PUBLICATIONS

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  1. Genetic drivers of m6A methylation in human brain, lung, heart and muscle. Nat Genet. 2021 Jul 01. View abstract
  2. Mining for METTL3 inhibitors to suppress cancer. Nat Struct Mol Biol. 2021 Jun; 28(6):460-462. View abstract
  3. Global miRNA dosage control of embryonic germ layer specification. Nature. 2021 May; 593(7860):602-606. View abstract
  4. Nucleotide resolution profiling of m3C RNA modification by HAC-seq. Nucleic Acids Res. 2021 03 18; 49(5):e27. View abstract
  5. The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function. J Exp Med. 2021 Mar 01; 218(3). View abstract
  6. An Informatics Pipeline for Profiling and Annotating RNA Modifications. Methods Mol Biol. 2021; 2298:15-27. View abstract
  7. Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia. Sci Transl Med. 2020 10 21; 12(566). View abstract
  8. TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs. Cell Cycle. 2020 09; 19(18):2314-2326. View abstract
  9. RiboToolkit: an integrated platform for analysis and annotation of ribosome profiling data to decode mRNA translation at codon resolution. Nucleic Acids Res. 2020 07 02; 48(W1):W218-W229. View abstract
  10. The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nat Commun. 2020 05 26; 11(1):2619. View abstract
  11. METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res. 2020 06; 30(6):544-547. View abstract
  12. Nucleotide resolution profiling of m7G tRNA modification by TRAC-Seq. Nat Protoc. 2019 11; 14(11):3220-3242. View abstract
  13. RNAmod: an integrated system for the annotation of mRNA modifications. Nucleic Acids Res. 2019 07 02; 47(W1):W548-W555. View abstract
  14. Exonuclease requirements for mammalian ribosomal RNA biogenesis and surveillance. Nat Struct Mol Biol. 2019 06; 26(6):490-500. View abstract
  15. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell. 2019 07 03; 25(1):137-148.e6. View abstract
  16. Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias. Cancer Cell. 2019 04 15; 35(4):664-676.e7. View abstract
  17. Unraveling 3'-end RNA uridylation at nucleotide resolution. Methods. 2019 02 15; 155:10-19. View abstract
  18. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature. 2018 09; 561(7724):556-560. View abstract
  19. DROSHA Knockout Leads to Enhancement of Viral Titers for Vectors Encoding miRNA-Adapted shRNAs. Mol Ther Nucleic Acids. 2018 Sep 07; 12:591-599. View abstract
  20. Mettl1/Wdr4-Mediated m7G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation. Mol Cell. 2018 07 19; 71(2):244-255.e5. View abstract
  21. An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition. Cell Stem Cell. 2018 Jun 01; 22(6):851-864.e5. View abstract
  22. TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß. Hum Mol Genet. 2018 05 01; 27(9):1654-1663. View abstract
  23. A small molecule screen to identify regulators of let-7 targets. Sci Rep. 2017 11 21; 7(1):15973. View abstract
  24. LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency. Nat Cell Biol. 2017 Jan; 19(1):60-67. View abstract
  25. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016 10 03; 126(10):3868-3878. View abstract
  26. Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs. Cell Rep. 2016 08 16; 16(7):1861-73. View abstract
  27. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016 05 05; 62(3):335-345. View abstract
  28. A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression. Cell Rep. 2015 Oct 13; 13(2):260-6. View abstract
  29. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells. Cell Rep. 2015 Sep 01; 12(9):1456-70. View abstract
  30. A Biogenesis Step Upstream of Microprocessor Controls miR-17~92 Expression. Cell. 2015 Aug 13; 162(4):885-99. View abstract
  31. miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction. Mol Ther. 2015 Sep; 23(9):1465-74. View abstract
  32. MicroRNA biogenesis pathways in cancer. Nat Rev Cancer. 2015 Jun; 15(6):321-33. View abstract
  33. Identification of small molecule inhibitors of Zcchc11 TUTase activity. RNA Biol. 2015; 12(8):792-800. View abstract
  34. Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4). Nucleic Acids Res. 2014 Oct; 42(18):11777-91. View abstract
  35. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Cell. 2014 Feb 27; 156(5):893-906. View abstract
  36. Methyltransferases modulate RNA stability in embryonic stem cells. Nat Cell Biol. 2014 Feb; 16(2):129-31. View abstract
  37. The imprinted H19 lncRNA antagonizes let-7 microRNAs. Mol Cell. 2013 Oct 10; 52(1):101-12. View abstract
  38. The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA. 2013 Nov; 19(11):1583-93. View abstract
  39. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. 2013 Aug; 31(8):1563-73. View abstract
  40. Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May; 31(5):1001-9. View abstract
  41. A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway. Nature. 2013 May 09; 497(7448):244-8. View abstract
  42. Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA. 2013 May; 19(5):605-12. View abstract
  43. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. Science. 2012 Dec 14; 338(6113):1465-9. View abstract
  44. Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr. 2012; 78(3):144-50. View abstract
  45. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). RNA. 2012 Oct; 18(10):1875-85. View abstract
  46. How does Lin28 let-7 control development and disease? Trends Cell Biol. 2012 Sep; 22(9):474-82. View abstract
  47. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. Nat Commun. 2012 Jun 26; 3:923. View abstract
  48. Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell. 2011 Nov 23; 147(5):1066-79. View abstract
  49. Molecular basis for interaction of let-7 microRNAs with Lin28. Cell. 2011 Nov 23; 147(5):1080-91. View abstract
  50. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 Sep 30; 147(1):81-94. View abstract
  51. MicroRNAs and reprogramming. Nat Biotechnol. 2011 Jun 07; 29(6):499-500. View abstract
  52. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. View abstract
  53. Reconstitution of human RNA interference in budding yeast. Nucleic Acids Res. 2011 Apr; 39(7):e43. View abstract
  54. Autoregulatory mechanisms controlling the microprocessor. Adv Exp Med Biol. 2011; 700:56-66. View abstract
  55. Pumilio turns on microRNA function. Nat Cell Biol. 2010 Oct; 12(10):928-9. View abstract
  56. MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity. Cell Stem Cell. 2010 Jul 02; 7(1):31-5. View abstract
  57. Autoregulatory mechanisms controlling the Microprocessor. Adv Exp Med Biol. 2010; 700:56-66. View abstract
  58. Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells. Nat Struct Mol Biol. 2009 Oct; 16(10):1021-5. View abstract
  59. Post-transcriptional control of DGCR8 expression by the Microprocessor. RNA. 2009 Jun; 15(6):1005-11. View abstract
  60. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009 Mar; 11(3):228-34. View abstract
  61. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol. 2008 Nov; 19(11):2069-75. View abstract
  62. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem. 2008 Aug 01; 283(31):21310-4. View abstract
  63. Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell. 2008 Jun; 13(6):467-9. View abstract
  64. MicroRNA regulation of stem cell fate. Cell Stem Cell. 2008 Mar 06; 2(3):195-6. View abstract
  65. Selective blockade of microRNA processing by Lin28. Science. 2008 Apr 04; 320(5872):97-100. View abstract
  66. MicroRNA silencing through RISC recruitment of eIF6. Nature. 2007 Jun 14; 447(7146):823-8. View abstract
  67. MicroRNA biogenesis: isolation and characterization of the microprocessor complex. Methods Mol Biol. 2006; 342:33-47. View abstract
  68. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell. 2005 Nov 18; 123(4):631-40. View abstract
  69. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005 Aug 04; 436(7051):740-4. View abstract
  70. MicroRNA biogenesis and cancer. Cancer Res. 2005 May 01; 65(9):3509-12. View abstract
  71. Chromatin modifiers and carcinogenesis. Trends Cell Biol. 2004 Dec; 14(12):695-702. View abstract
  72. The Microprocessor complex mediates the genesis of microRNAs. Nature. 2004 Nov 11; 432(7014):235-40. View abstract
  73. Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Hum Mol Genet. 2002 Dec 01; 11(25):3191-8. View abstract
  74. Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells. J Biol Chem. 2002 Apr 05; 277(14):11728-34. View abstract
  75. DNA methylation is linked to deacetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2af1-rs1. Mol Cell Biol. 2001 Aug; 21(16):5426-36. View abstract
  76. Environmental effects on genomic imprinting in mammals. Toxicol Lett. 2001 Mar 31; 120(1-3):143-50. View abstract
  77. Probing chromatin structure with nuclease sensitivity assays. Methods Mol Biol. 2001; 181:269-84. View abstract
  78. Analysis of chromatin in limited numbers of cells: a PCR-SSCP based assay of allele-specific nuclease sensitivity. Nucleic Acids Res. 1999 Nov 15; 27(22):e32. View abstract