PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Nucleotide resolution profiling of m3C RNA modification by HAC-seq. Nucleic Acids Res. 2021 03 18; 49(5):e27. View abstract
  2. The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. J Exp Med. 2021 Mar 01; 218(3). View abstract
  3. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). View abstract
  4. TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020 Sep; 19(18):2314-2326. View abstract
  5. RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution. Nucleic Acids Res. 2020 07 02; 48(W1):W218-W229. View abstract
  6. The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nat Commun. 2020 05 26; 11(1):2619. View abstract
  7. METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res. 2020 06; 30(6):544-547. View abstract
  8. Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq. Nat Protoc. 2019 11; 14(11):3220-3242. View abstract
  9. RNAmod: an integrated system for the annotation of mRNA modifications. Nucleic Acids Res. 2019 07 02; 47(W1):W548-W555. View abstract
  10. Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance. Nat Struct Mol Biol. 2019 06; 26(6):490-500. View abstract
  11. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019 07 03; 25(1):137-148.e6. View abstract
  12. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7. View abstract
  13. Unraveling 3'-end RNA uridylation at nucleotide resolution. Methods. 2019 02 15; 155:10-19. View abstract
  14. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. View abstract
  15. DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs. Mol Ther Nucleic Acids. 2018 Sep 07; 12:591-599. View abstract
  16. Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018 07 19; 71(2):244-255.e5. View abstract
  17. An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition. Cell Stem Cell. 2018 Jun 01; 22(6):851-864.e5. View abstract
  18. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß. Hum Mol Genet. 2018 05 01; 27(9):1654-1663. View abstract
  19. A small molecule screen to identify regulators of let-7 targets. Sci Rep. 2017 11 21; 7(1):15973. View abstract
  20. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67. View abstract
  21. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 10 03; 126(10):3868-3878. View abstract
  22. Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Rep. 2016 08 16; 16(7):1861-73. View abstract
  23. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 05 05; 62(3):335-345. View abstract
  24. A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep. 2015 Oct 13; 13(2):260-6. View abstract
  25. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2015 Sep 01; 12(9):1456-70. View abstract
  26. A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99. View abstract
  27. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74. View abstract
  28. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015 Jun; 15(6):321-33. View abstract
  29. Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015; 12(8):792-800. View abstract
  30. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View abstract
  31. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27; 156(5):893-906. View abstract
  32. Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol. 2014 Feb; 16(2):129-31. View abstract
  33. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 2013 Oct 10; 52(1):101-12. View abstract
  34. The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA. 2013 Nov; 19(11):1583-93. View abstract
  35. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug; 31(8):1563-73. View abstract
  36. Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May; 31(5):1001-9. View abstract
  37. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature. 2013 May 09; 497(7448):244-8. View abstract
  38. Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA. 2013 May; 19(5):605-12. View abstract
  39. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science. 2012 Dec 14; 338(6113):1465-9. View abstract
  40. Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr. 2012; 78(3):144-50. View abstract
  41. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA. 2012 Oct; 18(10):1875-85. View abstract
  42. How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012 Sep; 22(9):474-82. View abstract
  43. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26; 3:923. View abstract
  44. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011 Nov 23; 147(5):1066-79. View abstract
  45. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. View abstract
  46. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 Sep 30; 147(1):81-94. View abstract
  47. MicroRNAs and reprogramming. Nat Biotechnol. 2011 Jun 07; 29(6):499-500. View abstract
  48. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. View abstract
  49. Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011 Apr; 39(7):e43. View abstract
  50. Autoregulatory mechanisms controlling the microprocessor. Adv Exp Med Biol. 2011; 700:56-66. View abstract
  51. Pumilio turns on microRNA function. Nat Cell Biol. 2010 Oct; 12(10):928-9. View abstract
  52. MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell. 2010 Jul 02; 7(1):31-5. View abstract
  53. Autoregulatory mechanisms controlling the Microprocessor. Adv Exp Med Biol. 2010; 700:56-66. View abstract
  54. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009 Oct; 16(10):1021-5. View abstract
  55. Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA. 2009 Jun; 15(6):1005-11. View abstract
  56. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009 Mar; 11(3):228-34. View abstract
  57. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol. 2008 Nov; 19(11):2069-75. View abstract
  58. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4. View abstract
  59. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun; 13(6):467-9. View abstract
  60. MicroRNA regulation of stem cell fate. Cell Stem Cell. 2008 Mar 06; 2(3):195-6. View abstract
  61. Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 04; 320(5872):97-100. View abstract
  62. MicroRNA silencing through RISC recruitment of eIF6. Nature. 2007 Jun 14; 447(7146):823-8. View abstract
  63. MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol. 2006; 342:33-47. View abstract
  64. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell. 2005 Nov 18; 123(4):631-40. View abstract
  65. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005 Aug 04; 436(7051):740-4. View abstract
  66. MicroRNA biogenesis and cancer. Cancer Res. 2005 May 01; 65(9):3509-12. View abstract
  67. Chromatin modifiers and carcinogenesis. Trends Cell Biol. 2004 Dec; 14(12):695-702. View abstract
  68. The Microprocessor complex mediates the genesis of microRNAs. Nature. 2004 Nov 11; 432(7014):235-40. View abstract
  69. Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Hum Mol Genet. 2002 Dec 01; 11(25):3191-8. View abstract
  70. Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. J Biol Chem. 2002 Apr 05; 277(14):11728-34. View abstract
  71. DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol Cell Biol. 2001 Aug; 21(16):5426-36. View abstract
  72. Environmental effects on genomic imprinting in mammals. Toxicol Lett. 2001 Mar 31; 120(1-3):143-50. View abstract
  73. Probing chromatin structure with nuclease sensitivity assays. Methods Mol Biol. 2001; 181:269-84. View abstract
  74. Analysis of chromatin in limited numbers of cells: a PCR-SSCP based assay of allele-specific nuclease sensitivity. Nucleic Acids Res. 1999 Nov 15; 27(22):e32. View abstract