ABOUT THE RESEARCHER

OVERVIEW

Chatila’s research centers on elucidating the mechanisms involved in the breakdown of immune tolerance in monogenic disorders of immunity and in common allergic inflammatory disorders, including asthma and food allergy, with a particular focus on the role of regulatory T cells in disease pathogenesis. This research effort has led to the identification of several genetic networks that regulate immune tolerance in human subjects, including those involving FOXP3, DOCK8, LRBA and IL4R genes.

More recently, Chatila’s group has elucidated mechanisms by which the commensal microbiota and inflammatory signals via the Notch pathway control regulatory T cell functions, and established the role of pathogenic regulatory T cell reprogramming in precipitating tolerance breakdown to allergens in common allergic diseases. The long-term goal of these studies is to develop novel therapeutic approaches that re-establish immunological tolerance in diseases of immune dysregulation by manipulating regulatory T cell-specific molecular and metabolic interventions. His research is focused on genetic and regulatory mechanisms involved in the pathogenesis of human immunological diseases.

BACKGROUND

Talal Chatila, MD, was born in Beirut Lebanon, and completed his medical studies and residency training at the American University of Beirut School of Medicine. In 1985 he joined The Division of Immunology at the Boston Children’s Hospital. Thereafter, he occupied faculty positions at the Departments of Pediatrics at Harvard Medical School, Washington University in St. Louis and the University of California in Los Angeles.

In 2012, he was appointed as the Denise and David Bunning Professor of Pediatrics in the Field of Allergy and Immunology, Harvard Medical School, and senior physician, Division of Immunology, at Boston Children’s Hospital. In addition, he is the Director of the Food Allergy Program at Boston Children’s Hospital.

PUBLICATIONS

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  1. Essential functions of regulatory T cell TGF-ß1 revealed by differential gene-targeting approaches. Immunity. 2021 Mar 09; 54(3):397-398. View abstract
  2. Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming. J Clin Invest. 2021 Feb 02. View abstract
  3. Stepwise Reversal of Immune Dysregulation Due to STAT1 Gain-of-Function Mutation Following Ruxolitinib Bridge Therapy and Transplantation. J Clin Immunol. 2021 Jan 21. View abstract
  4. Author Correction: A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2021 Jan; 22(1):100. View abstract
  5. The microbial origins of food allergy. J Allergy Clin Immunol. 2021 Mar; 147(3):808-813. View abstract
  6. Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 Dec 15; 53(6):1331-1332. View abstract
  7. The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. Immunity. 2020 Nov 17; 53(5):971-984.e5. View abstract
  8. Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 Dec 15; 53(6):1202-1214.e6. View abstract
  9. A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma. Nat Immunol. 2020 11; 21(11):1359-1370. View abstract
  10. Dietary and Microbial Determinants in Food Allergy. Immunity. 2020 Aug 18; 53(2):277-289. View abstract
  11. Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. J Exp Med. 2020 06 01; 217(6). View abstract
  12. Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome. J Exp Med. 2020 06 01; 217(7). View abstract
  13. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020 03 26; 5(6). View abstract
  14. Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. J Clin Immunol. 2020 01; 40(1):66-81. View abstract
  15. Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2020 01; 40(1):24-64. View abstract
  16. Correction to: Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2020 Jan; 40(1):65. View abstract
  17. The immunologic features of patients with early-onset and polyautoimmunity. Clin Immunol. 2020 02; 211:108326. View abstract
  18. Hypomorphic DOCK8 deletion causes hypereosinophilic syndrome. Pediatr Blood Cancer. 2020 02; 67(2):e28084. View abstract
  19. ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients. Allergy. 2020 04; 75(4):921-932. View abstract
  20. Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma. J Allergy Clin Immunol. 2020 03; 145(3):897-906. View abstract
  21. Combined immunodeficiency caused by a loss-of-function mutation in DNA polymerase delta 1. J Allergy Clin Immunol. 2020 01; 145(1):391-401.e8. View abstract
  22. Mechanisms of Dupilumab. Clin Exp Allergy. 2020 01; 50(1):5-14. View abstract
  23. Regulatory T Cells: the Many Faces of Foxp3. J Clin Immunol. 2019 10; 39(7):623-640. View abstract
  24. Author Correction: Microbiota therapy acts via a regulatory T cell MyD88/ROR?t pathway to suppress food allergy. Nat Med. 2019 Sep; 25(9):1458. View abstract
  25. Functional reprogramming of regulatory T cells in the absence of Foxp3. Nat Immunol. 2019 09; 20(9):1208-1219. View abstract
  26. Regulation of oral immune tolerance by the microbiome in food allergy. Curr Opin Immunol. 2019 10; 60:141-147. View abstract
  27. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. View abstract
  28. Microbiota therapy acts via a regulatory T cell MyD88/ROR?t pathway to suppress food allergy. Nat Med. 2019 07; 25(7):1164-1174. View abstract
  29. Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency. J Allergy Clin Immunol Pract. 2019 Nov - Dec; 7(8):2790-2800.e15. View abstract
  30. Treatment of severe persistent asthma with IL-6 receptor blockade. J Allergy Clin Immunol Pract. 2019 May - Jun; 7(5):1639-1642.e4. View abstract
  31. Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions". J Allergy Clin Immunol. 2019 03; 143(3):894-913. View abstract
  32. Hematopoietic Stem Cell Transplantation in Patients with Heterozygous STAT1 Gain-of-Function Mutation. J Clin Immunol. 2019 01; 39(1):37-44. View abstract
  33. EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease. J Allergy Clin Immunol. 2019 02; 143(2):782-785.e1. View abstract
  34. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol. 2018 06 15; 3(24). View abstract
  35. Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function. Clin Exp Allergy. 2018 07; 48(7):825-836. View abstract
  36. Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects. J Allergy Clin Immunol. 2018 12; 142(6):1932-1946. View abstract
  37. WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779. View abstract
  38. A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles. J Allergy Clin Immunol. 2018 10; 142(4):1243-1256.e17. View abstract
  39. Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases. F1000Res. 2018; 7:38. View abstract
  40. A young girl with severe cerebral fungal infection due to card 9 deficiency. Clin Immunol. 2018 06; 191:21-26. View abstract
  41. International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity. J Clin Immunol. 2018 01; 38(1):96-128. View abstract
  42. The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. J Clin Immunol. 2018 01; 38(1):129-143. View abstract
  43. A simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells. Eur J Immunol. 2017 12; 47(12):2039-2042. View abstract
  44. DOCK8 Deficiency Presenting as an IPEX-Like Disorder. J Clin Immunol. 2017 Nov; 37(8):811-819. View abstract
  45. Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content. Front Immunol. 2017; 8:1244. View abstract
  46. Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children. J Allergy Clin Immunol. 2018 02; 141(2):794-796.e3. View abstract
  47. Monogenic Hashimoto thyroiditis associated with a variant in the thyroglobulin (TG) gene. J Autoimmun. 2018 01; 86:116-119. View abstract
  48. Clinical, immunologic, and genetic spectrum of 696 patients with combined immunodeficiency. J Allergy Clin Immunol. 2018 04; 141(4):1450-1458. View abstract
  49. DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells. Clin Immunol. 2017 10; 183:263-265. View abstract
  50. Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content. Front Immunol. 2017; 8:798. View abstract
  51. DOCK8 deficiency: Insights into pathophysiology, clinical features and management. Clin Immunol. 2017 08; 181:75-82. View abstract
  52. Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation. J Allergy Clin Immunol. 2018 03; 141(3):1050-1059.e10. View abstract
  53. CTLA-4 haploinsufficiency in a patient with an autoimmune lymphoproliferative disorder. J Allergy Clin Immunol. 2017 09; 140(3):862-864.e4. View abstract
  54. Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. J Allergy Clin Immunol. 2017 May; 139(5):1629-1640.e2. View abstract
  55. Deciphering the black box of food allergy mechanisms. Ann Allergy Asthma Immunol. 2017 01; 118(1):21-27. View abstract
  56. The role of the gut microbiota in food allergy. Curr Opin Pediatr. 2016 12; 28(6):748-753. View abstract
  57. Advances in food allergy oral immunotherapy: toward tolerance. Curr Opin Immunol. 2016 10; 42:119-123. View abstract
  58. Temporal Regulation by Innate Type 2 Cytokines in Food Allergies. Curr Allergy Asthma Rep. 2016 10; 16(10):75. View abstract
  59. Regulatory T cells in allergic diseases. J Allergy Clin Immunol. 2016 09; 138(3):639-652. View abstract
  60. Innate Immunity in Asthma. N Engl J Med. 2016 Aug 04; 375(5):477-9. View abstract
  61. An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. Nat Med. 2016 09; 22(9):1013-22. View abstract
  62. Severe Early-Onset Combined Immunodeficiency due to Heterozygous Gain-of-Function Mutations in STAT1. J Clin Immunol. 2016 10; 36(7):641-8. View abstract
  63. Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J Allergy Clin Immunol. 2016 07; 138(1):47-56. View abstract
  64. CD4(+)CD25(hi)Foxp3(+) Cells Exacerbate Bleomycin-Induced Pulmonary Fibrosis. Am J Pathol. 2016 08; 186(8):2008-2020. View abstract
  65. Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation. J Allergy Clin Immunol. 2016 11; 138(5):1384-1394.e2. View abstract
  66. IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J Allergy Clin Immunol. 2016 09; 138(3):801-811.e9. View abstract
  67. Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2016 09; 138(3):852-859.e3. View abstract
  68. T Regulatory Cell Biology in Health and Disease. Curr Allergy Asthma Rep. 2016 Apr; 16(4):27. View abstract
  69. Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis. J Immunol. 2016 Apr 15; 196(8):3305-17. View abstract
  70. Immunotherapy with iTreg and nTreg Cells in a Murine Model of Inflammatory Bowel Disease. Methods Mol Biol. 2016; 1422:197-211. View abstract
  71. Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015. J Clin Immunol. 2015 Nov; 35(8):696-726. View abstract
  72. The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies. J Clin Immunol. 2015 Nov; 35(8):727-38. View abstract
  73. Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling. Nat Immunol. 2015 Nov; 16(11):1162-73. View abstract
  74. MyD88 Adaptor-Dependent Microbial Sensing by Regulatory T Cells Promotes Mucosal Tolerance and Enforces Commensalism. Immunity. 2015 Aug 18; 43(2):289-303. View abstract
  75. Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med. 2015 Jun 18; 372(25):2409-22. View abstract
  76. Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder. Pediatr Nephrol. 2015 Jul; 30(7):1197-202. View abstract
  77. Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade. J Allergy Clin Immunol. 2015 Aug; 136(2):441-53. View abstract
  78. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with neonatal epidermolysis bullosa acquisita. Pediatr Dermatol. 2015 May-Jun; 32(3):e74-7. View abstract
  79. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity. 2015 Mar 17; 42(3):512-23. View abstract
  80. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015 Aug; 136(2):402-12. View abstract
  81. DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. J Clin Immunol. 2015 Feb; 35(2):189-98. View abstract
  82. Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA. J Allergy Clin Immunol. 2015 Jan; 135(1):217-27. View abstract
  83. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. J Allergy Clin Immunol. 2014 Dec; 134(6):1365-1374. View abstract
  84. Regulatory T cells: exosomes deliver tolerance. Immunity. 2014 Jul 17; 41(1):3-5. View abstract
  85. Oral immunotherapy induces IgG antibodies that act through Fc?RIIb to suppress IgE-mediated hypersensitivity. J Allergy Clin Immunol. 2014 Dec; 134(6):1310-1317.e6. View abstract
  86. Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. Immunity. 2014 Jul 17; 41(1):141-51. View abstract
  87. Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. J Allergy Clin Immunol. 2014 Jun; 133(6):1753-5.e3. View abstract
  88. Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency. Front Immunol. 2014; 5:162. View abstract
  89. Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency. Clin Immunol. 2014 Jul; 153(1):104-108. View abstract
  90. Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):221-3. View abstract
  91. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J Allergy Clin Immunol. 2014 Feb; 133(2):309-17. View abstract
  92. Editorial: Optimizing iTreg differentiation: STATs in the balance. J Leukoc Biol. 2014 Feb; 95(2):197-8. View abstract
  93. Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis. Clin Immunol. 2014 Feb; 150(2):220-4. View abstract
  94. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases. Curr Opin Pediatr. 2013 Dec; 25(6):708-14. View abstract
  95. Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014 Feb; 133(2):335-47. View abstract
  96. Fox family ties. Cell Res. 2013 Apr; 23(4):452-4. View abstract
  97. Inhaled alpha1-antitrypsin administered to treat pneumatocele in autosomal dominant hyperimmunoglobulin E syndrome. J Investig Allergol Clin Immunol. 2013; 23(5):359-61. View abstract
  98. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol. 2013 Jan; 131(1):201-12. View abstract
  99. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Mucosal Immunol. 2013 Jul; 6(4):740-50. View abstract
  100. Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder. Gene. 2013 Jan 10; 512(2):189-93. View abstract
  101. IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy. J Immunol. 2012 Dec 15; 189(12):5638-48. View abstract
  102. T cell receptor (TCR)-transgenic CD8 lymphocytes rendered insensitive to transforming growth factor beta (TGFß) signaling mediate superior tumor regression in an animal model of adoptive cell therapy. J Transl Med. 2012 Jun 19; 10:127. View abstract
  103. Foxp3: shades of tolerance. Immunity. 2012 May 25; 36(5):693-4. View abstract
  104. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20. View abstract
  105. Identification of an interleukin 13-induced epigenetic signature in allergic airway inflammation. Am J Transl Res. 2012; 4(2):219-28. View abstract
  106. MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice. J Clin Invest. 2012 May; 122(5):1933-47. View abstract
  107. Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Clin Immunol. 2012 Jun; 143(3):266-72. View abstract
  108. Glucagon regulates ACC activity in adipocytes through the CAMKKß/AMPK pathway. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1560-8. View abstract
  109. T-regulatory cells in primary immune deficiencies. Curr Opin Allergy Clin Immunol. 2011 Dec; 11(6):539-44. View abstract
  110. T cell receptor transgenic lymphocytes infiltrating murine tumors are not induced to express foxp3. J Hematol Oncol. 2011 Nov 23; 4:48. View abstract
  111. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. 2011 Jul 22; 35(1):109-22. View abstract
  112. Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening. Clin Immunol. 2011 Nov; 141(2):128-32. View abstract
  113. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011 May 20; 332(6032):974-7. View abstract
  114. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J Allergy Clin Immunol. 2011 Mar; 127(3):795-805.e1-6. View abstract
  115. Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1304-5.e3. View abstract
  116. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. J Immunol. 2010 Jul 15; 185(2):1295-302. View abstract
  117. In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol. 2010 May; 125(5):1128-1136.e8. View abstract
  118. GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells. Int Immunol. 2010 Apr; 22(4):259-70. View abstract
  119. DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction. Dis Markers. 2010; 29(3-4):151-6. View abstract
  120. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009 Dec; 124(6):1289-302.e4. View abstract
  121. Control of cortical axon elongation by a GABA-driven Ca2+/calmodulin-dependent protein kinase cascade. J Neurosci. 2009 Oct 28; 29(43):13720-9. View abstract
  122. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med. 2009 Sep 28; 206(10):2191-204. View abstract
  123. Idiopathic systemic capillary leak syndrome: novel therapy for acute attacks. J Allergy Clin Immunol. 2009 Nov; 124(5):1111-3. View abstract
  124. Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome. J Allergy Clin Immunol. 2009 Aug; 124(2):342-8, 348.e1-5. View abstract
  125. Regulatory T cells: key players in tolerance and autoimmunity. Endocrinol Metab Clin North Am. 2009 Jun; 38(2):265-72, vii. View abstract
  126. Crouching tigers, hidden dragons: the interplay of pathogens and hosts. Pediatr Res. 2009 May; 65(5 Pt 2):1R-2R. View abstract
  127. Impaired memory of eyeblink conditioning in CaMKIV KO mice. Behav Neurosci. 2009 Apr; 123(2):438-42. View abstract
  128. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol. 2009 Mar 15; 182(6):3461-8. View abstract
  129. Immunoglobulin replacement therapy in children. Immunol Allergy Clin North Am. 2008 Nov; 28(4):833-49, ix. View abstract
  130. Molecular mechanisms of regulatory T cell development. J Clin Immunol. 2008 Nov; 28(6):625-30. View abstract
  131. T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets. J Allergy Clin Immunol. 2008 Apr; 121(4):812-23; quiz 824-5. View abstract
  132. Molecular mechanisms of regulatory T-cell development. Chem Immunol Allergy. 2008; 94:16-28. View abstract
  133. The regulatory T cell transcriptosome: E pluribus unum. Immunity. 2007 Nov; 27(5):693-5. View abstract
  134. Extra-intestinal manifestations of gastro-intestinal allergy: effector and regulatory T cells in the balance. Clin Exp Allergy. 2007 Oct; 37(10):1417-8. View abstract
  135. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol. 2007 Jul; 19(7):825-35. View abstract
  136. Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol. 2007 Mar 01; 178(5):2961-72. View abstract
  137. Regulatory T cell development in the absence of functional Foxp3. Nat Immunol. 2007 Apr; 8(4):359-68. View abstract
  138. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol. 2007 Feb; 119(2):482-7. View abstract
  139. Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med. 2006 Dec; 12(12):1410-6. View abstract
  140. Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol. 2006 Dec; 26(23):9105-15. View abstract
  141. Selective engagement of plasticity mechanisms for motor memory storage. Neuron. 2006 Sep 21; 51(6):823-34. View abstract
  142. Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci. 2006 Apr; 23(8):2158-68. View abstract
  143. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol. 2005 Nov; 116(5):1106-15. View abstract
  144. Role of regulatory T cells in human diseases. J Allergy Clin Immunol. 2005 Nov; 116(5):949-59; quiz 960. View abstract
  145. Critical function of the CD40 pathway in parvovirus B19 infection revealed by a hypomorphic CD40 ligand mutation. Clin Immunol. 2005 Dec; 117(3):231-7. View abstract
  146. Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice. Mol Pain. 2005 Mar 22; 1:10. View abstract
  147. NF-kappaB and the innate immune response in the respiratory distress syndrome of the newborn: commentary on the article by Cheah et al. on page 616. Pediatr Res. 2005 May; 57(5 Pt 1):613-5. View abstract
  148. Epitope-specific crosslinking of CD45 down-regulates membrane-associated tyrosine phosphatase activity and triggers early signalling events in human activated T cells. Immunology. 2004 Dec; 113(4):441-52. View abstract
  149. Interleukin-4 receptor signaling pathways in asthma pathogenesis. Trends Mol Med. 2004 Oct; 10(10):493-9. View abstract
  150. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200. View abstract
  151. Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nat Neurosci. 2002 Jun; 5(6):573-9. View abstract
  152. Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis. Pediatrics. 2002 Jan; 109(1):E13. View abstract
  153. Requirement for Ca2+/calmodulin-dependent kinase type IV/Gr in setting the thymocyte selection threshold. J Immunol. 2001 Dec 01; 167(11):6270-8. View abstract
  154. CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells. Am J Physiol Endocrinol Metab. 2001 Nov; 281(5):E931-7. View abstract
  155. Response of refractory Kawasaki disease to pulse steroid and cyclosporin A therapy. Pediatr Infect Dis J. 2001 Jun; 20(6):635-7. View abstract
  156. Defective apoptosis in lymphocytes and the role of IL-2 in autoimmune hematologic cytopenias. Clin Immunol. 2001 May; 99(2):266-75. View abstract
  157. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest. 2000 Dec; 106(12):R75-81. View abstract
  158. Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci. 2000 Sep 01; 20(17):6459-72. View abstract
  159. Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis. EMBO J. 2000 Aug 15; 19(16):4323-31. View abstract
  160. Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome. J Pediatr. 2000 May; 136(5):682-7. View abstract
  161. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med. 2000 Mar; 6(3):343-5. View abstract
  162. Ca(2+)-dependent gene expression mediated by MEF2 transcription factors. J Biol Chem. 2000 Jan 07; 275(1):197-209. View abstract
  163. Light microscopic, immunophenotypic, and molecular genetic study of autoimmune lymphoproliferative syndrome caused by fas mutation. Pediatr Dev Pathol. 2000 Jan-Feb; 3(1):101-9. View abstract
  164. Calcium-dependent activation of TNF family gene expression by Ca2+/calmodulin kinase type IV/Gr and calcineurin. J Immunol. 1999 Feb 15; 162(4):2057-63. View abstract
  165. Genetics of atopic diseases. Curr Opin Pediatr. 1998 Dec; 10(6):584-7. View abstract
  166. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med. 1997 Dec 11; 337(24):1720-5. View abstract
  167. Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene. Trends Microbiol. 1997 Oct; 5(10):399-405. View abstract
  168. The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication. J Virol. 1997 Sep; 71(9):6560-7. View abstract
  169. Regulation of microtubule dynamics by Ca2+/calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18. Mol Cell Biol. 1997 Jun; 17(6):3459-67. View abstract
  170. Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member. EMBO J. 1997 Jan 02; 16(1):143-53. View abstract
  171. HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck. Int Immunol. 1997 Jan; 9(1):53-64. View abstract
  172. A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR. J Biol Chem. 1996 Aug 30; 271(35):21542-8. View abstract
  173. Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr. J Exp Med. 1996 Jul 01; 184(1):101-12. View abstract
  174. Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol. 1996 Mar; 103(3):408-13. View abstract
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