Research Overview

 Fred Wu is co-director of the Fontan clinic at Boston Children's Hospital. Dr. Wu received his MD from the University of Michigan. He completed residency in internal medicine and pediatrics and a fellowship in cardiovascular disease at the University of Minnesota Medical Center and an advanced
fellowship in adult congenital heart disease at Harvard Medical School.

Dr. Wu's research on innovative approaches to single ventricle care has been supported by the Boston Children’s Hospital’s Innovation & Digital Health Accelerator and the Additional Ventures Single Ventricle Research Fund.

Education

Undergraduate School

University of Michigan
1996 Ann Arbor MI

Medical School

University of Michigan
1999 Ann Arbor MI

Internship

University of Minnesota Medical School
2000 Minneapolis MN

Residency

University of Minnesota Medical School
2003 Minneapolis MN

Fellowship

Cardiovascular Medicine (Adult) University of Minnesota Medical School
2006 Minneapolis MN

Fellowship

Boston Children's Hospital
2007 Boston MA

Media

Cardiac Conversations

Listen to our experts as they discuss caring for the adult congenital heart.

Publications

  1. Characteristics and Survival Outcomes of Hepatocellular Carcinoma After the Fontan Operation. JACC Adv. 2025 Apr; 4(4):101646. View Abstract
  2. Acute Effects of Enhanced External Counterpulsation in Adults With Fontan Circulation. JACC Adv. 2025 Mar; 4(3):101591. View Abstract
  3. Electrocardiographic Changes in Pregnant Patients With Congenital Heart Disease Ann Noninvasive Electrocardiol. 2025 01; 30(1):e70037. View Abstract
  4. Hepatocellular carcinoma in survivors after Fontan operation: a case-control study. Eur Heart J. 2024 Apr 21; 45(16):1477-1480. View Abstract
  5. Dyslipidemia Among Adults With Congenital Heart Disease. JACC Adv. 2022 Oct; 1(4):100081. View Abstract
  6. Placental Findings in Pregnancies Complicated by Maternal Cardiovascular Disease. JACC Adv. 2022 Mar; 1(1):100008. View Abstract
  7. Placental Findings in Pregnancies Complicated by Maternal Cardiovascular Disease. JACC Advances. 2022; 1(1):1-11. View Abstract
  8. Associations Between Clinical Outcomes and a Recently Proposed Adult Congenital Heart Disease Anatomic and Physiological Classification System. J Am Heart Assoc. 2021 09 21; 10(18):e021345. View Abstract
  9. Timing of Delivery in Women with Cardiac Disease. Am J Perinatol. 2022 08; 39(11):1196-1203. View Abstract
  10. Intraperitoneal corticosteroids for recurrent ascites in patients with Fontan circulation: Initial clinical experience. J Card Surg. 2021 Feb; 36(2):735-738. View Abstract
  11. Cardiovascular outcomes of pregnancy in Turner syndrome. Heart. 2021 01; 107(1):61-66. View Abstract
  12. Assessment and management of heart failure in the systemic right ventricle. Heart Fail Rev. 2020 07; 25(4):609-621. View Abstract
  13. Surveillance and screening practices of New England congenital cardiologists for patients after the Fontan operation. Congenit Heart Dis. 2019 Nov; 14(6):1013-1023. View Abstract
  14. Fontan Liver Lesions: Not Always HCC. JACC Case Rep. 2019 Aug; 1(2):175-178. View Abstract
  15. Hemodynamic Effects of Paracentesis in a Patient With a Fontan Circulation. World J Pediatr Congenit Heart Surg. 2019 05; 10(3):357-359. View Abstract
  16. Relationship of Red Cell Distribution Width to Adverse Outcomes in Adults With Congenital Heart Disease (from the Boston Adult Congenital Heart Biobank). Am J Cardiol. 2018 11 01; 122(9):1557-1564. View Abstract
  17. A Pilot Study of Inspiratory Muscle Training to Improve Exercise Capacity in Patients with Fontan Physiology. Semin Thorac Cardiovasc Surg. 2018 Winter; 30(4):462-469. View Abstract
  18. Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association. Circulation. 2017 Nov 14; 136(20):e348-e392. View Abstract
  19. Liver health in adults with Fontan circulation: A multicenter cross-sectional study. J Thorac Cardiovasc Surg. 2017 03; 153(3):656-664. View Abstract
  20. Predictive value of biomarkers of hepatic fibrosis in adult Fontan patients. J Heart Lung Transplant. 2017 Feb; 36(2):211-219. View Abstract
  21. Clinical Approaches to the Patient with a Failing Fontan Procedure. Curr Cardiol Rep. 2016 May; 18(5):44. View Abstract
  22. Galectin-3 Is Elevated and Associated With Adverse Outcomes in Patients With Single-Ventricle Fontan Circulation. J Am Heart Assoc. 2016 Jan 11; 5(1). View Abstract
  23. Portal and centrilobular hepatic fibrosis in Fontan circulation and clinical outcomes. J Heart Lung Transplant. 2015 Jul; 34(7):883-91. View Abstract
  24. Pheochromocytoma and paraganglioma in cyanotic congenital heart disease. J Clin Endocrinol Metab. 2015 Apr; 100(4):1325-34. View Abstract
  25. Exercise oscillatory ventilation in patients with Fontan physiology. Circ Heart Fail. 2015 Mar; 8(2):304-11. View Abstract
  26. Rare case of undiagnosed supracardiac total anomalous pulmonary venous return in an adult. Circulation. 2014 Sep 30; 130(14):1205-7. View Abstract
  27. Inadequate venous return as a primary cause for Fontan circulatory limitation. J Heart Lung Transplant. 2014 Nov; 33(11):1194-6. View Abstract
  28. Abnormal spirometry after the Fontan procedure is common and associated with impaired aerobic capacity. Am J Physiol Heart Circ Physiol. 2014 Jul 01; 307(1):H110-7. View Abstract
  29. Transient elastography may identify Fontan patients with unfavorable hemodynamics and advanced hepatic fibrosis. Congenit Heart Dis. 2014 Sep-Oct; 9(5):438-47. View Abstract
  30. Outcomes of adolescents and adults undergoing primary Fontan procedure. Am J Cardiol. 2013 Dec 15; 112(12):1938-42. View Abstract
  31. MELD-XI score and cardiac mortality or transplantation in patients after Fontan surgery. Heart. 2013 Apr; 99(7):491-6. View Abstract
  32. Single ventricle anatomy is associated with increased frequency of nonalcoholic cirrhosis. Int J Cardiol. 2013 Sep 01; 167(5):1918-23. View Abstract
  33. Liver disease in the patient with Fontan circulation. Congenit Heart Dis. 2011 May-Jun; 6(3):190-201. View Abstract
  34. Images in clinical medicine. Colonic saccular diverticula. N Engl J Med. 2008 Sep 18; 359(12):e13. View Abstract
  35. Extrapericardial cardiac compression syndrome. Int J Cardiol. 2006 Nov 10; 113(2):285-7. View Abstract

Contact Fred Ming-Chieh Wu

Phone: 617-355-6508
Fax: 617-730-7540
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