ABOUT THE RESEARCHER

OVERVIEW

In his research, Alvin Kho builds mathematical models of developing biological systems to identify developmental programs that underwrite pathobiology in these systems with the aim of translating this knowledge into clinically-relevant endpoints. He has investigated transcriptomes of the developing central nervous system (PMID:15075291), skeletal muscle (PMID:21337346) and lung (PMID:16800721, 19815808, 18664640) and identified molecular correlates associated with (normal) organ-specific function and disease traits in these systems. Recently, he has focused on the role of in utero exposures (e.g., vitamin D, corticosteroids) in the pathobiology of chronic disease that occur later in life such as asthma and COPD (PMID:22983352, 24188128, 24668408).

PUBLICATIONS

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  1. Seasonal Variation in miR-328-3p and let-7d-3p Are Associated With Seasonal Allergies and Asthma Symptoms in Children. Allergy Asthma Immunol Res. 2021 Jul; 13(4):576-588. View abstract
  2. Commercially Available Blocking Oligonucleotides Effectively Suppress Unwanted Hemolysis-Related miRNAs in a Large Whole-Blood RNA Cohort. J Mol Diagn. 2021 06; 23(6):671-682. View abstract
  3. Circulating MicroRNA: Incident Asthma Prediction and Vitamin D Effect Modification. J Pers Med. 2021 Apr 16; 11(4). View abstract
  4. Drug Repurposing to Treat Glucocorticoid Resistance in Asthma. J Pers Med. 2021 Mar 03; 11(3). View abstract
  5. COPD-associated miR-145-5p is downregulated in early-decline FEV1 trajectories in childhood asthma. J Allergy Clin Immunol. 2021 Jun; 147(6):2181-2190. View abstract
  6. Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk. Healthcare (Basel). 2020 Dec 04; 8(4). View abstract
  7. Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD. Eur Respir J. 2020 10; 56(4). View abstract
  8. Enhancing the prediction of childhood asthma remission: Integrating clinical factors with microRNAs. J Allergy Clin Immunol. 2021 03; 147(3):1093-1095.e1. View abstract
  9. CASTER: Cross-Sectional Asthma STEroid Response Measurement. J Pers Med. 2020 Aug 20; 10(3). View abstract
  10. Circulating MicroRNAs and Treatment Response in Childhood Asthma. Am J Respir Crit Care Med. 2020 07 01; 202(1):65-72. View abstract
  11. COMPSRA: a COMprehensive Platform for Small RNA-Seq data Analysis. Sci Rep. 2020 03 12; 10(1):4552. View abstract
  12. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age. Genome Med. 2020 03 02; 12(1):25. View abstract
  13. Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. Respir Res. 2020 Jan 28; 21(1):31. View abstract
  14. Mechanical forces induce an asthma gene signature in healthy airway epithelial cells. Sci Rep. 2020 01 22; 10(1):966. View abstract
  15. Pulmonary Neuroendocrine Cells Secrete ?-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models. Am J Respir Cell Mol Biol. 2019 06; 60(6):687-694. View abstract
  16. Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812. View abstract
  17. Circulating microRNAs and prediction of asthma exacerbation in childhood asthma. Respir Res. 2018 06 26; 19(1):128. View abstract
  18. Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort. PLoS One. 2017; 12(7):e0180329. View abstract
  19. Zinc deficiency primes the lung for ventilator-induced injury. JCI Insight. 2017 Jun 02; 2(11). View abstract
  20. Asthma remission: Predicting future airways responsiveness using an miRNA network. J Allergy Clin Immunol. 2017 08; 140(2):598-600.e8. View abstract
  21. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474. View abstract
  22. CRISPLD2 (LGL1) inhibits proinflammatory mediators in human fetal, adult, and COPD lung fibroblasts and epithelial cells. Physiol Rep. 2016 09; 4(17). View abstract
  23. Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development. PeerJ. 2016; 4:e2318. View abstract
  24. Circulating MicroRNAs: Association with Lung Function in Asthma. PLoS One. 2016; 11(6):e0157998. View abstract
  25. Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome. Am J Respir Cell Mol Biol. 2016 06; 54(6):814-21. View abstract
  26. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12; 374(19):1842-1852. View abstract
  27. Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. Mol Cell Proteomics. 2016 06; 15(6):1877-94. View abstract
  28. Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures. Mol Autism. 2015; 6:66. View abstract
  29. Steroid Pathway Genes and Neonatal Respiratory Distress After Betamethasone Use in Anticipated Preterm Birth. Reprod Sci. 2016 May; 23(5):680-6. View abstract
  30. Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater. 2015 Oct; 14(10):1040-8. View abstract
  31. Glucocorticoid genes and the developmental origins of asthma susceptibility and treatment response. Am J Respir Cell Mol Biol. 2015 May; 52(5):543-53. View abstract
  32. Fetal lung and placental methylation is associated with in utero nicotine exposure. Epigenetics. 2014 Nov; 9(11):1473-84. View abstract
  33. Genetic variation in the HLA region is associated with susceptibility to herpes zoster. Genes Immun. 2015 Jan-Feb; 16(1):1-7. View abstract
  34. The genomic origins of asthma. Thorax. 2014 May; 69(5):481-7. View abstract
  35. Vitamin D related genes in lung development and asthma pathogenesis. BMC Med Genomics. 2013 Nov 05; 6:47. View abstract
  36. Identification of dedifferentiation and redevelopment phases during postpneumonectomy lung growth. . 2013 Oct 15; 305(8):L542-54. View abstract
  37. MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation. Cell Death Differ. 2013 Sep; 20(9):1194-208. View abstract
  38. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024. View abstract
  39. Maternal allergen exposure reprograms the developmental lung transcriptome in atopic and normoresponsive rat pups. . 2012 Nov 15; 303(10):L899-911. View abstract
  40. Expression analysis of asthma candidate genes during human and murine lung development. Respir Res. 2011 Jun 23; 12:86. View abstract
  41. Isolation and transcriptome analysis of adult zebrafish cells enriched for skeletal muscle progenitors. Muscle Nerve. 2011 May; 43(5):741-50. View abstract
  42. Proteomic temporal profile of human brain endothelium after oxidative stress. Stroke. 2011 Jan; 42(1):37-43. View abstract
  43. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010 Aug 23; 190(4):693-706. View abstract
  44. Genetic influences on asthma susceptibility in the developing lung. Am J Respir Cell Mol Biol. 2010 Dec; 43(6):720-30. View abstract
  45. An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium. FASEB J. 2010 May; 24(5):1604-15. View abstract
  46. Transcriptomic analysis of human lung development. Am J Respir Crit Care Med. 2010 Jan 01; 181(1):54-63. View abstract
  47. Platform dependence of inference on gene-wise and gene-set involvement in human lung development. BMC Bioinformatics. 2009 Jun 19; 10:189. View abstract
  48. Transcriptional regulation differs in affected facioscapulohumeral muscular dystrophy patients compared to asymptomatic related carriers. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6220-5. View abstract
  49. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12; 14(2):123-34. View abstract
  50. Expression profiles of the mouse lung identify a molecular signature of time-to-birth. Am J Respir Cell Mol Biol. 2009 Jan; 40(1):47-57. View abstract
  51. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther. 2007; 9(2):R36. View abstract
  52. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 09; 175(1):99-110. View abstract
  53. Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis. Mol Cell Neurosci. 2006 Nov; 33(3):247-59. View abstract
  54. Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model. J Proteome Res. 2006 Aug; 5(8):1866-78. View abstract
  55. Melanoma cell adhesion molecule is a novel marker for human fetal myogenic cells and affects myoblast fusion. J Cell Sci. 2006 Aug 01; 119(Pt 15):3117-27. View abstract
  56. Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development. PLoS Med. 2006 Jul; 3(7):e232. View abstract
  57. Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia. Stem Cells. 2006 Sep; 24(9):2034-44. View abstract
  58. Transcriptome-scale similarities between mouse and human skeletal muscles with normal and myopathic phenotypes. BMC Musculoskelet Disord. 2006 Mar 07; 7:23. View abstract
  59. Melanoma Cell Adhesion Molecule is a novel marker for human fetal myogenic cells and affects myoblast fusion. J Cell Sci. 119, 3117-27, 2006. 2006; 119(Pt 15):3117-27. View abstract
  60. Alteration of ribosomal protein gene expression, transcription, apoptosis and cancer pathways in Diamond-Blackfan anemia. Stem Cells. 2006; 24(9):2033-44. View abstract
  61. The influence of muscle type and dystrophin deficiency on murine expression profiles. Mamm Genome. 2005 Oct; 16(10):739-48. View abstract
  62. Variations in gene expression among different types of human skeletal muscle. Muscle Nerve. 2005 Oct; 32(4):483-91. View abstract
  63. Side population cells isolated from different tissues share transcriptome signatures and express tissue-specific markers. Exp Cell Res. 2005 Feb 15; 303(2):360-74. View abstract
  64. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol. 2004 May; 63(5):499-509. View abstract
  65. Molecular classification of nemaline myopathies: "nontyping" specimens exhibit unique patterns of gene expression. Neurobiol Dis. 2004 Apr; 15(3):590-600. View abstract
  66. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev. 2004 Mar 15; 18(6):629-40. View abstract
  67. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003 Dec 12; 278(50):50466-73. View abstract
  68. Gene expression profiling of Duchenne muscular dystrophy skeletal muscle. Neurogenetics. 2003 Aug; 4(4):163-71. View abstract
  69. Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4666-71. View abstract
  70. Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15000-5. View abstract
  71. Microarrays for an Integrative Genomics Microarrays for an Integrative Genomics. 2002; 326. View abstract
  72. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5704-9. View abstract
  73. CHIP TUNER: a web tool for evidence-based noise reduction in gene discovery. Proc AMIA Symp. 2002; 810-4. View abstract
  74. Stochastic mean curvature flows: Asymptotic derivation, level set formulation and numerics. Interfaces and Free Boundaries. 2001; 3:265-90. View abstract
  75. Multi-scale analysis for microscropic models in materials science and cell biology. 2000. View abstract