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Researcher | Research Overview

Hanno Steen is a pioneer in developing methods for the qualitative and quantitative analysis of protein modifications by mass spectrometry, with special emphasis on tyrosine phosphorylation. In carcinogenesis, the pivotal role of tyrosine phosphorylation is underscored by the notion that almost half of the oncogenes known to date encode tyrosine kinases.

Hanno Steen's interests are focused on proteomics and biological mass spectrometry in general. He is particularly interested in the mass spectrometric analysis of the composition of complex protein mixtures, which includes not only the cataloging but also the comprehensive characterization of the components.

Dr. Steen's lab is working on novel methods for identifying and quantifying various protein modifications that are involved in pediatric diseases in order to provide new insights into the underlying biological processes, a prerequisite for a rational approach to prevent and/or cure these diseases.

Another goal of the lab's research is the development and applications of screening methods to detect and identify diagnostic and prognostic disease markers in body fluids, which offer an easily accessible mirror of the state of the entire body. These biomarkers can guide treatment decisions, predict patient phenotypes, and allow for early diagnosis.

Researcher | Research Background

Dr. Steen studied chemistry at the University of Freiburg (Germany), UMIST/Manchester (UK), and Swiss Federal Institute of Technology (ETH) Zurich (Switzerland). He received his PhD in Biochemistry and Molecular Biology from the University of Southern Denmark, working in the laboratory of Dr. Matthias Mann on the mass spectrometric analysis of protein modifications. He completed postdoctoral fellowships in the laboratories of Drs. Steve Gygi and Marc Kirschner in the Departments of Cell Biology and Systems Biology at Harvard Medical School.

In 2004, Dr. Steen joined the faculty at Harvard Medical School and became principal investigator in the Department of Pathology at Boston Children's Hospital. Dr. Steen has published more than 180 papers in international peer-reviewed journals, which have been cited more than 23,000 times, resulting in an h-index of 66.

Publications

Researcher | Publications