ABOUT THE RESEARCHER

OVERVIEW

Dr Fu’s research interest is in the understanding of basic mechanism of retinal neurovascular biology, particularly the metabolic effects on diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration.

BACKGROUND

Dr. Fu graduated from the Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong with a Ph.D. in Ophthalmology and joined Prof. Lois Smith’s group at Ophthalmology, Boston Children’s Hospital for postdoctoral training. Dr. Fu’s current focus is to investigate the effects of diets, hormones, glucose/lipid metabolism on the progression of retinopathies.

PUBLICATIONS

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  1. Cellular senescence in pathologic retinal angiogenesis. Trends Endocrinol Metab. 2021 07; 32(7):415-416. View abstract
  2. Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration. iScience. 2021 Apr 23; 24(4):102376. View abstract
  3. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2021 Feb 06; 62:100035. View abstract
  4. Vitreous metabolomics profiling of proliferative diabetic retinopathy. Diabetologia. 2021 Jan; 64(1):70-82. View abstract
  5. IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants. JCI Insight. 2020 10 02; 5(19). View abstract
  6. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 Aug; 6(35):eaba7457. View abstract
  7. An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis. J Vis Exp. 2020 08 06; (162). View abstract
  8. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. View abstract
  9. Targeting Neurovascular Interaction in Retinal Disorders. Int J Mol Sci. 2020 Feb 22; 21(4). View abstract
  10. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. View abstract
  11. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). View abstract
  12. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. View abstract
  13. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. View abstract
  14. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018 01; 10(1):76-90. View abstract
  15. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. View abstract
  16. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. View abstract
  17. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View abstract
  18. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. View abstract
  19. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. View abstract
  20. Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity. Clin Exp Ophthalmol. 2017 Jul; 45(5):529-538. View abstract
  21. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. View abstract
  22. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. View abstract
  23. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. View abstract
  24. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View abstract
  25. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View abstract
  26. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2015 Sep; 253(9):1503-13. View abstract
  27. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View abstract
  28. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View abstract
  29. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View abstract
  30. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013; 126(3):2161-0940. View abstract
  31. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev. 2012; 2012:426769. View abstract
  32. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Invest Ophthalmol Vis Sci. 2012 Sep 06; 53(10):5976-84. View abstract
  33. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 20; 53(9):5698-712. View abstract
  34. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012 Jan; 45(1):624-32. View abstract
  35. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):836-43. View abstract