ABOUT THE RESEARCHER

OVERVIEW

Dr Fu’s research interest is in the understanding of basic mechanism of retinal neurovascular biology, particularly the metabolic effects on diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration.

BACKGROUND

Dr. Fu graduated from the Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong with a Ph.D. in Ophthalmology and joined Prof. Lois Smith’s group at Ophthalmology, Boston Children’s Hospital for postdoctoral training. Dr. Fu’s current focus is to investigate the effects of diets, hormones, glucose/lipid metabolism on the progression of retinopathies.

Awards:

  1. Asia-ARVO 2017 Travel Grant

2016: Knights Templar Eye Foundation Pediatric Ophthalmology Competitive Renewal Research Award

2015: The Bernadotte Foundation Travel Award, New York, USA.

2015: Knights Templar Eye Foundation Pediatric Ophthalmology Career-starter Research Award, Flower Mound, TX, USA.

Selected Publications

First-authored:

  1. Z Fu, Y Gong, R Liegl, Z Wang, CH Liu, S Meng, S Burnim, N Saba, TW Fredrick, PC Morss, A Hellstrom, S Talukdar, LEH Smith. FGF21 administration suppresses retinal and choroidal neovascularization. Cell Reports. 2017 Feb 14;18(7):1606-1613. PMID: 28199833.
  2. Z Fu, SS Meng, SS Burnim, LEH Smith, ACY Lo, Lutein facilitates physiological revascularization in a mouse model of oxygen-induced retinopathy. Clinical and Experimental Ophthalmology. 2017 Dec. PMID: 28002872.
  3. Z Fu, Y Gong, C Lofqvist, A Hellstrom, LEH Smith. Review: adiponectin in retinopathy. BBA – Molecular Basis of Disease. 2016 May 4;1862(8):1392-1400. PMID: 27155572.
  4. Z Fu, S Nian, SY Li, D Wong, SK Chung and ACY Lo. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefe's Archive for Clinical and Experimental Ophthalmology 2015. Sep;253(9):1503-13. PMID: 25921391.
  5. Z Fu, C. Lofqvist, Z Shao, Y Sun, JS Joyal, C Hurst, R Cui, L Evans, K Tian, J SanGiovanni, J Chen, D Ley, IH Pupp, A Hellstrom, LEH. Smith. Dietary ω3 polyunsaturated-fatty-acid decreases retinal neovascularization by adipose-ER-stress reduction to increase adiponectin. The American Journal of Clinical Nutrition. 2015 Apr;101(4):879-88. PMID: 25833984
  6. Z Shao*, Z Fu*, A Stahl, JS Joyal, C Hatton, A Juan, C Hurst, L Evans, Z Cui, D Pei, Y Gong, D Xu, K Tian, H Bogardus, ML Edin, F Lih, P Sapieha, J Chen, D Panigrahy, A Hellstrom, DC Zeldin, LEH Smith. Cytochrome P450 2C8 ω3LCPUFA metabolites increase mouse retinal pathologic neovascularization. Arteriosclerosis, Thrombosis, and Vascular Biology, Brief Report34(3):581-6. PMID: 24458713 (* Equal Contribution)
  7. Z Fu, SY Li, N Kociok, D Wong, SK Chung and ACY Lo. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Investigative Ophthalmology & Visual Science 2012 53(9):5698-712. PMID: 22836764

Co-authored:

  1. Gong, Z. Shao, Z Fu, ML. Edin, Y. Sun, RG. Liegl, Z. Wang, CH. Liu, SB. Burnim, SS. Meng, FB, Lih, JP SanGiovannie, DC. Zeldin, A. Hellstrom, LEH. Smith. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov;13:201-211. PMID: 27720395.
  2. Gong, Z Fu, ML. Edin, CH. Liu, Z. Wang, Z. Shao, TW. Fredrick, NJ. Saba, PC, Morss, SB. Burnim, SS. Meng, FB, Lih, KSS. Lee, EP. Moran, JP SanGiovannie, A. Hellstrom, BD. Hammock, DC. Zeldin, LEH. Smith. Cytochrome P450 oxidase 2C inhibition adds to omega-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016. Sep;36(9):1919-27. PMID:27417579.
  3. JS Joyal, Y Sun, M Gantner, Z Shao, L Evans, N Saba, T Fredrick, S Burnim, JS Kim, G Patel, A Juan, C Hurst, C Hatton, Z Cui, K Pierce, P Bherer, E Aguilar, M Powner, K Vevis, M Boisvert, Z Fu, E Levy, M Fruttiger, A Packard, F Rezende, B Maranda,, P Sapieha, J Chen, M Friedlander, CB. Clish and LEH Smith. Retinal lipid and glucose metabolism dictates angiogenesis through lipid sensor Ffar1. Nature Medicine. Apr;22(4):439-45. PMID: 26974308.
  4. Y Gong, J Li, Y Sun, Z Fu, CH Liu, L Evans, K Tian, N Saba, T Fredrick, P Morss, J Chen, LEH Smith. Optimization of an Image-guided Laser-induced Choroidal Neovascularization Model in Mice. PloS One. 2015. Jul 10;10(7). PMID: 26161975.
  5. J Li, C Liu, Y Sun, Y Gong, Z Fu, L Evans, K Tian, A Juan, Christian Hurst, A Mammoto, J Chen. Endothelial Twist1 promotes pathological ocular angiogenesis. Investigative Ophthalmology & Visual Science Nov 20;55(12):8267-77. PMID: 25414194
  6. AKW Lai, Z Fu, ACY Lo. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013. 3(126), 2161-0940.
  7. SY Li, Z Fu, ACY Lo. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxidative Medicine and Cellular LongevityReview. Vol Article number 426769. PMID: 23125893
  8. SY Li, FKC Fung, Z Fu, HHL Chan, ACY Lo. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro Investigative Ophthalmology & Visual Science 2012. 53(10):5976-84. PMID: 22871829
  9. SY Li, D Yang, Z Fu, T Woo, D Wong and ACY Lo. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiology of Disease 45(1): 624-632. PMID: 22024715
  10. SY Li, Z Fu, H Ma, WC Jang, KF So, D Wong and ACY Lo. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Investigative Ophthalmology & Visual Science 50(2): 836-842. PMID: 18936152.

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Cellular senescence in pathologic retinal angiogenesis. Trends Endocrinol Metab. 2021 Apr 13. View abstract
  2. Vitreous metabolomics profiling of proliferative diabetic retinopathy. Diabetologia. 2021 Jan; 64(1):70-82. View abstract
  3. IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants. JCI Insight. 2020 10 02; 5(19). View abstract
  4. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 Aug; 6(35):eaba7457. View abstract
  5. An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis. J Vis Exp. 2020 08 06; (162). View abstract
  6. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 08; 23(3):385-394. View abstract
  7. Fatty acid oxidation and photoreceptor metabolic needs. J Lipid Res. 2020 02 24; 100035. View abstract
  8. Targeting Neurovascular Interaction in Retinal Disorders. Int J Mol Sci. 2020 Feb 22; 21(4). View abstract
  9. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 03 23; 52(6):779-793.e7. View abstract
  10. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). View abstract
  11. Dyslipidemia in retinal metabolic disorders. EMBO Mol Med. 2019 10; 11(10):e10473. View abstract
  12. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. View abstract
  13. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018 01; 10(1):76-90. View abstract
  14. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. View abstract
  15. Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nat Commun. 2017 09 19; 8(1):584. View abstract
  16. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. View abstract
  17. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. View abstract
  18. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. View abstract
  19. Lutein facilitates physiological revascularization in a mouse model of retinopathy of prematurity. Clin Exp Ophthalmol. 2017 Jul; 45(5):529-538. View abstract
  20. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. View abstract
  21. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. View abstract
  22. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. View abstract
  23. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View abstract
  24. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View abstract
  25. Deficiency of aldose reductase attenuates inner retinal neuronal changes in a mouse model of retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2015 Sep; 253(9):1503-13. View abstract
  26. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View abstract
  27. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View abstract
  28. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View abstract
  29. Stem cell therapy for retinopathy of prematurity. Anatomy & Physiology. 2013; 126(3):2161-0940. View abstract
  30. Hypoxia-induced oxidative stress in ischemic retinopathy. Oxid Med Cell Longev. 2012; 2012:426769. View abstract
  31. Anti-inflammatory effects of lutein in retinal ischemic/hypoxic injury: in vivo and in vitro studies. Invest Ophthalmol Vis Sci. 2012 Sep 06; 53(10):5976-84. View abstract
  32. Aldose reductase deficiency reduced vascular changes in neonatal mouse retina in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 Aug 20; 53(9):5698-712. View abstract
  33. Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke. Neurobiol Dis. 2012 Jan; 45(1):624-32. View abstract
  34. Effect of lutein on retinal neurons and oxidative stress in a model of acute retinal ischemia/reperfusion. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):836-43. View abstract