ABOUT THE RESEARCHER

OVERVIEW

In his research, Alvin Kho builds mathematical models of developing biological systems to identify developmental programs that underwrite pathobiology in these systems with the aim of translating this knowledge into clinically-relevant endpoints. He has investigated transcriptomes of the developing central nervous system (PMID:15075291), skeletal muscle (PMID:21337346) and lung (PMID:16800721, 19815808, 18664640) and identified molecular correlates associated with (normal) organ-specific function and disease traits in these systems. Recently, he has focused on the role of in utero exposures (e.g., vitamin D, corticosteroids) in the pathobiology of chronic disease that occur later in life such as asthma and COPD (PMID:22983352, 24188128, 24668408).

PUBLICATIONS

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  1. COPD-associated miR-145-5p is downregulated in early-decline FEV1 trajectories in childhood asthma. J Allergy Clin Immunol. 2020 Dec 29. View abstract
  2. Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk. Healthcare (Basel). 2020 Dec 04; 8(4). View abstract
  3. Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD. Eur Respir J. 2020 10; 56(4). View abstract
  4. Enhancing the prediction of childhood asthma remission: Integrating clinical factors with microRNAs. J Allergy Clin Immunol. 2020 Sep 02. View abstract
  5. CASTER: Cross-Sectional Asthma STEroid Response Measurement. J Pers Med. 2020 Aug 20; 10(3). View abstract
  6. Circulating MicroRNAs and Treatment Response in Childhood Asthma. Am J Respir Crit Care Med. 2020 07 01; 202(1):65-72. View abstract
  7. COMPSRA: a COMprehensive Platform for Small RNA-Seq data Analysis. Sci Rep. 2020 03 12; 10(1):4552. View abstract
  8. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Med. 2020 03 02; 12(1):25. View abstract
  9. Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. Respir Res. 2020 Jan 28; 21(1):31. View abstract
  10. Mechanical forces induce an asthma gene signature in healthy airway epithelial cells. Sci Rep. 2020 01 22; 10(1):966. View abstract
  11. Pulmonary Neuroendocrine Cells Secrete ?-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models. Am J Respir Cell Mol Biol. 2019 06; 60(6):687-694. View abstract
  12. Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812. View abstract
  13. Circulating microRNAs and prediction of asthma exacerbation in childhood asthma. Respir Res. 2018 06 26; 19(1):128. View abstract
  14. Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort. PLoS One. 2017; 12(7):e0180329. View abstract
  15. Zinc deficiency primes the lung for ventilator-induced injury. JCI Insight. 2017 Jun 02; 2(11). View abstract
  16. Asthma remission: Predicting future airways responsiveness using an miRNA network. J Allergy Clin Immunol. 2017 08; 140(2):598-600.e8. View abstract
  17. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474. View abstract
  18. CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. Physiol Rep. 2016 09; 4(17). View abstract
  19. Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development. PeerJ. 2016; 4:e2318. View abstract
  20. Circulating MicroRNAs: Association with Lung Function in Asthma. PLoS One. 2016; 11(6):e0157998. View abstract
  21. Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome. Am J Respir Cell Mol Biol. 2016 06; 54(6):814-21. View abstract
  22. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12; 374(19):1842-1852. View abstract
  23. Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. Mol Cell Proteomics. 2016 06; 15(6):1877-94. View abstract
  24. Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures. Mol Autism. 2015; 6:66. View abstract
  25. Steroid Pathway Genes and Neonatal Respiratory Distress After Betamethasone Use in Anticipated Preterm Birth. Reprod Sci. 2016 May; 23(5):680-6. View abstract
  26. Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater. 2015 Oct; 14(10):1040-8. View abstract
  27. Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response. Am J Respir Cell Mol Biol. 2015 May; 52(5):543-53. View abstract
  28. Fetal lung and placental methylation is associated with in utero nicotine exposure. Epigenetics. 2014 Nov; 9(11):1473-84. View abstract
  29. Genetic variation in the HLA region is associated with susceptibility to herpes zoster. Genes Immun. 2015 Jan-Feb; 16(1):1-7. View abstract
  30. The genomic origins of asthma. Thorax. 2014 May; 69(5):481-7. View abstract
  31. Vitamin D related genes in lung development and asthma pathogenesis. BMC Med Genomics. 2013 Nov 05; 6:47. View abstract
  32. Identification of dedifferentiation and redevelopment phases during postpneumonectomy lung growth. . 2013 Oct 15; 305(8):L542-54. View abstract
  33. MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation. Cell Death Differ. 2013 Sep; 20(9):1194-208. View abstract
  34. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024. View abstract
  35. Maternal allergen exposure reprograms the developmental lung transcriptome in atopic and normoresponsive rat pups. . 2012 Nov 15; 303(10):L899-911. View abstract
  36. Expression analysis of asthma candidate genes during human and murine lung development. Respir Res. 2011 Jun 23; 12:86. View abstract
  37. Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors. Muscle Nerve. 2011 May; 43(5):741-50. View abstract
  38. Proteomic temporal profile of human brain endothelium after oxidative stress. Stroke. 2011 Jan; 42(1):37-43. View abstract
  39. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010 Aug 23; 190(4):693-706. View abstract
  40. Genetic influences on asthma susceptibility in the developing lung. Am J Respir Cell Mol Biol. 2010 Dec; 43(6):720-30. View abstract
  41. An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium. FASEB J. 2010 May; 24(5):1604-15. View abstract
  42. Transcriptomic analysis of human lung development. Am J Respir Crit Care Med. 2010 Jan 01; 181(1):54-63. View abstract
  43. Platform dependence of inference on gene-wise and gene-set involvement in human lung development. BMC Bioinformatics. 2009 Jun 19; 10:189. View abstract
  44. Transcriptional regulation differs in affected facioscapulohumeral muscular dystrophy patients compared to asymptomatic related carriers. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6220-5. View abstract
  45. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12; 14(2):123-34. View abstract
  46. Expression profiles of the mouse lung identify a molecular signature of time-to-birth. Am J Respir Cell Mol Biol. 2009 Jan; 40(1):47-57. View abstract
  47. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther. 2007; 9(2):R36. View abstract
  48. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 09; 175(1):99-110. View abstract
  49. Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis. Mol Cell Neurosci. 2006 Nov; 33(3):247-59. View abstract
  50. Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model. J Proteome Res. 2006 Aug; 5(8):1866-78. View abstract
  51. Melanoma cell adhesion molecule is a novel marker for human fetal myogenic cells and affects myoblast fusion. J Cell Sci. 2006 Aug 01; 119(Pt 15):3117-27. View abstract
  52. Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development. PLoS Med. 2006 Jul; 3(7):e232. View abstract
  53. Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. Stem Cells. 2006 Sep; 24(9):2034-44. View abstract
  54. Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes. BMC Musculoskelet Disord. 2006 Mar 07; 7:23. View abstract
  55. Melanoma Cell Adhesion Molecule is a novel marker for human fetal myogenic cells and affects myoblast fusion. J Cell Sci. 119, 3117-27, 2006. 2006; 119(Pt 15):3117-27. View abstract
  56. Alteration of ribosomal protein gene expression, transcription, apoptosis and cancer pathways in Diamond-Blackfan anemia. Stem Cells. 2006; 24(9):2033-44. View abstract
  57. The influence of muscle type and dystrophin deficiency on murine expression profiles. Mamm Genome. 2005 Oct; 16(10):739-48. View abstract
  58. Variations in gene expression among different types of human skeletal muscle. Muscle Nerve. 2005 Oct; 32(4):483-91. View abstract
  59. Side population cells isolated from different tissues share transcriptome signatures and express tissue-specific markers. Exp Cell Res. 2005 Feb 15; 303(2):360-74. View abstract
  60. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol. 2004 May; 63(5):499-509. View abstract
  61. Molecular classification of nemaline myopathies: "nontyping" specimens exhibit unique patterns of gene expression. Neurobiol Dis. 2004 Apr; 15(3):590-600. View abstract
  62. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev. 2004 Mar 15; 18(6):629-40. View abstract
  63. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003 Dec 12; 278(50):50466-73. View abstract
  64. Gene expression profiling of Duchenne muscular dystrophy skeletal muscle. Neurogenetics. 2003 Aug; 4(4):163-71. View abstract
  65. Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4666-71. View abstract
  66. Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15000-5. View abstract
  67. Microarrays for an Integrative Genomics Microarrays for an Integrative Genomics. 2002; 326. View abstract
  68. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5704-9. View abstract
  69. CHIP TUNER: a web tool for evidence-based noise reduction in gene discovery. Proc AMIA Symp. 2002; 810-4. View abstract
  70. Stochastic mean curvature flows: Asymptotic derivation, level set formulation and numerics. Interfaces and Free Boundaries. 2001; 3:265-90. View abstract
  71. Multi-scale analysis for microscropic models in materials science and cell biology. 2000. View abstract