ABOUT THE RESEARCHER

OVERVIEW

Our lab has three main broad areas of research: drug delivery, biomaterials, and nanomedicine, with considerable overlap between these. Some of our projects are driven by developing new technologies, others by trying to find cures for specific diseases. Pain, otitis media and other otic diseases, ophthalmic diseases, peritoneal adhesions, sepsis, and cancer are among the medical conditions that receive the most attention in our group.

BACKGROUND

Dr. Daniel S. Kohane obtained his MD and a PhD in Physiology from Boston University. He subsequently completed residencies in Pediatrics (Boston Children's Hospital) and Anesthesiology (Massachusetts general Hospital), followed by a fellowship in Pediatric Critical Care (Boston Children's Hospital). He is currently a Senior Associate in Pediatric Critical Care at Boston Children's Hospital at Harvard Medical School, where he directs the Laboratory for Biomaterials and Drug Delivery.

PUBLICATIONS

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  1. A novel, sensitive, and widely accessible besifloxacin quantification method by HPLC-fluorescence: Application to an ocular pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Nov 15; 1185:123010. View abstract
  2. Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols. Nat Commun. 2021 09 20; 12(1):5532. View abstract
  3. Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel. Nat Biomed Eng. 2021 09; 5(9):1099-1109. View abstract
  4. Dexamethasone-Eluting Contact Lens for the Prevention of Postphotorefractive Keratectomy Scar in a New Zealand White Rabbit Model. Cornea. 2021 Sep 01; 40(9):1175-1180. View abstract
  5. Targeting Nanoparticles to Bioengineered Human Vascular Networks. Nano Lett. 2021 08 11; 21(15):6609-6616. View abstract
  6. Synergy in Nanomedicine: What It Is Not, and What It Might Be. Nano Lett. 2021 07 14; 21(13):5457-5460. View abstract
  7. Permeation of polyethylene glycols across the tympanic membrane. Giant (Oxf). 2021 Jun; 6. View abstract
  8. Enhancement of the Mechanical and Drug-Releasing Properties of Poloxamer 407 Hydrogels with Casein. Pharm Res. 2021 Mar; 38(3):515-522. View abstract
  9. Initial Method for Characterization of Tympanic Membrane Drug Permeability in Human Temporal Bones In Situ. Front Neurol. 2021; 12:580392. View abstract
  10. Keeping Nanomedicine on Target. Nano Lett. 2021 01 13; 21(1):3-5. View abstract
  11. Drug Delivery across Barriers to the Middle and Inner Ear. Adv Funct Mater. 2021 Oct 26; 31(44). View abstract
  12. Local anesthesia enhanced with increasing high-frequency ultrasound intensity. Drug Deliv Transl Res. 2020 10; 10(5):1507-1516. View abstract
  13. Steroid-eluting contact lenses for corneal and intraocular inflammation. Acta Biomater. 2020 10 15; 116:149-161. View abstract
  14. Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy. Nano Lett. 2020 07 08; 20(7):5465-5472. View abstract
  15. Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia. Nat Commun. 2020 05 08; 11(1):2323. View abstract
  16. Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives. ACS Appl Mater Interfaces. 2020 Apr 15; 12(15):17314-17320. View abstract
  17. Synthesis of Poly(acyclic orthoester)s: Acid-Sensitive Biomaterials for Enhancing Immune Responses of Protein Vaccine. Angew Chem Int Ed Engl. 2020 04 27; 59(18):7235-7239. View abstract
  18. The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats. Pharm Res. 2019 Nov 08; 36(12):179. View abstract
  19. Transcytosis of Nanomedicine for Tumor Penetration. . 2019 11 13; 19(11):8010-8020. View abstract
  20. Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314. Transl Vis Sci Technol. 2019 Sep; 8(5):28. View abstract
  21. Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 09; 129(3):709-717. View abstract
  22. Nanoscale systems for local drug delivery. Nano Today. 2019 Oct; 28. View abstract
  23. A Simple, Yet Multifunctional, Nanoformulation for Eradicating Tumors and Preventing Recurrence with Safely Low Administration Dose. . 2019 08 14; 19(8):5515-5523. View abstract
  24. Topical sustained drug delivery to the retina with a drug-eluting contact lens. Biomaterials. 2019 10; 217:119285. View abstract
  25. Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. Nat Commun. 2019 06 12; 10(1):2566. View abstract
  26. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10674-10680. View abstract
  27. Quantile Regression and Its Applications: A Primer for Anesthesiologists. Anesth Analg. 2019 04; 128(4):820-830. View abstract
  28. Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 Mar 11. View abstract
  29. Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media. Mol Pharm. 2019 04 01; 16(4):1555-1562. View abstract
  30. Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat Commun. 2019 02 18; 10(1):804. View abstract
  31. Nanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia. ACS Nano. 2019 01 22; 13(1):18-25. View abstract
  32. PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia. Vaccine. 2018 11 12; 36(46):6926-6932. View abstract
  33. Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by transtympanic delivery of antibiotics. JCI Insight. 2018 10 04; 3(19). View abstract
  34. Externally triggered patient-controlled local anesthesia. Pain Manag. 2018 09 01; 8(5):313-315. View abstract
  35. Long-acting liposomal corneal anesthetics. Biomaterials. 2018 10; 181:372-377. View abstract
  36. Predicting the tissue depth for remote triggering of drug delivery systems. J Control Release. 2018 09 28; 286:55-63. View abstract
  37. Antibody-modified conduits for highly selective cytokine elimination from blood. JCI Insight. 2018 07 12; 3(13). View abstract
  38. Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane. J Control Release. 2018 11 10; 289:94-101. View abstract
  39. Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine. Anesth Analg. 2018 04; 126(4):1170-1175. View abstract
  40. BaTiO3-core Au-shell nanoparticles for photothermal therapy and bimodal imaging. Acta Biomater. 2018 05; 72:287-294. View abstract
  41. High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade. J Control Release. 2018 04 28; 276:150-156. View abstract
  42. Ultrasound-triggered liposomes for on-demand local anesthesia. Ther Deliv. 2018 01; 9(1):5-8. View abstract
  43. Hollow Silica Nanoparticles Penetrate the Peripheral Nerve and Enhance the Nerve Blockade from Tetrodotoxin. . 2018 01 10; 18(1):32-37. View abstract
  44. Light-Emitting Photon-Upconversion Nanoparticles in the Generation of Transdermal Reactive-Oxygen Species. ACS Appl Mater Interfaces. 2017 Dec 06; 9(48):41737-41747. View abstract
  45. Enhanced Triggering of Local Anesthetic Particles by Photosensitization and Photothermal Effect Using a Common Wavelength. . 2017 11 08; 17(11):7138-7145. View abstract
  46. Ultrasound-triggered local anaesthesia. Nat Biomed Eng. 2017; 1:644-653. View abstract
  47. Getting Drugs Across Biological Barriers. . 2017 Oct; 29(37). View abstract
  48. Tetrodotoxin, Epinephrine, and Chemical Permeation Enhancer Combinations in Peripheral Nerve Blockade. Anesth Analg. 2017 06; 124(6):1804-1812. View abstract
  49. Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose. Pediatrics. 2017 May; 139(5). View abstract
  50. Strong tissue glue with tunable elasticity. Acta Biomater. 2017 04 15; 53:93-99. View abstract
  51. Multiply repeatable and adjustable on-demand phototriggered local anesthesia. J Control Release. 2017 04 10; 251:68-74. View abstract
  52. Ultrasensitive Phototriggered Local Anesthesia. . 2017 02 08; 17(2):660-665. View abstract
  53. Drug delivery systems for prolonged duration local anesthesia. Mater Today (Kidlington). 2017 Jan-Feb; 20(1):22-31. View abstract
  54. 1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):344. View abstract
  55. Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. Int J Nanomedicine. 2016; 11:6149-6159. View abstract
  56. Phototriggered Drug Delivery Using Inorganic Nanomaterials. Bioconjug Chem. 2017 01 18; 28(1):98-104. View abstract
  57. Core-Shell Nanostars for Multimodal Therapy and Imaging. Theranostics. 2016; 6(13):2306-2313. View abstract
  58. Treatment of otitis media by transtympanic delivery of antibiotics. Sci Transl Med. 2016 09 14; 8(356):356ra120. View abstract
  59. Latanoprost-Eluting Contact Lenses in Glaucomatous Monkeys. Ophthalmology. 2016 10; 123(10):2085-92. View abstract
  60. Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane. Future Sci OA. 2016 Sep; 2(3):FSO138. View abstract
  61. Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance. . 2016 07 13; 16(7):4516-20. View abstract
  62. RNA therapeutics - The potential treatment for myocardial infarction. Regen Ther. 2016 Jun; 4:83-91. View abstract
  63. A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel. . 2016 Aug; 28(31):6680-6. View abstract
  64. Extended Release of Native Drug Conjugated in Polyketal Microparticles. J Am Chem Soc. 2016 05 18; 138(19):6127-30. View abstract
  65. Titanium Coating of the Boston Keratoprosthesis. Transl Vis Sci Technol. 2016 Apr; 5(2):17. View abstract
  66. Self-assembled gemcitabine-gadolinium nanoparticles for magnetic resonance imaging and cancer therapy. Acta Biomater. 2016 Mar; 33:34-9. View abstract
  67. Phototriggered Local Anesthesia. . 2016 Jan 13; 16(1):177-81. View abstract
  68. Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15719-24. View abstract
  69. Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF(165). Biomaterials. 2016 Jan; 77:130-138. View abstract
  70. New Strategies in Cancer Nanomedicine. Annu Rev Pharmacol Toxicol. 2016; 56:41-57. View abstract
  71. Ultraviolet light-mediated drug delivery: Principles, applications, and challenges. J Control Release. 2015 Dec 10; 219:31-42. View abstract
  72. Photoresponsive nanoparticles for drug delivery. Nano Today. 2015 Aug 01; 10(4):451-467. View abstract
  73. Efficient Triplet-Triplet Annihilation-Based Upconversion for Nanoparticle Phototargeting. . 2015 Oct 14; 15(10):6332-8. View abstract
  74. Nonlinear Optics: NIR-Triggered Drug Delivery by Collagen-Mediated Second Harmonic Generation (Adv. Healthcare Mater. 8/2015). Adv Healthc Mater. 2015 Jun; 4(8):1108. View abstract
  75. Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3820-6. View abstract
  76. NIR-triggered drug delivery by collagen-mediated second harmonic generation. Adv Healthc Mater. 2015 Jun 03; 4(8):1159-63. View abstract
  77. Preparation and characterization of SDF-1a-chitosan-dextran sulfate nanoparticles. J Vis Exp. 2015 Jan 22; (95):52323. View abstract
  78. Aptamer photoregulation in vivo. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):17099-103. View abstract
  79. Clinicians' perspectives on the use of drug-eluting contact lenses for the treatment of glaucoma. Ther Deliv. 2014 Oct; 5(10):1077-83. View abstract
  80. A two-component pre-seeded dermal-epidermal scaffold. Acta Biomater. 2014 Dec; 10(12):4928-4938. View abstract
  81. Prospects for near-infrared technology in remotely triggered drug delivery. Expert Opin Drug Deliv. 2014 Nov; 11(11):1681-5. View abstract
  82. Photothermally targeted thermosensitive polymer-masked nanoparticles. . 2014 Jul 09; 14(7):3697-701. View abstract
  83. Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red. Am J Respir Cell Mol Biol. 2014 Jun; 50(6):1107-17. View abstract
  84. Interview with Daniel Kohane. Ther Deliv. 2014 Apr; 5(4):387-9. View abstract
  85. Multivesicular liposomal bupivacaine at the sciatic nerve. Biomaterials. 2014 May; 35(15):4557-64. View abstract
  86. Near-infrared-actuated devices for remotely controlled drug delivery. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1349-54. View abstract
  87. Prevention of peritoneal adhesions using polymeric rheological blends. Acta Biomater. 2014 Mar; 10(3):1187-93. View abstract
  88. Photoswitchable nanoparticles for in vivo cancer chemotherapy. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19048-53. View abstract
  89. Photoactive electrospun fibers for inducing cell death. Adv Healthc Mater. 2014 Apr; 3(4):494-9. View abstract
  90. SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules. 2013 Nov 11; 14(11):4009-20. View abstract
  91. In vivo performance of a drug-eluting contact lens to treat glaucoma for a month. Biomaterials. 2014 Jan; 35(1):432-9. View abstract
  92. A photo-triggered layered surface coating producing reactive oxygen species. Biomaterials. 2013 Dec; 34(38):9763-9. View abstract
  93. Biodegradable mesostructured polymer membranes. Nano Lett. 2013 Sep 11; 13(9):4410-5. View abstract
  94. Enhanced photothermal effect of plasmonic nanoparticles coated with reduced graphene oxide. . 2013 Sep 11; 13(9):4075-9. View abstract
  95. Long-lasting antifouling coating from multi-armed polymer. Langmuir. 2013 Aug 13; 29(32):10087-94. View abstract
  96. Topical drug formulations for prolonged corneal anesthesia. Cornea. 2013 Jul; 32(7):1040-5. View abstract
  97. Microdevices for nanomedicine. Mol Pharm. 2013 Jun 03; 10(6):2127-44. View abstract
  98. A Stiff Injectable Biodegradable Elastomer. Adv Funct Mater. 2013 Mar 25; 23(12):1527-1533. View abstract
  99. Local toxicity from local anesthetic polymeric microparticles. Anesth Analg. 2013 Apr; 116(4):794-803. View abstract
  100. Controlled-release systems in neuropathic pain. Pain Manag. 2013 Mar; 3(2):91-3. View abstract
  101. Synthetic ligand-coated magnetic nanoparticles for microfluidic bacterial separation from blood. . 2014 Jan 08; 14(1):1-5. View abstract
  102. Synthesis and proton NMR spectroscopy of intra-vesicular gamma-aminobutyric acid (GABA). Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:1093-5. View abstract
  103. Modular 'click-in-emulsion' bone-targeted nanogels. Adv Mater. 2013 Mar 13; 25(10):1449-54. View abstract
  104. Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. Lab Chip. 2013 Jan 21; 13(2):252-9. View abstract
  105. Formulations for trans-tympanic antibiotic delivery. Biomaterials. 2013 Jan; 34(4):1281-8. View abstract
  106. Materials to clinical devices: technologies for remotely triggered drug delivery. Clin Ther. 2012 Nov; 34(11):S25-35. View abstract
  107. Prolonged nerve blockade delays the onset of neuropathic pain. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17555-60. View abstract
  108. Nanocomposite gold-silk nanofibers. Nano Lett. 2012 Oct 10; 12(10):5403-6. View abstract
  109. Duration and local toxicity of sciatic nerve blockade with coinjected site 1 sodium-channel blockers and quaternary lidocaine derivatives. Reg Anesth Pain Med. 2012 Sep-Oct; 37(5):483-9. View abstract
  110. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater. 2012 Nov; 11(11):986-94. View abstract
  111. Shedding light on nanomedicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Nov-Dec; 4(6):638-62. View abstract
  112. The smartest materials: the future of nanoelectronics in medicine. ACS Nano. 2012 Aug 28; 6(8):6541-5. View abstract
  113. Thermoresponsive nanogels for prolonged duration local anesthesia. Acta Biomater. 2012 Oct; 8(10):3596-605. View abstract
  114. Electrospun drug-eluting sutures for local anesthesia. J Control Release. 2012 Aug 10; 161(3):903-9. View abstract
  115. Delivering bioactive molecules as instructive cues to engineered tissues. Expert Opin Drug Deliv. 2012 Apr; 9(4):473-92. View abstract
  116. Photoswitchable nanoparticles for triggered tissue penetration and drug delivery. J Am Chem Soc. 2012 May 30; 134(21):8848-55. View abstract
  117. Injectable scaffolds achieve sustained siRNA release for tissue repair. Nanomedicine (Lond). 2012 Mar; 7(3):315-6. View abstract
  118. External electric fields trigger drug release from new hydrogel formulation. Nanomedicine (Lond). 2012 Mar; 7(3):316. View abstract
  119. Novel resonating nanowire arrays function as highly sensitive biosensors. Nanomedicine (Lond). 2012 Mar; 7(3):315. View abstract
  120. Toxicogenomic analysis of a sustained release local anesthetic delivery system. Biomaterials. 2012 May; 33(13):3586-93. View abstract
  121. An in situ cross-linking hybrid hydrogel for controlled release of proteins. Acta Biomater. 2012 May; 8(5):1703-9. View abstract
  122. Nanogel scavengers for drugs: local anesthetic uptake by thermoresponsive nanogels. Acta Biomater. 2012 Apr; 8(4):1450-8. View abstract
  123. Nanowired three-dimensional cardiac patches. Nat Nanotechnol. 2011 Sep 25; 6(11):720-5. View abstract
  124. Hydroxyapatite for keratoprosthesis biointegration. Invest Ophthalmol Vis Sci. 2011 Sep 22; 52(10):7392-9. View abstract
  125. Nanoparticles targeting the infarcted heart. Nano Lett. 2011 Oct 12; 11(10):4411-4. View abstract
  126. Liposomes for HIV prophylaxis. Biomaterials. 2011 Nov; 32(33):8663-8. View abstract
  127. A prototype antifungal contact lens. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6286-91. View abstract
  128. Microgels for efficient protein purification. Adv Mater. 2011 Sep 22; 23(36):H258-62. View abstract
  129. Surface modification and drug delivery for biointegration. Ther Deliv. 2011 Jun; 2(6):737-52. View abstract
  130. Elasticity and safety of alkoxyethyl cyanoacrylate tissue adhesives. Acta Biomater. 2011 Aug; 7(8):3150-7. View abstract
  131. Nanotechnology for surgeons. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 May-Jun; 3(3):223-8. View abstract
  132. Magnetically triggered nanocomposite membranes: a versatile platform for triggered drug release. Nano Lett. 2011 Mar 09; 11(3):1395-400. View abstract
  133. Drug delivery and translation. Drug Deliv Transl Res. 2011 Feb; 1(1):4-6. View abstract
  134. Nanotechnological strategies for engineering complex tissues. Nat Nanotechnol. 2011 Jan; 6(1):13-22. View abstract
  135. Remotely triggerable drug delivery systems. . 2010 Nov 24; 22(44):4925-43. View abstract
  136. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010 Aug 09; 11(8):1909-14. View abstract
  137. A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials. 2010 Jul; 31(19):5208-17. View abstract
  138. Prolonged sensory-selective nerve blockade. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3740-5. View abstract
  139. Rheological blends for drug delivery. II. Prolongation of nerve blockade, biocompatibility, and in vitro-in vivo correlations. J Biomed Mater Res A. 2010 Feb; 92(2):586-95. View abstract
  140. Rheological blends for drug delivery. I. Characterization in vitro. J Biomed Mater Res A. 2010 Feb; 92(2):575-85. View abstract
  141. Photo-targeted nanoparticles. Nano Lett. 2010 Jan; 10(1):250-4. View abstract
  142. Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials. 2010 Feb; 31(6):1444-52. View abstract
  143. Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov; 91(2):519-27. View abstract
  144. A magnetically triggered composite membrane for on-demand drug delivery. Nano Lett. 2009 Oct; 9(10):3651-7. View abstract
  145. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009 Jul; 5(13):1575-81. View abstract
  146. Contact lenses for drug delivery. Semin Ophthalmol. 2009 May-Jun; 24(3):156-60. View abstract
  147. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7125-30. View abstract
  148. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3346-52. View abstract
  149. Effect of chemical permeation enhancers on nerve blockade. Mol Pharm. 2009 Jan-Feb; 6(1):265-73. View abstract
  150. Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Mol Pharm. 2009 Jan-Feb; 6(1):190-201. View abstract
  151. Spray-dried lipid-hyaluronan-polymethacrylate microparticles for drug delivery in the peritoneum. J Biomed Mater Res A. 2008 Dec 01; 87(3):825-31. View abstract
  152. The biocompatibility of mesoporous silicates. Biomaterials. 2008 Oct; 29(30):4045-55. View abstract
  153. Microparticles for inhalational delivery of antipseudomonal antibiotics. AAPS J. 2008 Jun; 10(2):254-60. View abstract
  154. Local myotoxicity from sustained release of bupivacaine from microparticles. Anesthesiology. 2008 May; 108(5):921-8. View abstract
  155. Polymeric biomaterials in tissue engineering. Pediatr Res. 2008 May; 63(5):487-91. View abstract
  156. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1138-45. View abstract
  157. Antifungal hydrogels. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):12994-8. View abstract
  158. Polymers in the prevention of peritoneal adhesions. Eur J Pharm Biopharm. 2008 Jan; 68(1):57-66. View abstract
  159. Prevention of peritoneal adhesions with an in situ cross-linkable hyaluronan hydrogel delivering budesonide. J Control Release. 2007 Jul 31; 120(3):178-85. View abstract
  160. Peritoneal adhesion prevention with an in situ cross-linkable hyaluronan gel containing tissue-type plasminogen activator in a rabbit repeated-injury model. Biomaterials. 2007 Sep; 28(25):3704-13. View abstract
  161. In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. Ann Surg. 2007 May; 245(5):819-24. View abstract
  162. Photocrosslinkable hydrogel for myocyte cell culture and injection. . 2007 May; 81(2):312-22. View abstract
  163. Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions. Biomaterials. 2007 Aug; 28(23):3418-26. View abstract
  164. Microparticles and nanoparticles for drug delivery. Biotechnol Bioeng. 2007 Feb 01; 96(2):203-9. View abstract
  165. Anti-inflammatory function of an in situ cross-linkable conjugate hydrogel of hyaluronic acid and dexamethasone. Biomaterials. 2007 Apr; 28(10):1778-86. View abstract
  166. Tetrodotoxin for prolonged local anesthesia with minimal myotoxicity. Muscle Nerve. 2006 Dec; 34(6):747-53. View abstract
  167. Hyaluronic acid-based microgels and microgel networks for vocal fold regeneration. Biomacromolecules. 2006 Dec; 7(12):3336-44. View abstract
  168. The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives. Biomaterials. 2007 Feb; 28(6):975-83. View abstract
  169. Peritoneal application of chitosan and UV-cross-linkable chitosan. J Biomed Mater Res A. 2006 Sep 15; 78(4):668-75. View abstract
  170. Micromolding of photocrosslinkable chitosan hydrogel for spheroid microarray and co-cultures. Biomaterials. 2006 Oct; 27(30):5259-67. View abstract
  171. In situ cross-linkable hyaluronic acid hydrogels prevent post-operative abdominal adhesions in a rabbit model. Biomaterials. 2006 Sep; 27(27):4698-705. View abstract
  172. A photolithographic method to create cellular micropatterns. Biomaterials. 2006 Sep; 27(27):4755-64. View abstract
  173. Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J Biomed Mater Res A. 2006 May; 77(2):351-61. View abstract
  174. Tissue injury from tricyclic antidepressants used as local anesthetics. Anesth Analg. 2005 Dec; 101(6):1838-1843. View abstract
  175. Prolonged duration local anesthesia with lipid-protein-sugar particles containing bupivacaine and dexamethasone. J Biomed Mater Res A. 2005 Nov 01; 75(2):458-64. View abstract
  176. Complex coacervates for thermally sensitive controlled release of flavor compounds. J Agric Food Chem. 2005 Sep 21; 53(19):7518-25. View abstract
  177. Engineering vascularized skeletal muscle tissue. Nat Biotechnol. 2005 Jul; 23(7):879-84. View abstract
  178. Case records of the Massachusetts General Hospital. Case 16-2005. A nine-year-old girl with headaches and hypertension. N Engl J Med. 2005 May 26; 352(21):2223-31. View abstract
  179. In vivo evaluation of tetrahedral amorphous carbon. Biomaterials. 2005 Feb; 26(5):465-73. View abstract
  180. Injectable microparticle-gel system for prolonged and localized lidocaine release. I. In vitro characterization. J Biomed Mater Res A. 2004 Sep 01; 70(3):412-9. View abstract
  181. Injectable microparticle-gel system for prolonged and localized lidocaine release. II. In vivo anesthetic effects. J Biomed Mater Res A. 2004 Sep 01; 70(3):459-66. View abstract
  182. pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85. View abstract
  183. Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. Biomaterials. 2004 Aug; 25(19):4797-804. View abstract
  184. Site 1 sodium channel blockers prolong the duration of sciatic nerve blockade from tricyclic antidepressants. Pain. 2004 Jul; 110(1-2):432-8. View abstract
  185. Microparticulate formulations for the controlled release of interleukin-2. J Pharm Sci. 2004 May; 93(5):1100-9. View abstract
  186. Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J Biomed Mater Res A. 2004 Mar 15; 68(4):651-9. View abstract
  187. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res. 2003 Oct; 20(10):1533-8. View abstract
  188. Local anesthetics inhibit uterine activity in vitro. Possible application on preterm labor prevention and treatment. Fetal Diagn Ther. 2003 Sep-Oct; 18(5):292-6. View abstract
  189. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21. View abstract
  190. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 2002 Dec; 43(12):1462-8. View abstract
  191. Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain Res. 2002 Aug 16; 946(2):206-13. View abstract
  192. Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res. 2002 Mar 05; 59(3):450-9. View abstract
  193. BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia. Proc Natl Acad Sci U S A. 2001 Dec 18; 98(26):15318-23. View abstract
  194. High concentrations of adrenergic antagonists prolong sciatic nerve blockade by tetrodotoxin. Acta Anaesthesiol Scand. 2001 Aug; 45(7):899-905. View abstract
  195. Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med. 2001 May-Jun; 26(3):239-45. View abstract
  196. Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. Pharm Res. 2000 Oct; 17(10):1243-9. View abstract
  197. The local anesthetic properties and toxicity of saxitonin homologues for rat sciatic nerve block in vivo. Reg Anesth Pain Med. 2000 Jan-Feb; 25(1):52-9. View abstract
  198. Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 1999 Feb; 90(2):524-34. View abstract
  199. Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. Anesthesiology. 1998 Nov; 89(5):1199-208; discussion 10A. View abstract
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