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Research Fellowship Opportunities | Overview

Postdoctoral Research Fellow: Biobehavioral Research Lab

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Postdoctoral Fellowship in Biobehavioral Research Laboratory, Boston Children’s Hospital/Harvard School of Medicine (Michelle Bosquet Enlow, Ph.D.)

Job Summary

The Biobehavioral Research Laboratory, under the direction of Michelle Bosquet Enlow, Ph.D., seeks a highly qualified postdoctoral fellow with an interest in developmental psychopathology and neurodevelopment. The ideal candidate will have experience in EEG and related methods (e.g., evoked potential [ERP]), and the analytic/statistical skills to relate such data to a wealth of existing and to-be-collected clinical and behavioral data. The individual selected for this position will be integrated into a longitudinal study initially focused on the neural correlates of emotion perception, overseen by Charles A. Nelson, Ph.D., who collaborates with Dr.Bosquet Enlow on the current project. The infants in the original study have been followed over the past decade. Current activities are focused on the developmental psychopathology of anxiety, with a particular focus on EEG and related methods, integrated with physiological, behavioral, and clinical methods.

Eligible applicants should have training in clinical or developmental psychology or developmental cognitive neuroscience, ideally with solid experience in neuroscience methods (particularly EEG) and experience with children. The fellow will have the opportunity to supervise and mentor research coordinators/assistants and undergraduate students and will be expected to have extensive involvement in data processing and analysis, and, correspondingly, in manuscript preparation and grant writing. Experience in advanced signal processing and statistical skills are desirable, as is clinical/developmental psychopathology experience. Applicants with less EEG experience but strong clinical experience, particularly in the area of child anxiety, will also be strongly considered.

This position is open for a possible start date as early as November 1st 2022. A 2-year commitment is preferred. Applications will be accepted until the position is filled.

Qualifications:

  • Doctoral degree in clinical or developmental psychology, neuroscience, or cognitive neuroscience, with a history of research focused on neurodevelopment and/or child anxiety
  • Experience conducting research with children
  • Excellent interpersonal, clinical, and research skills
  • Experience with EEG/ERP
  • Clinical experience, particularly with child anxiety

Application Information

A complete application includes 1 copy of each of the following items (please include your full name on every page of your application):

  1. Letter of interest
  2. CV
  3. Names and contact information for three references

For consideration, please submit an application to Dr. Michelle Bosquet Enlow (michelle.bosquet@childrens.harvard.edu)

Postdoctoral Research Fellow: Wedel Lab

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Job Summary

Research in the Wedel Lab at the Transplant Research Program, Division of Nephrology, Boston Children’s Hospital/Harvard Medical School relates to the understanding and exploration of molecular mechanisms required for the development of transplant tolerance following solid organ transplantation. We are a new laboratory at Boston Children’s Hospital creating and developing tools to understand immunoregulation. Current methodologies include high throughput assays such as bulk- and single cell RNA-sequencing, ATAC-seq and proteomics to understand modulatory signaling networks that promote the resolution of inflammation in conventional T cells and/or optimize regulatory T cell (Treg) function and lineage stability. We combine bioinformatic approaches with advanced immunological in vitro and in vivo models to discover immunoregulatory mechanisms, including identification of novel immune cell types and signaling networks that can be exploited to induce operational tolerance following solid organ transplantation and/or are of relevance in autoimmunity.

A Postdoctoral Fellow Positions is now available for an enthusiastic, highly motivated, and intellectually curious researcher interested in transplant immunology research. Candidates must hold a doctoral degree (PhD, MD, MD/PhD or the equivalent) in immunology or related fields, and have laboratory research experience including mammalian cell isolation, cell culture, flow cytometry and cell sorting, immunological mouse models and immunological in vitro techniques such as ELISPOT, Luminex and/or CyTOF. This position is ideal for individuals with specific interest in employing high throughput methodologies to study modulation of pro-inflammatory stimuli, the resolution of inflammation and/or immunoregulation. The ideal candidate has experience in computer programing (R or python), bioinformatics and integration of multiomic datasets. Dr. Wedel provides one-on-one direct mentorship and additional training through his interactions with the Computational Health Informatics Program at Boston Children’s Hospital. Candidates are expected to work independently and collaboratively support additional efforts within the group. Strong oral and written communication skills, advanced analytical and critical thinking, excellent organizational and recordkeeping capabilities with attention to detail, and personal and professional integrity are required. This should be reflected by at least one first-authored publication in a respected peer-reviewed journal.

The Wedel Lab is located at Boston Children’s Hospital and is affiliated with Harvard Medical School, the Transplant Research Program, Division of Nephrology, and the Computational Health Informatics Program of the Boston Children’s Hospital. We actively support a vibrant, highly collaborative, multidisciplinary, and inclusive environment that consists of enthusiastic transplant immunologist, biostatisticians, and physician-scientists. We believe that a diverse, inclusive, and collaborative team is essential for the success of our research program and therefore strongly encourage candidates from underrepresented groups to apply. Salary will follow NIH guidelines commensurate with training and experience.

Interested candidates should send a cover letter & CV to:

Johannes.wedel@childrens.harvard.edu

Johannes Wedel, MD, PhD
Assistant Professor of Pediatrics, Harvard Medical School
Affiliate Faculty, Computational Health Informatics Program, Boston Children’s Hospital
Research Faculty, Transplant Research Program, Division of Nephrology, Boston Children’s Hospital

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Postdoctoral Research Fellow: Sampson Lab

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Job Summary

The focus of the Sampson Lab at Boston Children’s Hospital/Harvard Medical School is to discover the molecular basis of nephrotic syndrome through human genomics to inform mechanisms, treatments, and cures for this disease. We integrate genomics data with other molecular and clinical datasets to discover the biological and clinical impact of the disease-associated genomic variants we discover. Our research also focuses on using multiomics datasets and cellular model systems to make definitive genomic diagnoses for individuals patients with nephrotic syndrome.

We now seek an enthusiastic and intellectually curious researcher interested in these broad research areas, particularly in leading investigations into personalized, next-generation approaches to genomic diagnosis.

Specific topic of interests include:

  • Co-analysis of germline genome sequencing and kidney/fibroblast-derived omics data in patients with nephrotic syndrome
  • Analysis of long-read genome and RNA-sequencing from kidney tissue
  • Genome-wide association studies and eQTL studies of kidney diseases and traits

The applicant will have a strong understanding of human genetics, bioinformatics, and/or genome biology and skills in high-performance computing. They will use both well-established and newer methods for generation and analysis of diverse types of genomic data, including genome and exome sequencing, and bulk and single cell transcriptomics. They will drive their own projects and also support the efforts of other members of the group.

The Sampson Lab is located at Boston Children’s Hospital and is affiliated with Harvard Medical School. Brigham & Women’s Hospital, and the Broad Institute of MIT and Harvard. It is well-funded through multiple Federal grants and other resources. It is a vibrant, highly collaborative, and multidisciplinary environment made up of nephrologists, computational geneticists, biostatisticians, and epidemiologists, and bench researchers

Responsibilities:

  • Leading investigations into personalized, next-generation approaches to genomic diagnosis for children with proteinuric kidney disease.
  • Designing, troubleshooting, and analysis of diverse genomic discovery efforts using our own genomic phenotypic data those aggregated from publicly available resources
  • Communication with external collaborators, and contributions to the preparation of manuscripts, grants, and presentations

Minimum Qualifications:

  • PhD in genetics/genomics, biocomputing/bioinformatics, statistics, or a related field
  • Experience in any of the following: human genetics/genomics, variant calling, rare diseases, single cell approaches
  • Programming experience in UNIX, R, and/or Python
  • Familiarity with high-performance and/or cloud computing
  • Evidence of prior publication(s) and conference/oral presentations
  • Willingness to collaborate and interact with others

Preferred qualifications:

  • Working with bioinformatics analysis pipelines, code version control (e.g., git) tools and/or experience with standard bioinformatic tools (e.g., samtools, PLINK, bedtools)
  • Familiarity with reproducible data science using Jupyter Notebook or RMarkdown or other
  • An understanding of biological systems

Interested candidates should send a cover letter & CV to:

matthew.sampson@childrens.harvard.edu

Matt Sampson, MD MSCE
Warren E. Grupe Chair in Pediatric Nephrology, Boston Children’s Hospital
Associate Professor of Pediatrics, Harvard Medical School
Associate Member, Broad Institute Research Faculty, Brigham and Women’s Hospital

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Postdoctoral Fellowship Position: Laboratory for Biomaterials and Drug Delivery

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Description

The LBDD at Boston Children’s Hospital/Harvard Institute of Medicine is seeking a highly motivated postdoctoral research fellow that is interested in aptamer identification, modification, manufacturing, and application in in vitro and in vivo models focusing on drug design and delivery. Our lab’s overall goal is to understand and to develop customizable drug delivery systems.

Preferred qualifications include:

  • Aptamer chemistry, including synthesis
  • Molecular techniques for analysis and application of aptamer qualities
  • Animal handling, breeding, & surgical skills for experiments
  • Cell culture and associated techniques
  • Ability to work independently and as part of a team
  • Basic statistical methods
  • 0-3 years of post-doctoral expertise
  • MD and/or PhD

 

Salary is competitive and commensurate with years of post-doctoral experience/qualifications

Please send CV, statement of interest, and 3 references to both:

Daniel Kohane, MD, PhD

Christopher Weldon, MD, PhD

Postdoctoral Fellowship Position: Hematology/Oncology at Agarwal Lab

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Description

The Agarwal Laboratory at the Division of Hematology/Oncology at Boston Children’s Hospital, in affiliation with the Stem Cell Program and Harvard Stem Cell Institute, seeks a highly motivated postdoctoral research fellow to study RNA and telomere biology in human bone marrow failure syndromes. Our laboratory applies genetics, reprogramming, genome editing technologies, and small molecule approaches to patient-derived samples to study normal stem cell biology as well as the basis of stem cell failure and disease (Nagpal N., et al, Cell Stem Cell, 2020). The current research aims to understand gene regulation in order to identify novel approaches for the therapeutic manipulation of telomeres and non-coding RNAs.

The position offers an exciting opportunity to work closely with basic and translational scientists in a highly collaborative and stimulating environment in the Division of Hematology/Oncology at BCH, in the vibrant Longwood / Harvard Medical Area. An explicit goal of our work is to translate laboratory discoveries into novel therapies – small molecule-, genetic-, and/or cell-based – for patients with blood and bone marrow failure disorders. This is an excellent opportunity for scientists and physicianscientists who aim not only to further our fundamental understanding of biology, but also to see these advances applied to human diseases.

Requirements

The candidate should have a Ph.D. or an M.D./Ph.D or equivalent training. The position seeks applicants with a strong background in one or more relevant areas including molecular biology (particularly RNA or telomere biology), genome editing, protein biochemistry, development of animal models, and high-throughput screens.

Interested applicants should e-mail their CV, a cover letter indicating research experience, interests and goals, and names / contact information for at least three academic references to Dr. Suneet Agarwal at suneet.agarwal@childrens.harvard.edu, copied to Esther Kayode (esther.kayode@childrens.harvard.edu).

Postdoctoral Dry Lab Position: Gutierrez-Arcelus Lab

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The Gutierrez-Arcelus Lab at Boston Children’s Hospital and Harvard Medical School is seeking dry lab postdoctoral research fellow to work on systems immunology of immune mediated diseases. This is a fully funded position for at least two years. The postdoctoral fellow will be conducting research mainly in collaboration with Dr. Janet Chou’s lab to understand the role of obesity in multisystemic inflammatory syndrome in children (MIS-C). This will involve analyzing single cell and other functional genomics datasets, as well as genetic variation data..

The Gutierrez-Arcelus Lab is an interdisciplinary group that utilizes genetics and multi-omics quantitative approaches to deepen our understanding of human gene regulation, how it varies between individuals, and how these regulatory differences contribute to immune-mediated disease. The lab is part of the Division of Immunology at Boston Children’s Hospital, and Harvard Medical School. We have both dry and wet lab space, and we collaborate with immunology laboratories. The Boston area is a vibrant and dynamic scientific community that offers unique opportunities for scientific growth.

Successful candidates must hold or soon receive a PhD, MD, or MD/PhD in the field of immunology, biological sciences, genomics, biostatistics, bioinformatics, or other quantitative sciences; and should have a track record of research achievements and ability to work independently and collaboratively in a team. Other desired (but not required) skills for this position are an immunology background, transcriptomics or epigenomics background, and human genetics background.

Interested applicants should email maria.gutierrez-arcelus@childrens.harvard.edu with their CV.

Postdoctoral Fellowship Position: Decision Modeling and Cancer Survivorship

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The Division of General Pediatrics at Boston Children’s Hospital is seeking a highly motivated and capable decision scientist, epidemiologist or outcomes researcher with an interest in cancer prevention and survivorship. The fellow will work closely with Dr. Jennifer Yeh and her team on several NCI-funded projects across the cancer continuum, focusing primarily on childhood cancer and breast cancer. The work will entail using simulation models and conducting comparative and cost-effectiveness analyses to provide insight on important clinical and policy questions surrounding cancer control and disparities in high-risk populations. Leading original analyses and manuscripts, career development, and transition towards an independent research career will be the main areas of emphasis. The fellow will join a stimulating, interdisciplinary research environment with the opportunity to attend seminars, colloquia, and other regularly scheduled research activities at Boston Children’s Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute and partnering institutions.

Minimum Qualification

  • PhD, ScD or an equivalent doctoral degree in decision science, epidemiology, health services research, applied mathematics, computer science, or related quantitative field
  • Experience working with microsimulation models in general programming languages, such as C++, Java or R
  • Experience with model development and parameterization, economic evaluation and outcomes research
  • Familiarity and interest in cancer prevention, treatment and survivorship
  • Strong analytical and quantitative skills
  • Excellent written and oral communication skills
  • Demonstrated ability to work independently and with teams

Start Date

  • January 2023 (flexible)

Additional Details

  • The fellowship is a one-year, full-time commitment, renewable for a second year upon mutual consent. There will be opportunities for the fellow to write and submit his/her individual grant applications (e.g. career development grant) and develop new projects. The fellow will have a Harvard Medical School postdoctoral appointment.

How to Apply

Interested candidates should contact Dr. Jennifer Yeh with any questions and submit their CV, a detailed cover letter, one writing sample, and two academic references to jennifer.yeh@childrens.harvard.edu

Postdoctoral Fellowship Position: Decision Modeling and Cancer Survivorship

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The Division of General Pediatrics at Boston Children’s Hospital is seeking a highly motivated and capable decision scientist, epidemiologist or outcomes researcher with a strong interest in cancer survivorship. The fellow will work closely with Dr. Jennifer Yeh on several projects across the cancer continuum, focusing primarily on childhood cancer. The work will entail simulation modeling, cost-effectiveness analyses and comparative modeling. Leading original analyses and manuscripts, career development, and transition towards an independent research career will be the main areas of emphasis. The fellow will join a stimulating, interdisciplinary research environment with the opportunity to attend seminars, colloquia, and other regularly scheduled research activities at Boston Children’s Hospital, Harvard Medical School, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute and partnering institutions.

Minimum Qualification

  • PhD, ScD or an equivalent doctoral degree in decision science, epidemiology, applied mathematics, computer science, or related quantitative field
  • Experience working with microsimulation models in general programming languages, such as C++, Java or R
  • Experience with model development and parameterization, economic evaluation and outcomes research
  • Familiarity and interest in cancer prevention, treatment and survivorship
  • Strong analytical and quantitative skills
  • Excellent written and oral communication skills
  • Demonstrated ability to work independently and with team

Start Date

  • Summer or Fall 2022

Additional Details

  • The fellowship is a one-year, full-time commitment, renewable for a second year upon mutual consent. There will be opportunities for the fellow to write and submit his/her individual grant applications (e.g. career development grant) and develop new projects. The fellow will have a Harvard Medical School postdoctoral appointment.

How to Apply

Interested candidates should submit their CV, a detailed cover letter, one writing sample, and two academic references to Dr. Jennifer Yeh, jennifer.yeh@childrens.harvard.edu

Postdoctoral Fellowship Position: Division of Immunology

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A postdoctoral position is available for an enthusiastic scientist to work in the area of regulatory T cell immunology. The position is located at the division of Immunology, Boston Children’s Hospital and Harvard Medical School under the supervision of Dr. Louis-Marie Charbonnier. This lab focuses on elucidating the mechanisms involved in the breakdown of immune tolerance in monogenic disorders of immunity, autoimmune diseases and allergic inflammatory disorders, with a particular focus on the role of regulatory T cells in disease pathogenesis. More specifically, the projects involve the regulatory circuitries underlying Treg cell fate decisions, Treg cell heterogeneity and reprogramming as well as metabolic and molecular therapeutics to promote immune tolerance, in the context of autoimmunity, Hyper IgE syndrome and Primary Immunodeficiencies.

Relevant articles:

  1. Charbonnier LM, Wang S, Georgiev P, Sefik E and Chatila TA. Control of Peripheral Tolerance by Regulatory T Cell-Intrinsic Notch signaling. Nat. Immunol. 2015 Nov;16(11):1162-73

  2. Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, Garcia-Lloret MI, Chen K, Ozen A, Carmeliet P, Li MO, Pellegrini M, Chatila TA. Functional reprogramming of regulatory T cells in the absence of Foxp3. Nat Immunol. 2019 Sep;20(9):1208-1219

  3. Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, Garcia-Lloret MI, Ruemmele F, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, André I, Chatila TA, Mathis D, Benoist C. Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat Immunol. 2021 May;22(5):607-619.

  4. Abdel-Gadir A, Stephen-Victor E, Gerber GK, Noval Rivas M, Wang S, Harb H, Wang L, Li N, Crestani E, Spielman S, Secor W, Biehl H, DiBenedetto N, Dong X, Umetsu DT, Bry L, Rachid R, Chatila TA. Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy. Nat Med 2019 Jul;25(7):1164-1174.

This position is ideal for an individual with high interest in high throughput methodologies (scRNA-seq, ChIP-seq, ATAC-seq) to study basic and translational Treg cell immunoregulatory functions and development. Candidates are expected to be independent and self-motivated with experience and/or knowledge of contemporary high-throughput sequencing techniques as well as immunological mouse models, human blood sample processing as well as cell culture, flow cytometry and cell sorting. Candidates must hold a doctoral degree (PhD, MD, or the equivalent) in molecular , cell biology, immunology or related fields. Those with experience in Primary Immunodeficiencies, mouse models of immunology, mammalian cell isolation, cell culture, flow cytometry, in vitro gene manipulation, RNA isolation and handling, hands-on expertise in molecular biology and transcription regulation are highly encouraged to apply. Performing high-throughput sequencing library preparation is highly desirable. In addition, strong oral and written communication skills, excellent organizational and recordkeeping skills with high attention to detail, the ability to work independently as well as collaboratively with others, personal and professional integrity and flexibility in work scheduling are highly valued.

To apply, interested individuals should submit their CV, a cover letter outlining interests and accomplishments to Dr. Louis-Marie Charbonnier: Loius-Marie.Charbonnier@childrens.harvard.edu

Salary will follow NIH guidelines commensurate with training and experience. Boston Children’s Hospital, Harvard Medical School is an Affirmative Action/Equal Opportunity Employer.

Interdisciplinary–Translational Post-Doctoral Training Program in Neurodevelopment

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Postdoctoral research fellowships

Two year fellowships funded by the National Institute of Mental Health (NIMH) are available for MD, PhD, MD/PhD applicants from the fields of psychiatry, psychology, pediatrics, neurology, genetics, neuroscience, developmental biology, computer science and related fields who seek to improve or expand their ability to conduct interdisciplinary-translational research in neurodevelopmental disorders.

Trainees accepted into the postdoctoral training program will work collaboratively with two program mentors (one preclinical and one clinical), who will help to define, enhance and monitor the trainee’s research program and career trajectory. The training program also offers various didactic courses and activities (e.g.,workshops on research methods and grant writing, journal club and career lunches) to promote professional development.

This program has an outstanding success rate for training postdoctoral fellows who go on to become highly productive independent researchers. Creative, energetic and dedicated candidates are particularly encouraged to apply, as are candidates from backgrounds typically underrepresented in higher education.

The application deadline is April 15th, with the expectation that trainees will be selected by May 2nd and will start July 1st, 2022. Applicants must be U.S. citizens or permanent residents with an MD and/or PhD (must be completed at the time training begins). Commitment to the goals of the program and strong academic and research credentials are important criteria used in the selection process. For additional information on the T32 training program and application procedures, please contact the Program Administrator, Gregory Geisel at T32translationaldevelopment@childrens.harvard.edu

Boston Children’s Hospital / Harvard Medical School is committed to affirmative action, equal opportunity and the diversity of its workforce. We are an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.

Postdoctoral Fellowship Position: Henderson Lab

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Postdoctoral Fellow

Positions is available within the Division of Immunology at Boston Children’s Hospital to spearhead studies on the pathogenesis of juvenile arthritis. This position is ideal for candidates interested in translational immunology research and bioinformatics. A minimum two-year commitment is required.The research project will utilize human samples to study interactions between and T and B cells in the arthritic joint that may drive inflammatory arthritis in children. There will be a focus on understanding the functionality of several Treg subsets in the joint that were recently identified by the PI. Multidimensional analyses will be used to conduct the research, including flow cytometry, mass cytometry, bulk RNAseq, single cell RNAseq, metabolomics, high throughput T and B cell repertoire analysis, autoantibodyarrays, and in vitro functional assays. These techniques are all well established in the Lab, which will allow the Postdoctoral Fellow to learn in a supportive environment. In addition, there are plans to leverage CRISP-Cas to study the function of candidate transcription factors in human immune cells.

The PI is a NIH funded faculty member within the Division of Immunology and a practicing pediatric rheumatologist. The Lab has experience in leveraging detailed immunophenotyping to understand human diseases. The PI has established an infrastructure for translational research in pediatric rheumatology at Boston Children’s Hospital, including active IRB protocols and a large biorepository. The Postdoctoral Fellow will also have the opportunity to participate in patient based research in a pediatric setting and learn the intricacies of maintaining a biorepository. The Division of Immunology is a vibrant and collaborative research community that provides many opportunities to interact with other PIs and trainees. Further, the Postdoctoral Fellow will have access to the larger Harvard Medical School environment for training, access to core facilities, and seminars.

The applicant should have a PhD or MD with substantial laboratory/translational research experience related to immunology, molecular/cellular biology, and/or bioinformatics. Individuals with a master’s degree in bioinformatics will also be considered. The ideal candidate will have solid experience in computer programing and bioinformatics as a major focus of the project will include the analysis of complex data sets. If desired, the PI will support further training/classwork in bioinformatics through the Harvard Chan Bioinfromatics Core and other program in the Harvard system. The applicant should have a track record of productivity and an ability to work independently. The Postdoctoral Fellow should also be able to collaborate with others and function as a member of a research team. Potential for partial self-funding is welcome but not essential.

Interested applicants should email a current CV, the names/contact information for 2-3 references, and a brief statement on your experience and goals relevant to this position to:

Lauren A. Henderson, MD, MMSc
Attending Physician in Pediatric Rheumatology, Boston Children's Hospital
Assistant Professor of Pediatrics, Harvard Medical School
Laura.henderson@childrens.harvard.edu

Postdoctoral Fellowship Position: Division of Immunology

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A Postdoctoral Fellow Positions is available within the Division of Immunology at Boston Children’s Hospital to spearhead studies on the pathogenesis of juvenile arthritis. This position is ideal for candidates interested in translational immunology research and bioinformatics. A minimum two-year commitment is required. The research project will utilize human samples to study interactions between and T and B cells in the arthritic joint that may drive inflammatory arthritis in children. There will be a focus on understanding the functionality of several Treg subsets in the joint that were recently identified by the PI. Multidimensional analyses will be used to conduct the research, including flow cytometry, mass cytometry, bulk RNAseq, single cell RNAseq, metabolomics, high throughput T and B cell repertoire analysis, autoantibody arrays, and in vitro functional assays. These techniques are all well established in the Lab, which will allow the Postdoctoral Fellow to learn in a supportive environment. In addition, there are plans to leverage CRISP-Cas to study the function of candidate transcription factors in human immune cells.

The PI is a NIH funded faculty member within the Division of Immunology and a practicing pediatric rheumatologist. The Lab has experience in leveraging detailed immunophenotyping to understand human diseases. The PI has established an infrastructure for translational research in pediatric rheumatology at Boston Children’s Hospital, including active IRB protocols and a large biorepository. The Postdoctoral Fellow will also have the opportunity to participate in patient based research in a pediatric setting and learn the intricacies of maintaining a biorepository. The Division of Immunology is a vibrant and collaborative research community that provides many opportunities to interact with other PIs and trainees. Further, the Postdoctoral Fellow will have access to the larger Harvard Medical School environment for training, access to core facilities, and seminars.

The applicant should have a PhD or MD with substantial laboratory/translational research experience related to immunology, molecular/cellular biology, and/or bioinformatics. Individuals with a master’s degree in bioinformatics will also be considered. The ideal candidate will have solid experience in computer programing and bioinformatics as a major focus of the project will include the analysis of complex data sets. If desired, the PI will support further training/classwork in bioinformatics through the Harvard Chan Bioinfromatics Core and other program in the Harvard system. The applicant should have a track record of productivity and an ability to work independently. The Postdoctoral Fellow should also be able to collaborate with others and function as a member of a research team. Potential for partial self-funding is welcome but not essential.

Interested applicants should email a current CV, the names/contact information for 2-3 references, and a brief statement on your experience and goals relevant to this position to:

Lauren A. Henderson, MD, MMSc
Attending Physician in Pediatric Rheumatology, Boston Children’s Hospital
Assistant Professor of Pediatrics, Harvard Medical School
Lauren.henderson@childrens.harvard.edu

Postdoctoral Research Fellow in Cancer Biology: Vakili Lab

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Applications are currently being accepted for a postdoctoral fellow to join the laboratory of Khashayar Vakili at Boston Children’s Hospital/Harvard Medical School, Boston, Massachusetts. Our research focuses on liver cancer biology by analyzing patient-derived tumors and developing in vitro models with a focus on translational studies.

Qualified candidates must have a PhD or MD/PhD degree with a strong background in advanced molecular biology, gene editing, cloning, 3-D cell culture techniques, as well as an in-depth understanding of cancer biology. Candidates must be self-motivated and possess strong communication/organizational skills along with a collaborative attitude. A strong record of scientific achievement is strongly preferred. Salary will be determined based on the candidate’s experience and qualifications.

Please send cover letter, CV, and information for at least three references to:
Khashayar Vakili, MD c/o Tyler Vaz
tyler.vaz@childrens.harvard.edu

Postdoctoral Fellowship Position: Ke Yuan Lab

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An opening position of postdoctoral research fellow is available in Dr. Ke Yuan’s Lab in the Department of Pediatrics at Boston Children’s Hospital/Harvard Medical School. Both positions utilize cutting-edge interdisciplinary research and aim to understand the critical role of vascular cells including pericytes during angiogenesis and abnormal vascular remodeling in pulmonary arterial hypertension (PAH) and other pulmonary vascular diseases.

Postdoctoral Research Fellow:

Highly motivated Ph.D. with a strong background in one or more of the following areas Cell/Molecular/Developmental Biology, Rodent(mouse/rat) Genetics, and related biomedical science fields are encouraged to apply. The candidate must also have enthusiasm, excellent critical thinking skills, a track-record of productivity as demonstrated by at least one first-author peer-reviewed publication, an ability to work well both independently and as part of a team, and proficiency in written and oral English communication. Prior experience with right ventricular pressure measurements in rodents, confocal, primary cell culture, bioinformatics (Single-cell sequencing, ChIP-seq) and data analysis, and CRISPR mediated genome editing would be an advantage.

What we will offer you:

A successful candidate will have the opportunity to lead independent and and cutting-edge research projects with a world-class research facility while obtaining valuable experience with the relevant technology that prepares well for future positions in academia or industry. We will also provide a customizable curriculum, individual career development/support, and Interdisciplinary and collaborative research community.

To apply, please send 1) a cover letter with a brief statement of research experience and future proposed interests, 2) a detailed curriculum vitae to: ke.yuan@childrens.harvard.edu

Postdoctoral Research Fellow: Fu Lab

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The laboratories of Drs. Lois Smith, MD, PhD, and Zhongjie Fu, PhD, are seeking a talented and motivated research fellow in the field of retinal angiogenesis and retinal degeneration. The position is available immediately and the fellow will be co-mentored by Drs. Smith and Fu. This study involves using both genetic and pharmacologic approaches in animal models to study the mechanisms and identify potential therapeutics in vascular eye diseases, and for retinal neuronal degeneration. This includes (but is not limited to) a specific focus on the investigation of lipid metabolism in retinal vascular and neuronal diseases (glaucoma, retinal degeneration, retinopathy of prematurity).

Requirement:•Ph.D. in biomedical science or related fields with 0-1 years of experience.

  • Proficiency with experimental design, implementation and analysis.
  • Ability and willingness to work independently while also part of a dynamic research team.
  • Proficiency in written and spoken English.

Preferred

  • Experience with rodent care and animal husbandry, but a willingness to be trained in animal handling and husbandry techniques is acceptable.
  • Experience in retinal research.

Interested candidate please send a cover letter detailing your research interests and career objective, and CV with names of three references addressed to: Zhongjie Fu, PhD, Assistant Professor of Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Email: FuLAB.BCH@gmail.com

Postdoctoral Fellow in Eye Research: Chen Lab

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A National Institutes of Health-funded postdoctoral research fellow position is available immediately in Jing Chen Lab in the Department of Ophthalmology at Boston Children’s Hospital and Harvard Medical School to study the molecular basis of eye diseases. The successful candidate will perform research in animal models of eye diseases using both genetic and pharmacological approaches to study the underlying molecular mechanisms and identify potential therapeutics for vascular and neuronal degenerative eye diseases, including retinopathy of prematurity and age-related macular degeneration (AMD). Current projects in the lab include:

  1. Wnt signaling-mediated blood-retinal barrier control and vascular leakage
  2. nuclear receptor-mediated retinal pigment epithelium oxidative damage and degeneration in dry AMD
  3. a lipid-sensing nuclear receptor mediates chronic ocular inflammation in retinal aging and AMD

This position offers the opportunity to be trained with various techniques including. but not limited to, in vivo rodent retinal fundus and OCT imaging, confocal imaging and other skills needed for eye research, and access to cutting-edge techniques such as single-cell RNA sequencing. In addition, there will be many opportunities to enrich the training experience both within Boston Children’s Hospital and at surrounding Harvard-affiliated research institutions, to present research at local and national conferences, and to gain valuable collaborative network in ophthalmology and other related fields of medicine. Previous research fellow mentees have successfully gone on to independent positions in academic and/or industrial institutions.

Job responsibilities:

The research fellow will assist the PI in designing experiments; performing molecular, cellular, and imaging analysis in the projects; presenting findings in local seminars and national professional meetings; writing manuscripts for peer review; and assisting with research grant writing and reporting. Detailed information of the lab’s research can be found at Jing Chen Lab.

Requirements

  • PhD in molecular biology, cell biology, immunology, visual science, or a related field
  • track record of productive publishing in scientific journals
  • expertise in one or more of the following research areas preferred: molecular and cellular biology, immunology, vascular biology, lipid biology, ophthalmology, aging, oxidative stress, and transcription factor studies
  • ability to work independently and also in a team environment

Interested candidates should send a cover letter detailing their research interests and career goals, as well as a CV with names of three references, to Jing Chen, PhD, Associate Professor of Ophthalmology, Boston Children’s Hospital and Harvard Medical School, at chenlab.boston@gmail.com.

Postdoctoral Wet, Dry Lab Positions: Gutierrez-Arcelus Lab

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The Gutierrez-Arcelus Lab at Boston Children’s Hospital and Harvard Medical School is seeking wet lab and dry lab postdoctoral research fellows to work on systems immunology of immune mediated diseases. Experimental projects include studying B cells to understand lupus pathogenesis and heterogeneity. Computational projects include analyzing single cell profiling and other functional genomics datasets for the understanding of immune-mediated diseases, including lupus and multisystem inflammatory syndrome in children (MIS-C).

The Gutierrez-Arcelus Lab is an interdisciplinary group that utilizes genetics and multi-omics quantitative approaches to deepen our understanding of human gene regulation, how it varies between individuals, and how these regulatory differences contribute to immune-mediated disease. The lab is part of the Division of Immunology at Boston Children’s Hospital, and Harvard Medical School. We have both dry and wet lab space, and we collaborate with immunology laboratories. The Boston area is a vibrant and dynamic scientific community that offers unique opportunities for scientific growth.

Successful candidates must hold or soon receive a PhD, MD, or MD/PhD in the field of immunology, biological sciences, genomics, biostatistics, bioinformatics, or other quantitative sciences; and should have a track record of research achievements and ability to work independently and collaboratively in a team. Other desired (but not required) skills for this position are an immunology background, transcriptomics or epigenomics background, and human genetics background.

Interested applicants should email maria.gutierrez-arcelus@childrens.harvard.edu with their CV.

Postdoctoral Research Position: Whitman Lab

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The Whitman Lab is a young lab that provides room for growth and independence, along with mentoring by an MD/PhD clinician-scientist. In addition to professional development opportunities within the lab and the Department of Ophthalmology, the fellow will have ample opportunities to take advantage of the vibrant scientific community of Boston Children’s Hospital, Harvard Medical School, and its affiliated hospitals.

The Whitman Lab focuses on the molecular mechanisms of eye movement disorders, specifically the genetics of strabismus and the development of the ocular motor nerves. We approach these questions using a variety of cutting-edge techniques, including whole exome and whole genome sequencing of strabismus patients, modeling human genetic variants that increase risk of strabismus in human-induced pluripotent stem cells, a variety of functional assays for genetic variants, slice cultures of developing oculomotor nerve, and clearing and 3-D confocal microscopy of mutant mouse models. A full list of publications can be found here.

Requirements

Candidates should have a PhD or equivalent degree in genetics, the biological sciences, neurobiology, bioinformatics, or a related field. Candidates with an MD degree and significant research experience will also be considered. This position is ideal for a self-motivated, reliable, organized, and detail-oriented individual interested in genetics and developmental neuroscience research and working in a highly collaborative, dynamic environment.

Interested candidates should have past training and experience in one or more of the following:

  • genetic analyses including linkage, whole genome, and whole exome sequencing analysis
  • CRISPR protocols
  • luciferase assays
  • cell culture protocols
  • immunohistochemistry
  • fluorescence and confocal microscopy
  • image analysis and quantification

Application process

Review of applications will begin immediately and continue until the position is filled. Interested applicants should submit an application by email to mary.whitman@childrens.harvard.edu.

Required documents include:

  • cover letter including summary of your research experience, scientific interests, and academic and career goals
  • curriculum vitae
  • reference list including contact information (minimum of three)

Compile all documents into one PDF file in the order listed above.

The Whitman Lab is committed to diversity and inclusivity; Members of groups underrepresented in science are encouraged to apply.

Postdoctoral Positions: Zhou Lab

The Zhou Lab at Boston Children’s Hospital and Harvard Medical School is recruiting one to two postdoctoral fellows to join a growing team.

Learn more about the positions

The Zhou Lab at Boston Children’s Hospital and Harvard Medical School is recruiting one to two postdoc fellows to join a growing team. The lab is broadly interested in understanding molecular and cellular mechanisms that regulate tissue homeostasis and inflammation.

Mammalian tissues are ecological communities of diverse cell types. It has been more appreciated that immune cells are integral members of tissue ecosystem. We are interested in studying how immune cells communicate with their tissue neighbors and surrounding environment to maintain homeostatic states of tissues, and how dysregulation of cell-cell and cell-environment interactions may lead to inflammatory disorders. We use a combination of mammalian tissue culture, animal disease models, flow cytometry, immunological analysis, live-cell imaging, genetics, genomics, and computational approaches toward this goal. Our research interests include dissecting the molecular mechanisms and physiological impact of the interactions between immune and non-immune cell types (macrophages, fibroblasts, epithelial cells) as well as understanding the immunological functions of sensing tissue microenvironment. Ultimately, we aim to leverage the understanding of tissue homeostasis and inflammation to program immune cells to combat inflammatory disorders. Areas of potential projects include:

  1. macrophage-fibroblast circuit communication in the context of inflammation
  2. roles of sensing pH in modulating immune response
  3. novel approaches to identify cell-cell interactions and program innate immune response

Postdoctoral fellows: Candidates must have a good publication record, and are expected to finish full-time PhD or MD/PhD training within 12 months or have received the degrees in less than 2 years. Exceptional candidates with two or more years previous postdoctoral training will be considered as well. We are building a team with talented individuals from diverse backgrounds. Those with experience in immunity, mucosal immunology, systems biology, or relevant fields are strongly encouraged to apply, but this is not required. Prospective applicants please send the following materials to Xu Zhou (xu.zhou@childrens.harvard.edu).

  1. cover letter briefly stating your research achievement and future interests
  2. CV
  3. contact information of two to three references

Postdoctoral Position: Pal Lab

Learn more about the role

There is an immediate opening for a postdoctoral research fellow position in the laboratory of Dr. Soumitro Pal.

The applicant has to be a PhD in any branches of biological science (preferably within first year after completion of PhD); and must be motivated and hard working. Needs some experience in molecular biology/immunological techniques/flow cytometry/cancer-related works. The fellowship will be according to the National Institutes of Health scale.

Job description

The project involves mechanistic studies for the immune escape of tumor cells (mostly renal cancer cells); and the role(s) of tyrosine kinase receptors and metabolic pathways within the tumor cells. Both in vitro (tissue culture) and in vivo (murine models) approaches will be utilized.

Contact address

Soumitro Pal, PhD
Associate Professor
Harvard Medical School
Associate Director of Research
Division of Nephrology
Boston Children's Hospital
300 Longwood Avenue
Boston, MA 02115
Email: soumitro.pal@childrens.harvard.edu
Profile

Postdoctoral Position: Sleep Medicine/Sleep Health Education

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Boston Children’s Hospital/Harvard Medical School is seeking applications for an 18-month postdoctoral fellowship position beginning July 1, 2022 (or a mutually agreed-upon date). This research and clinical training fellowship represents a unique opportunity to combine interest in pediatric behavioral sleep medicine and sleep health education in the primary care setting.

The fellowship structure consists of a full-time opportunity to conduct clinical sleep research as part of a grant-funded initiative in sleep health education in pediatric primary care settings. The project will focus on the development, implementation, and evaluation of a sleep health and wellness education program targeting low-income racial/ethnic minority school-aged children, their caregivers, and their healthcare providers.

The fellow will be involved in project development and implementation, subject recruitment, data collection and analysis, and abstract and manuscript preparation. Research training will be directed by Judith Owens, MD MPH, the Co-Director of the BCH Sleep Medicine Program and Professor of Neurology at Harvard Medical School. Additional collaborators include Rebecca Robbins. PhD, an Associate Scientist in the Division of Sleep and Circadian Disorders at Brigham and Women’s Hospital and Instructor in Medicine at the Harvard Medical School, and Monica Ordway, PhD, PPCNP, a nurse-scientist and pediatric nurse practitioner at the Yale Pediatric Sleep Clinic and Associate Professor at Yale School of Nursing.

The fellow will be able to take advantage of the considerable education and training resources in the Division of Sleep Medicine at Harvard Medical School. In addition, an option to obtain additional clinical training in behavioral sleep medicine is available under the supervision of Eric Zhou PhD, Assistant Professor of Pediatrics at Harvard Medical School, and Dr. Owens.

Qualifications:

Applicants must have a doctoral degree in a relevant field (e.g., psychology, nursing). An established track record of research productivity is preferred. Candidates should demonstrate established quantitative research skills, experience in analysis of data, excellent written and oral communication skills, and the ability to work independently and with collaborators.

A competitive salary, benefits, and travel/educational opportunities in the rich interdisciplinary environment of Harvard Medical School and its many affiliated institutions are offered.

To apply, please send a cover letter, CV, contact information for three references, and one research sample (e.g., publication) by email to Dr. Owens at Judith.owens@childrens.harvard.edu.

Postdoctoral Position: Tang Lab

Join the Tang Lab to understand brain function and dysfunction: from model to mechanism to medicine

Learn more about the role

The Tang Lab in the Boston Children’s Hospital Department of Neurosurgery is recruiting highly motivated and talented postdoctoral fellows in the areas of molecular/cellular neuroscience, electrophysiology, or cancer biology to join our growing team. We are committed to understanding the molecular and cellular basis of human brain disorders to develop precision medicine therapeutics that relieve disease symptoms. With a focus on neurodevelopmental disorders, epilepsy, and brain cancer, we employ an integrated translational research approach that leverages technologies spanning genome engineering, human stem cell differentiation, organoid culture, single cell-omics, bioinformatics, biochemistry, electrophysiology, and high-throughput drug/gene screening.

The lab is funded by the Simons Foundation Autism Research Initiative (SFARI) through a SFARI Bridge to Independence Career Transition Award, and with startup funding from Boston Children’s Hospital. We operate in a spacious, fully equipped lab on the top floor of the Center for Life Sciences building, located at the heart of the Longwood medical biotechnology hub and within the larger Boston research community. With full access to state-of-the-art facilities and research services, our lab closely interfaces with both research teams at the F.M. Kirby Center and clinicians in the BCH Neurosurgery Department. More information about the lab can be found on our website.

Applicants who have a PhD degree or be nearing completion of it, in the fields broadly related to neuroscience or cancer biology, are strongly encouraged to apply. The best candidates will be comfortable working both independently and in a team setting to lead research projects, with an approach that demonstrates high ethical standards, responsibility, organization, and thoroughness. Dr. Tang is committed to promoting diversity and scientific excellence in his lab, and will work closely with you during your scientific training and formulate a career development plan with you, tailored to your professional and personal goals. To apply, please send a cover letter outlining your research interests and qualifications, a CV, and contact information for three references to Dr. Tang: xin.tang@childrens.harvard.edu.

Dr. Xin Tang’s diversity and mentorship statement

I am firmly committed to proactively supporting diversity, equity, and inclusion at Boston Children’s Hospital and the F.M. Kirby Neurobiology Center. My personal experience as an immigrant scientist, studying and working in the U.S., gave me first-hand knowledge of the importance of these values. I feel very fortunate to have had the educational and career support I’ve received, and I am dedicated to providing them to the next generations of researchers. It’s my cherished belief that scientific research aiming to understand universal truths is, by definition, a global collaboration, one providing a fair, merit-based, safe, and collegial forum through which everyone can communicate and contribute.

My lab and I will strive to ensure that every talented individual, regardless of gender, ethnic background, religion, sexual orientation, or nationality, is given equal opportunities to excel. Throughout my career, I have been deeply engaged in teaching and mentoring students and young scientists from diverse backgrounds, including underrepresented minorities, at different stages of their careers. If you become a member of our research team, your scientific progress and career development are my priority.

Postdoctoral Fellow: DART Lab

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The postdoctoral fellow will be responsible for developing novel methodologies and applications integrating data from smartphones and wearables in "real-world" settings, with the rich clinical data offered in hospital settings, and using this framework to evaluate and predict clinical and treatment progression in pediatric patients. The applicant will collaborate with colleagues within Boston Children’s Hospital, Harvard Medical School, and the National Institute of Mental Health in applying these methods in clinical projects related to pediatric chronic pain, mental health, sleep, and substance use. Several exciting projects are available depending on the experience of the candidate. The position includes a number of training opportunities for career development through Harvard Medical School and Boston Children's Hospital. Funding is secure for a minimum of two years.

Given the interdisciplinary nature of the projects, candidates can have a PhD degree (or MD/PhD) in psychology, epidemiology, biomedical informatics, computer science, or a related field. Strong quantitative and/or qualitative skills are necessary. Excellent written and verbal communication skills and project management skills are crucial. Preferred requirements for this position include experience in multilevel modelling and/or machine learning, ecological momentary assessment, and sleep assessment.

Interested candidates should send a cover letter, resume, and the names of three references to the below address. Pre-inquiries are welcome.

Joe Kossowsky, PhD, MMSc
Assistant Professor in Anesthesia, Harvard Medical School
Director, DART Lab, Boston Children’s Hospital
joe.kossowsky@childrens.harvard.edu

Postdoctoral Associate: Engle Lab

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We are currently looking for a collaborative, self-motivated Postdoctoral Associate to work in the laboratory of Dr. Elizabeth Engle at Boston Children’s Hospital (BCH) in the Longwood Medical and Academic Area campus in Boston. The Engle Lab has demonstrated that cranial motor neurons provide a powerful model system for the study of neuronal development and connectivity. The lab identifies human congenital disorders of eye and facial movement, defines their genetic etiologies, and uncovers molecular pathways and disease mechanisms. This informs determinants of motor neuron identity and the targeting of their axons during normal and abnormal development. More information can be found on our website.

The Postdoctoral Associate will have the opportunity to define disease mechanisms underlying human disorders of cytoskeletal development and function through the study of novel mouse models harboring mutations in tubulin- and kinesin-encoding genes.

This is an excellent opportunity for someone with an interest in neuroscience, neurodevelopment, and/or cell biology who wishes to investigate fundamental developmental processes and their impact on human health while working with other passionate scientists in a collegial, project-driven laboratory.

The Engle Lab believes that a diverse, inclusive, and collaborative team is essential for the success of its research program, and Dr. Engle is an experienced mentor dedicated to helping her trainees cultivate professional development skills and success in their independent scientific careers. In addition to professional development opportunities within the lab and exposure to a breadth of scientific disciplines, the postdoctoral associate will be able to take advantage of the vibrant scientific communities of BCH, Harvard Medical School, and its affiliated hospitals, and the Broad Institute of MIT and Harvard.

Preferred qualifications

Education

A PhD and/or MD is required. PhD students in the final year of their thesis work are eligible to apply. Specific degree areas include developmental neuroscience and cell biology (with a strong focus on the cytoskeleton).

Experience

We are looking for candidates with experience managing an independent research project to completion and publication. Experience with a variety of biochemistry and molecular biology techniques is strongly preferred.

To be considered for the neurodevelopment track:

  • Experience working with mice as a genetic model organism is required, and experience managing a mouse colony is strongly preferred.
  • Experience analyzing embryonic mouse neurodevelopment is strongly preferred.

To be considered for the cell biology/cytoskeleton track:

  • Experience working with microtubules and/or microtubule motors is required.
  • Experience with in vitro assays is required.

Skills and abilities

  • Ability to learn quickly and to work both independently and within a team.
  • Ability to work effectively with a wide variety of people from all backgrounds and at all levels of training.
  • Excellent oral and written communication skills.
  • High level of professionalism and excellent interpersonal skills.
  • Positive attitude with a problem-solving, resilient mindset.

Application instructions

Please include the following items as part of your application (preferably as one PDF):

  1. A cover letter including a summary of your research experience, your research interests, and your interest in this particular role.
  2. Your curriculum vitae, including list of publications.
  3. Name and contact information for three references.

To apply, please visit the Howard Hughes Medical Institute's careers page: here.

Postdoctoral Position: Department of Otolaryngology / F.M. Kirby Neurobiology Center

Learn more about the role

Qualifications:

Strong background and experience in electrophysiology.

Responsibilities:

The fellow will lead a program to study hair cell physiology in different mouse models with alterations in genes encoding for the mechanotransduction complex.

Funding is available immediately for a postdoctoral research position in the laboratory of Gwenaëlle Géléoc, PhD, Assistant Professor at Boston Children’s Hospital and Harvard Medical School.

Ongoing work involves the development and use of several mouse models, viral vectors, hair cell physiological recordings, whole animal physiological analyses, and imaging. The current position is open for applicants with a PhD in neuroscience or a related discipline and expertise in single cell electrophysiology. Experience in the auditory field is favored but not required.

The lab situated within the F.M. Kirby Neurobiology Center Children’s Hospital in the new Center for Life Sciences Building, 3rd floor, 3 Blackfan Circle, Boston, MA, adjacent to Boston Children’s Hospital and Harvard Medical School.

Website

Applicants should send a CV, a statement of research interests, and the names and contact information for three references to Dr. Gwenaelle Geleoc: Gwenaelle.Geleoc@childrens.harvard.edu

Boston Children’s Hospital and Harvard Medical School are equal opportunity employers, and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by law.

Postdoctoral Research Fellowship in Interpretable and Fair Machine Learning for Clinical Decision Support

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The Clarity- and Virtue-guided Algorithms (CAVA) Lab at Boston Children's Hospital / Harvard Medical School is seeking a postdoctoral research fellow to advance the interpretability and fairness of machine learning (ML) models deployed in critical healthcare settings. The fellow will join a multidisciplinary team of computer scientists, informaticists, clinicians, engineers, and bioethicists to develop and assess clinical prediction algorithms and advance our understanding of the behavior of machine learning models deployed in health settings.

The fellow will help us think critically about how machine learning methods affect clinical practice and outcomes; in particular, 1) the conditions under which ML provides or fails to provide insight into disease pathologies, and 2) the conditions under which ML exacerbates or mitigates treatment and outcome disparities between patient subgroups.

Prediction models are an increasingly important technology in the digital health landscape, and can produce large-scale changes in health care via their interactions with patients, clinicians, and hospital operations. This postdoctoral fellowship provides an opportunity to study these issues more deeply in order to improve our ability to diagnose and intervene in a more trustworthy and equitable way.

The fellowship includes an academic appointment at Harvard Medical School, as well as a hospital appointment at Boston Children’s Hospital. This position provides an excellent opportunity for the research fellow to work within a multidisciplinary research team to explore advanced areas in health information technology. CHIP is home to 20 faculty working at the forefront of research areas extending beyond clinical prediction algorithms to domains like clinical NLP, digital epidemiology, clinical genomics, and app ecosystems for health records. CHIP and the CAVA Lab value diversity and believe that it is essential to our research goals. We therefore strongly encourage candidates from underrepresented groups to apply.

Admissions

The position is available immediately and is renewable annually.

Qualifications

  • PhD degree in computer science, information science, biomedical informatics, data mining, engineering, applied mathematics, or a closely related field.
  • A track record of high-quality research that demonstrates the ability to independently identify important research topics and carry out experiments.
  • Candidates with strong experience in machine learning, preferably both in the assessment of ML algorithms in data science applications and in the development of novel methods.
  • Experience and familiarity with the machine learning literature on interpretability and fairness
  • Experience working with large, heterogeneous data collections, especially electronic health records, multi-omics data, or other health data
  • Programming experience in Python, R, and/or C++
  • Experience with collaborative software development (revision control, continuous integration, etc.) strongly preferred
  • Experience with open science practices (preprints, reproducible workflows, etc.) strongly preferred
  • Strong written and oral communication skills
  • Ability to work both independently and as a team player

How to apply

Interested candidates should email a CV, three letters of reference, and a sample publication to Dr. William La Cava, PI Clarity and Virtue-guided Algorithms Lab: william.lacava@childrens.harvard.edu.

Postdoctoral Training in Informatics, Genomics, Machine Learning, Artificial Intelligence, and Biomedical Data Science — Boston Children’s Hospital / Harvard Medical School

Learn more about the program

The Computational Health Informatics Program (CHIP) at Boston Children’s Hospital hosts a training program for postdoctoral fellows to be trained in Informatics, Genomics, Machine Learning, Artificial Intelligence, and Biomedical Data Science. The program is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (T32HD040128-16) and is open to U.S. citizens and permanent residents.

CHIP, an affiliate of Harvard Medical School and a collaborating program of the Harvard Medical School Department of Biomedical Informatics, is recruiting postdoctoral fellows. Founded in 1994, CHIP is a multidisciplinary applied research and education program. Biomedical informatics has become a major theme and methodology for biomedical science, health care delivery, and population health, involving high-dimensional modeling and understanding of patients from the molecular to the population levels. We design information infrastructure for medical decision making, diagnosis, care redesign, public health management, and reimagined clinical trials. The field is inherently interdisciplinary, drawing on traditional biomedical disciplines, the science and technology of computing, data science, biostatistics, epidemiology, decision theory, omics, implementation science, and health care policy and management. Our faculty are trained in medicine, data science, computer science, mathematics, and epidemiology. Our faculty have been featured in The New York Times, The Wall Street Journal, ABC News, CNBC, Bloomberg, CNN, Forbes, Financial Times, NBC News, GQ Magazine, U.S. News & World Report, Politico, and BBC News for their expertise on COVID-19.

We seek outstanding candidates passionate about advancing the ability to acquire and then reason over an entire spectrum of data types ranging from molecular and genomic all the way to clinical, epidemiological, environmental, and social. Focus areas may include, but are not limited to, research applications of machine learning/AI including COVID-19, medical applications of machine learning/AI including clinical decision support and predictive medicine, genomic and precision medicine, population health, health IT architectures and standards (e.g., SMART on FHIR apps and infrastructure), reimagined clinical trials, real-world evidence, data visualization, and integrative omics. Candidates should have strong quantitative backgrounds.

Over the past two decades, the program has trained a mix of MDs and PhDs. More than 90 percent have gone on to receive independent funding in faculty positions in academic medicine.

Program structure:

Fellows in the training program work toward independence in two interrelated phases:

  1. Mentored research project: fellows will be mentored by a faculty member of choice and will select a research topic.
  2. Formal course work: trainees may have the option of formal coursework. The program director and faculty mentor work with the fellow to tailor the curriculum based on the skills required for the fellow’s research project and long-term objectives. Often, this can lead to coursework at the Harvard Department of Biomedical Informatics or the Harvard School of Public Health. Many projects have an emphasis on pediatric emergency and acute care.

Admissions:

Applications are open, and admissions are available on a rolling basis.

Eligibility:

Citizens or permanent residents of the United States enrolled in a research doctoral, research postdoctoral, clinical doctoral, or clinical postdoctoral are eligible to apply. Preference will be given to candidates who have, or are seeking, board certification in pediatric emergency medicine, or who have research interests that are aligned with CHIP’s core research areas.

The program has been committed to recruiting and retaining postdoctoral trainees who are URiM. We have maintained our commitment to diversity through prioritizing applications from diverse and disadvantaged backgrounds. Women and underrepresented minority groups are strongly encouraged to apply.

How to apply:

Click here to ask questions. To apply, send a CV, cover letter, personal statement, and three letters of reference to megan.rollins@childrens.harvard.edu.

Studying heart development, stem cell, cardiac regeneration and cardiovascular disease using state-of-the art technologies

We are actively seeking highly motivated young scientists to join our lab as postdoctoral fellows.

Learn more about the role

Our lab studies the molecular mechanisms of heart development, cardiac function, and related diseases. Over the past several years, we focused on the functions of transcription factors and microRNAs, and we have demonstrated their critical roles in heart development, contraction, remodeling, and regeneration (Wang et al., Cell, 105: 851; Chen et al., Nature Genetics, 38:228; Huang et al., JCI, 125, 4122; Ding et al., Nature Genetics, 47:776). We are also studying the function of lncRNAs in the heart and skeletal muscle.

The postdoc candidates have the opportunity to work on exciting projects and state-of-the-art technologies. The Boston Children's Hospital and Harvard Medical School is the preeminent medical school in the country and offers a very rich and varied academic and cultural environment.

Please send your CV and three references to:

Da-Zhi Wang, PhD
Professor, Cardiovascular Research Division
Department of Cardiology
Boston Children's Hospital
Harvard Medical School
Enders 1262.1
320 Longwood Avenue
Boston, MA 02115

E-mail: dwang@enders.tch.harvard.edu
Phone: 617-919-4768
Fax: 617-731-0787
Website

Postdoctoral position: Division of Infectious Diseases

An NIH-funded position is available for an exceptionally talented and motivated postdoctoral fellow seeking to expand his or her knowledge of the host-intestinal microbe interaction by investigating the influence of intestinal pathogens and commensals on host metabolism.

Learn more about the role

The successful candidate will join a vibrant research team exploring the metabolic pathways of intestinal bacteria, their impact on host metabolism, and the role of novel vaccine platforms. He or she will have appointments both at Boston Children’s Hospital and Harvard Medical School, and will participate in the activities of the Infectious Diseases Division at BCH and the Department of Microbiology and Immunobiology at Harvard Medical School.

Recent graduates with a track record of productivity and excellent references are encouraged to apply. Candidates should send a statement of interest and future goals and a curriculum vitae, and should request three letters of reference to be sent directly from mentors familiar with their scientific abilities to paula.watnick@childrens.harvard.edu.

To learn more about our areas of interest, please see:

  • Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host Microbe. 2014 Nov 12;16(5):592-604.
  • Vanhove AS, Hang S, Vijayakumar V, Wong CAN, Asara JM, Watnick PI.Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide, PLoS Pathogens, 2017.

Postdoc in Type 2 diabetes, Obesity, and Metabolism

A postdoctoral fellow position is available in the lab of Dr. Sang Park at Boston Children’s Hospital and Harvard Medical School. We are located in the center of the Longwood medical area (3 Blackfan Circle, Boston). The fields of our interest are obesity, type 2 diabetes, and ER stress.

Learn more about the role

The goal of this project is to understand the molecular mechanisms by which insulin resistance and type 2 diabetes develop in obesity.

The project involves cell culture and mouse experiments.

Background in molecular biology (western blot, DNA/RNA works) is a must requirement. Please visit our website for more information.

Please send your CV and three references’ contact information to: sangpark2014@gmail.com

Postdoc in the Division of Infectious Diseases/Department of Medicine at Boston Children’s Hospital

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The Levy Laboratory is the focal point of the Precision Vaccines Program at Boston Children’s Hospital/Harvard Medical School. The program employs cutting-edge technologies to understand age-specific features of immune responses to inform development of vaccines tailored for optimal safety and immunogenicity towards distinct populations. Due to distinct immunity, most infection-induced death occurs at the extremes of life, and motivating development of improved vaccines that are safe and effective in the young and old. We seek a skilled and motivated postdoctoral scientist with background in Immunology (experience in T and B lymphocyte studies a plus), vaccinology, and/or systems biology and bioinformatics to lead projects employing systems biology to characterize age-specific vaccine responses and development of novel adjuvanted vaccines.

The project will employ recent knowledge in the areas of innate immune pathways (TLRs/inflammasome) and nanoparticle technology to identify adjuvants and enhance immune responses of those at the extremes of age in vitro and in vivo. Studies will employ in vitro modeling of human newborn, adult, and elderly antigen-presenting cells, T and B lymphocytes, as well as in vivo animal and human studies.

Our laboratory, comprised of 12 current members including postdoctoral scientists, clinical fellows, and technicians, is dynamic, international, supportive, and productive. We are well funded by NIH, Gates Foundation, and internal support, as well as multiple sponsored research agreements. We offer excellent opportunities for high-impact research, publication, attendance at scientific meetings, and career advancement, with graduates of the lab holding prominent positions in academia and industry. The candidate should have obtained their PhD within the last one to three years. Interested applicants should email their CV and arrange to have three statements of reference emailed to ofer.levy@childrens.harvard.edu.

Postdoctoral Fellowship in Vascular Biology and Genetics at Harvard Medical School

The D’Amato Lab of the Vascular Biology Program at Boston Children’s Hospital and Harvard Medical School is seeking a highly motivated postdoctoral researcher to study the genetic control of ocular angiogenesis.

Learn more about the role

The project investigates candidate genes found to control angiogenesis in the mouse eye. These candidate genes were identified through genome-wide association studies (GWAS) of inbred mouse strains and further validated in zebrafish. The fellow will lead a program to verify and elucidate the mechanism of action of these genes. The ideal postdoc (MD or PhD) will have a strong background in molecular and mammalian genetics with an interest in vascular biology and ophthalmology. Candidates should be able to work independently and have strong English writing skills. Salary is commensurate with experience. Position is available immediately for two years with potential for renewal and is fully funded with benefits.

If interested, please send via email a CV, a statement of research interests, as well as the names and contact information for three references to:

Dr. Robert D'Amato
Vascular Biology Program
Boston Children's Hospital
300 Longwood Ave.
Boston, MA 02115

robert.damato@childrens.harvard.edu

Website

Postdoctoral Position in Aldovini Lab: Division of Infectious Diseases

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A postdoctoral position is available in the Division of Infectious Diseases at Boston Children’s Hospital and Harvard Medical School to support in a research program on HIV biology and AIDS vaccine development. Highly motivated applicants must have a PhD or MD degree, strong experience in molecular biology and/or immunology techniques, and good communication skills.

Send curriculum vitae with names and addresses of three references to Dr. Anna Aldovini: anna.aldovini@childrens.harvard.edu