Information

Related Research Units

Neurology Research
Developmental Medicine Research
F.M. Kirby Neurobiology Center

Research Overview

Dr. Bo Zhang’s scientific career has been dedicated to developing innovative biostatistical methodologies for the design and analysis of clinical trials, longitudinal data analysis, and machine learning algorithms for predictive analytics. Dr. Zhang also collaborates with other investigators in clinical and translational research, providing high-quality support on clinical research design and data analysis methodologies.

Dr. Zhang has authored over 195 peer-reviewed publications in top-tier methodological and clinical journals. As a principal investigator, Dr. Zhang has received research grants from the NIH, FDA, and various research foundations. Through collaborative research, Dr. Zhang has contributed as a co-investigator and biostatistician to more than 25 extramural research grants, collectively amounting to over $25 million.

Research Background

Dr. Bo Zhang’s scientific career has been dedicated to developing innovative biostatistical methodologies for the design and analysis of clinical trials, longitudinal data analysis, and machine learning algorithms for predictive analytics. Dr. Zhang also collaborates with other investigators in clinical and translational research, providing high-quality support on clinical research design and data analysis methodologies. Dr. Zhang has authored over 195 peer-reviewed publications in top-tier methodological and clinical journals. As a principal investigator, Dr. Zhang received an extramural research grant from the NIH, a highly competitive FDA intramural research grant, and a research foundation grant. Through collaborative research, Dr. Zhang has contributed as a co-investigator and biostatistician to more than 25 extramural research grants, collectively amounting to over $25 million.

Publications

  1. A stochastic model for evaluating the progression of ductal carcinoma in situ breast cancer using Norwegian breast cancer screening program data. Informatics in Medicine Unlocked. 2025; Forthcoming. View Abstract
  2. Eating disorders in adolescents with functional seizures. Epilepsy & Behavior. 2025; Forthcoming. View Abstract
  3. Time to treatment in pediatric patients with repeated episodes of status epilepticus. BMC Neurology. 2025; Forthcoming. View Abstract
  4. Validation of neonatal encephalopathy scores with neurophysiology. Pediatric Research. 2025; Forthcoming. View Abstract
  5. A Phenome-Wide Association Study of Marijuana Use and Circulating Biomarkers in the United States: National Health and Nutrition Examination Survey 2009-2018. J Clin Pharmacol. 2025 Apr 01. View Abstract
  6. Assessment of Seizure Action Plans in Pediatric Convulsive Status Epilepticus: Focus on Benzodiazepine-Responsive and Resistant Cases. Neurol Clin Pract. 2025 Jun; 15(3):e200449. View Abstract
  7. Epilepsy surgery in Sturge-Weber syndrome with unilateral or bilateral asymmetric brain involvement: Boston Children's Hospital experience. Epilepsia. 2025 Mar 24. View Abstract
  8. Exploring the effect of valproic acid levels on patients with epilepsy treated with ketogenic diet: An observational study. Epilepsia Open. 2025 Apr; 10(2):615-619. View Abstract
  9. Evaluating the effectiveness of medical therapy in infantile epileptic spasms syndrome due to surgically-remediable lesions. Epilepsia. 2025 Feb 13. View Abstract
  10. Impaired sleep-dependent memory consolidation in pediatric narcolepsy type 1. Sleep. 2025 Feb 10; 48(2). View Abstract
  11. Characterizing disrupted nighttime sleep and associated functional outcomes in youth with narcolepsy type 1. J Clin Sleep Med. 2025 Feb 01; 21(2):355-363. View Abstract
  12. Development and Validation of a Postprocedure Stroke Screening Tool in Children With Cardiac Disease. J Child Neurol. 2025 Apr; 40(4):264-272. View Abstract
  13. Marijuana Use and Hemoglobin Concentrations in NHANES 2009-2018: Implications for Subclinical Hypoxemia. Ann Am Thorac Soc. 2024 Nov; 21(11):1488-1495. View Abstract
  14. Lack of association of first and second-line medication dosing and progression to refractory status epilepticus in children. Seizure. 2024 Dec; 123:133-141. View Abstract
  15. Prevalence Trends and Treatment Patterns of Autism Spectrum Disorder Among Children and Adolescents in the United States from 2017 to 2020. Neurol Ther. 2024 Dec; 13(6):1685-1700. View Abstract
  16. Developmental milestones for children with Down syndrome (Author Response to Comments. 2025 Feb 1;155(2):e2024069954D). Pediatrics. 2024; 154(4):e2023065402. PMID: 39279536. View Abstract
  17. Demographic and socioeconomic characteristics of patients diagnosed with autism through the Rapid Interactive screening Test for Autism in Toddlers. Pediatr Investig. 2024 Sep; 8(3):209-214. View Abstract
  18. Prevalence and trends of autism spectrum disorder and other developmental disabilities among children and adolescents in the United States from 2019 to 2021. Front Psychiatry. 2024; 15:1471969. View Abstract
  19. Assessment of supervised longitudinal learning methods: Insights from predicting low birth weight and very low birth weight using prenatal ultrasound measurements. Comput Biol Med. 2024 Nov; 182:109084. View Abstract
  20. Current practices in the diagnosis and treatment of Rasmussen syndrome: Results of an international survey. Seizure. 2024 Nov; 122:153-164. View Abstract
  21. Effect of oral faecal microbiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial. Clin Transl Med. 2024 Sep; 14(9):e70006. View Abstract
  22. Misprogramming of glucose metabolism impairs recovery of hippocampal slices from neuronal GLT-1 knockout mice and contributes to excitotoxic injury through mitochondrial superoxide production. J Neurochem. 2025 Jan; 169(1):e16205. View Abstract
  23. Deletions in the CDKL5 5' untranslated region lead to CDKL5 deficiency disorder. Am J Med Genet A. 2025 Jan; 197(1):e63843. View Abstract
  24. Triple digital divide and depressive symptoms among middle-aged and older Chinese adults: a disparity analysis. Gen Psychiatr. 2024; 37(4):e101562. View Abstract
  25. Enhancing the utility of tuberous sclerosis complex-associated neuropsychiatric disorders checklist in China. Pediatr Investig. 2024 Sep; 8(3):171-176. View Abstract
  26. FetalAI: A deep learning web-based application for predicting birthweight from prenatal ultrasound measurements. Informatics in Medicine Unlocked. 2024; 49(2004):101555. View Abstract
  27. Inaugural Patient-Reported Registry of Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome: Presentation, Diagnosis, and Treatment of 194 Patients. Pediatr Neurol. 2024 Sep; 158:128-134. View Abstract
  28. Exhaustive clinical examination of etiology and initial response to first-line treatment in 577 children with infantile epileptic spasm syndrome children: A 5-year retrospective observational study. Ann Clin Transl Neurol. 2024 Aug; 11(8):2049-2062. View Abstract
  29. An innovative supervised longitudinal learning procedure of recurrent neural networks with temporal data augmentation: Insights from predicting fetal macrosomia and large-for-gestational age. Comput Biol Med. 2024 Jul; 177:108665. View Abstract
  30. Abnormality of Early White Matter Development in Tuberous Sclerosis Complex and Autism Spectrum Disorder: Longitudinal Analysis of Diffusion Tensor Imaging Measures. J Child Neurol. 2024 May; 39(5-6):178-189. View Abstract
  31. Variation in neuroimaging and outcomes in patients with Sturge Weber syndrome Type III. Brain Dev. 2024 Aug; 46(7):244-249. View Abstract
  32. A network analysis of gender differences in PTSD symptoms among chinese adults during COVID-19 pandemic. Mental Illness. 2024; 2024:6259982. View Abstract
  33. Prevalence trends and racial-ethnic disparities of diabetes and prediabetes among children and adolescents in the United States from 2019 to 2021. Prev Med Rep. 2024 May; 41:102688. View Abstract
  34. Validation of factor structure of the neurodevelopmental parent report for outcome monitoring in down syndrome: confirmatory factor analysis. Front Psychiatry. 2024; 15:1293937. View Abstract
  35. Variable selection in modeling clustered data via within-cluster resampling. Canadian Journal of Statistics. 2024; 53(1):e11824. View Abstract
  36. Determinants of depressive symptoms at individual, school and province levels: a national survey of 398,520 Chinese children and adolescents. Public Health. 2024 Apr; 229:33-41. View Abstract
  37. Timing the clinical onset of epileptic spasms in infantile epileptic spasms syndrome: A tertiary health center's experience. Epilepsia. 2024 Apr; 65(4):984-994. View Abstract
  38. Marriage matching patterns associated with depressive symptoms among Chinese adults: A nationally representative age-period-cohort modeling study. J Affect Disord. 2024 04 15; 351:341-348. View Abstract
  39. The burden of acute lymphoid leukemia among adolescents and young adults in the Western Pacific Region: evidence from Global Burden Disease 2019. Cancer Causes Control. 2024 May; 35(5):839-848. View Abstract
  40. Parental and Adolescents' Anxiety during the COVID-19 Outbreak in Rural China: The role of Parent-child Communication. J Child Adolesc Trauma. 2024 Jun; 17(2):657-669. View Abstract
  41. Characteristics and use of patient-reported outcomes of clinical trials for high-risk neurological medical devices that received FDA premarket approval from 2001 to 2022. Contemp Clin Trials Commun. 2024 Feb; 37:101254. View Abstract
  42. Delays to care in infantile epileptic spasms syndrome: Racial and ethnic inequities. Epilepsia. 2024 Jan; 65(1):107-114. View Abstract
  43. Biases in Electronic Health Records Data for Generating Real-World Evidence: An Overview. J Healthc Inform Res. 2024 Mar; 8(1):121-139. View Abstract
  44. Childhood abuse as a mediator of the relationship between early family socio-economic status and geriatric depression: A population-based study in China. Heliyon. 2023 Nov; 9(11):e22021. View Abstract
  45. Safety and efficacy of melatonin supplementation as an add-on treatment for infantile epileptic spasms syndrome: A randomized, placebo-controlled, double-blind trial. J Pineal Res. 2024 Jan; 76(1):e12922. View Abstract
  46. Artificial intelligence-enhanced epileptic seizure detection by wearables. Epilepsia. 2023 Dec; 64(12):3213-3226. View Abstract
  47. Influence of extent and age at corpus callosotomy on seizure outcomes. A single center experience. Epilepsia Open. 2023 Dec; 8(4):1596-1601. View Abstract
  48. Factors Associated With Underutilization of Genetic Testing in Autism Spectrum Disorders. Pediatr Neurol. 2024 Jan; 150:17-23. View Abstract
  49. CDKL5 deficiency disorder and other infantile-onset genetic epilepsies. Dev Med Child Neurol. 2024 Apr; 66(4):456-468. View Abstract
  50. The RITA-T (Rapid Interactive Screening Test for Autism in Toddlers) Community Model to Improve Access and Early Identification of Autism in Young Children. Child Neurol Open. 2023 Jan-Dec; 10:2329048X231203817. View Abstract
  51. Eating disorders occur at high rates in adolescents with epilepsy and are associated with psychiatric comorbidities and suicidality. Epilepsia. 2023 11; 64(11):2982-2992. View Abstract
  52. Clinically derived 12-factor structure and confirmatory factor analysis of the neurodevelopmental parent report for outcome monitoring. Front Psychiatry. 2023; 14:1243467. View Abstract
  53. Toward representative genomic research: the children's rare disease cohorts experience. Ther Adv Rare Dis. 2023 Jan-Dec; 4:26330040231181406. View Abstract
  54. Joint evaluation of placebo and treatment effects in cluster randomized trials by causal inference models. Contemp Clin Trials. 2023 09; 132:107308. View Abstract
  55. Development of a Multivariable Seizure Likelihood Assessment Based on Clinical Information and Short Autonomic Activity Recordings for Children With Epilepsy. Pediatr Neurol. 2023 Nov; 148:118-127. View Abstract
  56. Autism Spectrum Disorder in Children With Perinatal Ischemic Stroke Varies by Stroke Type. J Child Neurol. 2023 08; 38(8-9):513-517. View Abstract
  57. Plasma Neurofilament Light Chain Is Elevated in Adaptor Protein Complex 4-Related Hereditary Spastic Paraplegia. Mov Disord. 2023 09; 38(9):1742-1750. View Abstract
  58. Utility of Exome Sequencing for Diagnosis in Unexplained Pediatric-Onset Epilepsy. JAMA Netw Open. 2023 07 03; 6(7):e2324380. View Abstract
  59. Assessment of Factors Associated With Mental Well-Being Among Chinese Youths at Individual, School, and Province Levels. JAMA Netw Open. 2023 07 03; 6(7):e2324025. View Abstract
  60. Subjective impact of COVID-19 pandemic on youth with tic and OCD spectrum disorders. Personalized Medicine in Psychiatry. 2023; 39-40:100103. View Abstract
  61. Do living arrangements and health behaviors associate with anxiety symptoms among Chinese older people? Differences between urban and rural areas. Psychol Health Med. 2023 Dec; 28(10):3117-3130. View Abstract
  62. Overall survival, late mortality, and cancer-directed surgery among children and adolescents with ultra-rare pediatric pancreatoblastoma in the United States, 1975-2018. Journal of Pancreatology. 2023; 6(2):61-66. View Abstract
  63. An International Pediatric-Onset Opsoclonus-Myoclonus Ataxia Syndrome Registry and Clinical Research Network: Development, Progress, and Vision. Pediatr Neurol. 2023 11; 148:145-147. View Abstract
  64. Epileptic spasms in CDKL5 deficiency disorder: Delayed treatment and poor response to first-line therapies. Epilepsia. 2023 07; 64(7):1821-1832. View Abstract
  65. Impact of the COVID-19 pandemic on cancer healthcare utilization in southwestern China on March 2021. Cancer Med. 2023 06; 12(12):13821-13833. View Abstract
  66. RARS1-related developmental and epileptic encephalopathy. Epilepsia Open. 2023 09; 8(3):867-876. View Abstract
  67. School-based Psychosocial interventions on mental health among Chinese rural children with traumatic experiences: a protocol using cluster randomized controlled trial. BMC Psychol. 2023 May 04; 11(1):148. View Abstract
  68. The clinical and molecular spectrum of ZFYVE26-associated hereditary spastic paraplegia: SPG15. Brain. 2023 05 02; 146(5):2003-2015. View Abstract
  69. The influence of healthy lifestyle behaviors on cognitive function among older Chinese adults across age and gender: Evidence from panel data. Arch Gerontol Geriatr. 2023 09; 112:105040. View Abstract
  70. Hospital readmissions in children with new-onset infantile epileptic spasms syndrome. Epilepsia Open. 2023 06; 8(2):444-455. View Abstract
  71. Epilepsy Severity Is Associated With Head Circumference and Growth Rate in Infants With Tuberous Sclerosis Complex. Pediatr Neurol. 2023 07; 144:26-32. View Abstract
  72. High-quality nuclei isolation from postmortem human heart muscle tissues for single-cell studies. J Mol Cell Cardiol. 2023 06; 179:7-17. View Abstract
  73. Evaluating Risk-Adjusted Hospital Performance Using Large-Scale Data on Mortality Rates of Patients in Intensive Care Units: A Flexible Semi-Nonparametric Modeling Approach. IEEE J Transl Eng Health Med. 2023; 11:232-246. View Abstract
  74. Effect of fecal microbiota transplantation in children with autism spectrum disorder: A systematic review. Front Psychiatry. 2023; 14:1123658. View Abstract
  75. Network analysis of COVID-19-related PTSD and depressive symptoms among Chinese general population and comorbidity subgroup. Psychol Trauma. 2023 Mar; 15(3):431-442. View Abstract
  76. Gender difference in the relationship between personality traits and changes in depressive symptoms before and after the COVID-19 outbreak: A follow-up study among Chinese adults. J Affect Disord. 2023 04 01; 326:49-56. View Abstract
  77. Social support profiles correlate with depressive symptoms among Chinese parents during the COVID-19 pandemic: A latent profile analysis. J Health Psychol. 2023 07; 28(8):760-773. View Abstract
  78. Vigabatrin-associated brain abnormalities on MRI in tuberous sclerosis complex patients with infantile spasms: are they preventable? Ther Adv Neurol Disord. 2022; 15:17562864221138148. View Abstract
  79. Molecular Diagnostic Yield of Exome Sequencing and Chromosomal Microarray in Cerebral Palsy: A Systematic Review and Meta-analysis. JAMA Neurol. 2022 12 01; 79(12):1287-1295. View Abstract
  80. Mimics of Pediatric Small Vessel Primary Angiitis of the Central Nervous System. Ann Neurol. 2023 01; 93(1):109-119. View Abstract
  81. A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins. PLoS Pathog. 2022 11; 18(11):e1010656. View Abstract
  82. 16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons. Front Psychiatry. 2022; 13:924956. View Abstract
  83. Changes in Opioid Prescriptions and Potential Misuse and Substance Use Disorders Among Childhood Cancer Survivors Following the 2016 Opioid Prescribing Guideline. JAMA Oncol. 2022 11 01; 8(11):1658-1662. View Abstract
  84. Genetic Diagnosis Impacts Medical Management for Pediatric Epilepsies. Pediatr Neurol. 2023 01; 138:71-80. View Abstract
  85. Diagnostic yield of a multi-strategy genetic testing procedure in a nationwide cohort of 728 patients with infantile spasms in China. Seizure. 2022 Dec; 103:51-57. View Abstract
  86. Incidence and trends of hepatic cancer among children and adolescents in the United States from 2000 to 2017: Evidence from the Surveillance, Epidemiology, and End Results registry data. Cancer Causes Control. 2023 Jan; 34(1):69-79. View Abstract
  87. Effects of chronic disease diagnoses on alcohol consumption among elderly individuals: longitudinal evidence from China. BMJ Open. 2022 10 11; 12(10):e062920. View Abstract
  88. A randomized controlled trial of everolimus for neurocognitive symptoms in PTEN hamartoma tumor syndrome. Hum Mol Genet. 2022 10 10; 31(20):3393-3404. View Abstract
  89. Changes in rate and socioeconomic inequality of cervical cancer screening in northeastern China from 2013 to 2018. Front Med (Lausanne). 2022; 9:913361. View Abstract
  90. IQSEC2-related encephalopathy in male children: Novel mutations and phenotypes. Front Mol Neurosci. 2022; 15:984776. View Abstract
  91. Design and analysis of crossover trials for investigating high-risk medical devices: A review. Contemp Clin Trials Commun. 2022 Dec; 30:101004. View Abstract
  92. Challenges in the Clinical Recognition of Acute Flaccid Myelitis and its Implications. J Pediatr. 2023 02; 253:55-62.e4. View Abstract
  93. Early-Onset and Severe Complex Hereditary Spastic Paraplegia Caused by De Novo Variants in SPAST. Mov Disord. 2022 12; 37(12):2440-2446. View Abstract
  94. Seizure-related differences in biosignal 24-h modulation patterns. Sci Rep. 2022 09 05; 12(1):15070. View Abstract
  95. Effectiveness of Training Programs for Reducing Adverse Psychological Outcomes in Parents of Children with Acquired Brain Injury: A Systematic Review and Meta-Analysis. Neurol Ther. 2022 Dec; 11(4):1691-1704. View Abstract
  96. Comparison of estimation methods and sample size calculation for parameter-driven interrupted time series models with count outcomes. Health Services and Outcomes Research Methodology. 2022; 22(3):349-396. View Abstract
  97. Neurobehavioral Associations with NREM and REM Sleep Architecture in Children with Autism Spectrum Disorder. Children (Basel). 2022 Aug 30; 9(9). View Abstract
  98. Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms. Neurology. 2022 11 29; 99(22):e2494-e2503. View Abstract
  99. Relationship among Child Maltreatment, Parental Conflict, and Mental Health of Children during the COVID-19 Lockdown in China. J Child Adolesc Trauma. 2022 Aug 26; 1-10. View Abstract
  100. Association between work stress and health behaviours in Korean and Japanese ageing studies: a cross-sectional study. BMJ Open. 2022 08 25; 12(8):e063538. View Abstract
  101. Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms. World J Pediatr. 2022 11; 18(11):761-770. View Abstract
  102. Identifying biomarkers for epilepsy after cerebral malaria in Zambian children: rationale and design of a prospective observational study. BMJ Open. 2022 07 18; 12(7):e062948. View Abstract
  103. Interrater and Intrarater Agreement of Epileptic Encephalopathy Among Electroencephalographers for Children with Infantile Spasms Using the Burden of Amplitudes and Epileptiform Discharges (BASED) EEG Grading Scale: Study Design and Statistical Considerations. Neurol Ther. 2022 Sep; 11(3):1427-1437. View Abstract
  104. Associations of youth mental health, parental psychological distress, and family relationships during the COVID-19 outbreak in China. BMC Psychiatry. 2022 04 19; 22(1):275. View Abstract
  105. Assessing Risk for Relapse among Children with Infantile Spasms Using the Based Score after ACTH Treatment: A Retrospective Study. Neurol Ther. 2022 Jun; 11(2):835-849. View Abstract
  106. Pivotal clinical trials with patient-reported outcome measures in premarket approval applications for high-risk medical devices from 2005 to 2018: Review, examples, and regulatory considerations. Contemp Clin Trials. 2022 05; 116:106757. View Abstract
  107. Infantile spasms: Assessing the diagnostic yield of an institutional guideline and the impact of etiology on long-term treatment response. Epilepsia. 2022 05; 63(5):1164-1176. View Abstract
  108. Pediatric neurological cancer incidence and trends in the United States, 2000-2018. Cancer Causes Control. 2022 May; 33(5):687-699. View Abstract
  109. Mendelian etiologies identified with whole exome sequencing in cerebral palsy. Ann Clin Transl Neurol. 2022 02; 9(2):193-205. View Abstract
  110. Clinical Characteristics and Outcomes of Children with Acute Catastrophic Brain Injury: A 13-Year Retrospective Cohort Study. Neurocrit Care. 2022 06; 36(3):715-726. View Abstract
  111. Network analysis of COVID-19-related PTSD symptoms in China: the similarities and differences between the general population and PTSD sub-population. Eur J Psychotraumatol. 2021; 12(1):1997181. View Abstract
  112. Confirmation of infantile spasms resolution by prolonged outpatient EEGs. Epilepsia Open. 2021 12; 6(4):714-719. View Abstract
  113. Remote Assessment of Pediatric Patients with Daytime Sleepiness and Healthy Controls: A Pilot Study of Feasibility and Reliability. Child Neurol Open. 2021 Jan-Dec; 8:2329048X211048064. View Abstract
  114. Social support as a mediator between internet addiction and quality of life among Chinese high school students. Children and Youth Services Review. 2021; 129:106181. View Abstract
  115. Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus. Epilepsia. 2021 11; 62(11):2766-2777. View Abstract
  116. Exposure assessment for Cox proportional hazards cure models with interval-censored survival data. Biom J. 2022 01; 64(1):91-104. View Abstract
  117. Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures. Epilepsy Behav. 2021 09; 122:108228. View Abstract
  118. Can Chronic Disease Diagnosis Urge the Patients to Quit Smoking? - Evidence from the China Health and Nutrition Survey. Risk Manag Healthc Policy. 2021; 14:3059-3077. View Abstract
  119. Disease Severity and Motor Impairment Correlate With Health-Related Quality of Life in AP-4-Associated Hereditary Spastic Paraplegia. Neurol Genet. 2021 Aug; 7(4):e605. View Abstract
  120. Factors associated with long-term outcomes in pediatric refractory status epilepticus. Epilepsia. 2021 09; 62(9):2190-2204. View Abstract
  121. Sporadic and Periodic Interictal Discharges in Critically Ill Children: Seizure Associations and Time to Seizure Identification. J Clin Neurophysiol. 2023 Feb 01; 40(2):130-135. View Abstract
  122. Factors influencing the acute pentylenetetrazole-induced seizure paradigm and a literature review. Ann Clin Transl Neurol. 2021 07; 8(7):1388-1397. View Abstract
  123. Subclinical seizures detected on intracranial EEG: Patient characteristics and impact on surgical outcome in a single pediatric epilepsy surgery center. Epilepsy Behav. 2021 08; 121(Pt A):108040. View Abstract
  124. Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome. Mol Autism. 2021 04 28; 12(1):29. View Abstract
  125. Therapy with PTH 1-34 or calcitriol and calcium in diverse etiologies of hypoparathyroidism over 27 years at a single tertiary care center. Bone. 2021 08; 149:115977. View Abstract
  126. Bayesian functional mixed-effects models with grouped smoothness for analyzing time-course gene expression data. Current Bioinformatics. 2021; 16(1):18-27. View Abstract
  127. An evaluation of treatments and survival rates for pancreatic adenocarcinoma through survival analysis with inverse probability of treatment weighting: A population-based study. Journal of Pancreatology. 2021; 4(1):18-27. View Abstract
  128. Developing outcome measures of disease activity in pediatric myasthenia. Muscle Nerve. 2021 05; 63(5):751-757. View Abstract
  129. Twenty-four-hour patterns in electrodermal activity recordings of patients with and without epileptic seizures. Epilepsia. 2021 04; 62(4):960-972. View Abstract
  130. Study Design and Data Analysis of Artificial Pancreas Device Systems with Closed-Loop Glucose-Sensing Insulin Delivery. Int J Endocrinol. 2021; 2021:8812695. View Abstract
  131. A randomized double-blind controlled trial of everolimus in individuals with PTEN mutations: Study design and statistical considerations. Contemp Clin Trials Commun. 2021 Mar; 21:100733. View Abstract
  132. The longitudinal effect of sensory loss on depression among Chinese older adults. J Affect Disord. 2021 03 15; 283:216-222. View Abstract
  133. Hippocampal Involvement With Vigabatrin-Related MRI Signal Abnormalities in Patients With Infantile Spasms: A Novel Finding. J Child Neurol. 2021 06; 36(7):575-582. View Abstract
  134. Depressive symptoms and health service utilization among Chinese middle-aged and older adults: a national population-based longitudinal survey. Int J Ment Health Syst. 2021 Jan 06; 15(1):2. View Abstract
  135. A note on the prediction of frailties with misspecified shared frailty models. Journal of Statistical Computation and Simulation. 2021; 91(2):219-241. View Abstract
  136. High-dimensional causal mediation analysis with a large number of mediators clumping at zero to assess the contribution of the microbiome to the risk of bacterial pathogen colonization in older adults. Current Bioinformatics. 2020; 15(7):671-696. View Abstract
  137. Are marginalized two-part models superior to non-marginalized two-part models for count data with excess zeroes? Estimation of marginal effects, model misspecification, and model selection. Health Services and Outcomes Research Methodology. 2020; 18(3):175-214. View Abstract
  138. The Relationship Between Being Bullied and Addictive Internet Use Among Chinese Rural Adolescents: The Mediating Effect of Adult Attachment. J Interpers Violence. 2022 05; 37(9-10):NP6466-NP6486. View Abstract
  139. Assessing the Survival Benefit of Surgery and Various Types of Radiation Therapy for Treatment of Hepatocellular Carcinoma: Evidence from the Surveillance, Epidemiology, and End Results Registries. J Hepatocell Carcinoma. 2020; 7:201-218. View Abstract
  140. Time-varying coefficient cumulative gap time models for intensive longitudinal ecological momentary assessment data with missingness. J Appl Stat. 2022; 49(2):498-521. View Abstract
  141. Is the psychological impact of exposure to COVID-19 stronger in adolescents with pre-pandemic maltreatment experiences? A survey of rural Chinese adolescents. Child Abuse Negl. 2020 12; 110(Pt 2):104667. View Abstract
  142. Comparison of different computational implementations on fitting generalized linear mixed-effects models for repeated count measures. Journal of Statistical Computation and Simulation. 2020; 86(12):2392-2404. View Abstract
  143. Marginal effects and incremental effects in two-part models for endogenous healthcare utilization in health services research. Health Services and Outcomes Research Methodology. 2020; 20(2-3):111-139. View Abstract
  144. Exploring the Dynamics of Hemorrhagic Fever with Renal Syndrome Incidence in East China Through Seasonal Autoregressive Integrated Moving Average Models. Infect Drug Resist. 2020; 13:2465-2475. View Abstract
  145. DYNC1H1-related disorders: A description of four new unrelated patients and a comprehensive review of previously reported variants. Am J Med Genet A. 2020 09; 182(9):2049-2057. View Abstract
  146. A Triple-Difference Approach to Re-Evaluating the Impact of China's New Cooperative Medical Scheme on Incidences of Chronic Diseases Among Older Adults in Rural Communities. Risk Manag Healthc Policy. 2020; 13:643-659. View Abstract
  147. Attitudes toward aging, social support and depression among older adults: Difference by urban and rural areas in China. J Affect Disord. 2020 09 01; 274:85-92. View Abstract
  148. A Segmented Logistic Regression Approach to Evaluating Change in Caesarean Section Rate with Reform of Birth Planning Policy in Two Regions in China from 2012 to 2016. Risk Manag Healthc Policy. 2020; 13:245-253. View Abstract
  149. Ensemble Learning to Improve the Prediction of Fetal Macrosomia and Large-for-Gestational Age. J Clin Med. 2020 Jan 31; 9(2). View Abstract
  150. Design and analysis of high-risk medical device clinical trials for diabetes monitoring and treatment: A review. Journal of Pancreatology. 2019; 2(4):123-130. View Abstract
  151. Understanding Healthcare Utilization In China Through The Andersen Behavioral Model: Review Of Evidence From The China Health And Nutrition Survey. Risk Manag Healthc Policy. 2019; 12:209-224. View Abstract
  152. Machine Learning For Tuning, Selection, And Ensemble Of Multiple Risk Scores For Predicting Type 2 Diabetes. Risk Manag Healthc Policy. 2019; 12:189-198. View Abstract
  153. Simulation-based power and sample size calculation for designing interrupted time series analyses of count outcomes in evaluation of health policy interventions. Contemp Clin Trials Commun. 2020 Mar; 17:100474. View Abstract
  154. Rural-urban disparities in caesarean section rates in minority areas in China: evidence from electronic health records. J Int Med Res. 2020 Feb; 48(2):300060519877996. View Abstract
  155. Association of diabetes mellitus with hepatitis B and hepatitis C virus infection: evidence from an epidemiological study. Infect Drug Resist. 2019; 12:2875-2883. View Abstract
  156. A note on error bars as a graphical representation of the variability of data in biomedical research: Choosing between standard deviation and standard error of the mean. Journal of Pancreatology. 2019; 2(3):69-71. View Abstract
  157. Neutral diagnosis: An innovative concept for medical device clinical trials. Contemp Clin Trials Commun. 2019 Dec; 16:100436. View Abstract
  158. Design, analysis, power, and sample size calculation for three-phase interrupted time series analysis in evaluation of health policy interventions. J Eval Clin Pract. 2020 Jun; 26(3):826-841. View Abstract
  159. A semiparametric marginalized zero-inflated model for analyzing healthcare utilization panel data with missingness. J Appl Stat. 2019; 46(16):2862-2883. View Abstract
  160. Plasma indoleamine 2,3-dioxygenase activity as a potential biomarker for early diagnosis of multidrug-resistant tuberculosis in tuberculosis patients. Infect Drug Resist. 2019; 12:1265-1276. View Abstract
  161. A note on misspecification in general linear models with correlated errors for the analysis of crossover clinical trials. PLoS One. 2019; 14(3):e0213436. View Abstract
  162. Body Mass Index and 30-Day Adverse Outcomes Among Newly Admitted Residents to Skilled Nursing Facilities. J Am Med Dir Assoc. 2019 03; 20(3):312-316. View Abstract
  163. Long-Term Parathyroid Hormone 1-34 Replacement Therapy in Children with Hypoparathyroidism. J Pediatr. 2018 12; 203:391-399.e1. View Abstract
  164. Distribution-free models for latent mixed population responses in a longitudinal setting with missing data. Stat Methods Med Res. 2019 Oct-Nov; 28(10-11):3273-3285. View Abstract
  165. Body Mass Index, Falls, and Hip Fractures Among Nursing Home Residents. J Gerontol A Biol Sci Med Sci. 2018 09 11; 73(10):1403-1409. View Abstract
  166. A collection of marginalized two-part random-effects models for analyzing medical expenditure panel data: Impact of the New Cooperative Medical Scheme on healthcare expenditures in China. Stat Methods Med Res. 2019 08; 28(8):2494-2523. View Abstract
  167. In vivo and in vitro studies of Cry5B and nicotinic acetylcholine receptor agonist anthelmintics reveal a powerful and unique combination therapy against intestinal nematode parasites. PLoS Negl Trop Dis. 2018 05; 12(5):e0006506. View Abstract
  168. Children with type 1 diabetes who experienced a honeymoon phase had significantly lower LDL cholesterol 5 years after diagnosis. PLoS One. 2018; 13(5):e0196912. View Abstract
  169. Robust multivariate nonparametric tests for detection of two-sample location shift in clinical trials. PLoS One. 2018; 13(4):e0195894. View Abstract
  170. Simulating comparisons of different computing algorithms fitting zero-inflated Poisson models for zero abundant counts. Journal of Statistical Computation and Simulation. 2017; 87(13):2609-2621. View Abstract
  171. Endogenous schooling, school proximity and returns to rural schooling in northwestern China. China Agricultural Economic Review. 2017; 9(2):270-286. View Abstract
  172. Estimating marginal and incremental effects in the analysis of medical expenditure panel data using marginalized two-part random-effects generalized Gamma models: Evidence from China healthcare cost data. Stat Methods Med Res. 2018 10; 27(10):3039-3061. View Abstract
  173. Joint Estimation of Treatment and Placebo Effects in Clinical Trials with Longitudinal Blinding Assessments. J Am Stat Assoc. 2016; 111(514):538-548. View Abstract
  174. Assessing natural direct and indirect effects for a continuous exposure and a dichotomous outcome. Journal of Statistical Theory and Practice. 2016; 10(3):574-587. View Abstract
  175. Composite likelihood and maximum likelihood methods for joint latent class modeling of disease prevalence and high-dimensional semicontinuous biomarker data. Computational Statistics. 2016; 31(2):425-449. View Abstract
  176. A note on misspecification in joint modeling of correlated data with informative cluster sizes. Journal of Statistical Planning and Inference. 2016; 170:46-63. View Abstract
  177. Model selection in finite mixture of regression models: a Bayesian approach with innovative weighted g-priors and reversible jump Markov chain Monte Carlo implementation. Journal of Statistical Computation and Simulation. 2015; 85(12):2456-2478. View Abstract
  178. Modeling of correlated data with informative cluster sizes: An evaluation of joint modeling and within-cluster resampling approaches. Stat Methods Med Res. 2017 Aug; 26(4):1881-1895. View Abstract
  179. A non-parametric model to address overdispersed count response in a longitudinal data setting with missingness. Stat Methods Med Res. 2017 Jun; 26(3):1461-1475. View Abstract
  180. An objective stepwise Bayes approach to small area estimation. Journal of Statistical Computation and Simulation. 2015; 85(7):1474-1494. View Abstract
  181. Generalized linear mixed models for multi-reader multi-case studies of diagnostic tests. Stat Methods Med Res. 2017 Jun; 26(3):1373-1388. View Abstract
  182. A pseudo-likelihood approach for estimating diagnostic accuracy of multiple binary medical tests. Computational Statistics & Data Analysis. 2015; 84:85-98. View Abstract
  183. Likelihood-based methods for evaluating principal surrogacy in augmented vaccine trials. Stat Methods Med Res. 2017 04; 26(2):984-996. View Abstract
  184. Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling. Bone. 2015 Feb; 71:227-36. View Abstract
  185. Sensitivity analysis in non-inferiority trials with residual inconstancy after covariate adjustment. Journal of the Royal Statistical Society: Series C (Applied Statistics). 2014; 63(4):515-538. View Abstract
  186. Use of auxiliary covariates in estimating a biomarker-adjusted treatment effect model with clinical trial data. Stat Methods Med Res. 2016 10; 25(5):2103-2119. View Abstract
  187. Causal inference with missing exposure information: Methods and applications to an obstetric study. Stat Methods Med Res. 2016 10; 25(5):2053-2066. View Abstract
  188. Improved confidence intervals of a small probability from pooled testing with misclassification. Front Public Health. 2013; 1:39. View Abstract
  189. Joint modeling of transitional patterns of Alzheimer's disease. PLoS One. 2013; 8(9):e75487. View Abstract
  190. Evaluation of long-term vitamin E insufficiency or excess on bone mass, density, and microarchitecture in rodents. Free Radic Biol Med. 2013 Dec; 65:1209-1214. View Abstract
  191. A likelihood paradigm for clinical trials (with discussion). Journal of Statistical Theory and Practice. 2013; 7(2):157-177 (Rejoinder: 196-203). View Abstract
  192. Nonparametric ROC summary statistics for correlated diagnostic marker data. Stat Med. 2013 Jun 15; 32(13):2209-20. View Abstract
  193. Estimating diagnostic accuracy of raters without a gold standard by exploiting a group of experts. Biometrics. 2012 Dec; 68(4):1294-302. View Abstract
  194. Interrater and intrarater reliability in the diagnosis and staging of endometriosis. Obstet Gynecol. 2012 Jul; 120(1):104-12. View Abstract
  195. Generalized Degrees of Freedom and Adaptive Model Selection in Linear Mixed-Effects Models. Comput Stat Data Anal. 2012 Mar 01; 56(3):574-586. View Abstract
  196. Synthetic human parathyroid hormone 1-34 replacement therapy: a randomized crossover trial comparing pump versus injections in the treatment of chronic hypoparathyroidism. J Clin Endocrinol Metab. 2012 Feb; 97(2):391-9. View Abstract
  197. Latent class models for joint analysis of disease prevalence and high-dimensional semicontinuous biomarker data. Biostatistics. 2012 Jan; 13(1):74-88. View Abstract
  198. A joint modeling approach to data with informative cluster size: robustness to the cluster size model. Stat Med. 2011 Jul 10; 30(15):1825-36. View Abstract

Contact Bo Zhang

Phone: 617-919-7741
Print Profile