is the physiological template of genetic information in eukaryotes composed primarily of DNA and histone proteins but also non-histone proteins and RNA. Histones are subject to a wide array of post-translational modifications with diverse roles in regulation of gene expression, DNA repair and 3D chromatin structure.

Adam is mainly interested in the pathways that place, interpret and erase histone modifications with a focus on how defects in such pathways contribute to tumorigenesis.

After joining the Shi lab, Adam has also grown interested in novel covalent modifications of DNA and RNA whose function remains relatively unknown.