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Researcher | Research Overview

The laboratory focuses on stem cell biology, with an emphasis on hematopoietic differentiation from human and mouse pluripotent stem cells, somatic cell reprogramming to model human blood diseases, and mechanisms of oncogenesis. Specific research programs are described briefly below: Directed differentiation of HSCs from pluripotent stem cells: We study hematopoietic development in mouse embryos and differentiating cultures of human and mouse pluripotent stem cells to define the molecular genetic programs that enable formation of HSCs in experimental and therapeutic models. 

Our long-term goal is improved transplantation therapies for genetic and malignant blood disorders. Derivation of genetically defined pluripotent stem cells: We use nuclear transfer, parthenogenesis, and reprogramming with defined genes to model combined cell and gene therapy of human genetic disorders. Mechanisms of oncogenesis: We have a long-standing interest in molecular mechanisms of leukemia induction by the BCR/ABL oncoprotein in human Chronic Myeloid Leukemia, the classic malignancy of hematopoietic stem cells. Recent studies in our lab have focused on the role of the Lin28A/B genes that are linked to a variety of cancer types. 

Researcher | Research Background

Dr. Daley received a PhD in biology from MIT and an MD degree from Harvard Medical School through the Harvard-MIT Division of Health Sciences and Technology. He has been elected to the Institute of Medicine of the National Academies, the American Society for Clinical Investigation, the American Association of Physicians, the American Pediatric Societies, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science. 

Dr. Daley was an inaugural winner of the NIH Director’s Pioneer Award for highly innovative research and has received the Judson Daland Prize from the American Philosophical Society for achievement in patient-oriented research, the E. Mead Johnson Award from the American Pediatric Society for contributions to stem cell research, and the E. Donnall Thomas Prize of the American Society for Hematology for advances in human induced pluripotent stem cells.

Researcher | Media

On Answers

Making ready-made CAR T cells for cancer immunotherapy

Researcher | Publications