ABOUT THE RESEARCHER

OVERVIEW

Dr. Kiapour’s research is focused on developing new methods for analyzing clinical data (e.g. imaging) to better understand the etiology and mechanisms of musculoskeletal diseases and to develop new tools for injury prediction and to facilitate clinical decision-making (e.g. treatment choice). His approaches have been applied in several domains, including studying joint morphogenesis and its implications in injury risk and treatment outcomes, development of new imaging biomarkers to track tissue healing and response to treatment, and development of simulation tools for surgical planning. Dr. Kiapour founded the Musculoskeletal Informatics Group (MIG) in 2021. The MIG was formed with the mission of developing novel analytical tools to facilitate the use of “big” clinical data to: 1) improve our understanding of musculoskeletal diseases among pediatrics and young adults, 2) optimize clinical care for such diseases, and 3) improve the quality of life of patients with such conditions.

BACKGROUND

Ata Kiapour is an Assistant Professor in Orthopaedic Surgery at Harvard Medical School, Principal Investigator at the Orthopaedic Research Laboratory, and the Director of the Musculoskeletal Informatics Group (MIG) in Department of Orthopaedic Surgery and Sports Medicine at Boston Children’s Hospital. He has a diverse training and have research and product development experience in both academia and industry. He holds BS and MS degrees in Material Science and Engineering (Iran University of Science & Technology 2004 and 2008), PhD in Biomedical Engineering (University of Toledo, OH), and Master of Medical Sciences in Clinical and Translational Investigation (HMS 2016). He has also conducted postdoctoral fellowship in Orthopedic Surgery (Boston Children’s Hospital 2013-2015).

PUBLICATIONS

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  1. Joint disease-specificity at the regulatory base-pair level. Nat Commun. 2021 07 06; 12(1):4161. View abstract
  2. The Readability of Online Educational Materials for Femoroacetabular Impingement Syndrome. J Am Acad Orthop Surg. 2021 Jun 01; 29(11):e548-e554. View abstract
  3. Sacroiliac joint stabilization using implants provide better fixation in females compared to males: a finite element analysis. Eur Spine J. 2021 08; 30(8):2351-2359. View abstract
  4. Does the Capital Femoral Physis Bony MorphologyDiffer in Children with Symptomatic Cam-type Femoroacetabular Impingement. Clin Orthop Relat Res. 2021 05 01; 479(5):922-931. View abstract
  5. What Is the Association Among Epiphyseal Rotation, Translation, and the Morphology of the Epiphysis and Metaphysis in Slipped Capital Femoral Epiphysis? Clin Orthop Relat Res. 2021 05 01; 479(5):935-944. View abstract
  6. Performance assessment of the metastatic spinal tumor frailty index using machine learning algorithms: limitations and future directions. Neurosurg Focus. 2021 05; 50(5):E5. View abstract
  7. Safety and efficacy of cement augmentation with fenestrated pedicle screws for tumor-related spinal instability. Neurosurg Focus. 2021 05; 50(5):E12. View abstract
  8. A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament. J Orthop Res. 2021 Jan 17. View abstract
  9. Automated magnetic resonance image segmentation of the anterior cruciate ligament. J Orthop Res. 2021 04; 39(4):831-840. View abstract
  10. Higher Physiologic Platelet Counts in Whole Blood Are Not Associated With Improved ACL Cross-sectional Area or Signal Intensity 6 Months After Bridge-Enhanced ACL Repair. Orthop J Sports Med. 2020 Jul; 8(7):2325967120927655. View abstract
  11. Sex Differences in Anatomic Features Linked to Anterior Cruciate Ligament Injuries During Skeletal Growth and Maturation. Am J Sports Med. 2020 07; 48(9):2205-2212. View abstract
  12. Biomechanics of the Sacroiliac Joint: Surgical Treatments. Int J Spine Surg. 2020 Jun; 14(3):355-367. View abstract
  13. Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature. Neurospine. 2020 Jun; 17(2):473. View abstract
  14. Females Have Earlier Muscle Strength and Functional Recovery After Bridge-Enhanced Anterior Cruciate Ligament Repair. Tissue Eng Part A. 2020 07; 26(13-14):702-711. View abstract
  15. Increased body mass index percentile is associated with decreased epiphyseal tubercle size in asymptomatic children and adolescents with healthy hips. J Child Orthop. 2020 Jun 01; 14(3):167-174. View abstract
  16. The metaphyseal fossa surrounding the epiphyseal tubercle is larger in hips with moderate and severe slipped capital femoral epiphysis than normal hips. J Child Orthop. 2020 Jun 01; 14(3):184-189. View abstract
  17. Age-related changes in ACL morphology during skeletal growth and maturation are different between females and males. J Orthop Res. 2021 04; 39(4):841-849. View abstract
  18. The point of epiphyseal penetration affects rotational stability of screw fixation in slipped capital femoral epiphysis: A biomechanical study. J Orthop Res. 2020 12; 38(12):2634-2639. View abstract
  19. Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial. Am J Sports Med. 2020 05; 48(6):1305-1315. View abstract
  20. Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature. Neurospine. 2020 Mar; 17(1):125-135. View abstract
  21. Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk. Cell. 2020 04 16; 181(2):362-381.e28. View abstract
  22. Age- and sex-specific morphologic changes in the metaphyseal fossa adjacent to epiphyseal tubercle in children and adolescents without hip disorders. J Orthop Res. 2020 10; 38(10):2213-2219. View abstract
  23. Biomechanics of the Sacroiliac Joint: Anatomy, Function, Biomechanics, Sexual Dimorphism, and Causes of Pain. Int J Spine Surg. 2020 Feb; 14(Suppl 1):3-13. View abstract
  24. Smaller Epiphyseal Tubercle and Larger Peripheral Cupping in Slipped Capital Femoral Epiphysis Compared with Healthy Hips: A 3-Dimensional Computed Tomography Study. J Bone Joint Surg Am. 2020 Jan 02; 102(1):29-36. View abstract
  25. Risk of Secondary ACL Injury in Adolescents Prescribed Functional Bracing After ACL Reconstruction. Orthop J Sports Med. 2019 Nov; 7(11):2325967119879880. View abstract
  26. Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair. J Orthop Res. 2019 10; 37(10):2249-2257. View abstract
  27. Changes in Cross-sectional Area and Signal Intensity of Healing Anterior Cruciate Ligaments and Grafts in the First 2 Years After Surgery. Am J Sports Med. 2019 07; 47(8):1831-1843. View abstract
  28. Predictors of Healing Ligament Size and Magnetic Resonance Signal Intensity at 6 Months After Bridge-Enhanced Anterior Cruciate Ligament Repair. Am J Sports Med. 2019 05; 47(6):1361-1369. View abstract
  29. Relative contribution of epiphyseal tubercle and peripheral cupping to capital femoral epiphysis stability during daily activities. J Orthop Res. 2019 07; 37(7):1571-1579. View abstract
  30. Synovial fluid proteome changes in ACL injury-induced posttraumatic osteoarthritis: Proteomics analysis of porcine knee synovial fluid. PLoS One. 2019; 14(3):e0212662. View abstract
  31. Anatomic Features of the Tibial Plateau Predict Outcomes of ACL Reconstruction Within 7 Years After Surgery. Am J Sports Med. 2019 02; 47(2):303-311. View abstract
  32. Optimal satellite rod constructs to mitigate rod failure following pedicle subtraction osteotomy (PSO): a finite element study. Spine J. 2019 05; 19(5):931-941. View abstract
  33. The role of Gdf5 regulatory regions in development of hip morphology. PLoS One. 2018; 13(11):e0202785. View abstract
  34. Sex Specific Sacroiliac Joint Biomechanics During Standing Upright: A Finite Element Study. Spine (Phila Pa 1976). 2018 09 15; 43(18):E1053-E1060. View abstract
  35. Age- and Sex-Specific Morphologic Variations of Capital Femoral Epiphysis Growth in Children and Adolescents Without Hip Disorders. Orthop J Sports Med. 2018 Jun; 6(6):2325967118781579. View abstract
  36. Sacroiliac joint stability: Finite element analysis of implant number, orientation, and superior implant length. World J Orthop. 2018 Mar 18; 9(3):14-23. View abstract
  37. Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Feb 20. View abstract
  38. Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis. Ann Rheum Dis. 2018 03; 77(3):450. View abstract
  39. Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL. J Orthop Res. 2018 06; 36(6):1701-1709. View abstract
  40. Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage. Orthop J Sports Med. 2017 Aug; 5(8):2325967117723886. View abstract
  41. Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 01; 36(1):318-329. View abstract
  42. Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair. J Orthop Res. 2017 12; 35(12):2606-2612. View abstract
  43. Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk. Nat Genet. 2017 Aug; 49(8):1202-1210. View abstract
  44. CORR Insights®: Knee Abduction Affects Greater Magnitude of Change in ACL and MCL Strains Than Matched Internal Tibial Rotation In Vitro. Clin Orthop Relat Res. 2017 10; 475(10):2397-2400. View abstract
  45. Trochleoplasty as a Solitary Treatment for Recurrent Patellar Dislocation Results in Good Clinical Outcome in Adolescents. Am J Sports Med. 2016 Nov; 44(11):2855-2863. View abstract
  46. Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. Arthritis Rheumatol. 2016 07; 68(7):1637-47. View abstract
  47. Strain Response of the Anterior Cruciate Ligament to Uniplanar and Multiplanar Loads During Simulated Landings: Implications for Injury Mechanism. Am J Sports Med. 2016. View abstract
  48. Strain Response of the Anterior Cruciate Ligament to Uniplanar and Multiplanar Loads During Simulated Landings: Implications for Injury Mechanism. Am J Sports Med. 2016 Aug; 44(8):2087-96. View abstract
  49. Risk of Noncontact Anterior Cruciate Ligament Injuries Is Not Associated With Slope and Concavity of the Tibial Plateau in Recreational Alpine Skiers: A Magnetic Resonance Imaging-Based Case-Control Study of 121 Patients. Am J Sports Med. 2016 Jun; 44(6):1508-14. View abstract
  50. Sacroiliac Joint Fusion Minimally Affects Adjacent Lumbar Segment Motion: A Finite Element Study. Int J Spine Surg. 2015; 9:64. View abstract
  51. Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model. Clin Orthop Relat Res. 2015 Aug; 473(8):2599-608. View abstract
  52. Uni-directional coupling between tibiofemoral frontal and axial plane rotation supports valgus collapse mechanism of ACL injury. J Biomech. 2015 Jul 16; 48(10):1745-51. View abstract
  53. Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model. Am J Sports Med. 2015 Jul; 43(7):1623-31. View abstract
  54. Biomechanical evaluation of the pedicle screw insertion depth effect on screw stability under cyclic loading and subsequent pullout. J Spinal Disord Tech. 2015 Apr; 28(3):E133-9. View abstract
  55. Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. Clin Orthop Relat Res. 2015 Feb; 473(2):639-50. View abstract
  56. Biomechanical analysis of various footprints of transforaminal lumbar interbody fusion devices. J Spinal Disord Tech. 2014 Jun; 27(4):E118-27. View abstract
  57. A computational biomechanical investigation of posterior dynamic instrumentation: combination of dynamic rod and hinged (dynamic) screw. J Biomech Eng. 2014 May; 136(5):051007. View abstract
  58. The Effect of Ligament Modeling Technique on Knee Joint Kinematics: A Finite Element Study. Appl Math (Irvine). 2014 May; 4(5A):91-97. View abstract
  59. Pedicle screw-based posterior dynamic stabilisation of the lumbar spine: in vitro cadaver investigation and a finite element study. Comput Methods Biomech Biomed Engin. 2015 Aug; 18(11):1252-1261. View abstract
  60. Comparison of eight published static finite element models of the intact lumbar spine: predictive power of models improves when combined together. J Biomech. 2014 Jun 03; 47(8):1757-66. View abstract
  61. A unique modular implant system enhances load sharing in anterior cervical interbody fusion: a finite element study. Biomed Eng Online. 2014 Mar 11; 13(1):26. View abstract
  62. Basic science of anterior cruciate ligament injury and repair. Bone Joint Res. 2014; 3(2):20-31. View abstract
  63. Finite element model of the knee for investigation of injury mechanisms: development and validation. J Biomech Eng. 2014 Jan; 136(1):011002. View abstract
  64. Diagnostic value of knee arthrometry in the prediction of anterior cruciate ligament strain during landing. Am J Sports Med. 2014 Feb; 42(2):312-9. View abstract
  65. Timing sequence of multi-planar knee kinematics revealed by physiologic cadaveric simulation of landing: implications for ACL injury mechanism. Clin Biomech (Bristol, Avon). 2014 Jan; 29(1):75-82. View abstract
  66. Preferential loading of the ACL compared with the MCL during landing: a novel in sim approach yields the multiplanar mechanism of dynamic valgus during ACL injuries. Am J Sports Med. 2014 Jan; 42(1):177-86. View abstract
  67. Clinically relevant injury patterns after an anterior cruciate ligament injury provide insight into injury mechanisms. Am J Sports Med. 2013 Feb; 41(2):385-95. View abstract
  68. Kinematic effects of a pedicle-lengthening osteotomy for the treatment of lumbar spinal stenosis. J Neurosurg Spine. 2012 Oct; 17(4):314-20. View abstract
  69. A Biomechanical Finite Element Study of Subsidence and Migration Tendencies in Stand-Alone Fusion Procedures – Comparison of an in situ Expandable Device with a Rigid Device. J Spine. 2012; 120(1). View abstract
  70. Effect of graded facetectomy on biomechanics of Dynesys dynamic stabilization system. Spine (Phila Pa 1976). 2012 May 01; 37(10):E581-9. View abstract
  71. Relationship between limb length discrepancy and load distribution across the sacroiliac joint--a finite element study. J Orthop Res. 2012 Oct; 30(10):1577-80. View abstract
  72. Models that incorporate spinal structures predict better wear performance of cervical artificial discs. Spine J. 2011 Aug; 11(8):766-76. View abstract
  73. Cartilage pressure distributions provide a footprint to define female anterior cruciate ligament injury mechanisms. Am J Sports Med. 2011 Aug; 39(8):1706-13. View abstract
  74. Biomechanical rationale of sacral rounding deformity in pediatric spondylolisthesis: a clinical and biomechanical study. Arch Orthop Trauma Surg. 2011 Sep; 131(9):1187-94. View abstract
  75. Lumbar fusion leads to increases in angular motion and stress across sacroiliac joint: a finite element study. Spine (Phila Pa 1976). 2009 Mar 01; 34(5):E162-9. View abstract
  76. Newly occurred L4 spondylolysis in the lumbar spine with pre-existence L5 spondylolysis among sports players: case reports and biomechanical analysis. Arch Orthop Trauma Surg. 2009 Oct; 129(10):1433-9. View abstract
  77. Finite element study of matched paired posterior disc implant and dynamic stabilizer (360° motion preservation system). SAS J. 2007; 1(1):55-61. View abstract
  78. Anatomic Facet Replacement System (AFRS) Restoration of Lumbar Segment Mechanics to Intact: A Finite Element Study and In Vitro Cadaver Investigation. SAS J. 2007; 1(1):46-54. View abstract
  79. Biomechanics of two-level Charité artificial disc placement in comparison to fusion plus single-level disc placement combination. Spine J. 2006 Nov-Dec; 6(6):659-66. View abstract