Dr. Alt received his Ph.D. in Biology from Stanford University in 1977 with Robert Schimke and he did his postdoctoral work at MIT with David Baltimore until 1982. He joined the faculty of the Biochemistry of Columbia University in 1982 and became a Professor of Biochemistry and Molecular Biophysics in 1985, a Professor of Microbiology in 1986 and a Howard Huges Medical Institute (HHMI) Investigator in 1987. In 1991, Dr. Alt moved to Boston Children's Hospital (BCH), the and the Harvard Medical School (HMS) Affiliated Center for Blood research (CBR), as a Professor of Genetics and Pediatrics at HMS, an HHMI Investigator at Boston Children's Hospital and a Senior Investigator at the CBR. He was appointed Charles A. Janeway Professor of Pediatrics in 1993 and Scientific Director of the CBR in 2005 and continued that role when the CBR's name was changed to the Immune Disease Institute (IDI). While leading a merger of IDI with Boston Children's Hospital, Dr. Alt served as Director and then President of IDI until it was incorporated into BCH as the Program in Cellular and Molecular Medicine (PCMM) of BCH in 2009 Dr Alt has continued to serve as PCMM director until present.

Dr. Alt has been elected to the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the European Molecular Biology Organization. His cancer biology awards include the American Association of Cancer Research Clowes Award, the Pasarow Foundation Prize for Extraordinary Achievement in Cancer Research, the National Cancer Institute Alfred K. Knudson Award for "Pioneering Contributions that Revolutionized the Field of Cancer Genetics", the Leukemia and Lymphoma Society de Villiers Award, The Katharine Berkan Judd Award from Memorial Sloan Kettering Cancer Center, the Albert Szent-Gyorgyi Prize for Progress in Cancer Research from the National Foundation for Cancer Research, and the American-Italian Cancer Foundation Prize for Excellence in Medicine. His immunology awards include the American Association of Immunologists (AAI) Huang Meritorious Career Award, the Cancer Research Institute (CRI) Coley Award (with Klaus Rajewsky), the Novartis Prize for Basic Immunology (with Klaus Rajwsky and Fritz Melchers) for his discoveries on B cell development and antigen responses and the AAI BioLegend Herzenberg Award. More generally, he has also received the Arthur Kornberg & Paul Berg Lifetime Achievement Award in Biomedical Science from Stanford Medical School and the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Science from Brandeis University.

Dr. Alt serves on numerous editorial boards and is Editor in Chief of Advances in Immunology. He also serves on many national and international advisory boards and is currently Chair of the Scientific Advisory Committee of the Cold Spring Harbor Laboratory and just finished a term as Chair of the National Academy of Sciences Class IV (Biomedical Sciences).

Dr. Alt has mentored over 150 students and research fellows, many of whom have become recognized academic leaders in immunology, genetics, or cancer biology or leaders in the biopharmaceutical industry. In recognition of his training and mentoring accomplishments, Dr. Alt has received the American Association of Immunologists Excellence in Mentoring Award and the Willam A. Silen Award for Lifetime Achievement in Mentoring from Harvard Medical School. The Cancer Research Institute of New York annually presents the Frederick W. Alt Award for New Discoveries in Immunology in recognition of Dr. Alt's efforts in developing the careers of young scientists.


Publications powered by Harvard Catalyst Profiles

  1. eccDNAs are apoptotic products with high innate immunostimulatory activity. Nature. 2021 Nov; 599(7884):308-314. View abstract
  2. Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Rep. 2021 Sep 07; 36(10):109666. View abstract
  3. Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. Proc Natl Acad Sci U S A. 2021 May 25; 118(21). View abstract
  4. An in vivo method for diversifying the functions of therapeutic antibodies. Proc Natl Acad Sci U S A. 2021 03 09; 118(10). View abstract
  5. Physiological role of the 3'IgH CBEs super-anchor in antibody class switching. Proc Natl Acad Sci U S A. 2021 01 19; 118(3). View abstract
  6. Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth. Immunity. 2021 02 09; 54(2):324-339.e8. View abstract
  7. Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature. 2021 02; 590(7845):338-343. View abstract
  8. Direct analysis of brain phenotypes via neural blastocyst complementation. Nat Protoc. 2020 10; 15(10):3154-3181. View abstract
  9. CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning. Nature. 2020 10; 586(7828):305-310. View abstract
  10. BCR selection and affinity maturation in Peyer's patch germinal centres. Nature. 2020 06; 582(7812):421-425. View abstract
  11. Induction of recurrent break cluster genes in neural progenitor cells differentiated from embryonic stem cells in culture. Proc Natl Acad Sci U S A. 2020 05 12; 117(19):10541-10546. View abstract
  12. Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7929-7940. View abstract
  13. Immune checkpoint modulation enhances HIV-1 antibody induction. Nat Commun. 2020 02 19; 11(1):948. View abstract
  14. Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. Cell Stem Cell. 2020 02 06; 26(2):221-233.e6. View abstract
  15. Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science. 2019 12 06; 366(6470). View abstract
  16. Fundamental roles of chromatin loop extrusion in antibody class switching. Nature. 2019 11; 575(7782):385-389. View abstract
  17. The fundamental role of chromatin loop extrusion in physiological V(D)J recombination. Nature. 2019 09; 573(7775):600-604. View abstract
  18. Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825. J Immunol. 2019 03 01; 202(5):1317-1320. View abstract
  19. Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors. Nat Commun. 2018 11 12; 9(1):4760. View abstract
  20. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature. 2018 11; 563(7729):126-130. View abstract
  21. Guiding a mutator in antibody diversification. Cell Res. 2018 10; 28(10):963-964. View abstract
  22. Parp3 promotes long-range end joining in murine cells. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10076-10081. View abstract
  23. RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes. Adv Immunol. 2018; 139:93-135. View abstract
  24. DNA double-strand breaks as drivers of neural genomic change, function, and disease. DNA Repair (Amst). 2018 11; 71:158-163. View abstract
  25. Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):8615-8620. View abstract
  26. Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies. Immunity. 2018 08 21; 49(2):301-311.e5. View abstract
  27. DNA melting initiates the RAG catalytic pathway. Nat Struct Mol Biol. 2018 08; 25(8):732-742. View abstract
  28. CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning. Cell. 2018 06 28; 174(1):102-116.e14. View abstract
  29. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1919-1924. View abstract
  30. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):762-767. View abstract
  31. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature. 2017 11 30; 551(7682):590-595. View abstract
  32. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proc Natl Acad Sci U S A. 2017 12 05; 114(49):E10560-E10567. View abstract
  33. Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nat Biomed Eng. 2017 11; 1(11):878-888. View abstract
  34. AID Recognizes Structured DNA for Class Switch Recombination. Mol Cell. 2017 Aug 03; 67(3):361-373.e4. View abstract
  35. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):8614-8619. View abstract
  36. Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70. DNA Repair (Amst). 2017 09; 57:133-138. View abstract
  37. Phosphatidylinositol 3-kinase d blockade increases genomic instability in B cells. Nature. 2017 02 23; 542(7642):489-493. View abstract
  38. Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies. Immunol Rev. 2017 01; 275(1):89-107. View abstract
  39. An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vd and Dd Gene Segments. J Immunol. 2016 10 15; 197(8):3188-3197. View abstract
  40. Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell. 2016 Sep 08; 166(6):1471-1484.e18. View abstract
  41. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):10619-24. View abstract
  42. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. J Exp Med. 2016 08 22; 213(9):1921-36. View abstract
  43. Highly sensitive and unbiased approach for elucidating antibody repertoires. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7846-51. View abstract
  44. Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. J Immunol. 2016 05 01; 196(9):3514-6. View abstract
  45. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nat Protoc. 2016 May; 11(5):853-71. View abstract
  46. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):2258-63. View abstract
  47. Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells. Cell. 2016 Feb 11; 164(4):644-55. View abstract
  48. Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):1618-23. View abstract
  49. Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell. 2015 Nov 19; 163(5):1124-1137. View abstract
  50. Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell. 2015 Nov 05; 163(4):947-59. View abstract
  51. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 2015 Sep 03; 525(7567):134-139. View abstract
  52. A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1. Cancer Immunol Res. 2015 Jun; 3(6):641-9. View abstract
  53. An oncogenic role for alternative NF-?B signaling in DLBCL revealed upon deregulated BCL6 expression. Cell Rep. 2015 May 05; 11(5):715-26. View abstract
  54. Aberrant TCRd rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. 2015 Apr 23; 125(17):2665-8. View abstract
  55. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination. Microbiol Spectr. 2015 Feb; 3(1):MDNA3-0037-2014. View abstract
  56. CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1815-20. View abstract
  57. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol. 2015 Feb; 33(2):179-86. View abstract
  58. Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability. Cell. 2014 Dec 18; 159(7):1538-48. View abstract
  59. Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10269-74. View abstract
  60. Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice. Cancer Immunol Res. 2014 Sep; 2(9):857-66. View abstract
  61. Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response". DNA Repair (Amst). 2014 May; 17:52-63. View abstract
  62. Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5147-52. View abstract
  63. Functional overlaps between XLF and the ATM-dependent DNA double strand break response. DNA Repair (Amst). 2014 Apr; 16:11-22. View abstract
  64. IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2644-9. View abstract
  65. Michael Neuberger (1953-2013). Immunity. 2013 Dec 12; 39(6):987-8. View abstract
  66. A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. J Allergy Clin Immunol. 2014 Apr; 133(4):1099-108. View abstract
  67. SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 2013 Nov 14; 5(3):654-665. View abstract
  68. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 2013 Nov 21; 503(7476):406-9. View abstract
  69. Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity. 2013 Aug 22; 39(2):229-44. View abstract
  70. Microbial colonization influences early B-lineage development in the gut lamina propria. Nature. 2013 Sep 05; 501(7465):112-5. View abstract
  71. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 2013 Jun 06; 153(6):1266-80. View abstract
  72. Genome architecture and expression. Curr Opin Genet Dev. 2013 Apr; 23(2):79-80. View abstract
  73. Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013; 9(2):e1003298. View abstract
  74. Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2934-9. View abstract
  75. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 2013 Jan 31; 152(3):417-29. View abstract
  76. Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. PLoS Biol. 2013; 11(1):e1001475. View abstract
  77. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem. 2013 Mar 08; 288(10):7086-95. View abstract
  78. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2234-9. View abstract
  79. Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions. Nat Immunol. 2012 Dec; 13(12):1205-12. View abstract
  80. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec; 80(12):4071-7. View abstract
  81. Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13745-50. View abstract
  82. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 2012 Apr 26; 119(17):3966-74. View abstract
  83. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell. 2012 Mar 02; 148(5):908-21. View abstract
  84. Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2455-60. View abstract
  85. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2473-8. View abstract
  86. Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol. 2012; 116:1-49. View abstract
  87. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985. 40: 271-281. J Immunol. 2012 Jan 01; 188(1):10-20. View abstract
  88. Immature B cells preferentially switch to IgE with increased direct Sµ to Se recombination. J Exp Med. 2011 Dec 19; 208(13):2733-46. View abstract
  89. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011 Oct 21; 44(2):177-90. View abstract
  90. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 2011 Sep 30; 147(1):107-19. View abstract
  91. CTCF-binding elements mediate control of V(D)J recombination. Nature. 2011 Sep 11; 477(7365):424-30. View abstract
  92. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 2011 Oct 13; 118(15):4169-73. View abstract
  93. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. J Exp Med. 2011 Aug 01; 208(8):1649-60. View abstract
  94. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011 Jun; 12(6):536-43. View abstract
  95. Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency. Front Immunol. 2011 May 10; 2(15). View abstract
  96. PAIRing for distal Igh locus V(D)J recombination. Immunity. 2011 Feb 25; 34(2):139-41. View abstract
  97. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2873-8. View abstract
  98. The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 04; 144(3):353-63. View abstract
  99. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2028-33. View abstract
  100. Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining. J Immunol. 2011 Feb 15; 186(4):2336-43. View abstract
  101. Mechanisms that promote and suppress chromosomal translocations in lymphocytes. Annu Rev Immunol. 2011; 29:319-50. View abstract
  102. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011 Jan 13; 469(7329):250-4. View abstract
  103. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 2010 Dec 01; 12(6):654-61. View abstract
  104. Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22207-12. View abstract
  105. Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21790-4. View abstract
  106. Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus. PLoS One. 2010 Nov 15; 5(11):e13992. View abstract
  107. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med. 2010 Jul 05; 207(7):1369-80. View abstract
  108. Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. J Exp Med. 2010 Jul 05; 207(7):1541-54. View abstract
  109. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. J Exp Med. 2010 Jun 07; 207(6):1145-52. View abstract
  110. Hypomorphic Rag mutations can cause destructive midline granulomatous disease. Blood. 2010 Aug 26; 116(8):1263-71. View abstract
  111. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. View abstract
  112. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15; 207(2):417-27. View abstract
  113. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3024-9. View abstract
  114. Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3040-5. View abstract
  115. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3034-9. View abstract
  116. The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol. 2010; 106:93-133. View abstract
  117. Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem Cells. 2010 Jan; 28(1):64-74. View abstract
  118. Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. Nature. 2009 Dec 10; 462(7274):803-7. View abstract
  119. Differential utilization of T cell receptor TCR alpha/TCR delta locus variable region gene segments is mediated by accessibility. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17487-92. View abstract
  120. Mre11: roles in DNA repair beyond homologous recombination. Nat Struct Mol Biol. 2009 Aug; 16(8):798-800. View abstract
  121. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 09; 460(7252):231-6. View abstract
  122. Calorie restriction alters mitochondrial protein acetylation. Aging Cell. 2009 Sep; 8(5):604-6. View abstract
  123. Regulation of activation-induced cytidine deaminase DNA deamination activity in B-cells by Ser38 phosphorylation. Biochem Soc Trans. 2009 Jun; 37(Pt 3):561-8. View abstract
  124. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell. 2009 May 15; 34(3):285-97. View abstract
  125. A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. J Exp Med. 2009 May 11; 206(5):1019-27. View abstract
  126. Assembled DJ beta complexes influence TCR beta chain selection and peripheral V beta repertoire. J Immunol. 2009 May 01; 182(9):5586-95. View abstract
  127. Post-translational regulation of activation-induced cytidine deaminase. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12; 364(1517):667-73. View abstract
  128. Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J Exp Med. 2009 Feb 16; 206(2):477-90. View abstract
  129. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2717-22. View abstract
  130. Chromosomal location targets different MYC family gene members for oncogenic translocations. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2265-70. View abstract
  131. Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat Med. 2009 Feb; 15(2):206-10. View abstract
  132. Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation. Blood. 2009 Mar 26; 113(13):2965-75. View abstract
  133. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med. 2008 Dec 22; 205(13):3079-90. View abstract
  134. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18. View abstract
  135. Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase. Mol Cell. 2008 Oct 24; 32(2):285-91. View abstract
  136. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell. 2008 Sep 05; 31(5):631-40. View abstract
  137. Vbeta cluster sequences reduce the frequency of primary Vbeta2 and Vbeta14 rearrangements. Eur J Immunol. 2008 Sep; 38(9):2564-72. View abstract
  138. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. J Exp Med. 2008 Sep 01; 205(9):1949-57. View abstract
  139. SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008 Jul 25; 134(2):317-28. View abstract
  140. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9302-6. View abstract
  141. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15; 22(12):1662-76. View abstract
  142. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 2008 Jul 01; 22(13):1753-7. View abstract
  143. Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching. J Exp Med. 2008 Jul 07; 205(7):1567-72. View abstract
  144. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med. 2008 Mar 17; 205(3):557-64. View abstract
  145. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3374-9. View abstract
  146. Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3843-8. View abstract
  147. Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement. J Immunol. 2008 Feb 15; 180(4):2339-46. View abstract
  148. SIRT6 in DNA repair, metabolism and ageing. J Intern Med. 2008 Feb; 263(2):128-41. View abstract
  149. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol. 2008 Mar; 28(5):1688-701. View abstract
  150. Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus. Adv Immunol. 2008; 99:1-32. View abstract
  151. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell. 2007 Dec 28; 28(6):1045-57. View abstract
  152. From gene amplification to V(D)J recombination and back: a personal account of my early years in B cell biology. Eur J Immunol. 2007 Nov; 37 Suppl 1:S138-47. View abstract
  153. S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Immunity. 2007 Nov; 27(5):711-22. View abstract
  154. SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev. 2007 Oct 15; 21(20):2644-58. View abstract
  155. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. View abstract
  156. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15424-9. View abstract
  157. Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood. 2008 Feb 15; 111(4):2163-9. View abstract
  158. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 2007 Sep 27; 449(7161):478-82. View abstract
  159. Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas. Oncogene. 2008 Jan 10; 27(3):318-22. View abstract
  160. Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin kappa-chain locus. Nat Immunol. 2007 Jul; 8(7):715-22. View abstract
  161. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 04; 26(7):1913-23. View abstract
  162. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4518-23. View abstract
  163. Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4002-7. View abstract
  164. Regulation of activation induced deaminase via phosphorylation. Adv Exp Med Biol. 2007; 596:129-37. View abstract
  165. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol. 2007; 94:157-214. View abstract
  166. Antibody class switching mediated by yeast endonuclease-generated DNA breaks. Science. 2007 Jan 19; 315(5810):377-81. View abstract
  167. Complete correction of murine Artemis immunodeficiency by lentiviral vector-mediated gene transfer. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16406-11. View abstract
  168. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 08; 126(5):941-54. View abstract
  169. Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations. DNA Repair (Amst). 2006 Sep 08; 5(9-10):1030-41. View abstract
  170. The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells. J Exp Med. 2006 Jun 12; 203(6):1543-50. View abstract
  171. Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation. Blood. 2006 Sep 15; 108(6):1991-8. View abstract
  172. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7378-83. View abstract
  173. Early embryonic lethality due to targeted inactivation of DNA ligase III. Mol Cell Biol. 2006 May; 26(10):3935-41. View abstract
  174. SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev. 2006 May 15; 20(10):1256-61. View abstract
  175. 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3310-5. View abstract
  176. AID in somatic hypermutation and class switch recombination. Curr Opin Immunol. 2006 Apr; 18(2):164-74. View abstract
  177. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell. 2006 Jan 27; 124(2):315-29. View abstract
  178. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan 20; 21(2):187-200. View abstract
  179. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20; 21(2):201-14. View abstract
  180. Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol. 2006; 24:541-70. View abstract
  181. A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. J Immunol. 2005 Nov 15; 175(10):6624-32. View abstract
  182. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature. 2005 Nov 24; 438(7067):508-11. View abstract
  183. Elucidation of IgH intronic enhancer functions via germ-line deletion. Proc Natl Acad Sci U S A. 2005 Oct 04; 102(40):14362-7. View abstract
  184. Activating Notch1 mutations in mouse models of T-ALL. Blood. 2006 Jan 15; 107(2):781-5. View abstract
  185. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab. 2005 Jul; 2(1):67-76. View abstract
  186. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. J Leukoc Biol. 2005 Jun; 77(6):993-8. View abstract
  187. DNA repair, genome stability, and aging. Cell. 2005 Feb 25; 120(4):497-512. View abstract
  188. Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2471-5. View abstract
  189. Influence of switch region length on immunoglobulin class switch recombination. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2466-70. View abstract
  190. Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol. 2005 Jan; 25(2):661-70. View abstract
  191. Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences. Adv Immunol. 2005; 86:43-112. View abstract
  192. Control of sister chromatid recombination by histone H2AX. Mol Cell. 2004 Dec 22; 16(6):1017-25. View abstract
  193. Antibody diversity: one enzyme to rule them all. Nat Med. 2004 Dec; 10(12):1304-5. View abstract
  194. An evolutionarily conserved target motif for immunoglobulin class-switch recombination. Nat Immunol. 2004 Dec; 5(12):1275-81. View abstract
  195. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nat Immunol. 2004 Dec; 5(12):1251-9. View abstract
  196. The lingering enigma of the allelic exclusion mechanism. Cell. 2004 Sep 03; 118(5):539-44. View abstract
  197. Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice. Nucleic Acids Res. 2004; 32(15):4539-49. View abstract
  198. The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev. 2004 Aug; 200:115-31. View abstract
  199. The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):781-96. View abstract
  200. Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature. 2004 Aug 26; 430(7003):992-8. View abstract
  201. Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol. 2004 Jul; 4(7):541-52. View abstract
  202. p63 and p73 are not required for the development and p53-dependent apoptosis of T cells. Cancer Cell. 2004 Jul; 6(1):85-9. View abstract
  203. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev. 2004 Jun 01; 18(11):1293-304. View abstract
  204. Receptor revision in T cells: an open question? Trends Immunol. 2004 Jun; 25(6):276-9. View abstract
  205. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev. 2004 Jun 01; 18(11):1283-92. View abstract
  206. V(D)J recombinational accessibility-heading in the opposite direction? Nat Immunol. 2004 Jun; 5(6):561-2. View abstract
  207. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol. 2004 May; 5(5):481-7. View abstract
  208. Molecular biology: case of mistaken identity. Nature. 2004 Mar 04; 428(6978):29-31. View abstract
  209. Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404. View abstract
  210. Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation. Mol Cell Biol. 2004 Mar; 24(6):2237-42. View abstract
  211. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2410-5. View abstract
  212. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004 Mar 26; 303(5666):2011-5. View abstract
  213. H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. . 2004 Feb; 3(2):149-53. View abstract
  214. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol Cell Biol. 2004 Feb; 24(3):1200-5. View abstract
  215. Unraveling V(D)J recombination; insights into gene regulation. Cell. 2004 Jan 23; 116(2):299-311. View abstract
  216. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec; 15(12):1431-40. View abstract
  217. Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell. 2003 Dec; 12(6):1511-23. View abstract
  218. Innate immune response to encephalomyocarditis virus infection mediated by CD1d. Immunology. 2003 Dec; 110(4):519-26. View abstract
  219. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003 Nov 17; 198(10):1595-608. View abstract
  220. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med. 2003 Nov 03; 198(9):1439-50. View abstract
  221. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10794-9. View abstract
  222. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell. 2003 Aug 08; 114(3):359-70. View abstract
  223. The role of DNA breaks in genomic instability and tumorigenesis. Immunol Rev. 2003 Aug; 194:77-95. View abstract
  224. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 2003 Jul 15; 22(14):3602-12. View abstract
  225. Chromatin dynamics and locus accessibility in the immune system. Nat Immunol. 2003 Jul; 4(7):603-6. View abstract
  226. Novel antibody switching defects in human patients. J Clin Invest. 2003 Jul; 112(1):19-22. View abstract
  227. Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med. 2003 May 05; 197(9):1213-9. View abstract
  228. The influence of transcriptional orientation on endogenous switch region function. Nat Immunol. 2003 May; 4(5):435-41. View abstract
  229. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature. 2003 Apr 17; 422(6933):726-30. View abstract
  230. Defective DNA repair and increased genomic instability in Artemis-deficient murine cells. J Exp Med. 2003 Mar 03; 197(5):553-65. View abstract
  231. T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2598-603. View abstract
  232. Essential role for Vav1 in activation, but not development, of gammadelta T cells. Int Immunol. 2003 Feb; 15(2):215-21. View abstract
  233. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 2003 Feb 06; 421(6923):643-8. View abstract
  234. Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1209-14. View abstract
  235. Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev. 2003 Jan 15; 17(2):229-39. View abstract
  236. Dramatically increased rearrangement and peripheral representation of Vbeta14 driven by the 3'Dbeta1 recombination signal sequence. Immunity. 2003 Jan; 18(1):75-85. View abstract
  237. Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells. Immunity. 2003 Jan; 18(1):65-74. View abstract
  238. Elucidation of a downstream boundary of the 3' IgH regulatory region. Mol Immunol. 2003 Jan; 39(12):753-60. View abstract
  239. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell. 2002 Dec; 10(6):1379-90. View abstract
  240. Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice. Blood. 2003 Mar 15; 101(6):2159-66. View abstract
  241. Analysis of the complex genomic structure of Bcl-x and its relationship to Bcl-x(gamma) expression after CD28-dependent costimulation. Mol Immunol. 2002 Sep; 39(1-2):45-55. View abstract
  242. Internal IgH class switch region deletions are position-independent and enhanced by AID expression. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9984-9. View abstract
  243. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity. 2002 Jul; 17(1):41-50. View abstract
  244. T cell costimulation through CD28 depends on induction of the Bcl-xgamma isoform: analysis of Bcl-xgamma-deficient mice. J Exp Med. 2002 Jul 01; 196(1):87-95. View abstract
  245. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell. 2002 Jun 28; 109(7):811-21. View abstract
  246. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8173-8. View abstract
  247. The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks. J Exp Med. 2002 May 06; 195(9):F37-41. View abstract
  248. Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylation. Nat Immunol. 2002 May; 3(5):463-8. View abstract
  249. The mechanism and regulation of chromosomal V(D)J recombination. Cell. 2002 Apr; 109 Suppl:S45-55. View abstract
  250. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity. 2002 Apr; 16(4):607-17. View abstract
  251. Vav3 is regulated during the cell cycle and effects cell division. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4313-8. View abstract
  252. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002 Mar; 16(3):331-43. View abstract
  253. Cdc42 facilitates invasion but not the actin-based motility of Shigella. Curr Biol. 2002 Feb 19; 12(4):341-5. View abstract
  254. Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells. Mol Immunol. 2002 Jan; 38(7):547-56. View abstract
  255. Mechanism and control of class-switch recombination. Trends Immunol. 2002 Jan; 23(1):31-9. View abstract
  256. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell. 2001 Dec; 8(6):1187-96. View abstract
  257. Increased accumulation of hybrid V(D)J joins in cells expressing truncated versus full-length RAGs. Mol Cell. 2001 Dec; 8(6):1383-90. View abstract
  258. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904. View abstract
  259. TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. Immunity. 2001 Oct; 15(4):647-57. View abstract
  260. DNA double strand break repair and chromosomal translocation: lessons from animal models. Oncogene. 2001 Sep 10; 20(40):5572-9. View abstract
  261. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7. View abstract
  262. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3243-8. View abstract
  263. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001 Jan; 14(1):45-55. View abstract
  264. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. J Exp Med. 2000 Dec 18; 192(12):1745-54. View abstract
  265. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000 Oct; 13(4):463-73. View abstract
  266. RNA editing meets DNA shuffling. Nature. 2000 Sep 07; 407(6800):31, 33. View abstract
  267. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev. 2000 Sep 01; 14(17):2185-91. View abstract
  268. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet. 2000 Sep; 26(1):85-8. View abstract
  269. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000 Sep; 20(17):6364-73. View abstract
  270. Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro. J Biol Chem. 2000 Aug 04; 275(31):24163-72. View abstract
  271. Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):7975-80. View abstract
  272. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29; 10(13):758-65. View abstract
  273. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6630-3. View abstract
  274. Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 2000 Jun 01; 405(6786):583-6. View abstract
  275. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell. 2000 Jun; 5(6):993-1002. View abstract
  276. Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene. Mol Cell Biol. 2000 Jun; 20(12):4405-10. View abstract
  277. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 01; 14(11):1390-9. View abstract
  278. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 2000 Apr 20; 404(6780):897-900. View abstract
  279. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3336-41. View abstract
  280. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc Natl Acad Sci U S A. 2000 Mar 14; 97(6):2668-73. View abstract
  281. Exposure-effect relationship of platinum salt allergy in a catalyst production plant: conclusions from a 5-year prospective cohort study. J Allergy Clin Immunol. 2000 Feb; 105(2 Pt 1):364-70. View abstract
  282. The cytoskeleton in lymphocyte signaling. Adv Immunol. 2000; 75:89-114. View abstract
  283. The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. Cold Spring Harb Symp Quant Biol. 2000; 65:395-403. View abstract
  284. RAG2 is regulated differentially in B and T cells by elements 5' of the promoter. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12713-8. View abstract
  285. Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein. J Exp Med. 1999 Oct 18; 190(8):1093-102. View abstract
  286. The Ig heavy chain intronic enhancer core region is necessary and sufficient to promote efficient class switch recombination. Int Immunol. 1999 Oct; 11(10):1709-13. View abstract
  287. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans. 1999 Aug; 27(4):624-9. View abstract
  288. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 1999 Aug; 11(2):201-12. View abstract
  289. Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients. Clin Immunol. 1999 Jun; 91(3):263-70. View abstract
  290. Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion. Immunity. 1999 May; 10(5):537-46. View abstract
  291. Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer. Immunity. 1999 May; 10(5):503-13. View abstract
  292. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3000-5. View abstract
  293. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2239-43. View abstract
  294. Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1526-31. View abstract
  295. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999 Jan 15; 283(5400):393-7. View abstract
  296. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. J Exp Med. 1999 Jan 04; 189(1):123-9. View abstract
  297. Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. Cold Spring Harb Symp Quant Biol. 1999; 64:169-81. View abstract
  298. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23; 95(7):891-902. View abstract
  299. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature. 1998 Nov 12; 396(6707):173-7. View abstract
  300. An expressed neo(r) cassette provides required functions of the 1gamma2b exon for class switching. Int Immunol. 1998 Nov; 10(11):1683-92. View abstract
  301. Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion. J Exp Med. 1998 Oct 19; 188(8):1465-71. View abstract
  302. Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers. J Exp Med. 1998 Oct 19; 188(8):1421-31. View abstract
  303. Accessibility control of variable region gene assembly during T-cell development. Immunol Rev. 1998 Oct; 165:121-30. View abstract
  304. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med. 1998 Sep 07; 188(5):833-44. View abstract
  305. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 1998 Sep; 9(3):367-76. View abstract
  306. Germline transcription and recombination of a murine VDJmudeltagamma1 transgene. Int Immunol. 1998 Aug; 10(8):1027-37. View abstract
  307. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 1998 Aug 01; 12(15):2392-402. View abstract
  308. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. Cell. 1998 Jul 24; 94(2):229-38. View abstract
  309. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 1998 Jul; 9(1):81-91. View abstract
  310. Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med. 1998 Jun 15; 187(12):2081-9. View abstract
  311. Deletion of the IgH intronic enhancer and associated matrix-attachment regions decreases, but does not abolish, class switching at the mu locus. Int Immunol. 1998 Jun; 10(6):799-806. View abstract
  312. Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation. Immunity. 1998 Jun; 8(6):743-50. View abstract
  313. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains. Science. 1998 May 08; 280(5365):905-8. View abstract
  314. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr Biol. 1998 May 07; 8(10):563-72. View abstract
  315. SEK1/MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity. 1998 May; 8(5):625-34. View abstract
  316. Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. J Exp Med. 1998 Apr 20; 187(8):1235-47. View abstract
  317. Potential regulatory elements for germline transcription in or near murine Sgamma1. Int Immunol. 1998 Apr; 10(4):527-36. View abstract
  318. Ig heavy chain class switching in Rag-deficient mice. Int Immunol. 1998 Mar; 10(3):325-32. View abstract
  319. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan; 8(1):125-34. View abstract
  320. Regulation of immunoglobulin light chain isotype expression. Adv Immunol. 1998; 69:113-81. View abstract
  321. Gene transfer into hepatocytes mediated by helper virus-free HSV/AAV hybrid vectors. Mol Med. 1997 Dec; 3(12):813-25. View abstract
  322. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity. 1997 Nov; 7(5):653-65. View abstract
  323. Molecular genetic characterization of XRCC4 function. Int Immunol. 1997 Oct; 9(10):1607-13. View abstract
  324. Function of the TCR alpha enhancer in alphabeta and gammadelta T cells. Immunity. 1997 Oct; 7(4):505-15. View abstract
  325. Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development. 1997 Aug; 124(15):2935-44. View abstract
  326. V(D)J recombination. From RAGs to stitches. Nature. 1997 Jul 31; 388(6641):428-9. View abstract
  327. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8076-81. View abstract
  328. Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chains. J Exp Med. 1997 Jul 07; 186(1):17-23. View abstract
  329. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6927-32. View abstract
  330. The absence of the transcription activator TFE3 impairs activation of B cells in vivo. Mol Cell Biol. 1997 Jun; 17(6):3335-44. View abstract
  331. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3938-42. View abstract
  332. Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. J Immunol. 1997 Apr 15; 158(8):3738-45. View abstract
  333. Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40. Int Immunol. 1997 Mar; 9(3):395-405. View abstract
  334. Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells. Immunity. 1997 Jan; 6(1):23-33. View abstract
  335. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 1996 Nov 15; 87(4):697-708. View abstract
  336. Developmental regulation of V(D)J recombination and lymphocyte differentiation. Curr Opin Genet Dev. 1996 Oct; 6(5):603-9. View abstract
  337. The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene. Int Immunol. 1996 Sep; 8(9):1467-71. View abstract
  338. The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Immunity. 1996 Sep; 5(3):241-52. View abstract
  339. Abnormal peripheral lymphocyte function in c-abl mutant mice. Cell Immunol. 1996 Aug 25; 172(1):100-7. View abstract
  340. Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7871-6. View abstract
  341. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 1996 Jul 12; 86(1):47-57. View abstract
  342. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5860-5. View abstract
  343. Activated Ras signals differentiation and expansion of CD4+8+ thymocytes. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4683-7. View abstract
  344. Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement. Immunity. 1996 Apr; 4(4):377-85. View abstract
  345. Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus. Proc Natl Acad Sci U S A. 1996 Mar 05; 93(5):2169-73. View abstract
  346. CD40 expression and function in murine B cell ontogeny. Int Immunol. 1996 Mar; 8(3):405-411. View abstract
  347. T cell responses in calcineurin A alpha-deficient mice. J Exp Med. 1996 Feb 01; 183(2):413-20. View abstract
  348. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu Rev Immunol. 1996; 14:459-81. View abstract
  349. Identification of the XRCC4 gene: complementation of the DSBR and V(D)J recombination defects of XR-1 cells. Curr Top Microbiol Immunol. 1996; 217:143-50. View abstract
  350. Repertoires of antigen receptors in Tdt congenitally deficient mice. Int Rev Immunol. 1996; 13(4):317-25. View abstract
  351. Genomic organization and chromosomal localization of the mouse Bp3 gene, a member of the CD38/ADP-ribosyl cyclase family. Immunogenetics. 1996; 45(1):35-43. View abstract
  352. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell. 1995 Dec 29; 83(7):1079-89. View abstract
  353. Promotion of V(D)J recombinational accessibility by the intronic E kappa element: role of the kappa B motif. Int Immunol. 1995 Dec; 7(12):1995-2003. View abstract
  354. A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion. Genomics. 1995 Nov 20; 30(2):320-8. View abstract
  355. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 1995 Oct 19; 377(6550):635-8. View abstract
  356. The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus. Immunity. 1995 Oct; 3(4):439-47. View abstract
  357. Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells. Int Immunol. 1995 Oct; 7(10):1637-47. View abstract
  358. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity. 1995 Oct; 3(4):521-30. View abstract
  359. Bone marrow B lymphocyte development in c-abl-deficient mice. Cell Immunol. 1995 Oct 01; 165(1):44-54. View abstract
  360. The role of Bruton's tyrosine kinase in B-cell development and function in mice and man. Ann N Y Acad Sci. 1995 Sep 29; 764:27-38. View abstract
  361. Defective B cell development and function in Btk-deficient mice. Immunity. 1995 Sep; 3(3):283-99. View abstract
  362. Potential targets for autosomal SCID mutations. Curr Opin Immunol. 1995 Aug; 7(4):436-40. View abstract
  363. Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4763-7. View abstract
  364. Expression and induction of nuclear factor-kappa B-related proteins in thymocytes. J Immunol. 1995 Apr 01; 154(7):3213-21. View abstract
  365. CD3 epsilon and CD3 zeta cytoplasmic domains can independently generate signals for T cell development and function. Immunity. 1995 Apr; 2(4):401-11. View abstract
  366. Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene. Nature. 1995 Mar 30; 374(6521):470-3. View abstract
  367. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell. 1995 Mar 10; 80(5):813-23. View abstract
  368. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12135-9. View abstract
  369. Antibody response elicited by T-dependent and T-independent antigens in gene targeted kappa-deficient mice. Int Immunol. 1994 Dec; 6(12):1839-47. View abstract
  370. Nuclear factors that mediate intrathymic signals are developmentally regulated. J Exp Med. 1994 Dec 01; 180(6):2321-7. View abstract
  371. An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 1994 Sep 15; 371(6494):221-6. View abstract
  372. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science. 1994 Sep 02; 265(5177):1442-5. View abstract
  373. IL-2 receptor alpha chain expression during early B lymphocyte differentiation. Int Immunol. 1994 Aug; 6(8):1265-8. View abstract
  374. Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells. J Exp Med. 1994 Jul 01; 180(1):261-72. View abstract
  375. CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression. Int Immunol. 1994 Jul; 6(7):995-1001. View abstract
  376. A class switch control region at the 3' end of the immunoglobulin heavy chain locus. Cell. 1994 Jun 03; 77(5):737-47. View abstract
  377. Mechanisms that control antigen receptor variable region gene assembly. Semin Immunol. 1994 Jun; 6(3):185-96. View abstract
  378. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev. 1994 May 01; 8(9):1043-57. View abstract
  379. The expression of Vpre-B/lambda 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell. 1994 Apr 08; 77(1):133-43. View abstract
  380. Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells. Immunity. 1994 Apr; 1(1):65-72. View abstract
  381. Probing immune functions in RAG-deficient mice. Curr Opin Immunol. 1994 Apr; 6(2):313-9. View abstract
  382. Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching. Int Immunol. 1994 Apr; 6(4):491-7. View abstract
  383. A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation. J Biol Chem. 1994 Mar 11; 269(10):7439-42. View abstract
  384. S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EMBO J. 1994 Feb 01; 13(3):665-74. View abstract
  385. Intact antiinfluenza virus immune response in targeted kappa-deficient mice. Viral Immunol. 1994; 7(1):25-30. View abstract
  386. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J. 1993 Dec; 12(12):4635-45. View abstract
  387. A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination. Mol Cell Biol. 1993 Oct; 13(10):6223-30. View abstract
  388. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science. 1993 Sep 17; 261(5128):1584-8. View abstract
  389. A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon. EMBO J. 1993 Sep; 12(9):3529-37. View abstract
  390. Binding of myc proteins to canonical and noncanonical DNA sequences. Mol Cell Biol. 1993 Sep; 13(9):5216-24. View abstract
  391. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science. 1993 Aug 27; 261(5125):1171-5. View abstract
  392. Comparison of RAG gene expression in normal and transformed precursor lymphocytes. Int Immunol. 1993 Aug; 5(8):997-1000. View abstract
  393. Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells. Curr Biol. 1993 Jul 01; 3(7):405-13. View abstract
  394. Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus. Int Immunol. 1993 Jun; 5(6):647-56. View abstract
  395. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4528-32. View abstract
  396. Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3705-9. View abstract
  397. Impairment of V(D)J recombination in double-strand break repair mutants. Science. 1993 Apr 09; 260(5105):207-10. View abstract
  398. Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status. J Exp Med. 1993 Apr 01; 177(4):1079-92. View abstract
  399. Gene rearrangement and B-cell development. Curr Opin Immunol. 1993 Apr; 5(2):194-200. View abstract
  400. DNA binding by N- and L-Myc proteins. Oncogene. 1993 Apr; 8(4):1093-8. View abstract
  401. B cell development in mice that lack one or both immunoglobulin kappa light chain genes. EMBO J. 1993 Mar; 12(3):821-30. View abstract
  402. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science. 1993 Feb 05; 259(5096):822-5. View abstract
  403. LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A. 1993 Jan 01; 90(1):227-31. View abstract
  404. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev. 1992 Dec; 6(12A):2248-57. View abstract
  405. VDJ recombination. Immunol Today. 1992 Aug; 13(8):306-14. View abstract
  406. A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. EMBO J. 1992 Jul; 11(7):2759-67. View abstract
  407. T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells. J Immunol. 1992 Jul 01; 149(1):60-4. View abstract
  408. Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines. EMBO J. 1992 Jul; 11(7):2727-34. View abstract
  409. Functional homology between N-myc and c-myc in murine plasmacytomagenesis: plasmacytoma development in N-myc transgenic mice. Oncogene. 1992 Jun; 7(6):1241-7. View abstract
  410. Function and control of recombination-activating gene activity. Ann N Y Acad Sci. 1992 May 04; 651:277-94. View abstract
  411. Transcriptional down-regulation of N-myc expression during B-cell development. Mol Cell Biol. 1992 Apr; 12(4):1578-84. View abstract
  412. High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice. J Exp Med. 1992 Feb 01; 175(2):313-22. View abstract
  413. Mutational analyses of lymphocyte differentiation. Harvey Lect. 1992-1993; 88:97-114. View abstract
  414. Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes. Genes Dev. 1992 Jan; 6(1):61-70. View abstract
  415. Activities involved in V(D)J recombination. Curr Top Microbiol Immunol. 1992; 182:107-14. View abstract
  416. E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice. Oncogene. 1991 Nov; 6(11):1941-8. View abstract
  417. Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts. Mol Cell Biol. 1991 Nov; 11(11):5551-61. View abstract
  418. Diversity of immunoglobulin heavy chain gene segment rearrangement in B lymphoblastoid cell lines from X-linked agammaglobulinemia patients. Eur J Immunol. 1991 Oct; 21(10):2355-63. View abstract
  419. Complexity of the immunoglobulin light chain V kappa 1 gene family in the New Zealand black mouse. Int Immunol. 1991 Aug; 3(8):751-60. View abstract
  420. Structure and expression of human germline VH transcripts. J Exp Med. 1991 Jun 01; 173(6):1529-35. View abstract
  421. VH gene usage in humans: biased usage of the VH6 gene in immature B lymphoid cells. Eur J Immunol. 1991 May; 21(5):1311-4. View abstract
  422. Correlation between the occurrence of lupus nephritis, anti-erythrocyte autoantibodies and V kappa haplotype in NZB x 129/J and NZB x SM/J recombinant inbred murine strains. Eur J Immunol. 1991 Apr; 21(4):959-65. View abstract
  423. Structure and expression of canary myc family genes. Mol Cell Biol. 1991 Mar; 11(3):1770-6. View abstract
  424. DNA recombination in the brain? Curr Biol. 1991 Feb; 1(1):3-5. View abstract
  425. myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res. 1991; 57:1-46. View abstract
  426. Control of immunoglobulin heavy chain constant region gene expression. Adv Exp Med Biol. 1991; 292:245-51. View abstract
  427. Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors. Mol Cell Biol. 1991 Jan; 11(1):440-4. View abstract
  428. Molecular cloning of a human immunoglobulin heavy chain variable (vh) region with anti-myelin-associated glycoprotein activity. J Neuroimmunol. 1990 Dec; 30(2-3):245. View abstract
  429. IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. EMBO J. 1990 Nov; 9(11):3659-66. View abstract
  430. Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice. J Exp Med. 1990 Jun 01; 171(6):1909-18. View abstract
  431. Differential regulation of the N-myc gene in transfected cells and transgenic mice. Mol Cell Biol. 1990 May; 10(5):2096-103. View abstract
  432. Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon. Mol Cell Biol. 1990 Apr; 10(4):1672-9. View abstract
  433. A novel fluorescence-based system for assaying and separating live cells according to VDJ recombinase activity. Mol Cell Biol. 1990 Apr; 10(4):1697-704. View abstract
  434. Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. J Immunol. 1990 Apr 01; 144(7):2821-8. View abstract
  435. High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination. Mol Cell Biol. 1990 Apr; 10(4):1799-804. View abstract
  436. Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice. J Exp Med. 1990 Mar 01; 171(3):843-59. View abstract
  437. Are myc proteins transcription factors? Cancer Cells. 1990 Mar; 2(3):69-75. View abstract
  438. Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate. EMBO J. 1990 Jan; 9(1):117-25. View abstract
  439. Expression and function of myc family genes. Crit Rev Oncog. 1990; 2(1):75-95. View abstract
  440. Human heavy chain variable region gene diversity, organization, and expression. Int Rev Immunol. 1990; 5(3-4):203-14. View abstract
  441. Structure and expression of germline immunoglobulin gamma 3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching. Int Immunol. 1990; 2(7):621-7. View abstract
  442. VH to VHDJH rearrangement is mediated by the internal VH heptamer. Int Immunol. 1990; 2(6):579-83. View abstract
  443. Molecular cloning of a human immunoglobulin heavy chain variable (VH) region with anti-myelin-associated glycoprotein activity. J Neuroimmunol. 1990 Jan; 26(1):35-41. View abstract
  444. Immunology: making antigen-receptor genes. Nature. 1989 Dec 21-28; 342(6252):863-4. View abstract
  445. Evolution of immunoglobulin genes: VH families in the amphibian Xenopus. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):8010-4. View abstract
  446. Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene. J Exp Med. 1989 Oct 01; 170(4):1347-55. View abstract
  447. The molecular events in heavy chain class-switching. Semin Immunol. 1989 Sep; 1(1):65-77. View abstract
  448. Molecular characterization of the lymphoid V(D)J recombination activity. J Biol Chem. 1989 Jun 25; 264(18):10327-30. View abstract
  449. Frequency of VH-gene utilization in human EBV-transformed B-cell lines: the most JH-proximal VH segment encodes autoantibodies. J Autoimmun. 1989 Jun; 2 Suppl:203-13. View abstract
  450. Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements. J Exp Med. 1989 Apr 01; 169(4):1391-403. View abstract
  451. IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO J. 1989 Apr; 8(4):1121-8. View abstract
  452. Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J. 1989 Mar; 8(3):735-42. View abstract
  453. Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu Rev Genet. 1989; 23:605-36. View abstract
  454. Chromosomal location of N-myc and L-myc genes in the mouse. Oncogene Res. 1989; 4(1):47-54. View abstract
  455. T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line. Int Immunol. 1989; 1(1):66-74. View abstract
  456. Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia. Int Immunol. 1989; 1(4):362-6. View abstract
  457. Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells. J Exp Med. 1988 Dec 01; 168(6):2385-9. View abstract
  458. Gene expression in renal growth and regrowth. J Urol. 1988 Nov; 140(5 Pt 2):1145-8. View abstract
  459. Structure of the gamma/delta T cell receptor of a human thymocyte clone. J Exp Med. 1988 Oct 01; 168(4):1481-6. View abstract
  460. N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization. J Cell Biol. 1988 Oct; 107(4):1325-35. View abstract
  461. Reconstruction of an immune system. Science. 1988 Sep 23; 241(4873):1581-3. View abstract
  462. The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell. 1988 Aug 12; 54(4):453-60. View abstract
  463. Developmentally regulated and strain-specific expression of murine VH gene families. J Exp Med. 1988 Jul 01; 168(1):417-35. View abstract
  464. N-myc oncogene expression in histopathologically unrelated bilateral pediatric renal tumors. Cancer. 1988 May 01; 61(9):1821-6. View abstract
  465. Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching. Cell. 1988 Apr 22; 53(2):177-84. View abstract
  466. Structure and expression of germ line immunoglobulin gamma 2b transcripts. Mol Cell Biol. 1988 Apr; 8(4):1849-52. View abstract
  467. Sequence and organization of the human T cell delta chain gene. Eur J Immunol. 1988 Feb; 18(2):283-7. View abstract
  468. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Curr Top Microbiol Immunol. 1988; 141:100-9. View abstract
  469. Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching. Ann N Y Acad Sci. 1988; 546:9-24. View abstract
  470. Structure and expression of the human and mouse T4 genes. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9155-9. View abstract
  471. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes Dev. 1987 Dec; 1(10):1311-26. View abstract
  472. Development of the primary antibody repertoire. Science. 1987 Nov 20; 238(4830):1079-87. View abstract
  473. Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO J. 1987 Nov; 6(11):3299-305. View abstract
  474. Structure and expression of the murine L-myc gene. EMBO J. 1987 Nov; 6(11):3359-66. View abstract
  475. Amplification of IMR-32 clones 8, G21, and N-myc in human neuroblastoma xenografts. Cancer Res. 1987 Jun 15; 47(12):3291-5. View abstract
  476. Circular T-cell receptor gene recombination products. Nature. 1987 May 21-27; 327(6119):189-90. View abstract
  477. High frequency of autoantibodies bearing cross-reactive idiotopes among hybridomas using VH7183 genes prepared from normal and autoimmune murine strains. J Clin Invest. 1987 Apr; 79(4):1044-53. View abstract
  478. Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells. EMBO J. 1987 Mar; 6(3):577-84. View abstract
  479. T cell receptor B chain rearrangements in human suppressor T lymphocytes. Transplant Proc. 1987 Feb; 19(1 Pt 1):811-4. View abstract
  480. Differentiation antigens associated with the function of alloreactive T lymphocytes. Transplant Proc. 1987 Feb; 19(1 Pt 1):268-72. View abstract
  481. Expression of the immunoglobulin heavy-chain variable gene repertoire. Curr Top Microbiol Immunol. 1987; 135:75-94. View abstract
  482. Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature. 1986 Dec 11-17; 324(6097):585-9. View abstract
  483. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J. 1986 Dec 01; 5(12):3259-66. View abstract
  484. Enhanced expression of the N-myc gene in Wilms' tumors. Cancer Res. 1986 Dec; 46(12 Pt 1):6217-22. View abstract
  485. Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire. Bioessays. 1986 Nov; 5(5):197-203. View abstract
  486. Fine specificity, idiotypy, and nature of cloned heavy-chain variable region genes of murine monoclonal rheumatoid factor antibodies. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8293-7. View abstract
  487. Amplification and rearrangement of DNA sequences from the chromosomal region 2p24 in human neuroblastomas. Cancer Res. 1986 Oct; 46(10):5297-301. View abstract
  488. VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments. EMBO J. 1986 Sep; 5(9):2131-8. View abstract
  489. Immunoglobulin heavy chain gene rearrangements in X-linked agammaglobulinemia. Eur J Immunol. 1986 Aug; 16(8):963-7. View abstract
  490. Antibody diversity. New mechanism revealed. Nature. 1986 Aug 28-Sep 3; 322(6082):772-3. View abstract
  491. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature. 1986 Jul 10-16; 322(6075):179-81. View abstract
  492. Regulation of immunoglobulin variable-region gene assembly. Mt Sinai J Med. 1986 Mar; 53(3):166-9. View abstract
  493. Structure and expression of the murine N-myc gene. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1827-31. View abstract
  494. Regulation of genome rearrangement events during lymphocyte differentiation. Immunol Rev. 1986 Feb; 89:5-30. View abstract
  495. Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell. 1986 Jan 31; 44(2):251-9. View abstract
  496. Myc family genes: a dispersed multi-gene family. Ann Clin Res. 1986; 18(5-6):284-9. View abstract
  497. The human myc gene family. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 2:931-41. View abstract
  498. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature. 1986 Jan 2-8; 319(6048):73-7. View abstract
  499. Regulation of the assembly and expression of variable-region genes. Annu Rev Immunol. 1986; 4:339-68. View abstract
  500. Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature. 1985 Sep 26-Oct 2; 317(6035):353-5. View abstract
  501. N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5455-9. View abstract
  502. Developmentally controlled and tissue-specific expression of unrearranged VH gene segments. Cell. 1985 Feb; 40(2):271-81. View abstract
  503. Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line. Mol Cell Biol. 1984 Dec; 4(12):2905-10. View abstract
  504. Exclusive immunoglobulin genes. Nature. 1984 Dec 6-12; 312(5994):502-3. View abstract
  505. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature. 1984 Nov 29-Dec 5; 312(5993):418-23. View abstract
  506. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature. 1984 Oct 25-31; 311(5988):752-5. View abstract
  507. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature. 1984 Oct 25-31; 311(5988):727-33. View abstract
  508. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 1984 Jun; 3(6):1209-19. View abstract
  509. Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line. Cell. 1984 May; 37(1):105-12. View abstract
  510. Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell. 1983 Dec; 35(2 Pt 1):359-67. View abstract
  511. Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):4069-73. View abstract
  512. Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. Cell. 1982 Oct; 30(3):807-16. View abstract
  513. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):4118-22. View abstract
  514. Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines. Mol Cell Biol. 1982 Apr; 2(4):386-400. View abstract
  515. Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line. Nature. 1982 Mar 25; 296(5855):325-31. View abstract
  516. Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell. 1981 Dec; 27(2 Pt 1):381-90. View abstract
  517. Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development. Proc Natl Acad Sci U S A. 1981 Mar; 78(3):1823-7. View abstract
  518. Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation. Cell. 1981 Feb; 23(2):369-78. View abstract
  519. Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain. Cell. 1980 Aug; 21(1):1-12. View abstract
  520. Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell. 1980 Jun; 20(2):293-301. View abstract
  521. Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harb Symp Quant Biol. 1978; 42 Pt 2:649-57. View abstract