ABOUT THE RESEARCHER

OVERVIEW

Elizabeth Blume's research is focused on the treatment of end-stage heart disease and heart transplantation in pediatric patients. Her research interests include mechanical support devices to improve bridging children to heart transplant and sequelae and quality of life in pediatric heart-transplant recipients. She is particularly interested in the family dynamic, family-physician communication, and the role of the primary care physician in improving treatment compliance and long-term outcomes. 

BACKGROUND

Elizabeth Blume received her MD from Case Western Reserve University. She completed an internship, residency, and fellowship at Children's Hospital Boston.

PUBLICATIONS

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  1. Palliative Care Referrals in Cardiac Disease. Pediatrics. 2021 Mar; 147(3). View abstract
  2. Parent and Physician Understanding of Prognosis in Hospitalized Children With Advanced Heart Disease. J Am Heart Assoc. 2021 Jan 19; 10(2):e018488. View abstract
  3. Variability in clinical decision-making for ventricular assist device implantation in pediatrics. Pediatr Transplant. 2020 12; 24(8):e13840. View abstract
  4. Fourth Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report. Ann Thorac Surg. 2020 12; 110(6):1819-1831. View abstract
  5. Comparison of tissue Doppler imaging and conventional echocardiography to discriminate rejection from non-rejection after pediatric heart transplantation. Pediatr Transplant. 2020 08; 24(5):e13738. View abstract
  6. The re-occurrence of cardiomyopathy in propionic acidemia after liver transplantation. JIMD Rep. 2020 Jul; 54(1):3-8. View abstract
  7. Extracorporeal Membrane Oxygenation Support After Heart Transplantation in Children-Outcomes of a Single Center Cohort. Pediatr Crit Care Med. 2020 04; 21(4):332-339. View abstract
  8. Three-Dimensional Speckle Tracking Echocardiography for Assessment of Left Ventricular Function and Myocardial Mechanics after Pediatric Heart Transplantation. J Heart Lung Transplant. 2020 Apr; 39(4S):S457. View abstract
  9. "How are You Doing?": Patient and Family Support Resources for Children on Ventricular Assist Device. J Heart Lung Transplant. 2020 Apr; 39(4S):S465. View abstract
  10. Obesity Leads to Increased Mortality in Pediatric Heart Transplant Recipients - A Pediatric Heart Transplant Society Study. J Heart Lung Transplant. 2020 Apr; 39(4S):S85-S86. View abstract
  11. Association of Clinical Rejection Versus Rejection on Protocol Biopsy With Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients. Transplantation. 2020 01; 104(1):e31-e37. View abstract
  12. Fears and Stressors of Trainees Starting Fellowship in Pediatric Cardiology. Pediatr Cardiol. 2020 Apr; 41(4):677-682. View abstract
  13. Medical and end-of-life decision making in adolescents' pre-heart transplant: A descriptive pilot study. Palliat Med. 2020 03; 34(3):272-280. View abstract
  14. Congenital Cardiothoracic Surgeons and Palliative Care: A National Survey Study. J Palliat Care. 2021 Jan; 36(1):17-21. View abstract
  15. Integration of Pediatric Palliative Care Into Cardiac Intensive Care: A Champion-Based Model. Pediatrics. 2019 08; 144(2). View abstract
  16. Phenotypic Manifestations of Arrhythmogenic Cardiomyopathy in Children and Adolescents. J Am Coll Cardiol. 2019 07 23; 74(3):346-358. View abstract
  17. Is Doppler echocardiography useful for estimating left ventricular filling pressures in pediatric heart transplant recipients? Pediatr Transplant. 2019 11; 23(7):e13543. View abstract
  18. Early outcomes for low-risk pediatric heart transplant recipients and steroid avoidance: A multicenter cohort study (Clinical Trials in Organ Transplantation in Children - CTOTC-04). J Heart Lung Transplant. 2019 09; 38(9):972-981. View abstract
  19. Palliative care and paediatric cardiology: current evidence and future directions. Lancet Child Adolesc Health. 2019 07; 3(7):502-510. View abstract
  20. Third Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report: Preimplant Characteristics and Outcomes. Ann Thorac Surg. 2019 04; 107(4):993-1004. View abstract
  21. Compassionate deactivation of ventricular assist devices in children: A survey of pediatric ventricular assist device clinicians' perspectives and practices. Pediatr Transplant. 2019 05; 23(3):e13359. View abstract
  22. When a Child Needs a Transplant but Lacks Familial Social Support. Pediatrics. 2019 01; 143(1). View abstract
  23. Ventricular Assist Device Support as a Bridge to Transplantation in Pediatric Patients. J Am Coll Cardiol. 2018 07 24; 72(4):402-415. View abstract
  24. Pediatric heart transplantation across a positive crossmatch: First year results from the CTOTC-04 multi-institutional study. Am J Transplant. 2018 09; 18(9):2148-2162. View abstract
  25. Incidence, characterization, and impact of newly detected donor-specific anti-HLA antibody in the first year after pediatric heart transplantation: A report from the CTOTC-04 study. Am J Transplant. 2018 09; 18(9):2163-2174. View abstract
  26. Study rationale, design, and pretransplantation alloantibody status: A first report of Clinical Trials in Organ Transplantation in Children-04 (CTOTC-04) in pediatric heart transplantation. Am J Transplant. 2018 09; 18(9):2135-2147. View abstract
  27. Physician Perspectives on Palliative Care for Children with Advanced Heart Disease: A Comparison between Pediatric Cardiology and Palliative Care Physicians. J Palliat Med. 2018 06; 21(6):773-779. View abstract
  28. Post-transplant outcomes in pediatric ventricular assist device patients: A PediMACS-Pediatric Heart Transplant Study linkage analysis. J Heart Lung Transplant. 2018 06; 37(6):715-722. View abstract
  29. Liver abnormalities and post-transplant survival in pediatric Fontan patients. Pediatr Transplant. 2017 Dec; 21(8). View abstract
  30. Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death. Hum Mol Genet. 2017 09 15; 26(18):3545-3552. View abstract
  31. Patterns and Outcomes of Care in Children With Advanced Heart Disease Receiving Palliative Care Consultation. J Pain Symptom Manage. 2018 02; 55(2):351-358. View abstract
  32. Eighth annual INTERMACS report: Special focus on framing the impact of adverse events. J Heart Lung Transplant. 2017 Oct; 36(10):1080-1086. View abstract
  33. Second annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) report: Pre-implant characteristics and outcomes. J Heart Lung Transplant. 2018 01; 37(1):38-45. View abstract
  34. Pediatric Cardiology Provider Attitudes About Palliative Care: A Multicenter Survey Study. Pediatr Cardiol. 2017 Oct; 38(7):1324-1331. View abstract
  35. The Evolution of a Pediatric Ventricular Assist Device Program: The Boston Children's Hospital Experience. Pediatr Cardiol. 2017 Jun; 38(5):1032-1041. View abstract
  36. Deactivation of Ventricular Assist Devices: Perspectives and Experiences of Adult Cardiovascular Providers. J Card Fail. 2017 06; 23(6):485-486. View abstract
  37. Outcomes following implantation of mechanical circulatory support in adults with congenital heart disease: An analysis of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). J Heart Lung Transplant. 2018 01; 37(1):89-99. View abstract
  38. Trans-Fontan baffle placement of an endocardial systemic ventricular pacing lead. HeartRhythm Case Rep. 2017 Feb; 3(2):129-132. View abstract
  39. Does Small Size Matter With Continuous Flow Devices?: Analysis of the INTERMACS Database of Adults With BSA =1.5 m2. JACC Heart Fail. 2017 02; 5(2):123-131. View abstract
  40. Vascular endothelial growth factor A is associated with the subsequent development of moderate or severe cardiac allograft vasculopathy in pediatric heart transplant recipients. J Heart Lung Transplant. 2017 Apr; 36(4):434-442. View abstract
  41. Palliative Care for Patients With End-Stage Cardiovascular Disease and Devices: A Report From the Palliative Care Working Group of the Geriatrics Section of the American College of Cardiology. JAMA Intern Med. 2016 07 01; 176(7):1017-9. View abstract
  42. Is Endomyocardial Biopsy a Safe and Useful Procedure in Children with Suspected Cardiomyopathy? Pediatr Cardiol. 2016 Oct; 37(7):1200-10. View abstract
  43. Report of the National Heart, Lung, and Blood Institute Working Group: An Integrated Network for Congenital Heart Disease Research. Circulation. 2016 Apr 05; 133(14):1410-8. View abstract
  44. Adverse events in children implanted with ventricular assist devices in the United States: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS). J Heart Lung Transplant. 2016 05; 35(5):569-77. View abstract
  45. Outcomes of children implanted with ventricular assist devices in the United States: First analysis of the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS). J Heart Lung Transplant. 2016 05; 35(5):578-84. View abstract
  46. Outcomes of pediatric patients supported with continuous-flow ventricular assist devices: A report from the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS). J Heart Lung Transplant. 2016 05; 35(5):585-90. View abstract
  47. Is Myocarditis an Independent Risk Factor for Post-Transplant Mortality in Pediatric Heart Transplant Recipients? Circ Heart Fail. 2016 Jan; 9(1):e002328. View abstract
  48. Seventh INTERMACS annual report: 15,000 patients and counting. J Heart Lung Transplant. 2015 Dec; 34(12):1495-504. View abstract
  49. Pediatric mechanical circulatory support: available devices and outcomes as bridge-to-transplant therapy. Curr Opin Organ Transplant. 2015 Oct; 20(5):557-61. View abstract
  50. Physician and parent perceptions of prognosis and end-of-life experience in children with advanced heart disease. J Palliat Med. 2015 Apr; 18(4):318-23. View abstract
  51. Adrenergic receptor genotype influences heart failure severity and ß-blocker response in children with dilated cardiomyopathy. Pediatr Res. 2015 Feb; 77(2):363-9. View abstract
  52. Association of hemodynamic profiles with wait-list mortality in children listed for heart transplantation with idiopathic dilated cardiomyopathy. Am J Cardiol. 2015 Jan 15; 115(2):243-8. View abstract
  53. Treatment and outcomes of immune cytopenias following solid organ transplant in children. Pediatr Blood Cancer. 2015 02; 62(2):214-218. View abstract
  54. Parental perspectives on suffering and quality of life at end-of-life in children with advanced heart disease: an exploratory study*. Pediatr Crit Care Med. 2014 May; 15(4):336-42. View abstract
  55. Risk factors and outcome of Fontan-associated plastic bronchitis: a case-control study. J Am Heart Assoc. 2014 Apr 22; 3(2):e000865. View abstract
  56. Sixth INTERMACS annual report: a 10,000-patient database. J Heart Lung Transplant. 2014 Jun; 33(6):555-64. View abstract
  57. Ventricular assist devices in children: progress with an orphan device application. Circulation. 2014 Apr 08; 129(14):1530-7. View abstract
  58. Survival in patients removed from the heart transplant waiting list before receiving a transplant. J Heart Lung Transplant. 2014 Mar; 33(3):261-9. View abstract
  59. Tissue Doppler imaging for rejection surveillance in pediatric heart transplant recipients. J Heart Lung Transplant. 2013 Oct; 32(10):1027-33. View abstract
  60. Antibody depletion for the treatment of crossmatch-positive pediatric heart transplant recipients. Pediatr Transplant. 2013 Nov; 17(7):661-9. View abstract
  61. Prognostic value of exercise testing during heart transplant evaluation in children. Circ Heart Fail. 2013 Jul; 6(4):792-9. View abstract
  62. Ten yr of pediatric heart transplantation: a report from the Pediatric Heart Transplant Study. Pediatr Transplant. 2013 Mar; 17(2):99-111. View abstract
  63. Cardiovascular outcomes after the arterial switch operation for D-transposition of the great arteries. Circulation. 2013 Jan 22; 127(3):331-9. View abstract
  64. Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States. J Heart Lung Transplant. 2012 Dec; 31(12):1241-52. View abstract
  65. Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States. Circ Heart Fail. 2013 Jan; 6(1):e1-e11. View abstract
  66. Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States: executive summary. Ann Thorac Surg. 2012 Dec; 94(6):e163-8. View abstract
  67. Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States. Ann Thorac Surg. 2012 Dec; 94(6):2147-58. View abstract
  68. Statement regarding the pre and post market assessment of durable, implantable ventricular assist devices in the United States: executive summary. Circ Heart Fail. 2013 Jan; 6(1):145-50. View abstract
  69. Cardiac allograft function during the first year after transplantation in rejection-free children and young adults. Circ Cardiovasc Imaging. 2012 Nov; 5(6):756-64. View abstract
  70. Allograft-Transmitted Histoplasma capsulatum Infection in a Solid Organ Transplant Recipient. J Pediatric Infect Dis Soc. 2013 Sep; 2(3):270-3. View abstract
  71. Patterns of care at end of life in children with advanced heart disease. Arch Pediatr Adolesc Med. 2012 Aug; 166(8):745-8. View abstract
  72. Utility of exercise stress echocardiography in pediatric cardiac transplant recipients: a single-center experience. J Heart Lung Transplant. 2012 May; 31(5):517-23. View abstract
  73. Endomyocardial biopsy and selective coronary angiography are low-risk procedures in pediatric heart transplant recipients: results of a multicenter experience. J Heart Lung Transplant. 2012 Apr; 31(4):398-409. View abstract
  74. Comparison of risk factors and outcomes for pediatric patients listed for heart transplantation after bidirectional Glenn and after Fontan: an analysis from the Pediatric Heart Transplant Study. J Heart Lung Transplant. 2012 Feb; 31(2):133-9. View abstract
  75. Sudden death after pediatric heart transplantation: analysis of data from the Pediatric Heart Transplant Study Group. J Heart Lung Transplant. 2011 Dec; 30(12):1395-402. View abstract
  76. Berlin Heart EXCOR Pediatric ventricular assist device Investigational Device Exemption study: study design and rationale. Am Heart J. 2011 Sep; 162(3):425-35.e6. View abstract
  77. Association of graft ischemic time with survival after heart transplant among children in the United States. J Heart Lung Transplant. 2011 Nov; 30(11):1244-9. View abstract
  78. Outcomes after listing for primary transplantation for infants with unoperated-on non-hypoplastic left heart syndrome congenital heart disease: a multi-institutional study. J Heart Lung Transplant. 2011 Sep; 30(9):1023-32. View abstract
  79. The impact of heart failure severity at time of listing for cardiac transplantation on survival in pediatric cardiomyopathy. J Heart Lung Transplant. 2011 Jul; 30(7):755-60. View abstract
  80. Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9. View abstract
  81. Patterns of End-of-Life Care in Children with Advanced Heart Disease (747). J Pain Symptom Manage. 2011 Jan; 41(1):301. View abstract
  82. Infection and malignancy after pediatric heart transplantation: the role of induction therapy. J Heart Lung Transplant. 2011 Mar; 30(3):299-308. View abstract
  83. Rejection with hemodynamic compromise in the current era of pediatric heart transplantation: a multi-institutional study. J Heart Lung Transplant. 2011 Mar; 30(3):282-8. View abstract
  84. Minimizing infection and rejection death: clues acquired from 19 years of multi-institutional cardiac transplantation data. J Heart Lung Transplant. 2011 Feb; 30(2):151-7. View abstract
  85. Association of race and socioeconomic position with outcomes in pediatric heart transplant recipients. Am J Transplant. 2010 Sep; 10(9):2116-23. View abstract
  86. Outcomes of heart transplantation using donor hearts from infants with sudden infant death syndrome. J Heart Lung Transplant. 2010 Nov; 29(11):1226-30. View abstract
  87. BNP levels predict outcome in pediatric heart failure patients: post hoc analysis of the Pediatric Carvedilol Trial. Circ Heart Fail. 2010 Sep; 3(5):606-11. View abstract
  88. Impact of ABO-incompatible listing on wait-list outcomes among infants listed for heart transplantation in the United States: a propensity analysis. Circulation. 2010 May 04; 121(17):1926-33. View abstract
  89. Decline in rejection in the first year after pediatric cardiac transplantation: a multi-institutional study. J Heart Lung Transplant. 2010 Jun; 29(6):625-32. View abstract
  90. Use of a virtual community as a psychosocial support system in pediatric transplantation. Pediatr Transplant. 2010 Mar; 14(2):261-7. View abstract
  91. Safety and early outcomes using a corticosteroid-avoidance immunosuppression protocol in pediatric heart transplant recipients. J Heart Lung Transplant. 2010 May; 29(5):517-22. View abstract
  92. Racial and ethnic differences in mortality in children awaiting heart transplant in the United States. Am J Transplant. 2009 Dec; 9(12):2808-15. View abstract
  93. Incidence and risk factors for mortality in infants awaiting heart transplantation in the USA. J Heart Lung Transplant. 2009 Dec; 28(12):1292-8. View abstract
  94. Evaluating failing Fontans for heart transplantation: predictors of death. Ann Thorac Surg. 2009 Aug; 88(2):558-63; discussion 563-4. View abstract
  95. Socioeconomic position and graft failure in pediatric heart transplant recipients. Circ Heart Fail. 2009 May; 2(3):160-5. View abstract
  96. Waiting list mortality among children listed for heart transplantation in the United States. Circulation. 2009 Feb 10; 119(5):717-727. View abstract
  97. Predictors of death and transplant in patients with a mechanical circulatory support device: a multi-institutional study. J Heart Lung Transplant. 2009 Jan; 28(1):44-50. View abstract
  98. The longitudinal course of cardiomyopathy in Friedreich's ataxia during childhood. Pediatr Cardiol. 2009 Apr; 30(3):306-10. View abstract
  99. Ventricular assist devices as a bridge to heart transplantation in children. J Cardiovasc Nurs. 2008 Jan-Feb; 23(1):25-9. View abstract
  100. Intra-aortic balloon pump use in the failing Fontan circulation. Congenit Heart Dis. 2008 Jan-Feb; 3(1):60-2. View abstract
  101. Longitudinal changes in heart rate recovery after maximal exercise in pediatric heart transplant recipients: evidence of autonomic re-innervation? J Heart Lung Transplant. 2007 Dec; 26(12):1306-12. View abstract
  102. Carvedilol for children and adolescents with heart failure: a randomized controlled trial. JAMA. 2007 Sep 12; 298(10):1171-9. View abstract
  103. Outcome after Fontan failure and takedown to an intermediate palliative circulation. Ann Thorac Surg. 2007 Sep; 84(3):880-7. View abstract
  104. Parenting stress and parental post-traumatic stress disorder in families after pediatric heart transplantation. J Heart Lung Transplant. 2007 Feb; 26(2):120-6. View abstract
  105. Indications for heart transplantation in pediatric heart disease: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young; the Councils on Clinical Cardiology, Cardiovascular Nursing, and Cardiovascular Surgery and Anesthesia; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007 Feb 06; 115(5):658-76. View abstract
  106. Successful use of bivalirudin for cardiac transplantation in a child with heparin-induced thrombocytopenia. J Heart Lung Transplant. 2006 Nov; 25(11):1376-9. View abstract
  107. Outcome of listing for cardiac transplantation for failed Fontan: a multi-institutional study. Circulation. 2006 Jul 25; 114(4):273-80. View abstract
  108. Successful implantation of a Berlin heart biventricular assist device in a failing single ventricle. J Thorac Cardiovasc Surg. 2006 Jun; 131(6):1407-8. View abstract
  109. Outcomes of children bridged to heart transplantation with ventricular assist devices: a multi-institutional study. Circulation. 2006 May 16; 113(19):2313-9. View abstract
  110. Prospective single-arm protocol of carvedilol in children with ventricular dysfunction. Pediatr Cardiol. 2006 May-Jun; 27(3):336-42. View abstract
  111. Lymphoproliferative disorders after paediatric heart transplantation: a multi-institutional study. Lancet. 2006 Jan 21; 367(9506):233-9. View abstract
  112. International Society for Heart and Lung Transplantation: Practice guidelines for management of heart failure in children. J Heart Lung Transplant. 2004 Dec; 23(12):1313-33. View abstract
  113. The longitudinal impact of psychological functioning, medical severity, and family functioning in pediatric heart transplantation. J Heart Lung Transplant. 2004 Apr; 23(4):473-80. View abstract
  114. Risk factors for recurrent rejection in pediatric heart transplantation: a multicenter experience. J Heart Lung Transplant. 2004 Feb; 23(2):178-85. View abstract
  115. Current status of heart transplantation in children: update 2003. Pediatr Clin North Am. 2003 Dec; 50(6):1375-91. View abstract
  116. Atrial tachyarrhythmias and permanent pacing after pediatric heart transplantation. J Heart Lung Transplant. 2003 Oct; 22(10):1126-33. View abstract
  117. Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in a patient with cardiomyopathy and hemophilia A. Intensive Care Med. 2003 Jun; 29(6):985-988. View abstract
  118. Gastrointestinal complications after pediatric cardiac transplantation. J Heart Lung Transplant. 2002 Jul; 21(7):751-9. View abstract
  119. Arterial switch operation with a single coronary artery. J Thorac Cardiovasc Surg. 2002 Jun; 123(6):1164-72. View abstract
  120. Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue. Adv Exp Med Biol. 2002; 507:107-12. View abstract
  121. Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency. Mayo Clin Proc. 2002 Jan; 77(1):92-6. View abstract
  122. Perioperative risk factors for development of protein-losing enteropathy following a Fontan procedure. Am J Cardiol. 2001 Nov 15; 88(10):1206-9. View abstract
  123. Carvedilol as therapy in pediatric heart failure: an initial multicenter experience. J Pediatr. 2001 Apr; 138(4):505-11. View abstract
  124. Clinical outcome of fenestrated Fontan patients after closure: the first 10 years. Circulation. 2000 Oct 24; 102(17):2094-9. View abstract
  125. Sialyl LewisX oligosaccharide preserves myocardial and endothelial function during cardioplegic ischemia. Ann Thorac Surg. 2000 Sep; 70(3):890-4. View abstract
  126. Long-term follow-up of pediatric cardiac patients requiring mechanical circulatory support. Ann Thorac Surg. 2000 Jan; 69(1):186-92. View abstract
  127. Left superior vena cava connection to unroofed coronary sinus associated with positional cyanosis: successful transcatheter treatment using Gianturco-Grifka vascular occlusion device. Catheter Cardiovasc Interv. 1999 Dec; 48(4):369-73. View abstract
  128. Sodium channel abnormalities are infrequent in patients with long QT syndrome: identification of two novel SCN5A mutations. Am J Med Genet. 1999 Oct 29; 86(5):470-6. View abstract
  129. Evolution of risk factors influencing early mortality of the arterial switch operation. J Am Coll Cardiol. 1999 May; 33(6):1702-9. View abstract
  130. Activated endothelial cells elicit paracrine induction of epithelial chloride secretion. 6-Keto-PGF1alpha is an epithelial secretagogue. J Clin Invest. 1998 Sep 15; 102(6):1161-72. View abstract
  131. Images in cardiovascular medicine. Anatomically corrected malposition of the great arteries [S,D,L]. Circulation. 1998 Mar 31; 97(12):1207. View abstract
  132. Long-term results of arterial switch repair of transposition of the great vessels. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 1998; 1:129-138. View abstract
  133. Soluble adhesion molecules in infants and children undergoing cardiopulmonary bypass. Circulation. 1997 Nov 04; 96(9 Suppl):II-352-7. View abstract
  134. A switch in time saves a statistical bind. JAMA. 1991 Dec 18; 266(23):3284-5. View abstract
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