The Harris laboratory studies fish as a model to understand the development of the skeleton and the inherent capacity for growth and repair in vertebrates. We use the power of forward genetics in the zebrafish as a means to identify genetic variants that regulate growth and form of the adult fish skeleton. These findings are then analyzed in the mouse and other vertebrates to understand the conservation of these mechanisms and the growth potential within the developing skeleton. In parallel to work in the zebrafish, comparative studies in other fish species are being conducted to take advantage of the genetic diversity among fish and the varied means by which they regulate development. The work in the lab has uncovered novel mechanisms by which size control is developmentally regulated that involve cell-extracellular matrix interactions as well as control of electrochemical signaling in tissues. Additionally, through the analysis of late development, we have identified genes that regulate the maintenance of tissues and the onset of pathologies associated with aging. We are currently investigating these genes and their role in vertebrate aging.

Articles on PubMed.org authored or co-authored by Dr. Harris.


Publications powered by Harvard Catalyst Profiles

  1. Modulation of bioelectric cues in the evolution of flying fishes. Curr Biol. 2021 Sep 13. View abstract
  2. The bowfin genome illuminates the developmental evolution of ray-finned fishes. Nat Genet. 2021 09; 53(9):1373-1384. View abstract
  3. Refining Convergent Rate Analysis with Topology in Mammalian Longevity and Marine Transitions. Mol Biol Evol. 2021 Jul 29. View abstract
  4. Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. Sci Rep. 2021 Mar 12; 11(1):5871. View abstract
  5. Atavisms in the avian hindlimb and early developmental polarity of the limb. Dev Dyn. 2021 Sep; 250(9):1358-1367. View abstract
  6. Latent developmental potential to form limb-like skeletal structures in zebrafish. Cell. 2021 02 18; 184(4):899-911.e13. View abstract
  7. Developmental constraint shaped genome evolution and erythrocyte loss in Antarctic fishes following paleoclimate change. PLoS Genet. 2020 10; 16(10):e1009173. View abstract
  8. Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. Curr Biol. 2020 07 20; 30(14):2805-2814.e3. View abstract
  9. Correction: Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development. 2020 May 18; 147(10). View abstract
  10. SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis. Curr Biol. 2020 06 22; 30(12):2363-2373.e6. View abstract
  11. Through veiled mirrors: Fish fins giving insight into size regulation. Wiley Interdiscip Rev Dev Biol. 2021 07; 10(4):e381. View abstract
  12. Author Correction: Historical contingency shapes adaptive radiation in Antarctic fishes. Nat Ecol Evol. 2020 Apr; 4(4):659. View abstract
  13. Regulation of human cerebral cortical development by EXOC7 and EXOC8, components of the exocyst complex, and roles in neural progenitor cell proliferation and survival. Genet Med. 2020 06; 22(6):1040-1050. View abstract
  14. celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. Elife. 2020 01 27; 9. View abstract
  15. Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development. 2020 01 22; 147(2). View abstract
  16. Integrated K+ channel and K+Cl- cotransporter functions are required for the coordination of size and proportion during development. Dev Biol. 2019 12 15; 456(2):164-178. View abstract
  17. Historical contingency shapes adaptive radiation in Antarctic fishes. Nat Ecol Evol. 2019 07; 3(7):1102-1109. View abstract
  18. Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):E8037-E8046. View abstract
  19. Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin. Sci Rep. 2018 Jul 10; 8(1):10391. View abstract
  20. Patterning the spine. Elife. 2018 05 16; 7. View abstract
  21. Conserved but flexible modularity in the zebrafish skull: implications for craniofacial evolvability. Proc Biol Sci. 2018 04 25; 285(1877). View abstract
  22. Cyclin-dependent kinase 21 is a novel regulator of proliferation and meiosis in the male germline of zebrafish. Reproduction. 2018 04 01; 157(4):383-398. View abstract
  23. Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form. Genetics. 2017 10; 207(2):609-623. View abstract
  24. Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis. Bone. 2017 Aug; 101:162-171. View abstract
  25. Introduction to the Special Edition on the Brazilian National Program to Improve Primary Care Access and Quality (PMAQ). J Ambul Care Manage. 2017 Apr/Jun; 40 Suppl 2:S1-S3. View abstract
  26. Brazil's National Program for Improving Primary Care Access and Quality (PMAQ): Fulfilling the Potential of the World's Largest Payment for Performance System in Primary Care. J Ambul Care Manage. 2017 Apr/Jun; 40 Suppl 2 Supplement, The Brazilian National Program for Improving Primary Care Access and Quality (PMAQ):S4-S11. View abstract
  27. Out of the Mouth of Minnows. Dev Cell. 2015 Nov 09; 35(3):263-4. View abstract
  28. Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies. Mol Biol Evol. 2016 Jan; 33(1):162-73. View abstract
  29. Katanin p80 regulates human cortical development by limiting centriole and cilia number. Neuron. 2014 Dec 17; 84(6):1240-57. View abstract
  30. The Society of Craniofacial Genetics and Developmental Biology 36th annual meeting. . 2014 Aug; 164A(8):1873-90. View abstract
  31. Bioelectric signaling regulates size in zebrafish fins. PLoS Genet. 2014 Jan; 10(1):e1004080. View abstract
  32. Identification of mutations in zebrafish using next-generation sequencing. Curr Protoc Mol Biol. 2013 Oct 11; 104:7.13.1-7.13.33. View abstract
  33. Perspectives for identification of mutations in the zebrafish: making use of next-generation sequencing technologies for forward genetic approaches. Methods. 2013 Aug 15; 62(3):185-96. View abstract
  34. New tools for the identification of developmentally regulated enhancer regions in embryonic and adult zebrafish. Zebrafish. 2013 Mar; 10(1):21-9. View abstract
  35. Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein. J Clin Endocrinol Metab. 2012 Nov; 97(11):E2140-51. View abstract
  36. Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes. Mech Dev. 2012 Mar-Jun; 129(1-4):13-23. View abstract
  37. Efficient mapping and cloning of mutations in zebrafish by low-coverage whole-genome sequencing. Genetics. 2012 Mar; 190(3):1017-24. View abstract
  38. Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome. J Neurosci. 2011 Sep 28; 31(39):13796-807. View abstract
  39. Enhancing the efficiency of N-ethyl-N-nitrosourea-induced mutagenesis in the zebrafish. Zebrafish. 2011 Sep; 8(3):119-23. View abstract
  40. Same but different: ontogeny and evolution of the Musculus adductor mandibulae in the Tetraodontiformes. J Exp Zool B Mol Dev Evol. 2011 Jan 15; 316(1):10-20. View abstract
  41. The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. J Comp Neurol. 2010 Jul 15; 518(14):2794-817. View abstract
  42. Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication. Curr Biol. 2009 Oct 13; 19(19):1642-7. View abstract
  43. Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genet. 2008 Oct 03; 4(10):e1000206. View abstract
  44. The development of archosaurian first-generation teeth in a chicken mutant. Curr Biol. 2006 Feb 21; 16(4):371-7. View abstract
  45. Molecular evidence for an activator-inhibitor mechanism in development of embryonic feather branching. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11734-9. View abstract
  46. Bmp7 mediates early signaling events during induction of chick epidermal organs. Dev Dyn. 2004 Sep; 231(1):22-32. View abstract
  47. FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body. Biochim Biophys Acta. 2003 Jul 21; 1633(2):127-31. View abstract
  48. Shh-Bmp2 signaling module and the evolutionary origin and diversification of feathers. J Exp Zool. 2002 Aug 15; 294(2):160-76. View abstract