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Researcher | Research Overview

In the Engle Lab, Dr. Arthur Lee’s current work focuses on two major areas:

  1. Identifying pathogenic structural variants (e.g., deletions, duplications, inversions, etc.) from patient whole genome sequencing data.
  2. Generating and analyzing single cell functional genomics data (e.g., scATAC-seq) for rare cell subtypes that are sparsely represented in public databases.

Ultimately, he hopes to integrate these layers of next-generation sequencing data as a powerful lever into rare, non-coding disease biology. Arthur collaborates closely with the lab of Daniel MacArthur, PhD at the Broad Institute of MIT and Harvard, where he is a Postdoctoral Scholar in the Program in Medical and Population Genetics.

Researcher | Research Background

Dr. Arthur Lee joined the Engle Lab in 2017 after earning his MD/PhD at Washington University School of Medicine in St. Louis with a PhD in Computational and Systems Biology. He conducted his doctoral research in the lab of Don Conrad, PhD, studying the impact of rare copy-number variants on common infertility in humans and mice.

Researcher | Publications