Overview

Dr. Chen’s primary interests are retinal vascular biology and pathologic vascular eye diseases, including retinopathy of prematurity, age-related macular degeneration, diabetic retinopathy, and rare orphan eye diseases: familiar exudative vitreoretinopathy (FEVR) and Norrie disease. Her lab studies animal models of these diseases to investigate disease pathogenesis and develop potential therapeutics. She has published numerous papers and lectured nationally and internationally on vascular eye disorders and angiogenesis research. Her current research projects include:

  1. Wnt signaling in controlling vascular growth and permeability in retinopathy;
  2. Lipid sensing nuclear receptor mediated ocular neovascularization and inflammation;
  3. MicroRNA regulation of pathologic vascular growth in eye diseases.

Background

Dr. Jing Chen received her PhD from Boston University and completed her postdoctoral fellowship training in Ophthalmology at Boston Children’s Hospital (BCH) / Harvard Medical School. Since then Dr. Chen was recruited as a faculty member in Ophthalmology Department at BCH and Harvard Medical School, and is also an associate at the BCH Manton Center for Orphan Disease Research.

PUBLICATIONS

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  1. Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier. Sci Adv. 2020 Aug; 6(35):eaba7457. View abstract
  2. MicroRNAs in Vascular Eye Diseases. Int J Mol Sci. 2020 Jan 19; 21(2). View abstract
  3. Loss of RAR-related orphan receptor alpha (RORa) selectively lowers docosahexaenoic acid in developing cerebellum. Prostaglandins Leukot Essent Fatty Acids. 2020 01; 152:102036. View abstract
  4. Assessment and Characterization of Hyaloid Vessels in Mice. J Vis Exp. 2019 05 15; (147). View abstract
  5. MicroRNA-145 Regulates Pathological Retinal Angiogenesis by Suppression of TMOD3. Mol Ther Nucleic Acids. 2019 Jun 07; 16:335-347. View abstract
  6. Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles. Nat Commun. 2019 02 18; 10(1):804. View abstract
  7. Wnt Signaling in vascular eye diseases. Prog Retin Eye Res. 2019 05; 70:110-133. View abstract
  8. Animal models of ocular angiogenesis: from development to pathologies. FASEB J. 2017 11; 31(11):4665-4681. View abstract
  9. RORa modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis. FASEB J. 2017 10; 31(10):4492-4502. View abstract
  10. Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Sci Rep. 2017 06 13; 7(1):3375. View abstract
  11. ?-3 and ?-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am J Clin Nutr. 2017 Jul; 106(1):16-26. View abstract
  12. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. View abstract
  13. Retinal expression of small non-coding RNAs in a murine model of proliferative retinopathy. Sci Rep. 2016 Sep 22; 6:33947. View abstract
  14. Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy. Am J Pathol. 2016 10; 186(10):2588-600. View abstract
  15. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. . 2016 09 01; 311(3):H738-49. View abstract
  16. Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 06 07; 22(6):692. View abstract
  17. TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circ Res. 2016 07 22; 119(3):450-62. View abstract
  18. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. View abstract
  19. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. View abstract
  20. Endothelial microRNA-150 is an intrinsic suppressor of pathologic ocular neovascularization. Proc Natl Acad Sci U S A. 2015 Sep 29; 112(39):12163-8. View abstract
  21. Nuclear receptor RORa regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10401-6. View abstract
  22. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. View abstract
  23. Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PLoS One. 2015; 10(5):e0125548. View abstract
  24. Nanoparticle-mediated expression of a Wnt pathway inhibitor ameliorates ocular neovascularization. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):855-64. View abstract
  25. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. View abstract
  26. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20; 55(12):8267-77. View abstract
  27. Enhancing reliability of the laser-induced choroidal neovascularization mouse model: insights from a new study. Invest Ophthalmol Vis Sci. 2014 Oct 16; 55(10):6535. View abstract
  28. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. View abstract
  29. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014; 9(1):e85031. View abstract
  30. Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. PLoS One. 2013; 8(9):e73407. View abstract
  31. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct; 16(4):985-92. View abstract
  32. Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One. 2013; 8(7):e69552. View abstract
  33. Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Cell Metab. 2013 Apr 02; 17(4):471-2. View abstract
  34. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS One. 2013; 8(1):e53155. View abstract
  35. Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains? Invest Ophthalmol Vis Sci. 2012 Nov 19; 53(12):7728-9. View abstract
  36. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596. View abstract
  37. Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes. 2012 Jul 23; 2:e36. View abstract
  38. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012 Oct 04; 120(14):2925-9. View abstract
  39. Propranolol inhibition of ß-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2968-77. View abstract
  40. Protective inflammasome activation in AMD. Nat Med. 2012 May 04; 18(5):658-60. View abstract
  41. Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS One. 2012; 7(1):e30203. View abstract
  42. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25; 124(17):1871-81. View abstract
  43. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. View abstract
  44. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16. View abstract
  45. Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr. 2011 Apr; 23(2):173-8. View abstract
  46. Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. Br J Ophthalmol. 2011 Nov; 95(11):1496-501. View abstract
  47. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. View abstract
  48. Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 2010 Dec; 177(6):2715-23. View abstract
  49. Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. Retina. 2010 Oct; 30(9):1524-9. View abstract
  50. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. View abstract
  51. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500. View abstract
  52. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26. View abstract
  53. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73. View abstract
  54. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009; 12(3):297-301. View abstract
  55. Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina. Mol Vis. 2008; 14:2509-17. View abstract
  56. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7. View abstract
  57. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35. View abstract
  58. A double-edged sword: erythropoietin eyed in retinopathy of prematurity. J AAPOS. 2008 Jun; 12(3):221-2. View abstract
  59. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33. View abstract
  60. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62. View abstract
  61. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873. View abstract
  62. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94. View abstract
  63. Retinopathy of prematurity. Angiogenesis. 2007; 10(2):133-40. View abstract
  64. Subcellular localization of phosducin in rod photoreceptors. Vis Neurosci. 2005 Jan-Feb; 22(1):19-25. View abstract
  65. Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4693-8. View abstract
  66. Protein-protein recognition: exploring the energy funnels near the binding sites. Proteins. 1999 Feb 01; 34(2):255-67. View abstract