ABOUT THE RESEARCHER

OVERVIEW

Dr. John Arnold has combined his clinical interest in mechanical ventilation with a research career focused on lung protective ventilation in both animal models and in humans. Past projects have studied the effects of high frequency oscillatory ventilation when combined with perfluorocarbons to provide optimal lung protection. He has led a research team that has measured changes in regional lung compliance to provide optimal tidal volumes and end expiratory volumes in both animals and humans. Most recently, his laboratory team has focused on computational medicine and applied machine learning to develop novel decision support tools to improve the quality and efficiency of care in the intensive care unit.

BACKGROUND

Dr. Arnold has been able to combine his roles as an experienced clinician, medical director of Respiratory Care and the Extracorporeal Membrane Oxygenation Program, a mentor to many now successful clinician-scientists and an active translational researcher to become a national and international leader in the management of pediatric acute respiratory distress syndrome.

 

Selected Publications

  1. Rettig JS, Smallwood CD, Walsh BK, Rimensberger PC, Bachman TE, Bollen CW, Duval EL, Gebistorf F, Markhorst DG, Tinnevelt M, Todd M, Zurakowski D, Arnold JH. High frequency oscillatory ventilation in pediatric acute lung injury: a multicenter international experience. Crit Care Med 2015;43:2660-2667.
  2. Walsh BK, Davis MD, Hunt JF, Kheir JK, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res 2015. DOI: 10.1088/1752-7155/9/3/036009.
  3. Walsh BK, Betit P, Fink JB, Pereira LM, Arnold JH. Characterization of ribavirin aerosol with small particle aerosol generator and vibrating mesh micropump aerosol technologies. Respir Care 2016;61:577-585.
  4. Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Kacmarek RM, Arnold JH. Categorization in mechanically ventilated pediatric subjects: a proposed method to improve quality. Respir Care 2016;61:1168 –1178.
  5. Walsh BK, Smallwood CD, Rettig JS, Kacmarek RM, Thompson JE, Arnold JH. Daily goals formulation and enhanced visualization of mechanical ventilation variance improves mechanical ventilation score. Respir Care 2017;62:268–278.
  6. Smallwood CD, Walsh BK, Arnold JH, Gouldstone A. Equilibration time required for respiratory system compliance and oxygenation response following changes in positive end-expiratory pressure in mechanically ventilated children. Crit Care Med DOI: 10.1097/CCM.0000000000003001.
  7. Ventre KM, Arnold JH. Acute parenchymal disease in pediatric patients, in Vincent J-L, Abraham E, Moore FA, Kochanek PM, Fink MP, (eds.), Textbook of Critical Care (7th edition), Elsevier, Philadelphia, 2017, 500-518.
  8. Rettig JS, Arnold JH. Dexmedetomidine in the PICU: can we get more for less? Pediatric Crit Care Med 2017;18:893-894.

PUBLICATIONS

Publications powered by Harvard Catalyst Profiles

  1. Life-Threatening Hemoptysis in a Pediatric Referral Center. Crit Care Med. 2021 03 01; 49(3):e291-e303. View abstract
  2. Adding Continuous Vital Sign Information to Static Clinical Data Improves the Prediction of Length of Stay After Intubation: A Data-Driven Machine Learning Approach. Respir Care. 2020 Sep; 65(9):1367-1377. View abstract
  3. Distribution of Ventilation Measured by Electrical Impedance Tomography in Critically Ill Children. Respir Care. 2020 May; 65(5):590-595. View abstract
  4. Noninvasive Ventilation Is Interrupted Frequently and Mostly Used at Night in the Pediatric Intensive Care Unit. Respir Care. 2020 Mar; 65(3):341-346. View abstract
  5. Empirical Probability of Positive Response to PEEP Changes and Mechanical Ventilation Factors Associated With Improved Oxygenation During Pediatric Ventilation. Respir Care. 2019 Oct; 64(10):1193-1198. View abstract
  6. Time versus treatment: interpreting longitudinal data analysis of treprostinil. J Pediatr. 2019 03; 206:304-305. View abstract
  7. Equilibration Time Required for Respiratory System Compliance and Oxygenation Response Following Changes in Positive End-Expiratory Pressure in Mechanically Ventilated Children. Crit Care Med. 2018 05; 46(5):e375-e379. View abstract
  8. Dexmedetomidine in the PICU: Can We Get More for Less? Pediatr Crit Care Med. 2017 09; 18(9):893-894. View abstract
  9. The Quality of Quality Metrics-Reply. Respir Care. 2017 02; 62(2):254-255. View abstract
  10. Daily Goals Formulation and Enhanced Visualization of Mechanical Ventilation Variance Improves Mechanical Ventilation Score. Respir Care. 2017 Mar; 62(3):268-278. View abstract
  11. 1015: IDENTIFICATION OF PEDIATRIC VENTILATOR-ASSOCIATED CONDITIONS USING CONTINUOUS VENTILATOR DATA. Crit Care Med. 2016 Dec; 44(12 Suppl 1):330. View abstract
  12. 1629: LIQUID FLUOROCARBON LAVAGE FOR AIRWAY THROMBUS AFTER SEVERE HEMOPTYSIS REQUIRING ECMO. Crit Care Med. 2016 Dec; 44(12 Suppl 1):482. View abstract
  13. 955: A MACHINE-LEARNING ALGORITHM FOR OXYGENATION RESPONSE PREDICTION IN MECHANICALLY VENTILATED CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):315. View abstract
  14. 949: DEVELOPMENT OF HEART, RESPIRATORY RATE, AND OXYGEN SATURATION PERCENTILE CURVES IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):313. View abstract
  15. Categorization in Mechanically Ventilated Pediatric Subjects: A Proposed Method to Improve Quality. Respir Care. 2016 Sep; 61(9):1168-78. View abstract
  16. Characterization of Ribavirin Aerosol With Small Particle Aerosol Generator and Vibrating Mesh Micropump Aerosol Technologies. Respir Care. 2016 May; 61(5):577-85. View abstract
  17. High-Frequency Oscillatory Ventilation in Pediatric Acute Lung Injury: A Multicenter International Experience. Crit Care Med. 2015 Dec; 43(12):2660-7. View abstract
  18. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep 03; 9(3):036009. View abstract
  19. Mechanical ventilation guided by electrical impedance tomography in experimental acute lung injury. Crit Care Med. 2013 May; 41(5):1296-304. View abstract
  20. Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre. Physiol Meas. 2013 Feb; 34(2):163-77. View abstract
  21. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90. View abstract
  22. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15. View abstract
  23. Quality of life of pediatric cardiac patients who previously required extracorporeal membrane oxygenation. Pediatr Crit Care Med. 2012 Jul; 13(4):428-34. View abstract
  24. Whither lung EIT: where are we, where do we want to go and what do we need to get there? Physiol Meas. 2012 May; 33(5):679-94. View abstract
  25. Isoflurane for life-threatening bronchospasm: a 15-year single-center experience. Respir Care. 2012 Nov; 57(11):1857-64. View abstract
  26. High-frequency oscillatory ventilation: learning which way to turn the dials. Pediatr Crit Care Med. 2012 Mar; 13(2):242-4. View abstract
  27. A unified approach for EIT imaging of regional overdistension and atelectasis in acute lung injury. IEEE Trans Med Imaging. 2012 Mar; 31(3):834-42. View abstract
  28. Electrical activity of the diaphragm during extubation readiness testing in critically ill children. Pediatr Crit Care Med. 2011 Nov; 12(6):e220-4. View abstract
  29. A spontaneous breathing trial with pressure support overestimates readiness for extubation in children. Pediatr Crit Care Med. 2011 Nov; 12(6):e330-5. View abstract
  30. Pediatric respiratory diseases: 2011 update for the Rogers' Textbook of Pediatric Intensive Care. Pediatr Crit Care Med. 2011 May; 12(3):325-38. View abstract
  31. Electrocardiographic guidance for the placement of gastric feeding tubes: a pediatric case series. Respir Care. 2011 Apr; 56(4):467-71. View abstract
  32. Factors associated with survival in pediatric extracorporeal membrane oxygenation--a single-center experience. J Pediatr Surg. 2010 Oct; 45(10):1995-2003. View abstract
  33. Adenovirus 36 and obesity in children and adolescents. Pediatrics. 2010 Oct; 126(4):721-6. View abstract
  34. Regional lung volume changes during high-frequency oscillatory ventilation. Pediatr Crit Care Med. 2010 Sep; 11(5):610-5. View abstract
  35. Towards lung EIT image segmentation: automatic classification of lung tissue state from analysis of EIT monitored recruitment manoeuvres. Physiol Meas. 2010 Aug; 31(8):S31-43. View abstract
  36. Regional overdistension identified with electrical impedance tomography in the perflubron-treated lung. Physiol Meas. 2010 Aug; 31(8):S85-95. View abstract
  37. Respiratory distress associated with inadequate mechanical ventilator flow response in a neonate with congenital diaphragmatic hernia. Respir Care. 2010 Mar; 55(3):342-5. View abstract
  38. Synchronizing ventilatory support with the neural signal to breathe. Pediatr Crit Care Med. 2010 Jan; 11(1):142-3. View abstract
  39. Infant botulism mimicking Hirschprung's disease. J Pediatr Surg. 2009 Oct; 44(10):e5-7. View abstract
  40. Automated measurement of the lower inflection point in a pediatric lung model. Pediatr Crit Care Med. 2009 Jul; 10(4):511-6. View abstract
  41. GREIT: a unified approach to 2D linear EIT reconstruction of lung images. Physiol Meas. 2009 Jun; 30(6):S35-55. View abstract
  42. Differences in regional pulmonary pressure-impedance curves before and after lung injury assessed with a novel algorithm. Physiol Meas. 2009 Jun; 30(6):S137-48. View abstract
  43. Gas exchange and lung mechanics during high frequency ventilation in the perflubron-treated lung. Pediatr Crit Care Med. 2008 Nov; 9(6):641-6. View abstract
  44. Polymicrobial bloodstream infection in pediatric patients: risk factors, microbiology, and antimicrobial management. Pediatr Infect Dis J. 2008 May; 27(5):400-5. View abstract
  45. Improving our approach to sedation in the pediatric intensive care unit: is it time to inhale? Pediatr Crit Care Med. 2008 Mar; 9(2):233-4. View abstract
  46. Assessing the benefits of noninvasive ventilation: the tissue is the issue. Crit Care Med. 2008 Jan; 36(1):349-50. View abstract
  47. A (large) step toward improved lung protection. Pediatr Crit Care Med. 2008 Jan; 9(1):127-8. View abstract
  48. Regional lung volume changes in children with acute respiratory distress syndrome during a derecruitment maneuver. Crit Care Med. 2007 Aug; 35(8):1972-8. View abstract
  49. Measurement of deadspace compartments: on the road to somewhere. Pediatr Crit Care Med. 2007 Jul; 8(4):408-9. View abstract
  50. Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. Intensive Care Med. 2007 Jun; 33(6):1018-24. View abstract
  51. Insights in pediatric ventilation: timing of intubation, ventilatory strategies, and weaning. Curr Opin Crit Care. 2007 Feb; 13(1):57-63. View abstract
  52. Electrical impedance tomography: Ready for prime time? Intensive Care Med. 2006 Sep; 32(9):1290-2. View abstract
  53. State Behavioral Scale: a sedation assessment instrument for infants and young children supported on mechanical ventilation. Pediatr Crit Care Med. 2006 Mar; 7(2):107-14. View abstract
  54. Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care. 2006 Mar; 21(1):23-32; discussion 32-7. View abstract
  55. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov; 6(6):642-7. View abstract
  56. Genetic polymorphisms in acute respiratory distress syndrome: new approach to an old problem. Crit Care Med. 2005 Oct; 33(10):2443-5. View abstract
  57. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005 Jul 13; 294(2):229-37. View abstract
  58. Noninvasive assessment of lung volume: respiratory inductance plethysmography and electrical impedance tomography. Crit Care Med. 2005 Mar; 33(3 Suppl):S163-9. View abstract
  59. Patient in impending respiratory failure. Paediatr Respir Rev. 2004 Dec; 5(4):339, 341. View abstract
  60. High frequency oscillatory ventilation in acute respiratory failure. Paediatr Respir Rev. 2004 Dec; 5(4):323-32. View abstract
  61. Bench-to-bedside review: Ventilator strategies to reduce lung injury -- lessons from pediatric and neonatal intensive care. Crit Care. 2005 Apr; 9(2):177-83. View abstract
  62. Intracranial hemorrhage in premature neonates treated with extracorporeal membrane oxygenation correlates with conceptional age. J Pediatr. 2004 Aug; 145(2):184-9. View abstract
  63. Electrical impedance tomography: on the path to the Holy Grail. Crit Care Med. 2004 Mar; 32(3):894-5. View abstract
  64. Mechanical ventilation in children with acute respiratory failure. Curr Opin Crit Care. 2004 Feb; 10(1):7-12. View abstract
  65. Acute parenchymal disease in infants and children, in Fink MB, Shoemaker WC, et al (eds.), Textbook of Critical Care (5th edition), Elsevier, Philadelphia, in press. 2004. View abstract
  66. Respiratory Disorders: ECMO, in Cloherty JP, Stark AR, Eichenwald E (eds). Manual of Neonatal Care (5th edition), Williams & Wilkins, Philadelphia. 2004; 364-70. View abstract
  67. Assessment of alveolar recruitment: new approaches. Yearbook of Critical Care, in press. 2004. View abstract
  68. Cumulative fluid balance does not influence weaning duration or extubation outcomes in children. Ped Crit Care Med, in press. 2004. View abstract
  69. Non-invasive assessment of lung volume: respiratory inductance plethysmography and electric impedance tomography. Critical Care Medicine, in press. 2004. View abstract
  70. Changes in Lung Impedance Following Derecruitment During High Frequency Ventilation. Presented at the Pediatric Academic Societies Annual Meeting, San Francisco, CA. 2004. View abstract
  71. Sublingual capnometry in pediatric patients. Yearbook of Critical Care, in press. 2004. View abstract
  72. Bench-to-bedside review: Ventilator strategies to reduce lung injury- lessons from pediatric and neonatal intensive care. Critical Care Forum, in press. 2004. View abstract
  73. Anesthesia and analgesia, in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (6th Edition), J.B. Lippincott, Philadelphia, in press. 2004. View abstract
  74. Electrical impedance tomography: on the path to the Holy Grail. Crit Care Med 32: 894-895, 2004. 2004; 32:894-5. View abstract
  75. Impact of AMICAR on hemorrhagic complications of ECMO: a ten-year review. J Pediatr Surg. 2003 Aug; 38(8):1212-6. View abstract
  76. Extended high-frequency partial liquid ventilation in lung injury: gas exchange, injury quantification, and vapor loss. J Appl Physiol (1985). 2003 Sep; 95(3):1248-58. View abstract
  77. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. Am J Respir Crit Care Med. 2003 May 15; 167(10):1334-40. View abstract
  78. Designing a Nurse-Implemented Sedation Algorithm for Use in a Pediatric Intensive Care Unit – A Preliminary Report. Ped Crit Care Med. 2003; 4:A158. View abstract
  79. The use of high frequency oscillatory ventilation in hydrocarbon pneumonitis. Int J Med Toxicol. 2003; 6:6. View abstract
  80. Comparison of fluconazole and nystatin oral suspensions for treatment of oral candidiasis in infants. Pediatr Infect Dis J. 2002 Dec; 21(12):1165-7. View abstract
  81. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27; 288(20):2561-8. View abstract
  82. To recruit or not derecruit: that is the question. Crit Care Med. 2002 Aug; 30(8):1925-7. View abstract
  83. Weaning critically ill children from ventilatory support: a randomized trial comparing two protocols to standard care. Am J Resp Crit Care Med. 2002; 165:A156. View abstract
  84. Identification of optimal lung volume during high-frequency oscillatory ventilation using respiratory inductive plethysmography. Crit Care Med. 2001 Dec; 29(12):2349-59. View abstract
  85. High-frequency oscillatory ventilation in pediatric patients. Respir Care Clin N Am. 2001 Dec; 7(4):633-45. View abstract
  86. Measurement of the alveolar deadspace: are we there yet? Crit Care Med. 2001 Jun; 29(6):1287-8. View abstract
  87. High-frequency oscillatory ventilation of the perfluorocarbon-filled lung: dose-response relationships in an animal model of acute lung injury. Crit Care Med. 2001 Apr; 29(4):847-54. View abstract
  88. Optimizing intrapulmonary perfluorocarbon distribution: fluoroscopic comparison of mode of ventilation and body position. Crit Care Med. 2001 Mar; 29(3):601-8. View abstract
  89. The effect of post-gestational age on the incidence of intracranial hemorrhage in premature infants treated with extracorporeal membrane oxygenation. Crit Care Med. 2001; 29:A140. View abstract
  90. Evaluation of a pediatric extubation readiness test. Crit Care Med. 2001; 29:A142. View abstract
  91. High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience. Crit Care Med. 2000 Dec; 28(12):3913-9. View abstract
  92. High-frequency ventilation in the pediatric intensive care unit. Pediatr Crit Care Med. 2000 Oct; 1(2):93-9. View abstract
  93. High-frequency oscillatory ventilation and partial liquid ventilation: liquid breathing to a different beat (frequency) Crit Care Med. 2000 Jul; 28(7):2660-2. View abstract
  94. The effects of early and repeated prone positioning in pediatric patients with acute lung injury. Chest. 2000 Jul; 118(1):156-63. View abstract
  95. Acute respiratory failure in children. Curr Opin Pediatr. 2000 Jun; 12(3):233-7. View abstract
  96. Partial liquid breathing: are we headed in the right direction? Crit Care Med. 2000 May; 28(5):1675-6. View abstract
  97. Aortic valve replacement: is valve size important? J Thorac Cardiovasc Surg. 2000 May; 119(5):963-74. View abstract
  98. Single-breath CO2 analysis as a predictor of lung volume change in a model of acute lung injury. Crit Care Med. 2000 Mar; 28(3):760-4. View abstract
  99. Innovative methods of respiratory support in infants and children. Clinical Pediatric Anesthesia. 2000; 6:29-34. View abstract
  100. Acute respiratory failure: pediatrics. Curr Opin Pediatr. 2000; 12:233-7. View abstract
  101. High frequency ventilation in the pediatric intensive care unit. Ped Crit Care Med 1:93-99, 2000. 2000; 1:93-9. View abstract
  102. Extended high frequency partial liquid ventilation in lung injury: gas exchange and lung injury scores. Am J Resp Crit Care Med. 2000; 161:A46. View abstract
  103. Identification of optimal lung volume during high frequency oscillatory ventilation using inductive plethysmography. Am J Resp Crit Care Med. 2000; 161:A47. View abstract
  104. Volatile anesthetic use in the pediatric ICU. Clinical Pediatric Anesthesia 6: 41-42, 2000. 2000; 6:41-2. View abstract
  105. Effect of prone positioning on clinical outcomes in pediatric patients with acute lung injury (ALI)/ARDS. Am J Resp Crit Care Med. 2000; 161:A81. View abstract
  106. Perfluorocarbon (PFC) vapor loss during high frequency ventilation: effect of intrapulmonary PFC distribution. Am J Resp Crit Care Med. 2000; 161:A46. View abstract
  107. High-frequency oscillatory ventilation of the perfluorocarbon-filled lung: preliminary results in an animal model of acute lung injury. Crit Care Med. 1999 Nov; 27(11):2500-7. View abstract
  108. When knowing is not understanding. Crit Care Med. 1999 Nov; 27(11):2598-9. View abstract
  109. Partial liquid breathing: more questions than answers. Crit Care Med. 1999 Sep; 27(9):2058-60. View abstract
  110. Surfactant replacement in acute lung injury--the saga continues. Crit Care Med. 1999 Jan; 27(1):31-2. View abstract
  111. Bench validation of respiratory inductive plethysmography in determining the end expiratory lung volume during high frequency ventilation. Ped Res. 1999; 45:37A. View abstract
  112. High frequency partial liquid ventilation in lung injury: dose-response and frequency manipulation data. Am J Resp Crit Care Med. 1999; 159:A78. View abstract
  113. Pediatric Respiratory Failure. New Horizons: The Science and Practice of Acute Medicine. 1999; 7:275-439. View abstract
  114. Mechanical support of acute lung injury: options for strategic ventilation. New Horizons. 1999; 7:359-373. View abstract
  115. Respiratory inductive plethysmography is stable during high frequency ventilation. Ped Res. 1999; 45:38A. View abstract
  116. Anesthesia and analgesia, in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (5th Edition), J.B. Lippincott, Philadelphia. 1999; 1447-59. View abstract
  117. Fluoroscopic comparisons of intrapulmonary perfluorocarbon distribution: supine vs. prone position using either conventional or high frequency oscillatory ventilation. Am J Resp Crit Care Med. 1999; 159:A602. View abstract
  118. Effects of early and repeated prone positioning in pediatric patients with acute lung injury. Crit Care Med. 1999; 27:A125. View abstract
  119. Taking the low (stretch) road. Chest. 1998 Oct; 114(4):955-7. View abstract
  120. Aortic valve replacement for octogenarians: are small valves bad? Ann Thorac Surg. 1998 Sep; 66(3):699-705; discussion 705-6. View abstract
  121. Single-breath CO2 analysis as a predictor of lung volume in a healthy animal model during controlled ventilation. Crit Care Med. 1998 Aug; 26(8):1409-13. View abstract
  122. Pulmonary blood flow distribution during partial liquid ventilation. J Appl Physiol (1985). 1998 May; 84(5):1540-50. View abstract
  123. Liquid ventilation: recent concepts, in Salvo I, Vidysagar D (eds.), Anaesthesia and Intensive Care in Neonates and Children, Springer-Verlag, Milan. 1998; 243-51. View abstract
  124. High frequency partial liquid ventilation in lung injury: dose-response data. Ped Res. 1998; 43:35A. View abstract
  125. High frequency ventilation. Respiratory Care. 1998; 43:961-65. View abstract
  126. Anesthetic principles and operating room anesthesia regimens, in Fuhrman BP, Zimmerman JJ (eds.), Pediatric Critical Care (2nd edition), C.V. Mosby, St. Louis. 1998; 1353-62. View abstract
  127. High frequency ventilation, in Salvo I, Vidysagar D (eds.), Anaesthesia and Intensive Care in Neonates and Children, Springer-Verlag, Milan. 1998; 219-25. View abstract
  128. Optimizing intrapulmonary perfluorocarbon: dosing method and mode of ventilation. Ped Res. 1998; 43:34A. View abstract
  129. Noninvasive determination of cardiac output in a model of acute lung injury. Crit Care Med. 1997 May; 25(5):864-8. View abstract
  130. Improved outcome for acute hypoxemic respiratory failure in children: interim results of a prospective, multi-institutional study from the PARF Study Group. Ped Res. 1997; 41:33A. View abstract
  131. Histopathology of acute lung injury: high frequency oscillation of the perfluorocarbon-filled lung. Ped Res. 1997; 41:32A. View abstract
  132. High frequency oscillation of the perfluorocarbon-filled lung: preliminary results in an animal model of acute lung injury. Ped Res 41: 32A, 1997. 1997; 41:32A. View abstract
  133. Noninvasive determination of cardiac output using single breath CO2 analysis. Crit Care Med. 1996 Oct; 24(10):1701-5. View abstract
  134. Effects of nitric oxide on hyperinflation-induced pulmonary hypertension in the isolated-perfused lung. Crit Care Med. 1996 Aug; 24(8):1388-95. View abstract
  135. High frequency oscillatory ventilation: theory and practice in paediatric patients. Paediatr Anaesth. 1996; 6(6):437-41. View abstract
  136. Liquid breathing: stretching the technological envelope. Crit Care Med. 1996 Jan; 24(1):4-6. View abstract
  137. Single breath CO2 analysis: description and validation of a method. Crit Care Med. 1996 Jan; 24(1):96-102. View abstract
  138. Redistribution of regional pulmonary blood flow during partial liquid ventilation. Ped Res. 1996; 39:46A. View abstract
  139. High frequency oscillatory ventilation: theory and practice in pediatric patients. Paediatric Anesthesia. 1996; 6:437-41. View abstract
  140. Acute Respiratory Failure Syndrome. In Rogers MC, (ed.), Textbook of Pediatric Intensive Care, 3rd Edition, Williams & Wilkins, Baltimore. 1996; 197-233. View abstract
  141. Sedation in the intensive care unit, in Todres D, Fugate J (eds.), A Practice of Pediatric Intensive Care, Little, Brown and Co., Boston. 1996; 582-94. View abstract
  142. Respiratory deadspace measurements in neonates with congenital diaphragmatic hernia. Crit Care Med. 1995 Feb; 23(2):371-5. View abstract
  143. Single breath CO2 analysis in an animal model of acute lung injury and pulmonary hypoperfusion. Anesthesiology. 1995; 83:A465. View abstract
  144. Loughlin GM, Eigen H (eds.), Respiratory Disease in Children: Diagnosis and Management. Crit Care Med. 1995; 23:1795. View abstract
  145. Single breath CO2 analysis as a predictor of lung volume in a healthy animal model. Anesthesiology 83:A1221, 1995. 1995; 83:A1221. View abstract
  146. The effect of nitric oxide on overdistension induced pulmonary hypertension in an isolated perfused sheep lung model. Crit Care Med. 1995; 23:A216. View abstract
  147. Prospective, randomized comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Crit Care Med. 1994 Oct; 22(10):1530-9. View abstract
  148. Size disparity in pediatric lung transplantation. J Pediatr Surg. 1994 Aug; 29(8):1152-5; discussion 1155-6. View abstract
  149. Pediatric critical care. Curr Opin Pediatr. 1994 Jun; 6(3):295-302. View abstract
  150. Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation. Ann Thorac Surg. 1994 May; 57(5):1311-8. View abstract
  151. Opioid tolerance and dependence in infants and children. Crit Care Med. 1994 Feb; 22(2):334-42. View abstract
  152. Anesthesia and analgesia. in Avery GB, Fletcher MA, MacDonald MG (eds.), Neonatology: Pathophysiology and Management of the Newborn (4th Edition), J.B. Lippincott, Philadelphia. 1994; 1334-45. View abstract
  153. Current opinion in pediatrics: pediatric critical care. Current Science. 1994; 6:295-302. View abstract
  154. Outcome of pediatric patients managed with high frequency oscillatory ventilation. Anesthesiology. 1994; 81:A269. View abstract
  155. Single breath CO2 analysis: bench validation in a lung model. Ped Res. 1994; 35:49A. View abstract
  156. Single breath CO2 analysis in a model of pulmonary hypoperfusion. Ped Res. 1994; 35:48A. View abstract
  157. Respiratory deadspace measurements in neonates during extracorporeal membrane oxygenation. Crit Care Med. 1993 Dec; 21(12):1895-900. View abstract
  158. Tolerance to isoflurane during prolonged administration. Anesthesiology. 1993 May; 78(5):985-8. View abstract
  159. Prolonged administration of isoflurane to pediatric patients during mechanical ventilation. Anesth Analg. 1993 Mar; 76(3):520-6. View abstract
  160. High-frequency oscillatory ventilation in pediatric respiratory failure. Crit Care Med. 1993 Feb; 21(2):272-8. View abstract
  161. Changes in dynamic lung compliance and VD/VT ratio during ECMO. Presented at the 8th Annual Children's Hospital National Medical Center ECMO Symposium. 1993. View abstract
  162. PEFIOS: A PEEP-FiO2-SpO2 closed loop controller of arterial oxygen saturation. Anesthesiology. 1993; 79:A287. View abstract
  163. Prospective randomized comparison of high frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. Anesthesiology. 1993; 79:A1221. View abstract
  164. "High frequency oscillatory ventilation in pediatric respiratory failure". 1993. View abstract
  165. Prolonged administration of isoflurane to pediatric patients during mechanical ventilation. Presented at the 6th Annual Pediatric Critical Care Colloquium. 1993. View abstract
  166. Laparoscopic highly selective vagotomy. J Laparoendosc Surg. 1992 Jun; 2(3):151-3. View abstract
  167. Videothoracoscopy: improved technique and expanded indications. Ann Thorac Surg. 1992 May; 53(5):776-8; discussion 779. View abstract
  168. The "ethics of evidence" and randomized controlled trials. J Clin Ethics. 1992; 3(1):65-7. View abstract
  169. Anesthetic principles and operating room anesthesia regimens. in Fuhrman BP, Zimmerman JJ (eds.), Pediatric Critical Care, C.V. Mosby, St. Louis. 1992; 1265-73. View abstract
  170. Changes in VD/VT in infants with pulmonary hypertension during extracorporeal membrane oxygenation (ECMO). Anesthesiology. 1992; 77:A240. View abstract
  171. Sedation in neonatal and pediatric intensive care. Sedation in neonatal and pediatric intensive care, Journal of Intensive Care Medicine. 1992; 7:244-60. View abstract
  172. High frequency oscillatory ventilation in pediatric respiratory failure. Presented at the 5th Annual Pediatric Critical Care Colloquium. 1992. View abstract
  173. Online measurement ofV CO2 during mechanical ventilation in infants. Anesthesiology. 1992; 77:A467. View abstract
  174. Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. J Pediatr. 1991 Oct; 119(4):639-43. View abstract
  175. Sedation before ventilator withdrawal: medical and ethical considerations. J Clin Ethics. 1991; 2(2):127-9. View abstract
  176. Fentanyl binding to the ECMO circuit: is the process saturable? Presented at the 7th Annual Children's Hospital National Medical Center ECMO Symposium. 1991. View abstract
  177. Plasma levels of midazolam during ECMO. Presented at the 7th Annual Children's Hospital National Medical Center ECMO Symposium. 1991. View abstract
  178. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990 Dec; 73(6):1136-40. View abstract
  179. ECMO: Ethical allocation of a scarce medical resource. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990. View abstract
  180. Neuropathologic findings in 23 neonates treated with extracorporeal membrane oxygenation. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990. View abstract
  181. Scarce ICU resources and the obligation to limit therapy. Presented at the annual meeting of the American Academy of Pediatrics. 1990. View abstract
  182. Sedation for infants undergoing extracorporeal membrane oxygenation. Presented at the 6th Annual Children's Hospital National Medical Center ECMO Symposium. 1990. View abstract
  183. Rapid development of tolerance during fentanyl infusion. Anesthesiology. 1990; 73:A406. View abstract
  184. Neonatal abstinence syndrome in infants sedated with fentanyl. Anesthesiology. 1989; 71:A218. View abstract
  185. Neuropathology of infants dying after extracorporeal membrane oxygenation. J Neuropathol Exp Neurol. 1989; 48:307. View abstract
  186. Specificity of PPD skin tests in childhood tuberculin converters: comparison with mycobacterial species from tissues and secretions. J Pediatr. 1970 Apr; 76(4):512-22. View abstract