ABOUT THE RESEARCHER

OVERVIEW

Laurie Cohen's research in basic science focuses on determining the pathogenesis of hypopituitarism in children with short stature and in characterizing growth hormone gene regulation. Her laboratory interests have dovetailed with her clinical work in treating hypopituitarism as a side effect of treatment for cancer, especially brain tumors. Her current goal is to characterize endocrine sequelae in patients with hematologic and oncologic disorders.

In other endocrine research, she is investigating growth and insulin resistance in neuroblastoma survivors and the mechanisms of hypothalamic obesity.

BACKGROUND

Laurie Cohen received her MD from Cornell University College of Medicine. She completed an internship and residency at Yale-New Haven Hospital and a fellowship at Boston Children's Hospital .

She is the recipient of the Priscilla and Richard Hunt Fellowship, Harvard Medical School 50th Anniversary Program for Scholars in Medicine.

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Pituitary Tumors in Children. Adv Pediatr. 2021 08; 68:211-225. View abstract
  2. Juvenile Granulosa Cell Tumor as the Presenting Feature of McCune-Albright Syndrome. J Endocr Soc. 2021 Sep 01; 5(9):bvab098. View abstract
  3. Undernutrition and Pubertal Timing in Female Survivors of Medulloblastoma and Other Embryonal Tumors. J Clin Endocrinol Metab. 2020 10 01; 105(10). View abstract
  4. Novel predictive scoring system for morbid hypothalamic obesity in patients with pediatric craniopharyngioma. Childs Nerv Syst. 2021 02; 37(2):403-410. View abstract
  5. Clinical Course of Nonfunctional Pituitary Microadenoma in Children: A Single-Center Experience. J Clin Endocrinol Metab. 2019 12 01; 104(12):5906-5912. View abstract
  6. Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective. Horm Res Paediatr. 2019; 92(1):1-14. View abstract
  7. GH Therapy in Childhood Cancer Survivors: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2018 08 01; 103(8):2794-2801. View abstract
  8. Hypothalamic-Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018 08 01; 103(8):2761-2784. View abstract
  9. Diagnosis of GH Deficiency as a Late Effect of Radiotherapy in Survivors of Childhood Cancers. J Clin Endocrinol Metab. 2018 08 01; 103(8):2785-2793. View abstract
  10. Endocrine Late Effects in Childhood Cancer Survivors. J Clin Oncol. 2018 07 20; 36(21):2153-2159. View abstract
  11. DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments. Eur J Endocrinol. 2017 04; 176(4):R183-R203. View abstract
  12. Fertility and sexual function: a gap in training in pediatric endocrinology. J Pediatr Endocrinol Metab. 2017 Jan 01; 30(1):3-10. View abstract
  13. Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency. Horm Res Paediatr. 2016; 86(6):361-397. View abstract
  14. Update on childhood craniopharyngiomas. Curr Opin Endocrinol Diabetes Obes. 2016 08; 23(4):339-44. View abstract
  15. Klinefelter syndrome: fertility considerations and gaps in knowledge. Transl Pediatr. 2016 Jul; 5(3):183-184. View abstract
  16. Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016 Jun; 174(6):C1-8. View abstract
  17. Sperm Retrieval in Adolescents and Young Adults with Klinefelter Syndrome: A Prospective, Pilot Study. J Pediatr. 2016 Mar; 170:260-5.e1-2. View abstract
  18. Management of testosterone therapy in adolescents and young men with hypogonadism: are we following adult clinical practice guidelines? J Pediatr Endocrinol Metab. 2015 May; 28(5-6):635-40. View abstract
  19. Idiopathic short stature: a clinical review. JAMA. 2014 May 07; 311(17):1787-96. View abstract
  20. JAMA patient page. Short stature. JAMA. 2014 May 07; 311(17):1822. View abstract
  21. Potential role of IGF-1 z score to predict permanent linear growth impairment in children with IBD. J Pediatr Gastroenterol Nutr. 2014 Apr; 58(4):472-6. View abstract
  22. Klinefelter syndrome: are we missing opportunities for early detection? Clin Pediatr (Phila). 2013 Oct; 52(10):936-41. View abstract
  23. Predictors of neoplastic disease in children with isolated pituitary stalk thickening. Pediatr Blood Cancer. 2013 Oct; 60(10):1630-5. View abstract
  24. Isolated central hypothyroidism in young siblings as a manifestation of PROP1 deficiency: clinical impact of whole exome sequencing. Horm Res Paediatr. 2013; 79(6):379-86. View abstract
  25. GLI2 mutations as a cause of hypopituitarism. Pediatr Endocrinol Rev. 2012 Aug; 9(4):706-9. View abstract
  26. Male reproductive health after childhood, adolescent, and young adult cancers: a report from the Children's Oncology Group. J Clin Oncol. 2012 Sep 20; 30(27):3408-16. View abstract
  27. Semen analysis in adolescent cancer patients prior to bone marrow transplantation: when is it too late for fertility preservation? Pediatr Blood Cancer. 2013 Jan; 60(1):129-32. View abstract
  28. Barriers to fertility preservation in male adolescents with cancer: it's time for a multidisciplinary approach that includes urologists. Urology. 2012 Jun; 79(6):1206-9. View abstract
  29. Sleep dysfunction in long term survivors of craniopharyngioma. J Neurooncol. 2012 Jul; 108(3):543-9. View abstract
  30. Genetic disorders of the pituitary. Curr Opin Endocrinol Diabetes Obes. 2012 Feb; 19(1):33-9. View abstract
  31. Late adolescent linear growth pattern in pediatric-onset inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011 Sep; 53(3):246-9. View abstract
  32. Bone density in post-pubertal adolescent survivors of childhood brain tumors. Pediatr Blood Cancer. 2012 Jun; 58(6):959-63. View abstract
  33. Long-term clinical outcomes following treatment of childhood craniopharyngioma. Pediatr Blood Cancer. 2011 Jul 01; 56(7):1120-6. View abstract
  34. Variation in methods of predicting adult height for children with idiopathic short stature. Pediatrics. 2010 Nov; 126(5):938-44. View abstract
  35. Relationship between blood-spot insulin-like growth factor 1 levels and hand-wrist assessment of skeletal maturity. Am J Orthod Dentofacial Orthop. 2009 Jul; 136(1):59-64. View abstract
  36. Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. Horm Res. 2009; 71(2):100-10. View abstract
  37. Assessing skeletal maturity by using blood spot insulin-like growth factor I (IGF-I) testing. Am J Orthod Dentofacial Orthop. 2008 Aug; 134(2):209-16. View abstract
  38. Short stature in a phenotypic male caused by mixed gonadal dysgenesis. Nat Clin Pract Endocrinol Metab. 2008 Sep; 4(9):524-8. View abstract
  39. Cancer treatment and the ovary: the effects of chemotherapy and radiation. Ann N Y Acad Sci. 2008; 1135:123-5. View abstract
  40. Assessment of adrenal suppression in children with asthma treated with inhaled corticosteroids: use of dehydroepiandrosterone sulfate as a screening test. Ann Allergy Asthma Immunol. 2006 Aug; 97(2):182-6. View abstract
  41. Endocrine late effects of cancer treatment. Endocrinol Metab Clin North Am. 2005 Sep; 34(3):769-89, xi. View abstract
  42. Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance. Pediatrics. 2005 Jun; 115(6):e742-8. View abstract
  43. Endocrine Sequelae of Therapy for Cancer in Children. Endo Metab Clin NA. 2005. View abstract
  44. “Endocrine Sequelae in Cancer Survivors”. Syllabus for A Current Review of Endocrinology, Serono Symposium, San Diego, CA. 2005. View abstract
  45. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab. 2003 Oct; 88(10):4832-9. View abstract
  46. Height and weight in children treated for acute lymphoblastic leukemia: relationship to CNS treatment. J Clin Oncol. 2003 Aug 01; 21(15):2953-60. View abstract
  47. A novel nonsense mutation in the Pit-1 gene: evidence for a gene dosage effect. J Clin Endocrinol Metab. 2003 Mar; 88(3):1241-7. View abstract
  48. Endocrine late effects of cancer treatment. Curr Opin Pediatr. 2003 Feb; 15(1):3-9. View abstract
  49. Hypopituitarism . Clinical Management of Pediatric Endocrine Disorders.Radovick S and MacGillivray M, editors. 2003; 3-36. View abstract
  50. “Molecular Basis of Hypopituitarism”. Syllabus for A Current Review of Endocrinology, Serono Symposium, Seattle, WA. 2003. View abstract
  51. Other transcription factors and hypopituitarism. Rev Endocr Metab Disord. 2002 Dec; 3(4):301-11. View abstract
  52. Molecular basis of combined pituitary hormone deficiencies. Endocr Rev. 2002 Aug; 23(4):431-42. View abstract
  53. Eating Dysfunction Following Endoscopic Third Ventriculostomy. American Association of Neurological Surgery. 2002. View abstract
  54. Memory deficits among children with craniopharyngiomas. Neurosurgery. 2001 Nov; 49(5):1053-7; discussion 1057-8. View abstract
  55. Understanding Growth Patterns. Contemporary Pediatrics. 2001; 18:94-122. View abstract
  56. Constitutional Short Stature: Timmy and the “Big Kids”. In: Knight JR and Emans SJ, editors. Bright Futures Case Studies for Primary Care Clinicians, A Guide to the Case Teaching Method; and Growth in Children and Adolescents. U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau. 2001. View abstract
  57. Understanding Growth: Normal vs. Abnormal Patterns. In: Knight JR and Emans SJ, editors. Bright Futures Case Studies for Primary Care Clinicians, A Guide to the Case Teaching Method; and Growth in Children and Adolescents. U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau. 2001. View abstract
  58. cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes. J Biol Chem. 2000 Oct 27; 275(43):33365-72. View abstract
  59. Genetic regulation of the embryology of the pituitary gland and somatotrophs. Endocrine. 2000 Apr; 12(2):99-106. View abstract
  60. CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression. J Clin Invest. 1999 Oct; 104(8):1123-30. View abstract
  61. Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency. Mol Endocrinol. 1999 Mar; 13(3):476-84. View abstract
  62. A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein. Mol Endocrinol. 1999 Feb; 13(2):268-75. View abstract
  63. Transcription Factors and Hypopituitarism. TEM. 1999; 10:326-332. View abstract
  64. “Anterior Pituitary Hormone Deficiencies”. Syllabus for A Current Review of Endocrinology, Serono Symposium, New Orleans, LA. 1999. View abstract
  65. The molecular basis of hypopituitarism. Horm Res. 1998; 49 Suppl 1:30-6. View abstract
  66. Familial Growth Hormone Deficiency Associated with MRI Abnormalities. Amer J Human Genetics. 1998; 80:128-132. View abstract
  67. Optic chiasm astrocytomas of childhood. 1. Long-term follow-up. Pediatr Neurosurg. 1997 Sep; 27(3):121-8. View abstract
  68. Molecular Aspects of Hormone Deficiency Caused by Pit-1 Gene Mutations. Advances in Molecular and Cellular Endocrinology. LeRoith D, editor. 1997; 1:31-50. View abstract
  69. Diencephalic syndrome: Clinical Features and Imaging Findings. Amer J of Neuroradiology. 1997; 18:1499-1505. View abstract
  70. Role of Pit-1 on the Expression of Growth Hormone, Prolactin, and Thyrotropin. Endo Metab Clin NA. 1996; 25:523-540. View abstract
  71. Controversies in Clinical and Surgical Endocrinology. Short Stature. In: Herrera MF, Lerman I, editors. 1996. View abstract
  72. A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates. J Clin Endocrinol Metab. 1995 Feb; 80(2):679-84. View abstract