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Koutsogiannaki S, Hou L, Okuno T, Shibamura-Fujiogi M, Luo HR, Yuki K. aDb2 as a novel target of experimental polymicrobial sepsis. Front Immunol 2022; 13: 1059996

Hou L, Yuki K. CD11c regulates late-stage T cell development in the thymus. Front Immunol 2022; 13: 1040818.

Shibamura-Fujiogi M, Wang X, Maisat W, Koutsogiannaki S, Li Y, Chen Y, Lee JC, Yuki K. GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus. Commun Biol 2022; 5(1): 1284

Hou L, Voit RA, Shibamura-Fujiogi M, Koutsogiannaki S, Li Y, Chen Y, Luo HR, Sanakaran VG, Yuki K. CD11c regulates neutrophil maturation. Blood Adv 2022

Hamilton ARL, Odegard KC, Yuki K. Exploring noncardiac surgical needs from infancy to adulthood in patients with congenital heart disease. J Cardiothorac Vasc Anesth 2022; 36(12): 4364-4369

Leng F, Zhang W, Ramirez RN, Leon J, Zhong Y, Hou L, Yuki K, van der Veeken J, Rudensky AY, Benoist C, Hur S. The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. Immunity 2022; 55(*): 1369.e8

Koutsogiannaki S, Bu W, Maisat W, Manzor M, Zhang Z, Ohto U, Eckenhoff RG, Yuki K. Propofol directly binds to and inhibits TLR7. FASEB J. 2022; 36(8): e22481

Manzor M, Asztalos G, Yuki K. The role of pulmonary function test in perioperative management of patients with cystic fibrosis Transl Perioper Pain Med 2022; 9(2): 438-444

Maisat W, Bermudez M, Yuki K. Use of clindamycin as an alternative antibiotic prophylaxis. Perioper Care Oper Room Manag. 2022; 28: 100278

Maisat W, Yuki K. Predictive factors for postoperative intensive care unit admission and mechanical ventilation after cardiac catheterization for pediatric pulmonary vein stenosis. J Cardiothorac Vasc Anesth 2022; 36: 2500-2508

Hamilton R, Odegard KC, Yuki K. How should we care for patients with congenital heart diseases undergoing surgical procedures in ambulatory settings? Transl Perioper Pain Med 2022; 9(1): 416-420

Koutsogiannaki S., Okuno T, Kobayashi Y, Ogawa N, Yuki K. Isoflurane attenuates sepsis-associated lung injury. Biochem Biophys Res Commun 2022; 599: 127-133

Hou L, Yuki K. CCR6 and CXCR6 identify the Th17 cells with cytotoxicity in experimental autoimmune encephalomyelitis. Front Immunol 2022; 13: 819224

Koutsogiannaki S, Huang SX, Lukovits K, Kim S, Bernier R, Odegard KC, Yuki K. The characterization of postoperative mechanical respiratory requirement in neonates and infants undergoing cardiac surgery on cardiopulmonary bypass in a single tertiary institution. J Cardiothorac Vasc Anesth 2022; 36(1): 215-221

Niimi N, Yuki K, Zaleski K. Long QT syndrome and perioperative torsades de Pointes: What the anesthesiologist should know. J Cardiothorac Vasc Anesth 2022; 36(1): 286-302



Yuki K, Koutsogiannaki S. Translational role of rodent models to study ventilator-induced lung injury. Transl Perioper Pain Med 2021; 8(4): 404-415

Yuki K. The role of general anesthetic drug selection in cancer outcome. Biomed Res Int 2021; 2021: 2563093

Yuki K, Koutsogiannaki S. Neutrophil and T cell functions in patients with congenital heart disease: A review. Pediatr Cardiol 2021; 42(7): 1478-1482

Yuki K, Koutsogiannaki S. Pattern recognition receptors as therapeutic targets for bacterial, viral and fungal sepsis. Int Immunopharmacol 2021; 98: 107909

Yuki K, DiNardo JA, Koutsogiannaki S. The role of anesthetic selection in perioperative bleeding. Biomed Res Int. 2021; 2021: 5510634

Hamano F, Matoba K, Hashidata-Yoshida T, Suzuki T, Miura K, Hishikawa D, Hayarama T, Yuki K, Kita Y, Noda NN, Shimizu T, Shindou H. FASEB J 2021; 35(6): e21501

Yuki K. The immunomodulatory mechanism of dexmedetomidine. Int Immunopharmacol 2021; 97: 107709

Yuki K, Mitsui Y, Shibamura-Fujiogi M, Hou L, Odegard KC, Soriano SG, Priebe GP, Koutsogiannaki S. Biochem Biophys Res Commun 2021; 557: 254-260

Shibamura-Fujiogi M, Ormsby J, Breibart M, Warf B, Priebe GP, Soriano SG, Sandora TJ, Yuki K. Risk factors for pediatric surgical site infection following neutrosurgical procedures for hydrocephalus: a retrospective single-center cohort study. BMC Anesthesiol 2021; 21(1): 124

Yuki K, Shibamura-Fujiogi M. Surgical site infections and perioperative optimization of host immunity by selection of anesthetics. Biomed Res Int 2021; 2021: 5576959

Out C, Vo V, Staffa SJ, Yuki K, Sullivan CA, Quinonez LG, Brown ML. The use of regional catheters in children undergoing repair of aortic coarctation. J Cardiothorac Vasc Anesth 2021; 35(12): 3694-3699

Shibamura-Fujiogi M, Yuki K, Hou L. Cathepsin L regulates pathogenic CD4 T cells in experimental autoimmune encephalomyelitis. Int Immunopharmacol 2021; 93: 107425

Shibamura-Fujiogi M, Koutsogiannaki S, Hou L, Yuki K. The microbial flora in an experimental polymicrobial abdominal sepsis model probed by 16S rRNA sequencing. Transl Perioper Pain Med 2021; 8(1): 305-311

Tan AYJ, Quiat D, Ghelani SJ, Yuki K. Left ventricular outflow tract gradient is associated with coronary artery obstruction in children with Williams-Beuren syndrome. J Cardiothorac Vasc Anesth 2021; 35(12) 3677-3680

Shibamura-Fujiogi M, Ormsby J, Breibart M, Zalieckas J, Sandora TJ, Priebe GP, Yuki K. The role of anesthetic management in surgical site infections after pediatric intestinal surgery. J Surg Res 2021; 259: 546-554

Yuki K, Hou L, Shibamura-Fujiogi M, Koutsogiannaki S, Soriano SG. Mechanistic consideration of the effect of perioperative volatile anesthetics on phagocytes. Clin Immunol 2021; 222: 108635.



Hou L, Voit RA, Sankaran VG, Springer TA, Yuki K. CD11c regulates hematopoietic stem and progenitor cells under stress. Blood Adv. 2020; 4(24): 6086-6097

Koutsogiannaki S, Bu W, Hou L, Shibamura-Fujiogi M, Ishida H, Ohto U, Eckenhoff RG, Yuki K. The effect of anesthetics on toll like receptor 9. FASEB J 2020; 34(11): 14645-14654

Brustowicz RM, Yuki K. A simple screening test of filtration efficiency for protecting the gas sampling line from coronavirus using fluorescent microsphreres. Paediatr Anaesth 2020; 30(11): 1269-1274

Hou L, Yuki K. Serpin B1 expression in Th17 cells depends on hypoxia-inducible factor 1-a. Int Immunopharmacol 2020; 87: 106826

Mitsui Y, Koutsogiannaki S, Fujiogi M, Yuki K. In vitro model of stretch-induced lung injury to study different lung ventilation regimens and the role of sedatives. Transl Perioper Pain Med 2020; 7(3): 258-264

Shaw R, Tighe N, Odegard KC, Alexander P, Emani S, Yuki K. Intubation precautions in a pediatric patient with severe COVID-19. J Pediatr Surg Case Rep. 2020; 58: 101495

Yuki K. Anesthetic management for heart transplantation in adults with congenital heart disease. Transl Perioper Pain Med 2020; 7(3); 248-252

Yuki K, Fujiogi M, Koutsogiannaki S, COVID-19 pathophysiology: A review. Clin Immunol 2020; 215: 108427

Yuki K, Hou L. Role of b2 integrins in neutrophils and sepsis. Infect Immun 2020; 88(^): e00031-20

Mitsui Y, Hou L, Huang X, Odegard KC, Pereira LM, Yuki K. Volatile anesthetic sevoflurane attenuates Toll-like receptor ½ activation. Anesth Analg 2020; 131(2): 631-639

Yuki K, Scholl R. Should we routinely reverse neuromuscular blockade with sugammadex in patients with a history of heart transplantation? Transl Periop Pain Med 2020; 7(2): 185-189

Lee Y, Banooni A, Yuki K, Staff SJ, DiNardo JA, Brown ML. Incidence and predictors of postoperative nausea and vomiting in children undergoing electrophysiology ablation procedures. Paediatr Anaesth 2020; 30(20: 147-152



Okuno T, Koutsogiannaki S, Hou L, Bu W, Ohto U, Eckenhoff RG, Yokomizo T, Yuki K. Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system. FASEB J. 2019; 33(12): 14528-14541

Hou L, Rao DA, Yuki K, Cooley J, Henderson LA, Johnsson AH, Kaiserman D, Gorman MP, Nigrovic PA, Bird PI, Becher B, Remold-O’Donnell E. Serpin B1 controls encephalitogenic T helper cells in neuroinflammation. Proc Natl Acad Sci USA. 2019; 116(41): 20635-20643

Koutsogiannaki S, Hou L, Babazada H, Okuno T, Blazon-Brown N, Soriano SG, Yokomizo T, Yuki K. The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction. FASEB J. 2019; 33(11): 12668-12679

Kwon R, Koutsogiannaki S, Staffa SJ, Yuki K. The outcome of pediatric hematopoietic stem cell transplantation recipients requiring intensive care unit admission- A single center experience. Transl Perioper Pain Med 2019; 6(3): 75-80

Zha H, Matsunami E, Blazon-Brown N, Koutsogiannaki S, Hou L, Bu W, Babazada H, Odegard KC, Liu R, Eckenhoff RG, Yuki K. Volatile anesthetics affect macrophage phagocytosis. Plos One 2019; 14(5): e0216163

Koutsogiannaki S, Shimaoka M, Yuki K. The use of volatile anestheics as sedatives for acute respiratory distress syndrome. Trasl Perioper Pain Med 2019; 6(2): 27-38

Koutsogiannaki S, Bernier R, Tazawa K, Yuki K. Volatile anesthetic attenuates phagocyte function and worsens bacterial loads in wounds. J Surg Res 2019; 233: 323-330.



Koutsogiannaki S, Zha H, Yuki K. Volatile anesthetic isoflurane attenuates liver injury in experimental polymicrobial sepsis model. Transl Perioper Pain Med 2018; 5(3): 63-74

Aubrey J, Zha H, Yuki K. Incidence and risk factors of perioperative mortality in pediatric ICU patients. Transl Perioper Pain Med 2018; 5(2): 49-54

Yuki K, Lee S, Staffa SJ, DiNardo JA. Induction techniques for pediatric patients with congenital heart disease undergoing noncardiac procedures are influenced by cardiac functional status and residual lesion burden. J Clin Anesth 2018; 50: 14-17

Yuki K, Koutsogiannaki S, Lee S, DiNardo JA. Unanticipated hospital admission in pediatric patients with congenital heart disease undergoing ambulatory noncardiac surgical procedures. Paediatr Anaesth 2018; 28(&): 607-611

Lee S, Reddington E, Koutsogiannaki S, Hernandez MR, Odegard KC, DiNardo JA, Yuki K. Incidence and risk factors for perioperative cardiovascular and respiratory adverse events in pediatric patients with congenital heart disease undergoing noncardiac procedures. Anesth Analg 2018; 127(3): 724-729

Sen M, Koksal AC, Yuki K, Wang J, Springer TA. Ligand- and cation-induced structural alternations of the leukocyte integrin LFA-1. J Biol Chem 2018; 293(17): 6565-6577

Fang ZA, Ghelani SJ, Koutsogiannaki S, DiNardo JA, Yuki K. Validation of a mathematical model of bidirectional Glenn circulation with aortopulmonary collaterals and the implications for Qp/Qs calculation. J Cardiothorac Vasc Anesth 2018; 32(1): 395-401



Yuki K, Matsunami E, Tazawa K, Wang W, DiNardo JA, Koutsogiannaki S. Pediatric perioperative stress response and anesthesia Transl Perioper Pain Med  2017; 2: 1-12

Okuno T, Koutsogiannaki S, Ohba M, Chamberlain M, Bu W, Lin FY, Eckenhoff RG, Yokomizo T, Yuki K. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. FASEB J 2017; 31(4): 1584-1594

Chamberlain M, Koutsogiannaki S, Schaefers MM, Babazada H, Liu R, Yuki K. The differential effects of anesthetics on bacterial behaviors. PLOS ONE 2017; 12: e0170089

Tazawa K, Koutsogiannaki S, Chamberlain M, Yuki K. The effect of different anesthetics on tumor cytotoxicity by natural killer cells. Toxicology Letters 2017; 266: 23-31

Ferradal SL*, Yuki K* (*co-first authors), Vyas R, Ha CG, Yi F, Stopp C, Wypij D, Cheng HH, Newburger J, Kaza A, Franceschini MA, Kussamn BD, Grant EP. Noninvasive assessment of cerebral blood flow and oxygen metabolism in neonates during hypothermic cardiopulmonary bypass. Scientific Reports 2017; 7: 44117

Koutsogiannaki S, Schaefers MM, Okuno T, Ohba M, Yokomizo T, Priebe GP, DiNardo JA, Sulpicio SG, Yuki K. From the Cover: Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis. Toxicol Sci 2017; 156(2): 402-411



Koutsogiannaki S, Schaefers MM, Okuno T, Ohba M, Yokomizo T, Priebe GP, DiNardo JA, Soriano SG, Yuki K. Prolonged exposure to volatile anesthetic isoflurane worsens the outcomes of polymicrobial abdominal sepsis. Toxicological Sciences2016 doi:10.1093/toxsci/kfw261

Liu JR, Yuki K, Baek C, Han XH, Soriano SG. Dexmedetomidine-induced neuroapoptosis is dependent on its cumulative dose. Anesth Analg 2016; 123: 1008-17

Faraoni D, Zurakowski D, Brown M, Vo D, Goobie S, Yuki K, DiNardo JA. Postoperative outcomes in children with and without congenital heart disease using non-cardiac surgery: a propensity matched analysis. J Am Coll Cardiol, 2016; 67: 793-801

Lee J, Faraoni D, Lee S, Odegard KC, Randolph A, DiNardo JA, Yuki K. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Pediatr Anaesth 2016; 26: 644-8

Williams MR, Atkinson DB, Bezzerides VJ, Yuki K, Franklin K, Alexander ME. Pausing with the gauze: Inhibition of temporary pacemakers by RF scan during cardiac surgery. Anesth Analg 2016; 123: 1143-8

Yuki K, Eckenhoff RG. Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review. Anesth Analg 2016; 123: 326-35

Greenwald E, Yuki K. A translational consideration of intracellular adhesion molecule-1 biology in the perioperative setting. Transl Perioper Pain Med 2016; 1: 17-23



Yuki K, DiNardo JA. Comparison of actual oxygen delivery kinetics to those predicted by mathematical modeling following Stage 1 palliation just prior to superior cavopulmonary anastomosis. Paediatr Anaesth 2015; 25: 174-9

Jung S, Yuki K. Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen J Immunotoxicol 2015; 9: 1-9

Liu JR, Han X, Soriano SG, Yuki K. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis World J Clin Cases 2015; 3: 793-806

Yuki K, Murakami N. Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets 2015; 15: 57-69

Whiting D, Yuki K, DiNardo JA. Cardiopulmonary bypass in the pediatric population. Best Pract Res Clin Anesthesiol 2015; 29: 241-56



Kollman CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel D, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer T, Shimaoka M, Evindar G. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen-1 (LFA-1) antagonists Bioorg Med Chem 2014: 22: 2353-65

Bu W, Pereira L, Eckenhoff RG, Yuki K. Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1 Plos One 2014; 9: e96649

Liu JR, Han X, Soriano SG, Yuki K. The role of macrophage 1 antigen in polymicrobial sepsis. Shock 2014; 42; 532-9



Yuki K, Chilson K, DiNardo JA. Improvement of PaO2 during one-lung ventilation with partial left-heart bypass in pediatric patients is caused by increased blood flow to the dependent lung. J Cardiothroac Vasc Anesth 2013; 27: 542-5

Carbo C*, Yuki K*, Demers M, Wagner DD, Shimaoka M (* equally contributed). Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth 2013; 27: 261-8  

Yuki K, Bu W, Shimaoka M, Eckenhoff RG. Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin aIIbb3. PLOS ONE 2013; 8: e60415

Sen M, Yuki K, Springer TA. An internal ligand-bound, metastable state of a leukocyte integrin aXb2. J Cell Biol 2013; 203: 629-642

Yuki K, Bu W, Jin X, Shimaoka M, Eckenhoff RG. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1 Anesth Analg 2013; 117: 803-11

Bertolizio G, Yuki K, Odegard K, Collard V, DiNardo JA. Cardiac arrest and neuromuscular blockade reversal agents in the transplanted heart. J Cardiothroac Vasc Anesth 2013; 27: 1374-8



Koeberle A, Shindou H, Harayama T, Yuki K, Shimizu T Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2012; 26: 169-80

Yuki K, Emani S, DiNardo JA. A mathematical model of transitional circulation toward biventricular repair in hypoplastic left heart syndrome. Anesth Analg 2012; 115: 618-26

Yuki K, Bu W, Xi J, Sen M, Shimaoka M, Eckenhoff RG. Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J 2012; 26: 4408-17

Collard V, Segura LG, Daaboul DG, Yuki K. Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. J Anesth 2012; 26: 273-4

Yuki K, Sharma R, DiNardo J. Ventricular assist device therapy in children. Best Prac Res Clin Anaesthesiol 2012; 26: 247-64



Yuki K, Soriano SG, Shimaoka M. Sedative drug modulates T-cell and lymophocyte function-associated antigen-1 function. Anesth Analg 2011; 112: 830-8

Wesley MC, Yuki K, Daaboul DG, DiNardo JA. Blood utilization in neonates and infants undergoing cardiac surgery requiring cardiopulmonary bypass. World J Pediatr Congenit Heart Surg. 2011; 2: 382-392

Daaboul DG, Yuki K, Wesley MC, DiNardo JA. Anesthetic and cardiopulmonary bypass considerations for cardiac surgery in unique pediatric patient populations: sickle cell disease and cold agglutinin disease. World J Pediatr Congenit Heart Surg. 2011; 2: 364-370

Yuki K, Casta A, Uezono S. Anesthetic management of noncardiac surgery for patients with single ventricle physiology. J Anesth 2011; 25; 247-56

Yuki K, Daaboul DG. Postoperative maladaptive behavioral changes in children. Middle East J Anaesthesiol 2011; 21: 183-9

Yuki K. Cell-free ligand-binding assays for integrin LFA-1. Methods Mol Biol 2012; 757: 73-8





Yuki K, Astrof N, Bracken C, Soriano SG, Shimaoka M.  Sevoflurane binds and allosterically blocks integrin leukocyte function-associated antigen-1 Anesthesiology 2010; 113: 600-609



Yuki K, Shindou H, Hishikawa D, Shimizu T.  Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual function in the testis.  J Lipid Res. 2009; 50: 860-869

Yuki K, Sakuramoto C, Matsumoto C, Hoshino M, Niimi,Y. The effect of left heart bypass on pulmonary blood flow and arterial oxygenation during one-lung ventilation in patients undergoing descending thoracic aortic surgery. J Clin Anesth 2009; 21: 562-566

Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T. Recent progress on acyl-CoA: lysophospholipid acyltransferase research. J Lipid Res. 2009; 50: S46-51

Yuki K, Casta. Management of difficult airway in pediatric patients with right ventricular outflow tract obstruction. J Anesth 2009; 23: 281-283



Yuki K, Astrof N, Bracken C, Yoo R, Silkworth W, Soriano SG, Shimaoka M. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity.  FASEB J 2008; 22: 4109-4116

Casta A, Brown DW, Yuki K. Induction of supraventricular tachycardia during transesophageal echocardiography: an unusual complication. J Cardiothorac Vasc Anesth 2008; 22: 592-3

Yuki K, Shamberger RC, McGowan FX Jr, Seefelder C. The perioperative management of a patient with Fontan physiology for pheochromocytoma resection. J Cardiothorac Vasc Anesth 2008; 22: 748-50



Yuki K, Chilson K, Odegard KC, DiNardo JA. Trendelenburg position, simulated Valsalva maneuver, and liver compression do not alter the size of the right internal jugular vein in patients with a bidirectional Glenn shunt. Anesth Analg 2007; 105: 365-8