Pharm Res. 2019 Nov 08; 36(12):179. View abstract
  9. Transcytosis of Nanomedicine for Tumor Penetration. . 2019 11 13; 19(11):8010-8020. View abstract
  10. Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314. Transl Vis Sci Technol. 2019 Sep; 8(5):28. View abstract
  11. Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 09; 129(3):709-717. View abstract
  12. Nanoscale systems for local drug delivery. Nano Today. 2019 Oct; 28. View abstract
  13. A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose. . 2019 08 14; 19(8):5515-5523. View abstract
  14. Topical sustained drug delivery to the retina with a drug-eluting contact lens. Biomaterials. 2019 10; 217:119285. View abstract
  15. Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. Nat Commun. 2019 06 12; 10(1):2566. View abstract
  16. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10674-10680. View abstract
  17. Quantile Regression and Its Applications: A Primer for Anesthesiologists. Anesth Analg. 2019 04; 128(4):820-830. View abstract
  18. Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 Mar 11. View abstract
  19. Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media. Mol Pharm. 2019 04 01; 16(4):1555-1562. View abstract
  20. Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat Commun. 2019 02 18; 10(1):804. View abstract
  21. Nanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia. ACS Nano. 2019 01 22; 13(1):18-25. View abstract
  22. PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia. Vaccine. 2018 11 12; 36(46):6926-6932. View abstract
  23. Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics. JCI Insight. 2018 10 04; 3(19). View abstract
  24. Externally triggered patient-controlled local anesthesia. Pain Manag. 2018 09 01; 8(5):313-315. View abstract
  25. Long-acting liposomal corneal anesthetics. Biomaterials. 2018 10; 181:372-377. View abstract
  26. Predicting the tissue depth for remote triggering of drug delivery systems. J Control Release. 2018 09 28; 286:55-63. View abstract
  27. Antibody-modified conduits for highly selective cytokine elimination from blood. JCI Insight. 2018 07 12; 3(13). View abstract
  28. Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane. J Control Release. 2018 11 10; 289:94-101. View abstract
  29. Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine. Anesth Analg. 2018 04; 126(4):1170-1175. View abstract
  30. BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging. Acta Biomater. 2018 05; 72:287-294. View abstract
  31. High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade. J Control Release. 2018 04 28; 276:150-156. View abstract
  32. Ultrasound-triggered liposomes for on-demand local anesthesia. Ther Deliv. 2018 01; 9(1):5-8. View abstract
  33. Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin. . 2018 01 10; 18(1):32-37. View abstract
  34. Light-Emitting Photon-Upconversion Nanoparticles in the Generation of Transdermal Reactive-Oxygen Species. ACS Appl Mater Interfaces. 2017 Dec 06; 9(48):41737-41747. View abstract
  35. Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength. . 2017 11 08; 17(11):7138-7145. View abstract
  36. Ultrasound-triggered local anaesthesia. Nat Biomed Eng. 2017; 1:644-653. View abstract
  37. Getting Drugs Across Biological Barriers. . 2017 Oct; 29(37). View abstract
  38. Tetrodotoxin, Epinephrine, and Chemical Permeation Enhancer Combinations in Peripheral Nerve Blockade. Anesth Analg. 2017 06; 124(6):1804-1812. View abstract
  39. Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics. 2017 May; 139(5). View abstract
  40. Strong tissue glue with tunable elasticity. Acta Biomater. 2017 04 15; 53:93-99. View abstract
  41. Multiply repeatable and adjustable on-demand phototriggered local anesthesia. J Control Release. 2017 04 10; 251:68-74. View abstract
  42. Ultrasensitive Phototriggered Local Anesthesia. . 2017 02 08; 17(2):660-665. View abstract
  43. Drug delivery systems for prolonged duration local anesthesia. Mater Today (Kidlington). 2017 Jan-Feb; 20(1):22-31. View abstract
  44. 1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):344. View abstract
  45. Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. Int J Nanomedicine. 2016; 11:6149-6159. View abstract
  46. Phototriggered Drug Delivery Using Inorganic Nanomaterials. Bioconjug Chem. 2017 01 18; 28(1):98-104. View abstract
  47. Core-Shell Nanostars for Multimodal Therapy and Imaging. Theranostics. 2016; 6(13):2306-2313. View abstract
  48. Treatment of otitis media by transtympanic delivery of antibiotics. Sci Transl Med. 2016 09 14; 8(356):356ra120. View abstract
  49. Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. Ophthalmology. 2016 10; 123(10):2085-92. View abstract
  50. Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane. Future Sci OA. 2016 Sep; 2(3):FSO138. View abstract
  51. Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance. . 2016 07 13; 16(7):4516-20. View abstract
  52. RNA therapeutics - The potential treatment for myocardial infarction. Regen Ther. 2016 Jun; 4:83-91. View abstract
  53. A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel. . 2016 Aug; 28(31):6680-6. View abstract
  54. Extended Release of Native Drug Conjugated in Polyketal Microparticles. J Am Chem Soc. 2016 05 18; 138(19):6127-30. View abstract
  55. Titanium Coating of the Boston Keratoprosthesis. Transl Vis Sci Technol. 2016 Apr; 5(2):17. View abstract
  56. Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. Acta Biomater. 2016 Mar; 33:34-9. View abstract
  57. Phototriggered Local Anesthesia. . 2016 Jan 13; 16(1):177-81. View abstract
  58. Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15719-24. View abstract
  59. Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF(165). Biomaterials. 2016 Jan; 77:130-138. View abstract
  60. New Strategies in Cancer Nanomedicine. Annu Rev Pharmacol Toxicol. 2016; 56:41-57. View abstract
  61. Ultraviolet light-mediated drug delivery: Principles, applications, and challenges. J Control Release. 2015 Dec 10; 219:31-42. View abstract
  62. Photoresponsive nanoparticles for drug delivery. Nano Today. 2015 Aug 01; 10(4):451-467. View abstract
  63. Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting. . 2015 Oct 14; 15(10):6332-8. View abstract
  64. Nonlinear Optics: NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation (Adv. Healthcare Mater. 8/2015). Adv Healthc Mater. 2015 Jun; 4(8):1108. View abstract
  65. Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3820-6. View abstract
  66. NIR-triggered drug delivery by collagen-mediated second harmonic generation. Adv Healthc Mater. 2015 Jun 03; 4(8):1159-63. View abstract
  67. Preparation and characterization of SDF-1a-chitosan-dextran sulfate nanoparticles. J Vis Exp. 2015 Jan 22; (95):52323. View abstract
  68. Aptamer photoregulation in vivo. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17099-103. View abstract
  69. Clinicians' perspectives on the use of drug-eluting contact lenses for the treatment of glaucoma. Ther Deliv. 2014 Oct; 5(10):1077-83. View abstract
  70. A two-component pre-seeded dermal-epidermal scaffold. Acta Biomater. 2014 Dec; 10(12):4928-4938. View abstract
  71. Prospects for near-infrared technology in remotely triggered drug delivery. Expert Opin Drug Deliv. 2014 Nov; 11(11):1681-5. View abstract
  72. Photothermally targeted thermosensitive polymer-masked nanoparticles. . 2014 Jul 09; 14(7):3697-701. View abstract
  73. Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1107-17. View abstract
  74. Interview with Daniel Kohane. Ther Deliv. 2014 Apr; 5(4):387-9. View abstract
  75. Multivesicular liposomal bupivacaine at the sciatic nerve. Biomaterials. 2014 May; 35(15):4557-64. View abstract
  76. Near-infrared-actuated devices for remotely controlled drug delivery. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1349-54. View abstract
  77. Prevention of peritoneal adhesions using polymeric rheological blends. Acta Biomater. 2014 Mar; 10(3):1187-93. View abstract
  78. Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19048-53. View abstract
  79. Photoactive electrospun fibers for inducing cell death. Adv Healthc Mater. 2014 Apr; 3(4):494-9. View abstract
  80. SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules. 2013 Nov 11; 14(11):4009-20. View abstract
  81. In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. Biomaterials. 2014 Jan; 35(1):432-9. View abstract
  82. A photo-triggered layered surface coating producing reactive oxygen species. Biomaterials. 2013 Dec; 34(38):9763-9. View abstract
  83. Biodegradable mesostructured polymer membranes. . 2013 Sep 11; 13(9):4410-5. View abstract
  84. Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. . 2013 Sep 11; 13(9):4075-9. View abstract
  85. Long-lasting antifouling coating from multi-armed polymer. Langmuir. 2013 Aug 13; 29(32):10087-94. View abstract
  86. Topical drug formulations for prolonged corneal anesthesia. Cornea. 2013 Jul; 32(7):1040-5. View abstract
  87. Microdevices for nanomedicine. Mol Pharm. 2013 Jun 03; 10(6):2127-44. View abstract
  88. A Stiff Injectable Biodegradable Elastomer. Adv Funct Mater. 2013 Mar 25; 23(12):1527-1533. View abstract
  89. Local toxicity from local anesthetic polymeric microparticles. Anesth Analg. 2013 Apr; 116(4):794-803. View abstract
  90. Controlled-release systems in neuropathic pain. Pain Manag. 2013 Mar; 3(2):91-3. View abstract
  91. Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. . 2014 Jan 08; 14(1):1-5. View abstract
  92. Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA). Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:1093-5. View abstract
  93. Modular 'click-in-emulsion' bone-targeted nanogels. . 2013 Mar 13; 25(10):1449-54. View abstract
  94. Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. Lab Chip. 2013 Jan 21; 13(2):252-9. View abstract
  95. Formulations for trans-tympanic antibiotic delivery. Biomaterials. 2013 Jan; 34(4):1281-8. View abstract
  96. Materials to clinical devices: technologies for remotely triggered drug delivery. Clin Ther. 2012 Nov; 34(11):S25-35. View abstract
  97. Prolonged nerve blockade delays the onset of neuropathic pain. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17555-60. View abstract
  98. Nanocomposite gold-silk nanofibers. . 2012 Oct 10; 12(10):5403-6. View abstract
  99. Duration and local toxicity of sciatic nerve blockade with coinjected site 1 sodium-channel blockers and quaternary lidocaine derivatives. Reg Anesth Pain Med. 2012 Sep-Oct; 37(5):483-9. View abstract
  100. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater. 2012 Nov; 11(11):986-94. View abstract
  101. Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Nov-Dec; 4(6):638-62. View abstract
  102. The smartest materials: the future of nanoelectronics in medicine. ACS Nano. 2012 Aug 28; 6(8):6541-5. View abstract
  103. Thermoresponsive nanogels for prolonged duration local anesthesia. Acta Biomater. 2012 Oct; 8(10):3596-605. View abstract
  104. Electrospun drug-eluting sutures for local anesthesia. J Control Release. 2012 Aug 10; 161(3):903-9. View abstract
  105. Delivering bioactive molecules as instructive cues to engineered tissues. Expert Opin Drug Deliv. 2012 Apr; 9(4):473-92. View abstract
  106. Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. J Am Chem Soc. 2012 May 30; 134(21):8848-55. View abstract
  107. Injectable scaffolds achieve sustained siRNA release for tissue repair. Nanomedicine (Lond). 2012 Mar; 7(3):315-6. View abstract
  108. External electric fields trigger drug release from new hydrogel formulation. Nanomedicine (Lond). 2012 Mar; 7(3):316. View abstract
  109. Novel resonating nanowire arrays function as highly sensitive biosensors. Nanomedicine (Lond). 2012 Mar; 7(3):315. View abstract
  110. Toxicogenomic analysis of a sustained release local anesthetic delivery system. Biomaterials. 2012 May; 33(13):3586-93. View abstract
  111. An in situ cross-linking hybrid hydrogel for controlled release of proteins. Acta Biomater. 2012 May; 8(5):1703-9. View abstract
  112. Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels. Acta Biomater. 2012 Apr; 8(4):1450-8. View abstract
  113. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011 Sep 25; 6(11):720-5. View abstract
  114. Hydroxyapatite for keratoprosthesis biointegration. Invest Ophthalmol Vis Sci. 2011 Sep 22; 52(10):7392-9. View abstract
  115. Nanoparticles targeting the infarcted heart. . 2011 Oct 12; 11(10):4411-4. View abstract
  116. Liposomes for HIV prophylaxis. Biomaterials. 2011 Nov; 32(33):8663-8. View abstract
  117. A prototype antifungal contact lens. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6286-91. View abstract
  118. Microgels for efficient protein purification. . 2011 Sep 22; 23(36):H258-62. View abstract
  119. Surface modification and drug delivery for biointegration. Ther Deliv. 2011 Jun; 2(6):737-52. View abstract
  120. Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. Acta Biomater. 2011 Aug; 7(8):3150-7. View abstract
  121. Nanotechnology for surgeons. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 May-Jun; 3(3):223-8. View abstract
  122. Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. . 2011 Mar 09; 11(3):1395-400. View abstract
  123. Drug delivery and translation. Drug Deliv Transl Res. 2011 Feb; 1(1):4-6. View abstract
  124. Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol. 2011 Jan; 6(1):13-22. View abstract
  125. Remotely triggerable drug delivery systems. . 2010 Nov 24; 22(44):4925-43. View abstract
  126. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010 Aug 09; 11(8):1909-14. View abstract
  127. A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials. 2010 Jul; 31(19):5208-17. View abstract
  128. Prolonged sensory-selective nerve blockade. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3740-5. View abstract
  129. Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations. J Biomed Mater Res A. 2010 Feb; 92(2):586-95. View abstract
  130. Rheological blends for drug delivery. I. Characterization in vitro. J Biomed Mater Res A. 2010 Feb; 92(2):575-85. View abstract
  131. Photo-targeted nanoparticles. . 2010 Jan; 10(1):250-4. View abstract
  132. Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials. 2010 Feb; 31(6):1444-52. View abstract
  133. Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov; 91(2):519-27. View abstract
  134. A magnetically triggered composite membrane for on-demand drug delivery. . 2009 Oct; 9(10):3651-7. View abstract
  135. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009 Jul; 5(13):1575-81. View abstract
  136. Contact lenses for drug delivery. Semin Ophthalmol. 2009 May-Jun; 24(3):156-60. View abstract
  137. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7125-30. View abstract
  138. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3346-52. View abstract
  139. Effect of chemical permeation enhancers on nerve blockade. Mol Pharm. 2009 Jan-Feb; 6(1):265-73. View abstract
  140. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharm. 2009 Jan-Feb; 6(1):190-201. View abstract
  141. Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. J Biomed Mater Res A. 2008 Dec 01; 87(3):825-31. View abstract
  142. The biocompatibility of mesoporous silicates. Biomaterials. 2008 Oct; 29(30):4045-55. View abstract
  143. Microparticles for inhalational delivery of antipseudomonal antibiotics. AAPS J. 2008 Jun; 10(2):254-60. View abstract
  144. Local myotoxicity from sustained release of bupivacaine from microparticles. Anesthesiology. 2008 May; 108(5):921-8. View abstract
  145. Polymeric biomaterials in tissue engineering. Pediatr Res. 2008 May; 63(5):487-91. View abstract
  146. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1138-45. View abstract
  147. Antifungal hydrogels. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):12994-8. View abstract
  148. Polymers in the prevention of peritoneal adhesions. Eur J Pharm Biopharm. 2008 Jan; 68(1):57-66. View abstract
  149. Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide. J Control Release. 2007 Jul 31; 120(3):178-85. View abstract
  150. Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. Biomaterials. 2007 Sep; 28(25):3704-13. View abstract
  151. In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. Ann Surg. 2007 May; 245(5):819-24. View abstract
  152. Photocrosslinkable hydrogel for myocyte cell culture and injection. . 2007 May; 81(2):312-22. View abstract
  153. Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions. Biomaterials. 2007 Aug; 28(23):3418-26. View abstract
  154. Microparticles and nanoparticles for drug delivery. Biotechnol Bioeng. 2007 Feb 01; 96(2):203-9. View abstract
  155. Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. Biomaterials. 2007 Apr; 28(10):1778-86. View abstract
  156. Tetrodotoxin for prolonged local anesthesia with minimal myotoxicity. Muscle Nerve. 2006 Dec; 34(6):747-53. View abstract
  157. Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules. 2006 Dec; 7(12):3336-44. View abstract
  158. The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives. Biomaterials. 2007 Feb; 28(6):975-83. View abstract
  159. Peritoneal application of chitosan and UV-cross-linkable chitosan. J Biomed Mater Res A. 2006 Sep 15; 78(4):668-75. View abstract
  160. Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. Biomaterials. 2006 Oct; 27(30):5259-67. View abstract
  161. In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. Biomaterials. 2006 Sep; 27(27):4698-705. View abstract
  162. A photolithographic method to create cellular micropatterns. Biomaterials. 2006 Sep; 27(27):4755-64. View abstract
  163. Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J Biomed Mater Res A. 2006 May; 77(2):351-61. View abstract
  164. Tissue injury from tricyclic antidepressants used as local anesthetics. Anesth Analg. 2005 Dec; 101(6):1838-43. View abstract
  165. Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. J Biomed Mater Res A. 2005 Nov 01; 75(2):458-64. View abstract
  166. Complex coacervates for thermally sensitive controlled release of flavor compounds. J Agric Food Chem. 2005 Sep 21; 53(19):7518-25. View abstract
  167. Engineering vascularized skeletal muscle tissue. Nat Biotechnol. 2005 Jul; 23(7):879-84. View abstract
  168. Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension. N Engl J Med. 2005 May 26; 352(21):2223-31. View abstract
  169. In vivo evaluation of tetrahedral amorphous carbon. Biomaterials. 2005 Feb; 26(5):465-73. View abstract
  170. Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization. J Biomed Mater Res A. 2004 Sep 01; 70(3):412-9. View abstract
  171. Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects. J Biomed Mater Res A. 2004 Sep 01; 70(3):459-66. View abstract
  172. pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85. View abstract
  173. Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. Biomaterials. 2004 Aug; 25(19):4797-804. View abstract
  174. Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants. Pain. 2004 Jul; 110(1-2):432-8. View abstract
  175. Microparticulate formulations for the controlled release of interleukin-2. J Pharm Sci. 2004 May; 93(5):1100-9. View abstract
  176. Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J Biomed Mater Res A. 2004 Mar 15; 68(4):651-9. View abstract
  177. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res. 2003 Oct; 20(10):1533-8. View abstract
  178. Local anesthetics inhibit uterine activity in vitro. Possible application on preterm labor prevention and treatment. Fetal Diagn Ther. 2003 Sep-Oct; 18(5):292-6. View abstract
  179. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21. View abstract
  180. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 2002 Dec; 43(12):1462-8. View abstract
  181. Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain Res. 2002 Aug 16; 946(2):206-13. View abstract
  182. Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res. 2002 Mar 05; 59(3):450-9. View abstract
  183. BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15318-23. View abstract
  184. High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. Acta Anaesthesiol Scand. 2001 Aug; 45(7):899-905. View abstract
  185. Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med. 2001 May-Jun; 26(3):239-45. View abstract
  186. Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. Pharm Res. 2000 Oct; 17(10):1243-9. View abstract
  187. The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med. 2000 Jan-Feb; 25(1):52-9. View abstract
  188. Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 1999 Feb; 90(2):524-34. View abstract
  189. Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology. 1998 Nov; 89(5):1199-208; discussion 10A. View abstract
  190. A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology. 1998 Jul; 89(1):119-31. View abstract
  191. Stress-induced proteins in aortic smooth muscle cells and aorta of hypertensive rats. Am J Physiol. 1990 Jun; 258(6 Pt 2):H1699-705. View abstract