Raif Geha, MD

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1. Mechanisms underlying genetic susceptibility to Multisystem Inflammatory Syndrome in Children (MIS-C). J Allergy Clin Immunol. 2021 Jul 02. View abstract
2. Basophil: The cell that itches. J Allergy Clin Immunol. 2021 Jun 17. View abstract
3. Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2021 Jun; 22(6):794-795. View abstract
4. Consensus Middle East and North Africa Registry on Inborn Errors of Immunity. J Clin Immunol. 2021 May 29. View abstract
5. Macabre TH2 skewing in DOCK8 deficiency. J Allergy Clin Immunol. 2021 Jul; 148(1):73-75. View abstract
6. Multi-kingdom ecological drivers of microbiota assembly in preterm infants. Nature. 2021 Mar; 591(7851):633-638. View abstract
7. Combined immunodeficiency due to a mutation in the ?1 subunit of the coat protein I complex. J Clin Invest. 2021 Feb 01; 131(3). View abstract
8. Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2021 Jan; 22(1):100. View abstract
9. Mast cell-derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure. J Allergy Clin Immunol. 2021 Jun; 147(6):2305-2315.e3. View abstract
10. Successful hematopoietic stem cell transplantation in a 4-1BB deficient patient with EBV-induced lymphoproliferation. Clin Immunol. 2021 01; 222:108639. View abstract
11. DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity. J Invest Dermatol. 2021 Jun; 141(6):1503-1511.e3. View abstract
12. Transferrin receptor 1 is a cellular receptor for human heme-albumin. Commun Biol. 2020 10 27; 3(1):621. View abstract
13. Hematopoietic Stem Cell Transplantation Is a Curative Therapy for Transferrin Receptor 1 (TFRC) Deficiency. J Allergy Clin Immunol Pract. 2021 02; 9(2):753-759.e2. View abstract
14. A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2020 11; 21(11):1359-1370. View abstract
15. Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency. J Allergy Clin Immunol. 2021 Feb; 147(2):723-726. View abstract
16. Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020 11; 146(5):1194-1200.e1. View abstract
17. APRIL expression is upregulated in atopic dermatitis skin lesions and at sites of antigen driven allergic skin inflammation in mice. Clin Immunol. 2020 10; 219:108556. View abstract
18. DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020 08 06; 5(15). View abstract
19. Acetaminophen Inhibits the Neutrophil Oxidative Burst: Implications for Diagnostic Testing. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3543-3548. View abstract
20. ITK deficiency presenting as autoimmune lymphoproliferative syndrome. J Allergy Clin Immunol. 2021 Feb; 147(2):743-745.e1. View abstract
21. Inherited human IFN-? deficiency underlies mycobacterial disease. J Clin Invest. 2020 06 01; 130(6):3158-3171. View abstract
22. Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! Clin Immunol. 2020 07; 216:108459. View abstract
23. Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome. J Allergy Clin Immunol. 2020 11; 146(5):1165-1179.e11. View abstract
24. ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. J Allergy Clin Immunol. 2020 06; 145(6):1606-1614.e4. View abstract
25. Severe combined immunodeficiency caused by inositol-trisphosphate 3-kinase B (ITPKB) deficiency. J Allergy Clin Immunol. 2020 06; 145(6):1696-1699.e6. View abstract
26. Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). J Allergy Clin Immunol. 2020 06; 145(6):1664-1672.e10. View abstract
27. Hypomorphic variants in AK2 reveal the contribution of mitochondrial function to B-cell activation. J Allergy Clin Immunol. 2020 07; 146(1):192-202. View abstract
28. Dysregulated actin dynamics in activated PI3Kd syndrome. Clin Immunol. 2020 01; 210:108311. View abstract
29. A novel truncating mutation in MYD88 in a patient with BCG adenitis, neutropenia and delayed umbilical cord separation. Clin Immunol. 2019 10; 207:40-42. View abstract
30. Combined immunodeficiency in a patient with c-Rel deficiency. J Allergy Clin Immunol. 2019 08; 144(2):606-608.e4. View abstract
31. A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. 2019 08; 144(2):611-613.e3. View abstract
32. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. View abstract
33. Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. J Allergy Clin Immunol Pract. 2019 Jul - Aug; 7(6):1970-1985.e4. View abstract
34. Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency. J Allergy Clin Immunol. 2019 08; 144(2):574-583.e5. View abstract
35. Rethinking newborn screening for severe combined immunodeficiency: Lessons from an international partnership for patients with primary immunodeficiencies in Pakistan. Clin Immunol. 2019 05; 202:29-32. View abstract
36. T-cell mitochondrial dysfunction and lymphopenia in DOCK2-deficient patients. J Allergy Clin Immunol. 2019 07; 144(1):306-309.e2. View abstract
37. F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. J Allergy Clin Immunol. 2019 06; 143(6):2317-2321.e12. View abstract
38. Comprehensive Genetic Results for Primary Immunodeficiency Disorders in a Highly Consanguineous Population. Front Immunol. 2018; 9:3146. View abstract
39. A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency. J Allergy Clin Immunol. 2019 04; 143(4):1649-1653.e3. View abstract
40. Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". J Allergy Clin Immunol. 2019 03; 143(3):894-913. View abstract
41. Primary immunodeficiencies caused by mutations in actin regulatory proteins. Immunol Rev. 2019 01; 287(1):121-134. View abstract
42. Atypical phenotype of an old disease or typical phenotype of a new disease: deficiency of adenosine deaminase 2. Turk J Pediatr. 2019; 61(3):413-417. View abstract
43. Immunologic reconstitution following hematopoietic stem cell transplantation despite lymph node paucity in NF-?B-inducing kinase deficiency. J Allergy Clin Immunol. 2019 03; 143(3):1240-1243.e4. View abstract
44. Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency. J Allergy Clin Immunol Pract. 2019 03; 7(3):848-855. View abstract
45. Human primary immunodeficiency caused by expression of a kinase-dead p110d mutant. J Allergy Clin Immunol. 2019 02; 143(2):797-799.e2. View abstract
46. Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1a release. J Allergy Clin Immunol. 2019 04; 143(4):1426-1443.e6. View abstract
47. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight. 2018 08 23; 3(16). View abstract
48. Defective TLR9-driven STAT3 activation in B cells of patients with CVID. Clin Immunol. 2018 12; 197:40-44. View abstract
49. MyD88 signaling in T regulatory cells by endogenous ligands dampens skin inflammation in filaggrin deficient mice. Clin Immunol. 2018 10; 195:88-92. View abstract
50. Autosomal Recessive Agammaglobulinemia - first case with a novel TCF3 mutation from Pakistan. Clin Immunol. 2019 01; 198:100-101. View abstract
51. The Lack of WIP Binding to Actin Results in Impaired B Cell Migration and Altered Humoral Immune Responses. Cell Rep. 2018 07 17; 24(3):619-629. View abstract
52. IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice. J Allergy Clin Immunol. 2019 02; 143(2):619-630.e7. View abstract
53. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779. View abstract
54. RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21). View abstract
55. Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay. Clin Immunol. 2018 03; 188:20-22. View abstract
56. Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses. . 2017 Nov 08; 22(5):653-666.e5. View abstract
57. A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations. J Clin Invest. 2017 12 01; 127(12):4415-4420. View abstract
58. DOCK8 Deficiency Presenting as an IPEX-Like Disorder. J Clin Immunol. 2017 Nov; 37(8):811-819. View abstract
59. DNA recombination defects in Kuwait: Clinical, immunologic and genetic profile. Clin Immunol. 2018 02; 187:68-75. View abstract
60. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs. JCI Insight. 2017 10 05; 2(19). View abstract
61. A novel mutation in the JH4 domain of JAK3 causing severe combined immunodeficiency complicated by vertebral osteomyelitis. Clin Immunol. 2017 10; 183:198-200. View abstract
62. Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency. J Allergy Clin Immunol. 2018 04; 141(4):1450-1458. View abstract
63. DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells. Clin Immunol. 2017 10; 183:263-265. View abstract
64. Advances in basic and clinical immunology in 2016. J Allergy Clin Immunol. 2017 Oct; 140(4):959-973. View abstract
65. Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1. Clin Immunol. 2017 10; 183:142-144. View abstract
66. Uses of Next-Generation Sequencing Technologies for the Diagnosis of Primary Immunodeficiencies. Front Immunol. 2017; 8:847. View abstract
67. Cernunnos deficiency associated with BCG adenitis and autoimmunity: First case from the national Iranian registry and review of the literature. Clin Immunol. 2017 10; 183:201-206. View abstract
68. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J Allergy Clin Immunol. 2018 03; 141(3):1060-1073.e3. View abstract
69. Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration. J Exp Med. 2017 Jul 03; 214(7):1937-1947. View abstract
70. Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. J Allergy Clin Immunol. 2018 03; 141(3):1050-1059.e10. View abstract
71. The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils. Front Pharmacol. 2017; 8:262. View abstract
72. Disseminated Mycobacterium malmoense and Salmonella Infections Associated with a Novel Variant in NFKBIA. J Clin Immunol. 2017 07; 37(5):415-418. View abstract
73. Leucine-rich repeat containing 8A (LRRC8A)-dependent volume-regulated anion channel activity is dispensable for T-cell development and function. J Allergy Clin Immunol. 2017 Dec; 140(6):1651-1659.e1. View abstract
74. Janus kinase 3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site. J Allergy Clin Immunol. 2017 07; 140(1):268-271.e6. View abstract
75. Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity. J Clin Invest. 2016 11 01; 126(11):4219-4236. View abstract
76. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 10 03; 126(10):3837-3851. View abstract
77. Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice. J Allergy Clin Immunol. 2017 Apr; 139(4):1293-1301.e4. View abstract
78. Epidermodysplasia verruciformis as a manifestation of ARTEMIS deficiency in a young adult. J Allergy Clin Immunol. 2017 01; 139(1):372-375.e4. View abstract
79. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66. View abstract
80. Mutations in pyrin masquerading as a primary immunodeficiency. Clin Immunol. 2016 Oct; 171:65-66. View abstract
81. IL-22 derived from ?d T cells restricts Staphylococcus aureus infection of mechanically injured skin. J Allergy Clin Immunol. 2016 10; 138(4):1098-1107.e3. View abstract
82. Rapid molecular diagnostics of severe primary immunodeficiency determined by using targeted next-generation sequencing. J Allergy Clin Immunol. 2016 10; 138(4):1142-1151.e2. View abstract
83. Staphylococcus aureus Exploits Epidermal Barrier Defects in Atopic Dermatitis to Trigger Cytokine Expression. J Invest Dermatol. 2016 11; 136(11):2192-2200. View abstract
84. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol. 2016 11; 138(5):1356-1366. View abstract
85. Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation. J Allergy Clin Immunol. 2016 11; 138(5):1384-1394.e2. View abstract
86. Hyper IgM Syndrome: a Report from the USIDNET Registry. J Clin Immunol. 2016 07; 36(5):490-501. View abstract
87. Combined immunodeficiency due to a homozygous mutation in ORAI1 that deletes the C-terminus that interacts with STIM 1. Clin Immunol. 2016 05; 166-167:100-2. View abstract
88. Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2016 09; 138(3):852-859.e3. View abstract
89. Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. J Allergy Clin Immunol. 2016 07; 138(1):297-299. View abstract
90. O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S3. View abstract
91. Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2016 07; 138(1):283-286. View abstract
92. Spectrum of Phenotypes Associated with Mutations in LRBA. J Clin Immunol. 2016 Jan; 36(1):33-45. View abstract
93. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat Genet. 2016 Jan; 48(1):74-8. View abstract
94. Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. J Allergy Clin Immunol. 2016 Mar; 137(3):879-88.e2. View abstract
95. Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly. J Allergy Clin Immunol. 2016 Jan; 137(1):324-327.e2. View abstract
96. Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase Signaling in B Cells. Immunity. 2015 Oct 20; 43(4):660-73. View abstract
97. Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol. 2015 Nov; 136(5):1401-4.e1-3. View abstract
98. Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum. J Allergy Clin Immunol. 2015 Dec; 136(6):1591-1600. View abstract
99. A novel mutation in NCF2 associated with autoimmune disease and a solitary late-onset infection. Clin Immunol. 2015 Dec; 161(2):128-30. View abstract
100. Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med. 2015 Jun 18; 372(25):2409-22. View abstract
101. A novel mutation in ORAI1 presenting with combined immunodeficiency and residual T-cell function. J Allergy Clin Immunol. 2015 Aug; 136(2):479-482.e1. View abstract
102. The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells. J Immunol. 2015 May 15; 194(10):4750-8. View abstract
103. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015 Aug; 136(2):402-12. View abstract
104. A novel mutation in ICOS presenting as hypogammaglobulinemia with susceptibility to opportunistic pathogens. J Allergy Clin Immunol. 2015 Sep; 136(3):794-797.e1. View abstract
105. Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. J Allergy Clin Immunol. 2015 Jun; 135(6):1511-8.e6. View abstract
106. Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in I?Ba. J Exp Med. 2015 Feb 09; 212(2):185-202. View abstract
107. The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) mice. Clin Immunol. 2015 Feb; 156(2):128-30. View abstract
108. Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. J Allergy Clin Immunol. 2015 Jan; 135(1):217-27. View abstract
109. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 01; 34(23):4343-54. View abstract
110. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. J Allergy Clin Immunol. 2014 Dec; 134(6):1365-1374. View abstract
111. A novel mutation in FOXN1 resulting in SCID: a case report and literature review. Clin Immunol. 2014 Nov; 155(1):30-32. View abstract
112. The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency. J Allergy Clin Immunol. 2014 Aug; 134(2):276-84. View abstract
113. CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis. Inflamm Bowel Dis. 2014 Jul; 20(7):1165-76. View abstract
114. Lessons in gene hunting: a RAG1 mutation presenting with agammaglobulinemia and absence of B cells. J Allergy Clin Immunol. 2014 Oct; 134(4):983-5.e1. View abstract
115. A novel disease-causing CD40L mutation reduces expression of CD40 ligand, but preserves CD40 binding capacity. Clin Immunol. 2014 Aug; 153(2):288-91. View abstract
116. Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. J Allergy Clin Immunol. 2014 Jun; 133(6):1667-75. View abstract
117. Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. J Allergy Clin Immunol. 2014 Jun; 133(6):1753-5.e3. View abstract
118. Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 05; 211(5):929-42. View abstract
119. Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):223-6. View abstract
120. Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):221-3. View abstract
121. TRIF signaling is essential for TLR4-driven IgE class switching. J Immunol. 2014 Mar 15; 192(6):2651-8. View abstract
122. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J Allergy Clin Immunol. 2014 Feb; 133(2):309-17. View abstract
123. Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis. Clin Immunol. 2014 Feb; 150(2):220-4. View abstract
124. A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. J Allergy Clin Immunol. 2014 Apr; 133(4):1099-108. View abstract
125. Gene hunting in the genomic era: approaches to diagnostic dilemmas in patients with primary immunodeficiencies. J Allergy Clin Immunol. 2014 Aug; 134(2):262-8. View abstract
126. A homozygous mucosa-associated lymphoid tissue 1 (MALT1) mutation in a family with combined immunodeficiency. J Allergy Clin Immunol. 2013 Jul; 132(1):151-8. View abstract
127. C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation. J Allergy Clin Immunol. 2013 Sep; 132(3):746-748.e3. View abstract
128. T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation. J Allergy Clin Immunol. 2013 Sep; 132(3):648-655.e1. View abstract
129. A phenotypic approach for IUIS PID classification and diagnosis: guidelines for clinicians at the bedside. J Clin Immunol. 2013 Aug; 33(6):1078-87. View abstract
130. Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity. J Allergy Clin Immunol. 2013 Apr; 131(4):1247-50, 1250.e1. View abstract
131. Wiskott-Aldrich syndrome: a comprehensive review. Ann N Y Acad Sci. 2013 May; 1285:26-43. View abstract
132. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2013 Mar; 131(3):840-8. View abstract
133. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013 Feb; 131(2):451-60.e1-6. View abstract
134. Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal a-toxin-induced keratinocyte death. J Allergy Clin Immunol. 2013 Feb; 131(2):421-7.e1-2. View abstract
135. Intronic SH2D1A mutation with impaired SAP expression and agammaglobulinemia. Clin Immunol. 2013 Feb; 146(2):84-9. View abstract
136. Use of whole exome and genome sequencing in the identification of genetic causes of primary immunodeficiencies. Curr Opin Allergy Clin Immunol. 2012 Dec; 12(6):623-8. View abstract
137. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19; 37(4):747-58. View abstract
138. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec; 80(12):4071-7. View abstract
139. SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils. Int Immunol. 2012 Nov; 24(11):719-27. View abstract
140. A novel homozygous mutation in recombination activating gene 2 in 2 relatives with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome. J Allergy Clin Immunol. 2012 Dec; 130(6):1414-6. View abstract
141. LPS-responsive beige-like anchor (LRBA) gene mutation in a family with inflammatory bowel disease and combined immunodeficiency. J Allergy Clin Immunol. 2012 Aug; 130(2):481-8.e2. View abstract
142. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20. View abstract
143. Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Clin Immunol. 2012 Jun; 143(3):266-72. View abstract
144. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4992-7. View abstract
145. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28. View abstract
146. A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. J Exp Med. 2012 Jan 16; 209(1):29-34. View abstract
147. Vaccinia Ig ameliorates eczema vaccinatum in a murine model of atopic dermatitis. J Invest Dermatol. 2012 Apr; 132(4):1299-301. View abstract
148. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol. 2011; 2:54. View abstract
149. Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis. J Allergy Clin Immunol. 2011 Oct; 128(4):890-892.e3. View abstract
150. Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation. J Allergy Clin Immunol. 2011 Sep; 128(3):601-9.e1-4. View abstract
151. Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin. J Clin Invest. 2011 Jun; 121(6):2210-20. View abstract
152. Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency. J Allergy Clin Immunol. 2011 Jul; 128(1):226-228.e1. View abstract
153. A peptide derived from the Wiskott-Aldrich syndrome (WAS) protein-interacting protein (WIP) restores WAS protein level and actin cytoskeleton reorganization in lymphocytes from patients with WAS mutations that disrupt WIP binding. J Allergy Clin Immunol. 2011 Apr; 127(4):998-1005.e1-2. View abstract
154. Ligation of CD46 to CD40 inhibits CD40 signaling in B cells. Int Immunol. 2011 Mar; 23(3):215-21. View abstract
155. Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1304-5.e3. View abstract
156. The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1234-41.e2. View abstract
157. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010 Nov; 89(6):403-425. View abstract
158. Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. J Allergy Clin Immunol. 2010 Nov; 126(5):976-84, 984.e1-5. View abstract
159. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6. View abstract
160. The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol. 2010 Oct; 126(4):784-90. View abstract
161. Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. J Allergy Clin Immunol. 2010 Aug; 126(2):332-7, 337.e1-2. View abstract
162. Parental consanguinity and the risk of primary immunodeficiency disorders: report from the Kuwait National Primary Immunodeficiency Disorders Registry. Int Arch Allergy Immunol. 2011; 154(1):76-80. View abstract
163. Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. J Allergy Clin Immunol. 2010 Jul; 126(1):127-32.e7. View abstract
164. Thymic stromal lymphopoietin. Ann N Y Acad Sci. 2010 Jan; 1183:13-24. View abstract
165. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009 Dec; 124(6):1161-78. View abstract
166. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol. 2009 Oct; 124(4):761-70.e1. View abstract
167. Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009 Nov 19; 114(21):4729-37. View abstract
168. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14954-9. View abstract
169. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol. 2009 Sep; 124(3):485-93, 493.e1. View abstract
170. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood. 2009 Sep 10; 114(11):2254-62. View abstract
171. Reply to Narra. J Allergy Clin Immunol. 2009 Jun 01; 123(6):1419-1420. View abstract
172. Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. J Allergy Clin Immunol. 2009 Jun; 123(6):1277-86.e5. View abstract
173. Common variable immunodeficiency. Pediatr Res. 2009 May; 65(5 Pt 2):13R-19R. View abstract
174. WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7519-24. View abstract
175. Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization. J Allergy Clin Immunol. 2009 Apr; 123(4):875-82.e1. View abstract
176. TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. Int Immunol. 2009 Apr; 21(4):477-88. View abstract
177. Recent advances in the biology of WASP and WIP. Immunol Res. 2009; 44(1-3):99-111. View abstract
178. Animal models of atopic dermatitis. J Invest Dermatol. 2009 Jan; 129(1):31-40. View abstract
179. Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol. 2009; 102:135-226. View abstract
180. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60. View abstract
181. Primary immune deficiencies with aberrant IgE production. J Allergy Clin Immunol. 2008 Dec; 122(6):1054-62; quiz 1063-4. View abstract
182. Transmembrane activator and calcium-modulator and cyclophilin ligand interactor mutations in common variable immunodeficiency. Curr Opin Allergy Clin Immunol. 2008 Dec; 8(6):520-6. View abstract
183. Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency. J Allergy Clin Immunol. 2008 Dec; 122(6):1113-1118.e1. View abstract
184. A girl with severe hand swelling and abdominal cramps. Clin Chem. 2008 Oct; 54(10):1733-6; discussion 1736-7. View abstract
185. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11875-80. View abstract
186. Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J Immunol. 2008 Mar 15; 180(6):3655-9. View abstract
187. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell. 2008 Mar 07; 132(5):794-806. View abstract
188. Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production. Int Immunol. 2008 Mar; 20(3):345-52. View abstract
189. Images in immunodeficiency. J Allergy Clin Immunol. 2007 Oct; 120(4):982-4. View abstract
190. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol. 2007 Oct; 120(4):776-94. View abstract
191. Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. J Allergy Clin Immunol. 2007 Oct; 120(4):900-7. View abstract
192. B-cell receptor cross-linking delays activation-induced cytidine deaminase induction and inhibits class-switch recombination to IgE. J Allergy Clin Immunol. 2008 Jan; 121(1):191-196.e2. View abstract
193. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15817-22. View abstract
194. Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol. 2007 Dec; 120(6):1382-8. View abstract
195. Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation. J Allergy Clin Immunol. 2007 Oct; 120(4):885-91. View abstract
196. Transcellular diapedesis is initiated by invasive podosomes. Immunity. 2007 Jun; 26(6):784-97. View abstract
197. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007 Jun; 117(6):1550-7. View abstract
198. WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):926-31. View abstract
199. TACI, isotype switching, CVID and IgAD. Immunol Res. 2007; 38(1-3):102-11. View abstract
200. A novel anti-WIP monoclonal antibody detects an isoform of WIP that lacks the WASP binding domain. Biochem Biophys Res Commun. 2007 Feb 23; 353(4):875-81. View abstract
201. Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. J Allergy Clin Immunol. 2006 Dec; 118(6):1357-62. View abstract
202. CD1d restricted natural killer T cells are not required for allergic skin inflammation. J Allergy Clin Immunol. 2006 Dec; 118(6):1363-8. View abstract
203. TACI mutation in common variable immunodeficiency and IgA deficiency. Curr Allergy Asthma Rep. 2006 Sep; 6(5):357-62. View abstract
204. 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. Mol Cell Biol. 2006 Jul; 26(14):5214-25. View abstract
205. IPEX and the role of Foxp3 in the development and function of human Tregs. J Clin Invest. 2006 Jun; 116(6):1473-5. View abstract
206. The H1 histamine receptor regulates allergic lung responses. J Clin Invest. 2006 Jun; 116(6):1624-32. View abstract
207. Molecular basis of common variable immunodeficiency. J Allergy Clin Immunol. 2006 Apr; 117(4):740-6; quiz 747. View abstract
208. A second-site mutation in the initiation codon of WAS (WASP) results in expansion of subsets of lymphocytes in an Wiskott-Aldrich syndrome patient. Hum Mutat. 2006 Apr; 27(4):370-5. View abstract
209. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005. J Allergy Clin Immunol. 2006 Apr; 117(4):883-96. View abstract
210. The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. J Allergy Clin Immunol. 2006 Jun; 117(6):1455-61. View abstract
211. 2. Update on primary immunodeficiency diseases. J Allergy Clin Immunol. 2006 Feb; 117(2 Suppl Mini-Primer):S435-41. View abstract
212. Lessons learned from molecular defects in nuclear factor kappaB dependent signaling. Microbes Infect. 2006 Apr; 8(4):1151-6. View abstract
213. A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19063-8. View abstract
214. Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome. J Allergy Clin Immunol. 2005 Dec; 116(6):1364-71. View abstract
215. Charles A. Janeway and Fred S. Rosen: the discovery of gamma globulin therapy and primary immunodeficiency diseases at Boston Children's Hospital. J Allergy Clin Immunol. 2005 Oct; 116(4):937-40. View abstract
216. WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. Int Immunol. 2006 Feb; 18(2):221-32. View abstract
217. Are you immunodeficient? J Allergy Clin Immunol. 2005 Aug; 116(2):423-5. View abstract
218. COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. J Allergy Clin Immunol. 2005 Aug; 116(2):390-6. View abstract
219. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet. 2005 Aug; 37(8):829-34. View abstract
220. Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol. 2005 Jul 04; 170(1):115-26. View abstract
221. Role of APRIL in the mucosal Iga antibody response. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S27. View abstract
222. Jun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells. J Allergy Clin Immunol. 2005 Apr; 115(4):856-63. View abstract
223. Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kappaB activation. Immunol Rev. 2005 Feb; 203:21-37. View abstract
224. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med. 2005 Jan 03; 201(1):35-9. View abstract
225. Characteristics of mycobacterial infection in patients with immunodeficiency and nuclear factor-kappaB essential modulator mutation, with or without ectodermal dysplasia. J Am Acad Dermatol. 2004 Nov; 51(5):718-22. View abstract
226. Primary immunodeficiency diseases: an update. J Allergy Clin Immunol. 2004 Sep; 114(3):677-87. View abstract
227. Human nuclear factor kappa B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. J Allergy Clin Immunol. 2004 Sep; 114(3):650-6. View abstract
228. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest. 2004 Aug; 114(3):399-407. View abstract
229. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med. 2004 Aug 02; 200(3):399-404. View abstract
230. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol. 2004 Jun; 24(12):5269-80. View abstract
231. The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation. J Allergy Clin Immunol. 2004 Apr; 113(4):725-33. View abstract
232. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. View abstract
233. Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3903-8. View abstract
234. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med. 2004 Feb 02; 199(3):357-68. View abstract
235. Allergy and hypersensitivity. Nature versus nurture in allergy and hypersensitivity. Curr Opin Immunol. 2003 Dec; 15(6):603-8. View abstract
236. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec; 15(12):1431-40. View abstract
237. The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14151-6. View abstract
238. The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients. Medicine (Baltimore). 2003 Nov; 82(6):373-84. View abstract
239. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol. 2003 Nov; 112(5):981-7. View abstract
240. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200. View abstract
241. Finding NEMO: genetic disorders of NF-[kappa]B activation. J Clin Invest. 2003 Oct; 112(7):983-5. View abstract
242. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest. 2003 Oct; 112(7):1058-66. View abstract
243. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. J Infect Dis. 2003 Oct 01; 188(7):948-53. View abstract
244. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol. 2003 Sep; 3(9):721-32. View abstract
245. Acute chylothorax in children: selective retention of memory T cells and natural killer cells. J Pediatr. 2003 Aug; 143(2):243-9. View abstract
246. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 2003 Jul 15; 22(14):3602-12. View abstract
247. Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. J Allergy Clin Immunol. 2003 Jul; 112(1):149-58. View abstract
248. C4b-binding protein (C4BP) activates B cells through the CD40 receptor. Immunity. 2003 Jun; 18(6):837-48. View abstract
249. WIP participates in actin reorganization and ruffle formation induced by PDGF. J Cell Sci. 2003 Jun 15; 116(Pt 12):2443-51. View abstract
250. Primary immunodeficiency diseases: an update. Clin Exp Immunol. 2003 Apr; 132(1):9-15. View abstract
251. IgG Fc receptor polymorphisms in human disease: implications for intravenous immunoglobulin therapy. J Allergy Clin Immunol. 2003 Apr; 111(4):697-703. View abstract
252. Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol. 2003 Apr; 23(7):2395-406. View abstract
253. 12. Primary immunodeficiency diseases. J Allergy Clin Immunol. 2003 Feb; 111(2 Suppl):S571-81. View abstract
254. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol Cell. 2002 Dec; 10(6):1269-81. View abstract
255. X-linked lymphoproliferative disease: genetic lesions and clinical consequences. Curr Allergy Asthma Rep. 2002 Sep; 2(5):361-7. View abstract
256. The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. Immunity. 2002 Sep; 17(3):265-76. View abstract
257. Wiskott-Aldrich syndrome protein is required for NK cell cytotoxicity and colocalizes with actin to NK cell-activating immunologic synapses. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11351-6. View abstract
258. Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma. J Allergy Clin Immunol. 2002 Jun; 109(6):980-7. View abstract
259. Deficient natural killer cell cytotoxicity in patients with IKK-gamma/NEMO mutations. J Clin Invest. 2002 Jun; 109(11):1501-9. View abstract
260. Aspartame: review of safety. Regul Toxicol Pharmacol. 2002 Apr; 35(2 Pt 2):S1-93. View abstract
261. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest. 2002 Mar; 109(5):621-8. View abstract
262. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity. 2002 Feb; 16(2):193-204. View abstract
263. Differential role of SLP-76 domains in T cell development and function. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):884-9. View abstract
264. Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. J Allergy Clin Immunol. 2002 Jan; 109(1):106-13. View abstract
265. IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils. J Immunol. 2001 Dec 01; 167(11):6097-104. View abstract
266. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904. View abstract
267. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity. 2001 Oct; 15(4):647-57. View abstract
268. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol. 2001 May; 3(5):484-91. View abstract
269. Desloratadine: A new, nonsedating, oral antihistamine. J Allergy Clin Immunol. 2001 Apr; 107(4):751-62. View abstract
270. IgE regulation and roles in asthma pathogenesis. J Allergy Clin Immunol. 2001 Mar; 107(3):429-40. View abstract
271. An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2001 Feb; 107(2):359-66. View abstract
272. Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching. J Clin Invest. 2001 Feb; 107(3):371-8. View abstract
273. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood. 2000 Dec 01; 96(12):3786-92. View abstract
274. Allergy, a disease of the internal and external environments Curr Opin Immunol. 2000 Dec; 12(6):615-7. View abstract
275. Identification and characterization of two CD40-inducible enhancers in the mouse TRAF1 gene locus. Mol Immunol. 2000 Nov; 37(16):961-73. View abstract
276. CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2000 Nov; 23(5):646-51. View abstract
277. Multicenter, double-blind, placebo-controlled, multiple-challenge evaluation of reported reactions to monosodium glutamate. J Allergy Clin Immunol. 2000 Nov; 106(5):973-80. View abstract
278. Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr. 2000 04; 130(4S Suppl):1058S-62S. View abstract
279. The role of SLP-76 and LAT in lymphocyte development. Curr Opin Immunol. 2000 Apr; 12(2):173-8. View abstract
280. Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcgamma receptors I and II/III. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1725-30. View abstract
281. Molecular mechanisms of IgE regulation. J Allergy Clin Immunol. 2000 Feb; 105(2 Pt 2):S547-58. View abstract
282. Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. J Exp Med. 1999 Oct 18; 190(8):1093-102. View abstract
283. IgE in asthma and atopy: cellular and molecular connections. J Clin Invest. 1999 Oct; 104(7):829-35. View abstract
284. Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity. 1999 Sep; 11(3):339-48. View abstract
285. The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast. J Biol Chem. 1999 Jun 11; 274(24):17103-8. View abstract
286. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun; 103(12):1737-43. View abstract
287. Structure of the murine TRAF1 gene. Mol Immunol. 1999 Jun; 36(9):611-7. View abstract
288. Contribution of CD40-CD154-mediated costimulation to an alloresponse in vivo. Transplantation. 1999 May 15; 67(9):1284-7. View abstract
289. Effect of intravenous immunoglobulin on steroid consumption in patients with severe asthma: a double-blind, placebo-controlled, randomized trial. J Allergy Clin Immunol. 1999 May; 103(5 Pt 1):810-5. View abstract
290. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest. 1999 Apr; 103(8):1103-11. View abstract
291. Regulation of IgE synthesis: the molecular basis and implications for clinical modulation. Allergy Asthma Proc. 1999 Jan-Feb; 20(1):1-8. View abstract
292. Waltzing with WASP. Trends Cell Biol. 1999 Jan; 9(1):15-9. View abstract
293. The mouse genome contains two expressed intronless retroposed pseudogenes for the sentrin/sumo-1/PIC1 conjugating enzyme Ubc9. Mol Immunol. 1998 Nov; 35(16):1057-67. View abstract
294. Role of JAK3 in CD40-mediated signaling. Blood. 1998 Oct 01; 92(7):2435-40. View abstract
295. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998 Oct 01; 395(6701):462-9. View abstract
296. The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. J Biol Chem. 1998 Aug 14; 273(33):20992-5. View abstract
297. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 1998 Jul 24; 94(2):229-38. View abstract
298. IgE-mediated allergy and desensitization to factor IX in hemophilia B. J Allergy Clin Immunol. 1998 Jul; 102(1):113-7. View abstract
299. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest. 1998 Apr 15; 101(8):1614-22. View abstract
300. Molecular mechanisms of immunoglobulin E regulation. Int Arch Allergy Immunol. 1998 Apr; 115(4):257-69. View abstract
301. CD40 ligation and IL-4 use different mechanisms of transcriptional activation of the human lymphotoxin alpha promoter in B cells. Eur J Immunol. 1998 Mar; 28(3):901-6. View abstract
302. The hyper-IgM (HIM) syndrome. Springer Semin Immunopathol. 1998; 19(4):383-99. View abstract
303. WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14671-6. View abstract
304. Targeted gene disruption of murine CD7. Int Immunol. 1997 Dec; 9(12):1875-83. View abstract
305. Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10844-9. View abstract
306. Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5866-71. View abstract
307. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity. 1997 Apr; 6(4):379-87. View abstract
308. Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts. J Clin Immunol. 1997 Mar; 17(2):109-26. View abstract
309. Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. Int Immunol. 1997 Mar; 9(3):395-405. View abstract
310. CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1390-5. View abstract
311. HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. Int Immunol. 1997 Jan; 9(1):53-64. View abstract
312. Association of human fas (CD95) with a ubiquitin-conjugating enzyme (UBC-FAP). J Biol Chem. 1996 Dec 06; 271(49):31037-43. View abstract
313. The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching. Int Immunol. 1996 Oct; 8(10):1503-10. View abstract
314. Large-volume leukapheresis in pediatric patients: processing more blood diminishes the apparent magnitude of intra-apheresis recruitment. Transfusion. 1996 Oct; 36(10):879-85. View abstract
315. Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4994-8. View abstract
316. Mechanisms of inhibition of IgE synthesis by nedocromil sodium: nedocromil sodium inhibits deletional switch recombination in human B cells. J Allergy Clin Immunol. 1996 May; 97(5):1141-50. View abstract
317. Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol. 1996 Mar; 103(3):408-13. View abstract
318. CD40 expression and function in murine B cell ontogeny. Int Immunol. 1996 Mar; 8(3):405-411. View abstract
319. The CD40L promoter contains nuclear factor of activated T cells-binding motifs which require AP-1 binding for activation of transcription. J Biol Chem. 1996 Feb 16; 271(7):3763-70. View abstract
320. Characterization of a 23-kDa protein associated with CD40. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11633-6. View abstract
321. Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes. Int Immunol. 1995 Oct; 7(10):1665-70. View abstract
322. Defective expression of early activation genes in cartilage-hair hypoplasia (CHH) with severe combined immunodeficiency (SCID). Clin Exp Immunol. 1995 Oct; 102(1):6-10. View abstract
323. CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). Clin Immunol Immunopathol. 1995 Sep; 76(3 Pt 2):S208-13. View abstract
324. CD40-mediated lymphotoxin alpha expression in human B cells is tyrosine kinase dependent. Eur J Immunol. 1995 Sep; 25(9):2438-44. View abstract
325. Bacterial superantigens induce the proliferation of resting gamma/delta receptor bearing T cells. Immunol Invest. 1995 Aug; 24(5):713-24. View abstract
326. Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells: role of NF-kappa B. J Immunol. 1995 Jul 15; 155(2):902-8. View abstract
327. CD40 ligand expression is developmentally regulated in human thymocytes. Clin Immunol Immunopathol. 1995 Jul; 76(1 Pt 1):52-8. View abstract
328. Association of the high-affinity receptor for IgG with the protein tyrosine kinases Hck and Lyn. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):135. View abstract
329. CD40 ligand/CD40 deficiency. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):37-9. View abstract
330. Expression of the CD40 ligand in T lymphocytes and induction of IgE isotype switching. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):43-4. View abstract
331. Activation of tumor necrosis factor-alpha and lymphotoxin-alpha via anti-CD40 in human B cells. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):368-9. View abstract
332. A point mutation in exon 2 of the CD40 ligand gene causes the simultaneous expression of two defective mRNA species in X-linked hyperimmunoglobulinemia M. Hum Mol Genet. 1995 Apr; 4(4):759-61. View abstract
333. Interleukin-4 receptor expression by human B cells: functional analysis with a human interleukin-4 toxin, DAB389IL-4. J Allergy Clin Immunol. 1995 Apr; 95(4):893-900. View abstract
334. gamma/delta T lymphocytes express CD40 ligand and induce isotype switching in B lymphocytes. J Exp Med. 1995 Mar 01; 181(3):1239-44. View abstract
335. Role of protein tyrosine kinases and phosphatases in isotype switching: crosslinking CD45 to CD40 inhibits IgE isotype switching in human B cells. Immunol Lett. 1995 Feb; 45(1-2):99-106. View abstract
336. X-linked agammaglobulinemia and immunoglobulin deficiency with normal or elevated IgM: immunodeficiencies of B cell development and differentiation. Adv Immunol. 1995; 60:37-56. View abstract
337. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12135-9. View abstract
338. CD40 ligation induces lymphotoxin alpha gene expression in human B cells. Int Immunol. 1994 Dec; 6(12):1883-90. View abstract
339. Protein tyrosine kinase activation and protein kinase C translocation are functional components of CD40 signal transduction in resting human B cells. Immunol Invest. 1994 Nov; 23(6-7):437-48. View abstract
340. A toxic shock syndrome toxin-1 peptide that shows homology to amino acids 180-193 of mycobacterial heat shock protein 65 is presented as conventional antigen. Immunol Invest. 1994 Nov; 23(6-7):381-91. View abstract
341. Immunosuppressant deoxyspergualin inhibits antigen processing in monocytes. J Immunol. 1994 Nov 01; 153(9):3908-16. View abstract
342. Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE. J Allergy Clin Immunol. 1994 Oct; 94(4):784-92. View abstract
343. Superantigens activate HIV-1 gene expression in monocytic cells. Clin Immunol Immunopathol. 1994 Sep; 72(3):357-61. View abstract
344. MHC class II signaling in B-cell activation. Immunol Today. 1994 Sep; 15(9):418-22. View abstract
345. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn. J Exp Med. 1994 Sep 01; 180(3):1165-70. View abstract
346. Engagement of the common leukocyte antigen CD45 induces homotypic adhesion of activated human T cells. J Immunol. 1994 Aug 15; 153(4):1593-602. View abstract
347. Decreased expression of the ligand for CD40 in newborn lymphocytes. Eur J Immunol. 1994 Aug; 24(8):1925-8. View abstract
348. Structure of the murine CD40 ligand gene. Mol Immunol. 1994 Aug; 31(12):895-900. View abstract
349. Disodium cromoglycate inhibits S mu-->S epsilon deletional switch recombination and IgE synthesis in human B cells. J Exp Med. 1994 Aug 01; 180(2):663-71. View abstract
350. Molecular pathology of X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). Immunol Rev. 1994 Apr; 138:87-104. View abstract
351. Engagement of MHC class II molecules by staphylococcal superantigens activates src-type protein tyrosine kinases. Eur J Immunol. 1994 Mar; 24(3):651-8. View abstract
352. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J Clin Invest. 1994 Mar; 93(3):1315-20. View abstract
353. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2. J Exp Med. 1994 Feb 01; 179(2):673-80. View abstract
354. Early activation events induced by the staphylococcal superantigen toxic shock syndrome toxin-1 in human peripheral blood monocytes. Clin Immunol Immunopathol. 1994 Feb; 70(2):137-44. View abstract
355. Role of CD40-CD40-ligand interaction in Ig-isotype switching. Curr Opin Immunol. 1993 Dec; 5(6):963-7. View abstract
356. Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone. J Immunol. 1993 Nov 01; 151(9):4528-33. View abstract
357. Aspartame is no more likely than placebo to cause urticaria/angioedema: results of a multicenter, randomized, double-blind, placebo-controlled, crossover study. J Allergy Clin Immunol. 1993 Oct; 92(4):513-20. View abstract
358. Physical association between the high-affinity IgG receptor (Fc gamma RI) and the gamma subunit of the high-affinity IgE receptor (Fc epsilon RI gamma). Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):8847-50. View abstract
359. Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells. Eur J Immunol. 1993 Sep; 23(9):2129-35. View abstract
360. Therapy for patients with recurrent infections and low serum IgG3 levels. J Allergy Clin Immunol. 1993 Aug; 92(2):353-5. View abstract
361. Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1). Int Immunol. 1993 Jul; 5(7):769-73. View abstract
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