PUBLICATIONS
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- The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. J Exp Med. 2021 Mar 01; 218(3). View abstract
- Nucleotide resolution profiling of m3C RNA modification by HAC-seq. Nucleic Acids Res. 2020 Dec 11. View abstract
- Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). View abstract
- TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020 Sep; 19(18):2314-2326. View abstract
- RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution. Nucleic Acids Res. 2020 07 02; 48(W1):W218-W229. View abstract
- The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nat Commun. 2020 05 26; 11(1):2619. View abstract
- METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res. 2020 06; 30(6):544-547. View abstract
- Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq. Nat Protoc. 2019 11; 14(11):3220-3242. View abstract
- RNAmod: an integrated system for the annotation of mRNA modifications. Nucleic Acids Res. 2019 07 02; 47(W1):W548-W555. View abstract
- Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance. Nat Struct Mol Biol. 2019 06; 26(6):490-500. View abstract
- Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019 07 03; 25(1):137-148.e6. View abstract
- Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7. View abstract
- Unraveling 3'-end RNA uridylation at nucleotide resolution. Methods. 2019 02 15; 155:10-19. View abstract
- mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. View abstract
- DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs. Mol Ther Nucleic Acids. 2018 Sep 07; 12:591-599. View abstract
- Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018 07 19; 71(2):244-255.e5. View abstract
- An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition. Cell Stem Cell. 2018 Jun 01; 22(6):851-864.e5. View abstract
- TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß. Hum Mol Genet. 2018 05 01; 27(9):1654-1663. View abstract
- A small molecule screen to identify regulators of let-7 targets. Sci Rep. 2017 11 21; 7(1):15973. View abstract
- LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67. View abstract
- Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 10 03; 126(10):3868-3878. View abstract
- Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Rep. 2016 08 16; 16(7):1861-73. View abstract
- The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 05 05; 62(3):335-345. View abstract
- A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep. 2015 Oct 13; 13(2):260-6. View abstract
- PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2015 Sep 01; 12(9):1456-70. View abstract
- A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99. View abstract
- miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74. View abstract
- MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015 Jun; 15(6):321-33. View abstract
- Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015; 12(8):792-800. View abstract
- Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View abstract
- Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27; 156(5):893-906. View abstract
- Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol. 2014 Feb; 16(2):129-31. View abstract
- The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 2013 Oct 10; 52(1):101-12. View abstract
- The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA. 2013 Nov; 19(11):1583-93. View abstract
- Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug; 31(8):1563-73. View abstract
- Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May; 31(5):1001-9. View abstract
- A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature. 2013 May 09; 497(7448):244-8. View abstract
- Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA. 2013 May; 19(5):605-12. View abstract
- EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science. 2012 Dec 14; 338(6113):1465-9. View abstract
- Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr. 2012; 78(3):144-50. View abstract
- Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA. 2012 Oct; 18(10):1875-85. View abstract
- How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012 Sep; 22(9):474-82. View abstract
- Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26; 3:923. View abstract
- Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011 Nov 23; 147(5):1066-79. View abstract
- Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. View abstract
- The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 Sep 30; 147(1):81-94. View abstract
- MicroRNAs and reprogramming. Nat Biotechnol. 2011 Jun 07; 29(6):499-500. View abstract
- The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. View abstract
- Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011 Apr; 39(7):e43. View abstract
- Autoregulatory mechanisms controlling the microprocessor. Adv Exp Med Biol. 2011; 700:56-66. View abstract
- Pumilio turns on microRNA function. Nat Cell Biol. 2010 Oct; 12(10):928-9. View abstract
- MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell. 2010 Jul 02; 7(1):31-5. View abstract
- Autoregulatory mechanisms controlling the Microprocessor. Adv Exp Med Biol. 2010; 700:56-66. View abstract
- Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009 Oct; 16(10):1021-5. View abstract
- Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA. 2009 Jun; 15(6):1005-11. View abstract
- Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009 Mar; 11(3):228-34. View abstract
- Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol. 2008 Nov; 19(11):2069-75. View abstract
- Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4. View abstract
- Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun; 13(6):467-9. View abstract
- MicroRNA regulation of stem cell fate. Cell Stem Cell. 2008 Mar 06; 2(3):195-6. View abstract
- Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 04; 320(5872):97-100. View abstract
- MicroRNA silencing through RISC recruitment of eIF6. Nature. 2007 Jun 14; 447(7146):823-8. View abstract
- MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol. 2006; 342:33-47. View abstract
- Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell. 2005 Nov 18; 123(4):631-40. View abstract
- TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005 Aug 04; 436(7051):740-4. View abstract
- MicroRNA biogenesis and cancer. Cancer Res. 2005 May 01; 65(9):3509-12. View abstract
- Chromatin modifiers and carcinogenesis. Trends Cell Biol. 2004 Dec; 14(12):695-702. View abstract
- The Microprocessor complex mediates the genesis of microRNAs. Nature. 2004 Nov 11; 432(7014):235-40. View abstract
- Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Hum Mol Genet. 2002 Dec 01; 11(25):3191-8. View abstract
- Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. J Biol Chem. 2002 Apr 05; 277(14):11728-34. View abstract
- DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol Cell Biol. 2001 Aug; 21(16):5426-36. View abstract
- Environmental effects on genomic imprinting in mammals. Toxicol Lett. 2001 Mar 31; 120(1-3):143-50. View abstract
- Probing chromatin structure with nuclease sensitivity assays. Methods Mol Biol. 2001; 181:269-84. View abstract
- Analysis of chromatin in limited numbers of cells: a PCR-SSCP based assay of allele-specific nuclease sensitivity. Nucleic Acids Res. 1999 Nov 15; 27(22):e32. View abstract