ABOUT THE RESEARCHER

OVERVIEW

The overarching goal of Dr. David Glahn’s research is to discover genes and environmental mechanisms that predispose affective and psychotic disorders in children and adults. To achieve this goal, he develops and applies neuroanatomic, functional neuroimaging, and neurocognitive endophenotypes in large-scale family-based studies. Dr. Glahn’s research program involves four broad scientific aims: 1) To identify and characterize genes and environmental factors influencing risk for psychotic and affective disorders and their endophenotypes; 2) To specify genetic and environmental influences on normal variation of brain structure/function and cognitive ability; 3) To isolate genetic and environmental factors involved in human cognitive and brain development, particularly during adolescence; and 4) To develop novel endophenotypes for psychotic and affective disorders and markers of cognitive and brain development.

Given that psychiatric and cognitive/imaging antecedents of psychosis or affective dysregulation appear in childhood and adolescence, typically years before the formal onset of the illness, a major component of his research focuses on genetic and environmental aspects of individual differences across development. Dr. Glahn believes that recognizing antecedents of psychosis in young children could open a window of opportunity for targeted interventions to forestall disturbing symptoms and mitigate the risk of full-blown disease.

BACKGROUND

Dr. David Glahn is the Associate Chief for Research in the Department of Psychiatry at Boston Children’s Hospital and the Director of the Tommy Fuss Center for Neuropsychiatric Disease Research. In addition, he directs the Early Psychosis Investigation Center (EPICenter) and the Neuropsychiatric Genetics Program (NPG). Dr. Glahn received his PhD in Clinical Psychology from the University of Pennsylvania and a post-doctoral fellowship the University of California at Los Angeles. Glahn has served as Co-Director for the Division of Neurocognition, Neurocomputation, and Neurogenetics at the Yale University School of Medicine, prior to joining Boston Children’s Hospital and Harvard Medical School.

PUBLICATIONS

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  1. Effects of weather and season on human brain volume. PLoS One. 2021; 16(3):e0236303. View abstract
  2. 1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans. Transl Psychiatry. 2021 Mar 22; 11(1):182. View abstract
  3. Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets. J Child Psychol Psychiatry. 2021 Mar 22. View abstract
  4. RCL1 copy number variants are associated with a range of neuropsychiatric phenotypes. Mol Psychiatry. 2021 Feb 17. View abstract
  5. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90?years. Hum Brain Mapp. 2021 Feb 17. View abstract
  6. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90?years. Hum Brain Mapp. 2021 Feb 11. View abstract
  7. A White Matter Connection of Schizophrenia and Alzheimer's Disease. Schizophr Bull. 2021 Jan 23; 47(1):197-206. View abstract
  8. Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability. Mol Psychiatry. 2021 Jan 07. View abstract
  9. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings. Mol Psychiatry. 2021 Jan 07. View abstract
  10. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA Psychiatry. 2021 Jan 01; 78(1):47-63. View abstract
  11. Searching for Imaging Biomarkers of Psychotic Dysconnectivity. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Dec 16. View abstract
  12. Personalized estimates of morphometric similarity in bipolar disorder and schizophrenia. NPJ Schizophr. 2020 Dec 04; 6(1):39. View abstract
  13. Using the Schmahmann Syndrome Scale to Assess Cognitive Impairment in Young Adults with Metabolic Syndrome: a Hypothesis-Generating Report. Cerebellum. 2021 Apr; 20(2):295-299. View abstract
  14. Greater male than female variability in regional brain structure across the lifespan. Hum Brain Mapp. 2020 Oct 12. View abstract
  15. Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder. Hum Brain Mapp. 2020 Oct 07. View abstract
  16. Role of miRNA-mRNA Interaction in Neural Stem Cell Differentiation of Induced Pluripotent Stem Cells. Int J Mol Sci. 2020 Sep 23; 21(19). View abstract
  17. The reliability and heritability of cortical folds and their genetic correlations across hemispheres. Commun Biol. 2020 Sep 15; 3(1):510. View abstract
  18. Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome. Am J Psychiatry. 2021 01 01; 178(1):87-98. View abstract
  19. Structural Brain Architectures Match Intrinsic Functional Networks and Vary across Domains: A Study from 15?000+ Individuals. Cereb Cortex. 2020 Sep 03; 30(10):5460-5470. View abstract
  20. Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry. Cereb Cortex. 2020 Jul 30; 30(9):4899-4913. View abstract
  21. Influence of Processing Pipeline on Cortical Thickness Measurement. Cereb Cortex. 2020 Jul 30; 30(9):5014-5027. View abstract
  22. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Hum Brain Mapp. 2020 Jul 29. View abstract
  23. Person-based similarity in brain structure and functional connectivity in bipolar disorder. J Affect Disord. 2020 11 01; 276:38-44. View abstract
  24. How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings. Hum Brain Mapp. 2020 Jul 09. View abstract
  25. The architecture of co-morbidity networks of physical and mental health conditions in military veterans. Proc Math Phys Eng Sci. 2020 Jul; 476(2239):20190790. View abstract
  26. Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans. Cereb Cortex. 2020 May 18; 30(6):3439-3450. View abstract
  27. Mapping brain asymmetry in health and disease through the ENIGMA consortium. Hum Brain Mapp. 2020 May 18. View abstract
  28. Heritability and Cognitive Relevance of Structural Brain Controllability. Cereb Cortex. 2020 05 14; 30(5):3044-3054. View abstract
  29. ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research. Hum Brain Mapp. 2020 Apr 16. View abstract
  30. The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium. Am J Psychiatry. 2020 06 01; 177(6):537-547. View abstract
  31. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Transl Psychiatry. 2020 03 20; 10(1):100. View abstract
  32. Imaging local genetic influences on cortical folding. Proc Natl Acad Sci U S A. 2020 03 31; 117(13):7430-7436. View abstract
  33. Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Mol Psychiatry. 2020 Mar; 25(3):692-695. View abstract
  34. Extensions of Multiple-Group Item Response Theory Alignment: Application to Psychiatric Phenotypes in an International Genomics Consortium. Educ Psychol Meas. 2020 Oct; 80(5):870-909. View abstract
  35. Neurocognitive impairment in type 2 diabetes: evidence for shared genetic aetiology. Diabetologia. 2020 05; 63(5):977-986. View abstract
  36. Highly efficient induced pluripotent stem cell reprogramming of cryopreserved lymphoblastoid cell lines. J Biol Methods. 2020; 7(1):e124. View abstract
  37. Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets. Nat Commun. 2019 10 31; 10(1):4958. View abstract
  38. A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: an ENIGMA rs-fMRI protocol. Brain Imaging Behav. 2019 Oct; 13(5):1453-1467. View abstract
  39. A framework for the investigation of rare genetic disorders in neuropsychiatry. Nat Med. 2019 10; 25(10):1477-1487. View abstract
  40. NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis. Transl Psychiatry. 2019 09 17; 9(1):230. View abstract
  41. Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways. Am J Hum Genet. 2019 08 01; 105(2):334-350. View abstract
  42. No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis. Am J Psychiatry. 2019 12 01; 176(12):1039-1049. View abstract
  43. Rare DEGS1 variant significantly alters de novo ceramide synthesis pathway. J Lipid Res. 2019 09; 60(9):1630-1639. View abstract
  44. The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder. Biol Psychiatry. 2019 10 01; 86(7):545-556. View abstract
  45. Evidence for genetic correlation between human cerebral white matter microstructure and inflammation. Hum Brain Mapp. 2019 10 01; 40(14):4180-4191. View abstract
  46. A neural signature of metabolic syndrome. Hum Brain Mapp. 2019 08 15; 40(12):3575-3588. View abstract
  47. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2019 May 01; 10(1):2068. View abstract
  48. Family-based analyses reveal novel genetic overlap between cytokine interleukin-8 and risk for suicide attempt. Brain Behav Immun. 2019 08; 80:292-299. View abstract
  49. Distinct resting state functional connectivity abnormalities in hoarding disorder and major depressive disorder. J Psychiatr Res. 2019 06; 113:108-116. View abstract
  50. Person-Based Brain Morphometric Similarity is Heritable and Correlates With Biological Features. Cereb Cortex. 2019 02 01; 29(2):852-862. View abstract
  51. Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies. Am J Hum Genet. 2019 02 07; 104(2):260-274. View abstract
  52. Cognitive impairment from early to middle adulthood in patients with affective and nonaffective psychotic disorders. Psychol Med. 2020 01; 50(1):48-57. View abstract
  53. Human Cortical Thickness Organized into Genetically-determined Communities across Spatial Resolutions. Cereb Cortex. 2019 01 01; 29(1):106-118. View abstract
  54. fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder. Hum Brain Mapp. 2019 04 01; 40(5):1608-1617. View abstract
  55. Genomic kinship construction to enhance genetic analyses in the human connectome project data. Hum Brain Mapp. 2019 04 01; 40(5):1677-1688. View abstract
  56. Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process? Biol Psychiatry. 2019 04 01; 85(7):e35-e39. View abstract
  57. A QTL on chromosome 3q23 influences processing speed in humans. Genes Brain Behav. 2019 04; 18(4):e12530. View abstract
  58. Altered amygdala circuits underlying valence processing among manic and depressed phases in bipolar adults. J Affect Disord. 2019 02 15; 245:394-402. View abstract
  59. Clinical correlates of subsyndromal depression in African American individuals with psychosis: The relationship with positive symptoms and comorbid substance dependence. Schizophr Res. 2019 04; 206:333-346. View abstract
  60. Mega-Analysis of Gray Matter Volume in Substance Dependence: General and Substance-Specific Regional Effects. Am J Psychiatry. 2019 02 01; 176(2):119-128. View abstract
  61. Genetic influence on cognitive development between childhood and adulthood. Mol Psychiatry. 2021 02; 26(2):656-665. View abstract
  62. Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia. Mol Psychiatry. 2020 03; 25(3):584-602. View abstract
  63. Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Mol Psychiatry. 2020 09; 25(9):2130-2143. View abstract
  64. Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes. Nat Commun. 2018 08 14; 9(1):3254. View abstract
  65. Comparison of heritability estimates on resting state fMRI connectivity phenotypes using the ENIGMA analysis pipeline. Hum Brain Mapp. 2018 12; 39(12):4893-4902. View abstract
  66. Disentangling the genetic overlap between cholesterol and suicide risk. Neuropsychopharmacology. 2018 12; 43(13):2556-2563. View abstract
  67. Multi-Trait Analysis of GWAS and Biological Insights Into Cognition: A Response to Hill (2018). Twin Res Hum Genet. 2018 10; 21(5):394-397. View abstract
  68. Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat Neurosci. 2018 Jul; 21(7):1017. View abstract
  69. Rediscovering the value of families for psychiatric genetics research. Mol Psychiatry. 2019 04; 24(4):523-535. View abstract
  70. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet. 2018 07; 50(7):912-919. View abstract
  71. Assessment of Cognition and Personality as Potential Endophenotypes in the Western Australian Family Study of Schizophrenia. Schizophr Bull. 2018 06 06; 44(4):908-921. View abstract
  72. On testing for spatial correspondence between maps of human brain structure and function. Neuroimage. 2018 09; 178:540-551. View abstract
  73. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun. 2018 05 29; 9(1):2098. View abstract
  74. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Proc Natl Acad Sci U S A. 2018 05 29; 115(22):E5154-E5163. View abstract
  75. Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry. 2018 11 01; 84(9):644-654. View abstract
  76. Reproducibility of myelin content-based human habenula segmentation at 3 Tesla. Hum Brain Mapp. 2018 07; 39(7):3058-3071. View abstract
  77. Heritability estimates on resting state fMRI data using ENIGMA analysis pipeline. Pac Symp Biocomput. 2018; 23:307-318. View abstract
  78. Neural mechanism and heritability of complex motor sequence and audiovisual integration: A healthy twin study. Hum Brain Mapp. 2018 03; 39(3):1438-1448. View abstract
  79. Shared Genetic Factors Influence Head Motion During MRI and Body Mass Index. Cereb Cortex. 2017 12 01; 27(12):5539-5546. View abstract
  80. Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nat Neurosci. 2017 12; 20(12):1661-1668. View abstract
  81. Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets. Cell Rep. 2017 Nov 28; 21(9):2597-2613. View abstract
  82. Cognitive genomics: Searching for the genetic roots of neuropsychological functioning. Neuropsychology. 2017 11; 31(8):1003-1019. View abstract
  83. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Mol Psychiatry. 2018 05; 23(5):1261-1269. View abstract
  84. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging Behav. 2017 Oct; 11(5):1497-1514. View abstract
  85. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol Psychiatry. 2017 11; 22(11):1651-1652. View abstract
  86. Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging. Mach Learn Med Imaging. 2017 Sep; 10541:371-378. View abstract
  87. Assessing neural tuning for object perception in schizophrenia and bipolar disorder with multivariate pattern analysis of fMRI data. Neuroimage Clin. 2017; 16:491-497. View abstract
  88. Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies. Eur Psychiatry. 2017 10; 46:25-32. View abstract
  89. Deficits in visual working-memory capacity and general cognition in African Americans with psychosis. Schizophr Res. 2018 03; 193:100-106. View abstract
  90. The Role of Intrinsic Brain Functional Connectivity in Vulnerability and Resilience to Bipolar Disorder. Am J Psychiatry. 2017 12 01; 174(12):1214-1222. View abstract
  91. The Processing-Speed Impairment in Psychosis Is More Than Just Accelerated Aging. Schizophr Bull. 2017 07 01; 43(4):814-823. View abstract
  92. Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group. Hum Brain Mapp. 2017 09; 38(9):4444-4458. View abstract
  93. Inferring pathobiology from structural MRI in schizophrenia and bipolar disorder: Modeling head motion and neuroanatomical specificity. Hum Brain Mapp. 2017 08; 38(8):3757-3770. View abstract
  94. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 2018 04; 23(4):932-942. View abstract
  95. Epigenetic Age Acceleration Assessed with Human White-Matter Images. J Neurosci. 2017 05 03; 37(18):4735-4743. View abstract
  96. Using Polygenic Risk Scores to Establish Endophenotypes: Considerations and Current Constraints. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 03; 2(2):113-114. View abstract
  97. Serum phosphatidylinositol as a biomarker for bipolar disorder liability. Bipolar Disord. 2017 03; 19(2):107-115. View abstract
  98. The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk. Eur Psychiatry. 2017 06; 43:44-50. View abstract
  99. Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 01 18; 8:13624. View abstract
  100. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium. Mol Psychiatry. 2017 03; 22(3):336-345. View abstract
  101. Deconstructing Bipolar Disorder and Schizophrenia: A cross-diagnostic cluster analysis of cognitive phenotypes. J Affect Disord. 2017 Feb; 209:71-79. View abstract
  102. Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. BMC Proc. 2016; 10(Suppl 7):71-77. View abstract
  103. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016 12; 19(12):1569-1582. View abstract
  104. The genetic basis of the comorbidity between cannabis use and major depression. Addiction. 2017 01; 112(1):113-123. View abstract
  105. Enhancing the Informativeness and Replicability of Imaging Genomics Studies. Biol Psychiatry. 2017 08 01; 82(3):157-164. View abstract
  106. Effect of alcohol and illicit substance use on verbal memory among individuals with bipolar disorder. Psychiatry Res. 2016 Sep 30; 243:225-231. View abstract
  107. Genome-wide significant loci for addiction and anxiety. Eur Psychiatry. 2016 08; 36:47-54. View abstract
  108. Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades. Front Aging Neurosci. 2016; 8:137. View abstract
  109. Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation. Stem Cells Int. 2016; 2016:2349261. View abstract
  110. A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings. Hum Brain Mapp. 2016 10; 37(10):3474-85. View abstract
  111. Lipidomic risk score independently and cost-effectively predicts risk of future type 2 diabetes: results from diverse cohorts. Lipids Health Dis. 2016 Apr 04; 15:67. View abstract
  112. Soluble Forms of Intercellular and Vascular Cell Adhesion Molecules Independently Predict Progression to Type 2 Diabetes in Mexican American Families. PLoS One. 2016; 11(3):e0151177. View abstract
  113. Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele. J Affect Disord. 2016 Jul 01; 198:198-205. View abstract
  114. Abnormal Ventral and Dorsal Attention Network Activity during Single and Dual Target Detection in Schizophrenia. Front Psychol. 2016; 7:323. View abstract
  115. Electrophysiological Endophenotypes for Schizophrenia. Harv Rev Psychiatry. 2016 Mar-Apr; 24(2):129-47. View abstract
  116. Subcortical volumetric abnormalities in bipolar disorder. Mol Psychiatry. 2016 12; 21(12):1710-1716. View abstract
  117. Psychotic Experiences and Neuropsychological Functioning in a Population-based Sample. JAMA Psychiatry. 2016 Feb; 73(2):129-38. View abstract
  118. Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families. Clin Epigenetics. 2016; 8:6. View abstract
  119. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E219-28. View abstract
  120. Long-term neural and physiological phenotyping of a single human. Nat Commun. 2015 Dec 09; 6:8885. View abstract
  121. ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. Neuroimage. 2017 01 15; 145(Pt B):389-408. View abstract
  122. Genome-wide linkage on chromosome 10q26 for a dimensional scale of major depression. J Affect Disord. 2016 Feb; 191:123-31. View abstract
  123. Genetic imaging consortium for addiction medicine: From neuroimaging to genes. Prog Brain Res. 2016; 224:203-23. View abstract
  124. Recurrent major depression and right hippocampal volume: A bivariate linkage and association study. Hum Brain Mapp. 2016 Jan; 37(1):191-202. View abstract
  125. Genome-wide significant linkage of schizophrenia-related neuroanatomical trait to 12q24. . 2015 Dec; 168(8):678-86. View abstract
  126. Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk. Schizophr Bull. 2016 Mar; 42(2):288-300. View abstract
  127. Genome-wide autozygosity is associated with lower general cognitive ability. Mol Psychiatry. 2016 06; 21(6):837-43. View abstract
  128. Genetics of cognitive control: Implications for Nimh's research domain criteria initiative. . 2016 Jan; 171B(1):111-20. View abstract
  129. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry. 2016 Apr; 21(4):585. View abstract
  130. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Mol Psychiatry. 2016 Apr; 21(4):547-53. View abstract
  131. Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment. . 2015 Jul; 168B(5):363-73. View abstract
  132. Brain structure-function associations in multi-generational families genetically enriched for bipolar disorder. Brain. 2015 Jul; 138(Pt 7):2087-102. View abstract
  133. Neuroimaging data sharing on the neuroinformatics database platform. Neuroimage. 2016 Jan 01; 124(Pt B):1089-1092. View abstract
  134. Cortisol Stress Response in Men and Women Modulated Differentially by the Mu-Opioid Receptor Gene Polymorphism OPRM1 A118G. Neuropsychopharmacology. 2015 Oct; 40(11):2546-54. View abstract
  135. Fast and powerful heritability inference for family-based neuroimaging studies. Neuroimage. 2015 Jul 15; 115:256-68. View abstract
  136. Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. Neuroimage. 2015 May 01; 111:300-11. View abstract
  137. The puzzle of processing speed, memory, and executive function impairments in schizophrenia: fitting the pieces together. Biol Psychiatry. 2015 Dec 01; 78(11):786-93. View abstract
  138. Shared genetic variance between obesity and white matter integrity in Mexican Americans. Front Genet. 2015; 6:26. View abstract
  139. Common genetic variants influence human subcortical brain structures. Nature. 2015 Apr 09; 520(7546):224-9. View abstract
  140. Patterns of Gray Matter Abnormalities in Schizophrenia Based on an International Mega-analysis. Schizophr Bull. 2015 Sep; 41(5):1133-42. View abstract
  141. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):18031-6. View abstract
  142. Genome-Wide Analyses of Working-Memory Ability: A Review. Curr Behav Neurosci Rep. 2014 Dec; 1(4):224-233. View abstract
  143. Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage. Am J Psychiatry. 2015 Feb 01; 172(2):190-9. View abstract
  144. Shared genetic factors influence amygdala volumes and risk for alcoholism. Neuropsychopharmacology. 2015 Jan; 40(2):412-20. View abstract
  145. Discovering schizophrenia endophenotypes in randomly ascertained pedigrees. Biol Psychiatry. 2015 Jan 01; 77(1):75-83. View abstract
  146. Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history. Schizophr Bull. 2014 Nov; 40(6):1227-43. View abstract
  147. Impact of family structure and common environment on heritability estimation for neuroimaging genetics studies using Sequential Oligogenic Linkage Analysis Routines. J Med Imaging (Bellingham). 2014 Jun 27; 1(1):014005. View abstract
  148. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav. 2014 Jun; 8(2):153-82. View abstract
  149. Influence of age, sex and genetic factors on the human brain. Brain Imaging Behav. 2014 Jun; 8(2):143-52. View abstract
  150. Anomalous temporoparietal activity in individuals with a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res. 2014 Jun; 38(6):1639-45. View abstract
  151. Altered global brain signal in schizophrenia. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7438-43. View abstract
  152. Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res. 2014 Jun; 38(6):1575-81. View abstract
  153. KIBRA, aging, and gene by environmental interaction: an effect to remember? Biol Psychiatry. 2014 May 01; 75(9):674-5. View abstract
  154. Ventral anterior cingulate connectivity distinguished nonpsychotic bipolar illness from psychotic bipolar disorder and schizophrenia. Schizophr Bull. 2015 Jan; 41(1):133-43. View abstract
  155. Heritable changes in regional cortical thickness with age. Brain Imaging Behav. 2014 Jun; 8(2):208-16. View abstract
  156. Cortical Volume Alterations in Conduct Disordered Adolescents with and without Bipolar Disorder. J Clin Med. 2014 Apr 16; 3(2):416-31. View abstract
  157. Common genetic variants and gene expression associated with white matter microstructure in the human brain. Neuroimage. 2014 Aug 15; 97:252-61. View abstract
  158. Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees. JAMA Psychiatry. 2014 Apr; 71(4):375-87. View abstract
  159. Novel QTL at chromosome 6p22 for alcohol consumption: Implications for the genetic liability of alcohol use disorders. . 2014 Jun; 165B(4):294-302. View abstract
  160. Neural substrates of visual masking by object substitution in schizophrenia. Hum Brain Mapp. 2014 Sep; 35(9):4654-62. View abstract
  161. Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling. Neuroimage. 2014 Jul 15; 95:136-50. View abstract
  162. Changes in GABA and glutamate concentrations during memory tasks in patients with Parkinson's disease undergoing DBS surgery. Front Hum Neurosci. 2014; 8:81. View abstract
  163. Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics. . 2014 Mar; 165B(2):122-30. View abstract
  164. Cross-diagnostic comparison of visual processing in bipolar disorder and schizophrenia. J Psychiatr Res. 2014 Apr; 51:42-8. View abstract
  165. Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Front Psychiatry. 2013 Dec 24; 4:169. View abstract
  166. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT). Mol Psychiatry. 2014 Feb; 19(2):168-74. View abstract
  167. Shared genetic factors influence risk for bipolar disorder and alcohol use disorders. Eur Psychiatry. 2014 Jun; 29(5):282-7. View abstract
  168. Genome-wide significant localization for working and spatial memory: Identifying genes for psychosis using models of cognition. . 2014 Jan; 165B(1):84-95. View abstract
  169. Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19006-11. View abstract
  170. Reduced white matter integrity in sibling pairs discordant for bipolar disorder. Am J Psychiatry. 2013 Nov; 170(11):1317-25. View abstract
  171. Neuroinformatics Database (NiDB)--a modular, portable database for the storage, analysis, and sharing of neuroimaging data. Neuroinformatics. 2013 Oct; 11(4):495-505. View abstract
  172. Identification of pleiotropic genetic effects on obesity and brain anatomy. Hum Hered. 2013; 75(2-4):136-43. View abstract
  173. Sulcal depth-position profile is a genetically mediated neuroscientific trait: description and characterization in the central sulcus. J Neurosci. 2013 Sep 25; 33(39):15618-25. View abstract
  174. Impulsivity and risk taking in bipolar disorder and schizophrenia. Neuropsychopharmacology. 2014 Jan; 39(2):456-63. View abstract
  175. Multi-region hemispheric specialization differentiates human from nonhuman primate brain function. Brain Struct Funct. 2014 Nov; 219(6):2187-94. View abstract
  176. Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness. Cereb Cortex. 2014 Dec; 24(12):3116-30. View abstract
  177. Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study. Biol Psychiatry. 2013 Sep 15; 74(6):458-66. View abstract
  178. Transcriptomics of cortical gray matter thickness decline during normal aging. Neuroimage. 2013 Nov 15; 82:273-83. View abstract
  179. Genetics of the connectome. Neuroimage. 2013 Oct 15; 80:475-88. View abstract
  180. Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. Neuroimage. 2013 Nov 01; 81:455-469. View abstract
  181. Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment. Am J Psychiatry. 2013 Mar; 170(3):334-41. View abstract
  182. Polygenic risk and white matter integrity in individuals at high risk of mood disorder. Biol Psychiatry. 2013 Aug 15; 74(4):280-6. View abstract
  183. Can risk-taking be an endophenotype for bipolar disorder? A study on patients with bipolar disorder type I and their first-degree relatives. J Int Neuropsychol Soc. 2013 Apr; 19(4):474-82. View abstract
  184. Neurocognitive phenomics: examining the genetic basis of cognitive abilities. Psychol Med. 2013 Oct; 43(10):2027-36. View abstract
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